Hub : Genes

ACBD5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0730	0.0320	8.3e-04	0.049	NA	0.029	NA	0.039	7.5e-05	NA	2.0e-03	NA	3.8e-04
2	GTEx	Artery Aorta	0.0590	0.0280	8.2e-03	0.028	NA	0.017	NA	0.015	1.1e-02	NA	3.7e-02	NA	5.0e-02
3	GTEx	Artery Tibial	0.0732	0.0240	3.5e-05	0.030	NA	0.024	NA	0.022	2.0e-03	NA	5.3e-03	NA	6.6e-03
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1580	0.0700	7.3e-03	0.018	NA	0.000	NA	0.006	3.5e-02	NA	3.3e-01	NA	1.4e-01
5	GTEx	Testis	0.1560	0.0530	3.1e-04	0.040	NA	0.011	NA	0.015	7.0e-03	NA	9.7e-02	NA	6.7e-02
6	GTEx	Thyroid	0.1820	0.0430	2.7e-10	0.168	NA	0.205	NA	0.177	7.8e-13	NA	1.2e-15	NA	1.6e-13
7	TCGA	Breast Invasive Carcinoma	0.0438	0.0213	1.8e-05	0.027	0.018	0.021	NA	0.022	2.8e-06	8.9e-05	2.9e-05	NA	1.7e-05
8	TCGA	Colon Adenocarcinoma	0.0810	0.0420	1.1e-03	0.066	0.053	0.057	NA	0.052	1.1e-04	5.0e-04	3.3e-04	NA	5.4e-04
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0420	0.0244	1.1e-03	0.019	0.028	0.019	NA	0.024	3.1e-03	3.9e-04	2.7e-03	NA	8.8e-04
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0600	0.0390	5.7e-03	0.015	0.004	0.000	NA	0.004	4.2e-02	1.7e-01	3.1e-01	NA	1.7e-01
11	TCGA	Liver Hepatocellular Carcinoma	0.0480	0.0290	6.2e-03	0.030	0.043	0.017	NA	0.034	1.5e-02	4.1e-03	5.0e-02	NA	9.9e-03
12	TCGA	Prostate Adenocarcinoma	0.0786	0.0436	1.2e-06	0.064	0.060	0.055	NA	0.059	2.7e-07	6.2e-07	1.9e-06	NA	7.9e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.0	1.6	3.9	-1.1	-1.0	-1.2	-0.3	-1.0	-1.2	1.8	1.1	-2.0	-1.2	1.2	1.4
Bipolar Disorder or Schizophrenia	2.2	5.3	9.2	-2.7	-1.7	-2.5	-0.4	-1.2	-1.9	2.4	2.3	-3.0	-2.1	2.9	2.9
Depressed Affect (Nagel 2018)	1.4	3.0	5.2	-1.6	-2.2	-1.7	-1.6	-0.3	-2.3	1.9	1.9	-0.1	-1.1	2.3	1.9
Depression (Nagel 2018)	1.3	1.9	3.2	-1.3	-1.6	-1.3	-1.4	-0.5	-1.6	1.8	1.7	-1.0	-1.0	1.5	1.6
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.8	0.9	0.5	0.6	0.8	0.3	-0.5	-0.2	0.0	0.8	0.3	-0.5	-0.4
Neuroticism (Nagel 2018)	1.7	4.1	7.8	-1.8	-2.5	-1.9	-1.7	-1.2	-2.8	2.6	2.1	-0.9	-1.5	2.3	2.1
Schizophrenia (2018)	1.9	3.9	7.3	-2.5	-1.4	-2.2	-0.3	-0.7	-1.5	1.6	2.1	-2.3	-1.8	2.7	2.7
Schizophrenia vs Biploar Disorder	0.8	1.1	2.1	-1.2	-1.3	-1.2	-0.3	0.2	-0.1	1.4	1.4	-1.0	-0.8	1.3	1.1
