Best TWAS P=6.23e-38 · Best GWAS P=1.1e-34 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FLJ33630 | 0.06 | 0.07 | lasso | 6 | 0.07 | 8.6e-09 | 6.10 | 8.8 | 1.2e-18 | -0.52 | 0.62 | 0.38 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CTC-228N24.3 | 0.24 | 0.15 | enet | 16 | 0.20 | 3.4e-16 | -12.28 | 11.8 | 6.1e-32 | -0.97 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | CTC-228N24.3 | 0.24 | 0.16 | enet | 19 | 0.16 | 1.8e-08 | -12.28 | 12.7 | 4.1e-37 | -0.80 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Adrenal Gland | CTC-228N24.3 | 0.34 | 0.10 | lasso | 9 | 0.09 | 4.2e-04 | -9.46 | 10.9 | 9.1e-28 | -0.88 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Artery Aorta | CTC-228N24.3 | 0.20 | 0.04 | lasso | 8 | 0.07 | 7.4e-05 | -6.40 | 11.4 | 5.6e-30 | -0.91 | 0.11 | 0.86 | FALSE |
| 6 | GTEx | Artery Coronary | CTC-228N24.3 | 0.31 | 0.10 | lasso | 3 | 0.10 | 2.9e-04 | -11.78 | 12.2 | 2.6e-34 | -0.86 | 0.01 | 0.90 | FALSE |
| 7 | GTEx | Artery Tibial | CTC-228N24.3 | 0.20 | 0.16 | lasso | 7 | 0.14 | 3.0e-11 | -12.28 | 12.9 | 6.2e-38 | -0.99 | 0.00 | 1.00 | TRUE |
| 8 | GTEx | Brain Caudate basal ganglia | PRRC1 | 0.39 | 0.00 | enet | 5 | 0.06 | 7.1e-03 | -5.90 | 5.9 | 4.4e-09 | -0.19 | 0.07 | 0.05 | FALSE |
| 9 | GTEx | Brain Caudate basal ganglia | CTC-228N24.3 | 0.28 | -0.01 | enet | 50 | 0.05 | 1.2e-02 | 4.50 | 8.3 | 1.0e-16 | -0.30 | 0.04 | 0.55 | TRUE |
| 10 | GTEx | Brain Cerebellar Hemisphere | SLC12A2 | 0.45 | -0.01 | enet | 20 | 0.01 | 2.1e-01 | -8.45 | 6.3 | 3.7e-10 | -0.46 | 0.04 | 0.33 | FALSE |
| 11 | GTEx | Brain Cerebellar Hemisphere | CTC-228N24.3 | 0.25 | 0.00 | lasso | 6 | 0.05 | 2.2e-02 | 0.32 | 7.4 | 1.5e-13 | -0.49 | 0.03 | 0.62 | FALSE |
| 12 | GTEx | Brain Cerebellum | C5orf63 | 0.20 | 0.07 | lasso | 3 | 0.05 | 1.7e-02 | -5.96 | 5.5 | 4.8e-08 | 0.04 | 0.02 | 0.95 | TRUE |
| 13 | GTEx | Brain Cerebellum | CTC-228N24.3 | 0.31 | 0.04 | lasso | 5 | 0.12 | 2.9e-04 | -12.28 | 12.0 | 5.2e-33 | -0.84 | 0.01 | 0.97 | FALSE |
| 14 | GTEx | Brain Frontal Cortex BA9 | CTC-228N24.3 | 0.25 | 0.00 | enet | 26 | 0.05 | 2.2e-02 | 5.28 | 7.3 | 2.6e-13 | -0.36 | 0.08 | 0.30 | FALSE |
| 15 | GTEx | Brain Nucleus accumbens basal ganglia | CTC-228N24.3 | 0.43 | 0.13 | lasso | 6 | 0.18 | 1.7e-05 | 5.28 | 6.2 | 6.1e-10 | -0.28 | 0.81 | 0.03 | FALSE |
| 16 | GTEx | Cells EBV-transformed lymphocytes | CTC-228N24.3 | 0.24 | -0.01 | enet | 26 | 0.04 | 2.2e-02 | -5.71 | 5.5 | 3.3e-08 | -0.57 | 0.03 | 0.70 | FALSE |
| 17 | GTEx | Cells Transformed fibroblasts | CTC-228N24.3 | 0.24 | 0.16 | enet | 26 | 0.16 | 8.6e-12 | -12.28 | 12.5 | 6.8e-36 | -0.89 | 0.00 | 1.00 | FALSE |
