Best TWAS P=1.67e-16 · Best GWAS P=1.63e-24 conditioned to 0.0476
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RAB24 | 0.14 | 0.06 | enet | 14 | 0.09 | 4.2e-11 | 4.8 | 5.5 | 3.6e-08 | -0.31 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Visceral Omentum | MXD3 | 0.33 | 0.06 | lasso | 6 | 0.05 | 9.1e-04 | -6.0 | -6.3 | 4.0e-10 | 0.32 | 0.27 | 0.12 | FALSE |
3 | GTEx | Artery Tibial | MXD3 | 0.12 | 0.13 | enet | 5 | 0.12 | 7.0e-10 | -5.9 | -5.5 | 3.6e-08 | 0.29 | 0.94 | 0.06 | FALSE |
4 | GTEx | Brain Cerebellum | MXD3 | 0.28 | 0.31 | lasso | 2 | 0.30 | 1.6e-09 | -6.0 | -5.9 | 3.1e-09 | 0.32 | 0.48 | 0.47 | FALSE |
5 | GTEx | Cells EBV-transformed lymphocytes | RAB24 | 0.37 | 0.26 | lasso | 6 | 0.24 | 1.7e-08 | -6.1 | 6.6 | 5.5e-11 | -0.52 | 0.21 | 0.79 | FALSE |
6 | GTEx | Colon Sigmoid | MXD3 | 0.35 | 0.27 | lasso | 9 | 0.29 | 6.3e-11 | -6.0 | -5.9 | 2.9e-09 | 0.39 | 0.44 | 0.55 | FALSE |
7 | GTEx | Colon Transverse | PRELID1 | 0.31 | 0.28 | lasso | 4 | 0.26 | 1.1e-12 | -5.9 | 5.9 | 3.0e-09 | -0.34 | 0.97 | 0.03 | FALSE |
8 | GTEx | Esophagus Gastroesophageal Junction | MXD3 | 0.17 | 0.12 | lasso | 3 | 0.08 | 9.5e-04 | -5.9 | -6.9 | 4.4e-12 | 0.34 | 0.06 | 0.29 | TRUE |
9 | GTEx | Esophagus Muscularis | MXD3 | 0.27 | 0.20 | enet | 10 | 0.24 | 1.6e-14 | -5.9 | -5.6 | 2.3e-08 | 0.33 | 0.97 | 0.03 | FALSE |
10 | GTEx | Heart Left Ventricle | MXD3 | 0.17 | 0.03 | lasso | 3 | 0.03 | 1.5e-02 | -6.0 | -6.0 | 2.2e-09 | 0.31 | 0.08 | 0.51 | FALSE |
11 | GTEx | Lung | MXD3 | 0.20 | 0.12 | lasso | 10 | 0.12 | 1.8e-09 | -5.9 | -5.2 | 1.7e-07 | 0.31 | 0.89 | 0.10 | FALSE |
12 | GTEx | Pituitary | MXD3 | 0.25 | 0.20 | lasso | 6 | 0.16 | 7.5e-05 | -4.7 | -5.5 | 3.7e-08 | 0.46 | 0.06 | 0.84 | FALSE |
13 | GTEx | Skin Not Sun Exposed Suprapubic | MXD3 | 0.22 | 0.18 | lasso | 3 | 0.17 | 1.8e-09 | -6.0 | -5.4 | 6.6e-08 | 0.32 | 0.97 | 0.03 | FALSE |
14 | GTEx | Skin Sun Exposed Lower leg | PRELID1 | 0.06 | 0.02 | enet | 5 | 0.03 | 3.4e-03 | -5.9 | 6.1 | 1.4e-09 | -0.43 | 0.06 | 0.91 | FALSE |
15 | GTEx | Stomach | MXD3 | 0.21 | 0.03 | lasso | 7 | 0.08 | 1.4e-04 | -6.1 | -6.0 | 1.9e-09 | 0.51 | 0.06 | 0.89 | FALSE |
16 | ROSMAP | Brain Pre-frontal Cortex | PRELID1 | 0.05 | 0.05 | enet | 10 | 0.05 | 1.8e-07 | -5.9 | 6.1 | 1.0e-09 | -0.52 | 1.00 | 0.00 | FALSE |
17 | YFS | Blood | PRELID1 | 0.18 | 0.14 | enet | 18 | 0.18 | 4.0e-58 | -6.0 | 6.9 | 6.9e-12 | -0.39 | 1.00 | 0.00 | FALSE |
18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MXD3 | 0.02 | 0.02 | enet | 4 | 0.02 | 1.8e-04 | -6.0 | -6.0 | 1.7e-09 | 0.52 | 0.22 | 0.74 | FALSE |
19 | The Cancer Genome Atlas | Colon Adenocarcinoma | PRELID1 | 0.09 | 0.01 | blup | 38 | 0.05 | 1.1e-03 | -5.8 | 5.5 | 3.2e-08 | -0.16 | 0.05 | 0.37 | FALSE |
20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FGFR4 | 0.08 | 0.06 | blup | 46 | 0.07 | 2.5e-08 | -10.2 | 5.8 | 7.5e-09 | -0.75 | 0.00 | 1.00 | FALSE |
21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MXD3 | 0.05 | 0.00 | lasso | 6 | 0.00 | 6.9e-01 | -6.4 | -5.8 | 4.9e-09 | 0.22 | 0.02 | 0.09 | FALSE |
22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PRELID1 | 0.24 | 0.11 | lasso | 5 | 0.10 | 1.2e-11 | -5.8 | 6.0 | 2.6e-09 | -0.32 | 0.97 | 0.03 | FALSE |
23 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PRELID1 | 0.33 | 0.08 | enet | 4 | 0.08 | 2.7e-05 | -5.9 | 6.1 | 1.4e-09 | -0.33 | 0.48 | 0.07 | FALSE |
24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MXD3 | 0.04 | 0.02 | lasso | 3 | 0.02 | 2.9e-03 | -5.4 | -6.0 | 2.1e-09 | 0.53 | 0.02 | 0.58 | FALSE |
25 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PRELID1 | 0.08 | 0.10 | lasso | 4 | 0.07 | 2.9e-04 | -6.0 | 6.1 | 7.9e-10 | -0.27 | 0.11 | 0.48 | FALSE |
26 | The Cancer Genome Atlas | Lung Adenocarcinoma | MXD3 | 0.04 | 0.02 | blup | 41 | 0.02 | 5.6e-04 | -5.4 | -6.8 | 7.5e-12 | 0.52 | 0.02 | 0.91 | FALSE |
27 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FGFR4 | 0.11 | 0.04 | enet | 19 | 0.06 | 8.7e-07 | -10.2 | 8.2 | 1.7e-16 | -0.87 | 0.00 | 1.00 | TRUE |
28 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MXD3 | 0.04 | 0.02 | blup | 40 | 0.03 | 2.8e-04 | -5.9 | -7.0 | 2.1e-12 | 0.48 | 0.02 | 0.96 | FALSE |
29 | The Cancer Genome Atlas | Thyroid Carcinoma | MXD3 | 0.05 | 0.04 | lasso | 5 | 0.04 | 1.8e-04 | -6.0 | -5.9 | 3.5e-09 | 0.53 | 0.20 | 0.68 | FALSE |