Worry (Nagel 2018)	0.7	1.6	3.2	-1.4	-1.8	-1.0	-0.9	-0.5	-1.7	1.8	1.0	-1.0	-0.7	1.3	1.2
Alzheimer’s Disease (in mother)	3.0	3.5	7.8	1.9	2.8	2.1	1.1	0.8	1.1	-2.3	-2.3	1.3	1.7	-2.1	-2.1
Alzheimer’s Disease (in father)	1.4	1.6	2.6	1.2	1.4	1.2	0.5	-0.9	1.2	-1.4	-1.6	1.4	1.2	-1.2	-1.3
Alzheimer’s Disease (including proxy)	2.1	3.1	7.3	1.9	2.7	1.9	0.6	-0.0	1.2	-2.2	-2.0	1.4	1.8	-1.9	-1.8
Crohns Disease (2017)	0.2	0.4	1.8	-0.5	-0.2	-0.4	0.0	-1.3	-0.3	0.9	0.2	-1.0	-0.5	0.0	0.2
Irritable Bowel Disease (IBD)	0.1	0.1	0.7	-0.4	-0.0	-0.1	0.1	-0.9	0.3	-0.2	-0.3	-0.4	-0.6	-0.3	-0.1
Ulcerative Colitis (UC)	0.1	0.2	0.8	-0.2	0.1	0.0	0.1	-0.5	0.8	-0.9	-0.5	0.1	-0.7	-0.4	-0.4
Major Depression (MDD)	0.3	0.3	2.4	0.1	0.6	0.1	-0.4	1.5	0.9	0.1	-0.1	-0.3	0.4	0.2	0.1
Reaction Time	0.2	0.3	1.1	-0.4	0.3	-0.5	0.2	-0.0	-1.1	0.3	0.5	-0.7	-0.4	0.6	0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.8	0.3	-0.2	-0.1	-0.9	-0.0	0.1	0.6	0.2	0.4	-0.1	0.0	-0.2
Breast Cancer	0.4	1.1	4.0	1.0	-0.1	0.8	0.5	0.7	0.2	-1.3	-0.5	2.0	-0.8	-1.3	-1.4
Ovarian Cancer	5.0	6.6	10.1	-2.2	-3.1	-2.6	-0.4	-1.8	-2.9	3.0	3.2	-2.0	-2.9	2.7	2.6
Prostate Cancer	0.2	0.2	0.9	0.2	-0.1	-0.3	-0.8	-0.1	-0.3	0.5	1.0	0.3	-0.3	0.5	0.6
Age at First Birth	1.5	2.2	5.4	-1.6	-1.2	-1.7	-0.3	-1.0	-2.3	1.3	1.5	-1.0	-1.7	1.7	1.7
Bipolar Disorder (2011)	5.9	5.7	8.5	-2.3	-2.1	-2.6	-0.5	-0.9	-2.1	2.9	2.9	-2.8	-2.5	2.8	2.8
Body Mass Index (BMI) (2010)	2.1	2.8	6.1	1.8	2.0	1.8	0.9	1.4	2.2	-1.5	-1.8	0.8	2.5	-1.6	-1.4
Coronary Artery Disease (CAD)	1.2	1.5	4.4	1.2	1.5	1.1	-2.1	0.3	1.2	-1.0	-1.0	1.1	1.2	-1.0	-1.1
Crohns Disease (2012)	0.8	1.3	2.5	-0.9	-1.0	-1.0	-0.1	-1.6	-1.5	1.5	0.9	-1.3	-1.2	0.9	0.9
Mean Putamen Volume	0.2	0.3	1.2	0.7	-0.7	0.6	0.2	0.4	-0.2	-0.0	0.3	1.1	0.4	-0.3	-0.1
Fasting Glucose	0.4	0.5	2.2	-0.4	-0.5	-0.7	-1.5	-0.9	-0.3	0.4	0.7	-0.1	-0.3	0.6	0.6
HbA1C	0.3	0.3	1.2	-0.4	-1.1	-0.5	-0.7	0.3	-0.1	0.6	0.8	-0.2	-0.6	0.4	0.2
HDL Cholesterol	1.0	1.7	6.9	-1.4	-1.0	-1.2	-1.0	-0.9	-2.6	1.1	1.3	-0.5	-1.0	1.3	1.1
LDL Cholesterol	0.3	0.5	2.6	0.5	0.5	0.3	1.6	1.3	-0.1	0.5	-0.1	-0.5	1.1	0.1	0.2
Lupus	1.6	2.4	4.4	1.4	1.8	1.6	-0.3	0.7	1.3	-1.8	-1.6	2.1	2.0	-1.4	-1.5
Neuroticism (2016)	0.9	1.3	2.8	-1.7	-1.5	-1.5	-0.2	-0.6	-1.0	0.8	1.2	-1.0	-1.0	1.3	1.1