| 18 | GTEx | Colon Sigmoid | CTC-228N24.3 | 0.20 | 0.22 | enet | 11 | 0.23 | 1.1e-08 | -11.78 | 11.9 | 8.9e-33 | -0.92 | 0.01 | 0.99 | FALSE |
| 19 | GTEx | Esophagus Gastroesophageal Junction | CTC-228N24.3 | 0.20 | 0.04 | enet | 22 | 0.13 | 2.1e-05 | 6.08 | 9.9 | 2.8e-23 | -0.51 | 0.05 | 0.68 | FALSE |
| 20 | GTEx | Esophagus Mucosa | CTC-228N24.3 | 0.18 | 0.14 | enet | 11 | 0.14 | 9.8e-10 | -12.28 | 12.7 | 7.5e-37 | -0.93 | 0.00 | 1.00 | FALSE |
| 21 | GTEx | Esophagus Muscularis | CTC-228N24.3 | 0.24 | 0.08 | enet | 29 | 0.14 | 1.4e-08 | -11.78 | 12.2 | 4.9e-34 | -0.75 | 0.01 | 0.99 | FALSE |
| 22 | GTEx | Heart Atrial Appendage | CTC-228N24.3 | 0.22 | 0.07 | lasso | 5 | 0.07 | 4.1e-04 | -11.66 | 10.9 | 1.2e-27 | -0.87 | 0.00 | 0.99 | FALSE |
| 23 | GTEx | Heart Left Ventricle | CTC-228N24.3 | 0.24 | 0.15 | lasso | 7 | 0.19 | 1.9e-10 | -10.98 | 11.9 | 6.6e-33 | -0.84 | 0.01 | 0.99 | FALSE |
| 24 | GTEx | Lung | CTC-228N24.3 | 0.18 | 0.14 | enet | 16 | 0.14 | 3.2e-11 | -12.28 | 11.0 | 2.2e-28 | -0.95 | 0.00 | 1.00 | FALSE |
| 25 | GTEx | Muscle Skeletal | CTC-228N24.3 | 0.25 | 0.20 | lasso | 5 | 0.21 | 1.6e-20 | -12.28 | 12.3 | 1.0e-34 | -0.95 | 0.00 | 1.00 | FALSE |
| 26 | GTEx | Nerve Tibial | CTC-228N24.3 | 0.32 | 0.18 | lasso | 10 | 0.16 | 1.6e-11 | -11.78 | 12.1 | 7.5e-34 | -0.96 | 0.01 | 0.99 | FALSE |
| 27 | GTEx | Pancreas | CTC-228N24.3 | 0.14 | 0.19 | lasso | 2 | 0.17 | 1.1e-07 | -12.28 | 12.3 | 1.2e-34 | -1.00 | 0.00 | 1.00 | FALSE |
| 28 | GTEx | Skin Not Sun Exposed Suprapubic | CTC-228N24.3 | 0.29 | 0.21 | lasso | 7 | 0.22 | 1.7e-12 | -12.28 | 11.9 | 1.4e-32 | -0.97 | 0.00 | 1.00 | FALSE |
| 29 | GTEx | Skin Sun Exposed Lower leg | CTC-228N24.3 | 0.29 | 0.17 | enet | 12 | 0.22 | 4.3e-18 | -11.66 | 12.0 | 5.1e-33 | -0.90 | 0.00 | 1.00 | FALSE |
| 30 | GTEx | Spleen | CTC-228N24.3 | 0.26 | 0.03 | enet | 15 | 0.05 | 1.8e-02 | -6.40 | 11.1 | 1.3e-28 | -0.66 | 0.04 | 0.56 | FALSE |
| 31 | GTEx | Stomach | SLC12A2 | 0.23 | 0.17 | enet | 19 | 0.17 | 1.6e-08 | -7.81 | 7.5 | 5.6e-14 | -0.45 | 0.80 | 0.16 | FALSE |
| 32 | GTEx | Stomach | CTC-228N24.3 | 0.17 | 0.04 | lasso | 6 | 0.08 | 1.5e-04 | -10.98 | 11.4 | 3.1e-30 | -0.81 | 0.02 | 0.95 | FALSE |
| 33 | GTEx | Testis | CTC-228N24.3 | 0.30 | 0.16 | lasso | 6 | 0.14 | 1.1e-06 | -12.28 | 11.8 | 3.4e-32 | -0.93 | 0.00 | 1.00 | FALSE |
| 34 | GTEx | Thyroid | CTC-228N24.3 | 0.31 | 0.15 | enet | 32 | 0.18 | 4.6e-14 | -12.28 | 11.7 | 1.2e-31 | -0.78 | 0.00 | 1.00 | FALSE |
