Best TWAS P=1.13e-08 · Best GWAS P=7.49e-15 conditioned to 5.34e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | MASTL | 0.27 | 0.30 | lasso | 14 | 0.27 | 6.0e-10 | -4.5 | 5.3 | 1.2e-07 | -0.04 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Pituitary | MASTL | 0.35 | 0.44 | enet | 39 | 0.39 | 8.4e-11 | -4.7 | 5.7 | 1.1e-08 | -0.10 | 0.99 | 0.00 | TRUE |
| 3 | GTEx | Thyroid | ACBD5 | 0.18 | 0.17 | enet | 25 | 0.20 | 1.2e-15 | -4.1 | -5.3 | 1.5e-07 | 0.09 | 1.00 | 0.00 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | ANKRD26 | 0.16 | 0.13 | lasso | 4 | 0.14 | 4.2e-18 | -4.8 | -5.2 | 1.9e-07 | 0.02 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Glioblastoma Multiforme | MASTL | 0.14 | 0.14 | blup | 60 | 0.11 | 2.8e-04 | -4.7 | 5.2 | 2.5e-07 | -0.03 | 0.02 | 0.85 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MASTL | 0.25 | 0.30 | lasso | 10 | 0.31 | 2.1e-35 | -4.7 | 5.1 | 3.1e-07 | -0.01 | 0.02 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | MASTL | 0.22 | 0.06 | blup | 61 | 0.08 | 4.2e-03 | -4.3 | 5.3 | 1.2e-07 | -0.03 | 0.01 | 0.34 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | ANKRD26 | 0.08 | 0.04 | blup | 81 | 0.07 | 3.8e-07 | -4.6 | 5.2 | 1.8e-07 | -0.02 | 0.04 | 0.95 | FALSE |