Primary Biliary Cirrhosis	0.3	0.4	1.9	-0.3	-0.6	-0.4	-0.2	-1.0	0.3	0.8	0.4	-1.4	-0.3	0.1	0.5
Rheumatoid Arthritis	0.8	1.1	3.4	-1.6	-0.1	-1.6	0.3	0.4	-0.3	0.6	0.3	-1.8	-1.3	1.2	0.8
Schizophrenia (2014)	2.2	4.9	9.1	-2.6	-1.8	-2.4	-1.2	-1.2	-1.3	2.5	2.6	-2.1	-1.8	3.0	3.0
Triglycerides	0.2	0.3	0.9	0.2	-0.2	0.2	0.9	1.0	0.8	-0.1	-0.5	-0.1	0.7	-0.2	-0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	3.6	-0.0	-0.4	0.1	-1.9	-1.7	0.6	0.4	0.2	-0.2	0.0	-0.1	0.1
Ulcerative Colitis	0.4	0.5	2.1	0.2	0.2	0.5	0.5	0.3	1.5	-1.1	-0.8	0.5	-0.2	-0.9	-0.8
Blood Eosinophil Count	0.9	7.2	25.0	2.3	2.2	2.6	-0.6	1.4	2.3	-3.1	-2.7	5.0	2.2	-2.4	-3.1
Blood Platelet Count	0.9	10.1	25.4	-3.4	-2.5	-3.3	-1.3	-1.2	-2.3	4.4	2.5	-5.0	-0.7	4.0	4.1
Blood Red Count	0.1	1.2	5.2	-1.3	-1.5	-0.8	-0.8	-0.1	-0.3	-1.5	-0.2	1.3	-2.3	-0.0	-0.6
Blood White Count	1.6	11.5	32.8	2.9	2.9	3.5	0.2	2.2	2.5	-4.1	-3.8	5.7	3.3	-3.2	-3.7
Heel T-Score	0.8	6.1	21.9	2.8	0.5	2.2	2.5	4.7	3.3	-1.1	-0.6	3.0	2.2	-1.6	-1.9
BMI	2.0	11.3	19.3	3.4	4.4	3.5	1.1	2.8	4.0	-3.8	-3.6	2.4	4.3	-3.1	-2.8
Height	0.1	1.5	7.8	-0.6	1.8	0.1	2.8	2.1	-0.6	-0.6	-1.1	-0.3	0.5	-0.1	-0.2
Waist Hip Ratio (WHR)	0.1	0.4	1.1	0.1	0.2	-0.1	-0.8	-1.0	-1.0	0.7	-0.1	-1.0	0.2	0.1	0.5
Systolic Blood Pressure	0.2	1.1	5.1	-1.1	-0.4	-0.8	-1.0	-1.6	-2.2	0.5	0.5	-1.0	-0.8	0.4	0.4
Smoking Status	1.0	2.4	4.8	1.7	1.4	1.7	-0.4	1.9	1.9	-0.8	-1.0	2.2	2.0	-1.1	-1.2
Allergy or Eczema	0.1	0.2	0.4	-0.4	-0.5	-0.5	-0.4	-0.3	0.1	0.5	0.3	0.2	-0.6	0.3	0.1
Cardiovascular Disease	0.4	1.4	3.4	1.6	1.8	1.3	0.3	0.3	0.5	-1.5	-1.2	-0.0	1.1	-1.5	-1.3
Hypothyroidism (self reported)	2.9	6.7	15.7	-2.3	-2.5	-2.2	-1.5	-4.0	-2.9	2.7	2.6	-2.6	-2.5	2.1	2.5
Respiratory disease	0.4	0.8	5.2	-0.4	0.0	-0.0	-2.3	-0.3	0.4	-1.0	-0.3	1.8	-0.1	0.3	-0.2
Type 2 Diabetes (T2D) (2018)	4.9	9.2	13.1	2.9	3.0	2.9	2.9	2.6	3.6	-2.7	-3.6	1.8	3.3	-3.2	-3.4
Lung FEV1/FVC ratio	0.1	0.5	1.1	-1.0	-0.2	-0.9	-0.5	0.9	0.5	0.5	0.4	-0.6	-0.8	0.8	0.6
Lung FVC	0.3	1.4	3.7	-0.9	-1.9	-0.9	0.5	-0.4	-0.5	1.2	1.6	-0.8	-1.2	1.2	1.7
Neuroticism	1.3	3.2	6.1	-2.0	-2.3	-1.9	-2.0	-0.4	-2.0	1.8	1.9	-0.1	-1.1	2.5	1.9
Chronotype (morning person)	0.4	1.0	1.8	1.0	0.9	1.2	0.4	-0.0	0.9	-1.3	-1.0	0.9	1.1	-1.2	-1.2
Hair Pigment	0.1	1.6	3.4	1.1	1.5	1.3	1.8	0.5	1.0	-0.6	-1.8	-0.1	1.6	-1.3	-1.1