| 35 | METSIM | Adipose | CTC-228N24.3 | 0.17 | 0.19 | lasso | 6 | 0.18 | 1.9e-26 | -12.28 | 12.2 | 1.9e-34 | -1.00 | 0.00 | 1.00 | FALSE |
| 36 | ROSMAP | Brain Pre-frontal Cortex | CTC-228N24.3 | 0.15 | 0.09 | lasso | 3 | 0.12 | 8.0e-15 | -12.28 | 10.2 | 1.6e-24 | -0.88 | 0.00 | 1.00 | FALSE |
| 37 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FLJ33630 | 0.05 | 0.04 | enet | 14 | 0.03 | 2.1e-07 | -12.28 | 11.6 | 2.5e-31 | -0.88 | 0.00 | 1.00 | FALSE |
| 38 | The Cancer Genome Atlas | Glioblastoma Multiforme | FLJ33630 | 0.38 | 0.20 | lasso | 5 | 0.17 | 6.5e-06 | -12.28 | 12.2 | 3.7e-34 | -0.99 | 0.00 | 1.00 | FALSE |
| 39 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FLJ33630 | 0.10 | 0.07 | lasso | 3 | 0.08 | 7.0e-09 | -11.78 | 11.4 | 5.5e-30 | -0.95 | 0.00 | 1.00 | FALSE |
| 40 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FLJ33630 | 0.10 | 0.06 | enet | 18 | 0.08 | 2.0e-09 | -12.28 | 10.6 | 4.3e-26 | -0.79 | 0.00 | 1.00 | FALSE |
| 41 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FLJ33630 | 0.14 | 0.00 | blup | 72 | 0.09 | 9.1e-06 | -0.24 | 5.4 | 8.3e-08 | -0.28 | 0.06 | 0.39 | FALSE |
| 42 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FLJ33630 | 0.19 | 0.16 | enet | 4 | 0.16 | 1.2e-17 | -12.28 | 12.2 | 2.2e-34 | -1.00 | 0.00 | 1.00 | FALSE |
| 43 | The Cancer Genome Atlas | Lung Adenocarcinoma | FLJ33630 | 0.07 | 0.05 | lasso | 1 | 0.04 | 1.3e-05 | -11.78 | 11.8 | 4.8e-32 | -0.96 | 0.01 | 0.99 | FALSE |
| 44 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FLJ33630 | 0.09 | 0.08 | lasso | 4 | 0.09 | 4.9e-10 | -12.28 | 12.2 | 2.6e-34 | -1.00 | 0.00 | 1.00 | FALSE |
| 45 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FLJ33630 | 0.08 | 0.03 | lasso | 2 | 0.04 | 5.7e-03 | -11.78 | 12.1 | 9.4e-34 | -0.90 | 0.01 | 0.88 | FALSE |
| 46 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FLJ33630 | 0.08 | 0.05 | blup | 70 | 0.04 | 4.4e-05 | -11.78 | 12.5 | 8.0e-36 | -0.86 | 0.00 | 1.00 | FALSE |
| 47 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC12A2 | 0.04 | 0.02 | enet | 17 | 0.02 | 3.3e-03 | -11.78 | -5.7 | 9.3e-09 | 0.69 | 0.01 | 0.87 | TRUE |
| 48 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FLJ33630 | 0.07 | 0.02 | blup | 70 | 0.02 | 1.5e-02 | -7.16 | 10.6 | 3.9e-26 | -0.48 | 0.12 | 0.14 | FALSE |
| 49 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FLJ33630 | 0.26 | 0.14 | lasso | 3 | 0.13 | 2.2e-05 | -12.28 | 12.6 | 2.3e-36 | -0.99 | 0.00 | 1.00 | FALSE |
| 50 | The Cancer Genome Atlas | Thyroid Carcinoma | FLJ33630 | 0.10 | 0.10 | lasso | 2 | 0.09 | 5.3e-09 | -12.28 | 12.3 | 1.6e-34 | -1.00 | 0.00 | 1.00 | FALSE |