Tanning	0.1	0.8	2.2	-0.6	-1.5	-0.6	-0.2	0.1	-0.8	1.0	1.4	0.0	-1.1	0.8	1.0
Hand grip strength (left)	0.6	1.5	5.6	-0.7	1.2	-0.2	1.7	2.4	1.9	-0.9	-1.5	-0.8	0.5	-0.1	-0.3
Number of treatments/medications taken	0.6	1.1	2.0	1.0	1.3	0.9	-0.7	-0.3	0.4	-1.4	-1.2	1.2	0.7	-1.2	-1.4
Average weekly spirits intake	0.3	0.3	1.4	0.1	0.4	0.3	-1.2	-0.9	0.7	0.4	-0.3	-0.2	0.1	-0.6	-0.5
Sensitivity / hurt feelings	2.1	3.6	5.2	-2.0	-1.4	-2.1	-1.3	-1.7	-1.9	2.3	1.6	-2.1	-1.4	2.3	2.2
Frequency of depressed mood in last 2 weeks	1.4	2.0	3.2	-1.3	-1.5	-1.4	0.4	-0.2	-1.6	1.8	1.6	-1.6	-1.1	1.5	1.7
Hearing difficulty/problems: Yes	0.9	1.4	8.5	-0.2	-1.3	-0.4	-2.9	-1.0	-0.1	1.1	1.6	0.1	-0.8	0.4	0.7
Relative age of first facial hair	0.9	1.8	4.0	0.5	1.5	0.7	1.9	2.0	2.0	-1.0	-1.4	1.0	1.2	-0.7	-1.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.4	0.2	1.1	0.6	-0.9	0.3	1.5	-1.2	-0.5	1.2	0.9	-0.1	-0.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.6	-0.0	-1.3	-0.3	-1.6	-1.1	-1.3	0.8	1.2	0.4	-0.8	0.7	0.7
Ever had hysterectomy (womb removed)	0.1	0.2	0.4	0.1	0.5	0.1	-0.0	0.6	-0.3	-0.3	-0.7	0.1	0.2	-0.3	-0.6
Systolic blood pressure, automated reading	1.0	2.9	7.6	-1.4	-0.9	-1.6	-1.0	-2.6	-2.8	1.2	1.4	-2.3	-1.7	1.2	1.3
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	4.8	1.0	1.4	1.1	1.5	2.2	2.0	-1.3	-1.6	1.3	1.1	-1.6	-1.9
Angina	0.4	0.5	2.5	0.8	0.2	0.5	-1.0	0.6	-0.3	-0.5	-0.3	1.6	0.7	-0.4	-0.7
Medication for hormone replacement therapy	0.2	0.2	0.9	0.2	-0.0	0.2	-1.0	-0.4	0.7	0.5	-0.2	0.3	0.6	-0.1	-0.0
Vitamin and mineral supplements	0.2	0.3	1.0	0.0	0.7	-0.1	0.5	1.0	0.1	-0.9	-0.7	0.3	0.1	0.0	-0.5
Supplements: Zinc	0.1	0.1	0.2	-0.1	0.3	-0.1	0.2	0.3	-0.4	0.2	0.0	-0.3	0.1	0.3	0.3
Medication: Co-codamol	1.5	1.7	3.3	1.4	1.6	1.3	-0.8	-0.0	1.4	-1.4	-1.0	1.8	1.6	-1.1	-1.1
Medication: Metformin	5.4	7.7	11.1	2.3	3.1	2.5	2.2	2.7	3.1	-3.0	-3.3	2.4	3.1	-2.5	-2.8
Diabetes (father)	0.9	1.1	3.2	0.3	1.3	0.4	0.7	1.0	1.5	-1.4	-1.8	0.3	0.5	-0.8	-1.2
Diabetes (mother)	2.6	3.3	5.5	1.6	2.2	1.7	-0.4	0.8	2.2	-2.1	-2.4	1.1	1.5	-2.1	-2.2
Severe depression (siblings)	2.8	3.2	5.0	-2.1	-2.2	-2.0	-0.5	-0.2	-1.8	1.8	2.0	-1.5	-1.6	2.2	2.1
Pack years adult smoking proportion	0.4	0.6	2.2	0.9	0.5	1.0	-0.1	0.4	0.4	-0.5	-0.7	0.8	1.5	-0.7	-0.6
Impedance of leg (right)	3.6	17.5	27.6	-4.4	-4.8	-4.5	-2.5	-3.8	-5.3	4.3	4.1	-3.0	-4.5	4.3	4.1
Leg fat-free mass (left)	2.4	12.7	22.4	3.1	4.7	3.4	3.1	4.1	4.1	-3.4	-3.7	2.1	4.3	-3.0	-2.9
Trunk fat percentage	0.1	0.2	1.0	-0.0	0.7	-0.2	-1.0	-0.3	0.4	-0.6	-0.5	-0.3	0.3	0.2	0.1
Hand grip strength (right)	0.4	1.2	4.4	-0.5	1.1	-0.1	2.1	1.7	1.4	-0.8	-1.3	-0.5	0.6	-0.2	-0.2
Townsend deprivation index at recruitment	1.6	2.3	10.0	-0.6	-1.7	-1.0	-3.2	-2.1	-0.6	1.1	1.6	-1.0	-1.4	0.9	1.1
Current tobacco smoking	0.7	1.2	2.9	0.9	0.9	0.9	-0.6	1.6	1.7	-0.2	-0.8	1.4	1.3	-0.7	-1.1
Average weekly fortified wine intake	0.7	0.8	1.5	-1.0	-1.0	-1.0	-0.6	-0.9	-1.2	0.4	0.9	-0.4	-1.1	0.9	0.8
Maternal smoking around birth	0.2	0.3	2.4	0.3	-0.5	0.4	-0.8	0.3	0.1	0.1	0.6	1.5	0.1	-0.2	-0.1
Fed-up feelings	1.2	2.1	4.5	-1.3	-2.1	-1.6	-0.9	-0.7	-1.6	1.8	1.7	-0.6	-1.2	1.7	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.5	-1.8	-1.9	-1.5	-1.1	-0.5	-1.1	1.3	1.5	-1.0	-1.2	1.7	1.6
Relative age voice broke	2.5	3.8	7.6	1.7	2.2	1.9	1.2	1.2	2.8	-1.6	-2.5	1.7	2.1	-1.9	-2.1
Taking other prescription medications	0.6	0.9	2.7	0.5	0.8	0.4	-1.6	-0.4	1.3	-1.0	-1.1	1.1	0.5	-0.7	-1.1
Age when periods started (menarche)	0.6	1.4	2.9	0.9	1.3	1.1	0.3	1.0	1.7	-1.2	-1.5	1.1	1.4	-0.9	-1.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.9	0.3	-0.1	0.3	-0.7	-1.4	-0.7	0.6	-0.0	-0.3	0.0	-0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	11.6	1.3	0.8	1.1	1.6	3.4	1.6	-0.5	-0.6	1.5	1.4	-0.6	-0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.4	0.5	0.0	0.2	-1.2	-0.9	0.1	-0.7	-0.1	0.8	0.0	-0.3	-0.5
Qualifications: CSEs or equivalent	0.6	0.8	5.6	-0.8	-0.8	-0.7	-2.4	-1.0	0.6	0.2	0.5	-0.3	-0.7	0.4	0.2
Serious illness, injury or assault to yourself	0.4	0.5	1.3	0.7	1.0	0.8	0.3	-0.0	-0.1	-0.9	-0.7	0.8	1.1	-0.6	-0.5
High blood pressure	0.1	0.2	1.0	0.7	0.6	0.2	-1.0	-0.2	-0.1	-0.3	-0.2	-0.4	-0.1	-0.4	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.7	0.1	0.1	0.1	0.2	-0.8	0.3	0.1	-0.4	0.3	-0.1	-0.3	-0.4
Multivitamins +/- minerals	0.2	0.3	1.0	0.0	-0.8	-0.0	-0.0	-0.4	-0.1	1.0	0.9	-0.4	-0.4	0.1	0.6
Stomach or abdominal pain in last month	1.0	1.3	3.2	-1.4	-1.0	-1.4	-1.8	-0.7	-0.3	0.6	1.0	-0.5	-1.3	1.3	1.2
Supplements: Glucosamine	3.3	4.4	7.0	-2.4	-2.5	-1.9	1.2	-1.0	-1.8	2.5	2.1	-2.6	-1.7	2.0	2.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.3	-0.9	-1.4	-0.9	-1.8	-1.7	-1.3	1.1	1.1	-0.9	-0.9	0.8	0.8
Medication: Atenolol	0.2	0.2	1.1	-0.5	0.3	-0.5	-0.7	1.0	-0.6	-0.2	-0.1	0.0	-0.2	0.5	0.0
Medication: Levothyroxine sodium	1.6	2.7	4.8	-1.7	-1.7	-1.4	-0.5	-1.6	-1.9	2.2	1.7	-1.7	-1.4	1.5	1.8
Sitting height	0.3	2.1	13.2	-0.4	1.0	0.4	3.6	3.0	0.2	-0.5	-0.9	-0.0	0.6	-0.3	-0.4
Chronic bronchitis/emphysema (father)	0.1	0.2	1.0	0.2	-0.6	-0.0	-0.5	-1.0	-0.1	-0.1	-0.1	-0.3	-0.1	-0.2	-0.3
High blood pressure (mother)	1.5	2.2	5.5	-1.4	-1.9	-1.4	-0.2	-2.3	-1.7	0.8	1.4	-0.9	-1.8	1.2	1.3
Body mass index (BMI)	1.1	4.6	7.7	2.2	2.7	2.2	0.6	1.8	2.8	-2.3	-2.3	1.2	2.8	-2.0	-1.8
Impedance of leg (left)	3.5	17.1	26.9	-4.3	-5.0	-4.3	-2.5	-4.1	-5.2	4.1	3.9	-3.1	-4.7	3.9	3.8
Leg predicted mass (left)	2.4	12.7	22.5	3.1	4.7	3.4	3.1	4.1	4.1	-3.4	-3.7	2.1	4.3	-3.0	-2.9
Trunk fat mass	0.4	1.9	5.0	1.1	2.2	1.1	0.4	1.0	1.6	-1.6	-1.9	0.3	1.8	-1.0	-1.0
Waist circumference	0.6	2.3	5.9	1.6	2.4	1.5	0.2	0.9	1.5	-1.5	-1.9	0.4	2.3	-1.3	-1.1
Number of incorrect matches in round	0.5	0.8	1.6	-0.7	-1.3	-0.9	-0.2	-0.1	-1.2	0.9	1.2	-0.2	-1.2	0.9	0.8
Past tobacco smoking	2.8	5.1	10.2	-2.6	-1.7	-2.7	-0.2	-1.5	-2.5	1.8	1.7	-3.2	-2.8	2.3	2.3
Alcohol usually taken with meals	1.2	1.9	7.5	-1.2	-0.2	-1.3	2.1	-0.7	-1.3	0.4	0.7	-2.7	-1.2	1.0	1.5
Nervous feelings	2.0	3.7	6.5	-2.5	-2.3	-2.0	-1.7	-0.8	-2.1	1.8	1.9	-0.8	-1.9	2.2	2.0
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	5.9	-1.6	-2.2	-1.6	-0.4	-1.4	-2.3	2.4	1.9	-2.0	-1.2	1.8	2.1
Hearing difficulty/problems with background noise	1.1	1.7	13.9	-0.4	-0.8	-0.5	-3.7	-1.2	0.1	1.2	1.1	0.5	-0.4	0.9	0.8
Hair/balding pattern: Pattern 2	14.1	17.9	22.9	-4.4	-4.3	-4.8	-2.8	-2.8	-4.1	4.2	4.7	-3.9	-4.6	4.8	4.8
Had menopause	1.4	1.7	3.9	-1.4	-1.7	-1.4	-2.0	-1.2	-1.2	0.5	1.1	-0.2	-1.7	1.2	0.9
Had other major operations	0.6	0.7	1.6	1.2	0.6	0.9	1.2	1.0	0.0	-0.6	-0.3	1.3	0.9	-0.6	-0.6
Forced vital capacity (FVC)	0.1	0.4	2.7	-0.2	0.7	0.2	1.6	1.2	0.4	-0.2	-0.2	-0.0	0.3	0.0	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	7.9	1.3	1.2	1.1	1.1	2.8	1.8	-0.8	-0.8	1.6	1.3	-0.6	-0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	-0.8	0.1	-0.6	-0.5	-0.2	-0.7	-0.1	-0.4	-0.7	-0.1	0.2	-0.1
Qualifications: None of the above	0.2	0.4	1.3	1.1	0.3	0.7	-1.0	-0.2	0.8	-0.4	-0.3	0.2	0.1	-0.9	-0.8
Financial difficulties in last 2 years	0.4	0.6	1.2	-0.6	-1.1	-0.6	-1.1	-0.8	-0.4	0.4	1.0	0.3	-0.5	1.0	1.0
Mouth/teeth dental problems	1.2	1.8	5.2	0.9	1.3	0.9	1.9	2.3	1.7	-0.5	-1.5	0.4	1.2	-1.1	-1.4
Heart attack	0.9	1.1	2.4	0.7	1.3	0.8	-0.5	0.5	1.2	-1.6	-1.2	1.2	1.0	-1.0	-1.2
Allergy	0.2	0.4	1.7	-0.2	-0.0	-0.2	1.2	1.3	-0.1	0.3	0.3	-0.9	0.0	0.1	0.2
Pain all over the body in last month	0.1	0.1	0.3	0.0	-0.2	0.1	0.5	-0.2	-0.6	0.2	0.3	-0.3	0.2	0.1	0.3
Diabetes (self-reported)	3.0	4.6	6.7	2.2	2.0	2.1	2.0	1.7	2.4	-2.2	-2.6	1.4	2.2	-2.4	-2.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.8	0.0	-0.7	-0.1	0.9	-0.0	-0.4	-0.2	0.6	0.1	-0.6	0.2	0.2
Medication: Ramipril	0.7	1.0	3.0	0.3	0.6	0.4	-1.5	0.2	0.7	-1.1	-1.3	1.7	0.3	-0.7	-1.4
Medication: Simvastatin	0.1	0.2	0.5	-0.3	-0.3	-0.5	-0.4	0.6	-0.6	-0.2	0.4	0.4	-0.6	0.7	0.2
Fluid intelligence score	0.1	0.3	1.7	0.5	0.0	0.2	1.3	0.6	-0.2	0.6	0.1	0.3	0.1	-0.2	-0.2
Illnesses of siblings	0.2	0.3	2.9	-0.2	0.3	-0.1	1.7	-0.0	-0.4	0.5	-0.2	-0.2	-0.3	-0.1	-0.0
Neuroticism score	1.8	3.9	7.0	-2.3	-2.7	-2.1	-1.1	-0.5	-2.0	2.4	2.2	-0.7	-1.3	2.6	2.2
Weight	1.3	6.4	13.1	2.2	3.6	2.4	2.1	2.5	2.8	-2.6	-2.9	1.0	3.3	-2.1	-1.9
Impedance of arm (right)	2.4	11.0	14.8	-3.4	-3.6	-3.7	-2.8	-3.2	-3.6	2.9	3.5	-2.1	-3.9	3.5	3.3
Arm fat percentage (right)	0.3	1.3	2.7	1.3	1.6	1.0	-0.4	0.7	1.7	-1.3	-1.2	0.4	1.5	-0.9	-0.9
Trunk fat-free mass	2.0	11.7	20.7	2.8	4.3	3.3	4.5	4.2	3.3	-2.6	-3.6	1.0	4.1	-3.0	-2.6
Hip circumference	0.5	2.1	4.4	0.8	2.1	1.1	1.0	1.6	1.6	-1.9	-1.7	0.7	1.8	-1.0	-1.0
Time employed in main current job	0.9	1.0	3.4	1.2	1.1	0.5	-0.8	0.7	0.9	-1.3	-0.7	1.8	0.4	-0.7	-1.0
Alcohol intake versus 10 years previously	0.6	0.9	2.5	-0.4	-1.6	-0.8	-0.5	0.6	0.5	1.0	1.6	0.1	-1.4	0.8	0.6
Father’s age at death	0.4	0.6	1.7	0.7	1.3	0.4	0.4	-0.1	0.8	-1.1	-1.2	0.3	0.3	-0.6	-0.9
Worrier / anxious feelings	0.1	0.1	0.8	-0.0	-0.9	0.1	-0.5	-0.1	-0.5	0.4	0.3	0.3	0.0	-0.1	-0.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.3	-1.7	-1.3	-1.5	-0.8	-0.4	-1.0	1.1	1.3	-0.6	-0.9	1.8	1.8
Falls in the last year	1.6	2.1	5.1	2.2	1.5	1.9	-0.3	0.6	1.6	-0.8	-1.1	1.5	2.1	-1.4	-1.3
Hair/balding pattern: Pattern 3	1.5	2.2	4.7	1.9	2.2	1.7	0.9	1.0	1.8	-0.9	-1.5	0.2	1.9	-1.6	-1.3
Number of live births	0.6	0.9	2.4	1.6	0.8	1.5	-0.1	-0.6	1.0	-0.5	-0.7	0.6	1.2	-1.2	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	3.4	-0.8	0.3	-0.4	1.8	1.6	0.4	0.1	0.1	-0.4	-0.2	0.6	0.8
Pulse rate	0.2	0.3	2.2	0.2	0.9	-0.2	-1.5	-0.5	0.6	-0.0	0.1	-0.5	0.1	0.3	0.3
Happiness	0.2	0.2	0.8	0.1	0.1	0.4	0.2	0.0	-0.6	-0.9	-0.6	0.6	0.4	-0.6	-0.6
Noisy workplace	0.4	0.5	2.9	0.3	0.8	0.3	-1.2	0.1	1.7	-0.2	-0.5	-0.5	0.9	-0.1	0.1
Qualifications: A levels/AS levels or equivalent	0.4	1.0	3.5	-1.0	-0.5	-0.7	1.9	0.4	-1.2	1.2	0.9	-0.9	-0.5	0.9	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.1	-0.2	0.0	0.5	-0.2	-0.2	-0.3	0.2	0.2	-0.4	0.0	0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	0.0	0.6	0.3	0.0	0.7	0.1	-0.3	-0.5	-0.1	0.7	-0.0	0.1
Asthma	0.5	1.1	5.6	0.4	0.0	0.3	-2.4	-0.3	0.2	-0.8	-0.3	2.3	0.2	-0.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.6	-0.2	0.0	-0.5	-0.8	-0.1	-0.1	0.0	0.2	-0.1	-0.4	0.5	0.4
Medication: Cholesterol lowering	0.5	0.8	2.5	0.8	1.0	0.6	0.1	0.9	0.1	-1.6	-1.0	1.4	0.5	-0.6	-1.1
Depression (self-reported)	1.8	2.1	3.0	-1.5	-1.6	-1.6	-1.1	-1.0	-1.7	1.7	1.4	-1.5	-1.3	1.4	1.3
Medication: Lansoprazole	0.2	0.3	0.6	0.5	0.7	0.7	0.2	0.1	0.5	-0.1	-0.7	0.1	0.6	-0.7	-0.6
Prospective memory result	3.9	4.8	9.6	2.1	3.1	2.3	-0.6	0.7	2.0	-2.5	-2.8	1.8	2.5	-2.3	-2.4
Lung cancer (father)	1.3	1.5	5.7	-0.9	-0.8	-1.2	0.1	-0.4	-0.5	1.6	1.1	-2.4	-0.6	1.4	1.6
Illnesses of mother	0.2	0.2	0.6	-0.1	-0.1	0.0	-0.2	0.8	0.7	0.8	0.1	0.0	0.6	0.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	4.8	-0.2	0.4	0.1	2.2	1.2	0.8	0.1	-0.1	-0.1	0.2	0.1	0.6
Pulse wave Arterial Stiffness index	0.4	0.4	1.2	0.4	1.1	0.4	-0.4	0.4	0.4	-1.0	-0.7	0.8	0.7	-0.3	-0.5
Impedance of arm (left)	2.2	10.4	14.5	-3.3	-3.5	-3.6	-2.5	-3.4	-3.6	2.8	3.4	-1.9	-3.8	3.4	3.1
Arm fat mass (right)	1.0	4.1	8.1	2.0	2.8	2.0	0.8	1.9	2.6	-2.0	-2.2	0.8	2.6	-1.7	-1.6
Trunk predicted mass	2.0	11.5	20.7	2.8	4.3	3.3	4.5	4.2	3.2	-2.5	-3.6	0.9	4.0	-3.0	-2.6
Standing height	0.2	2.0	10.8	0.1	2.2	0.7	3.3	1.9	0.2	-0.7	-1.3	-0.4	1.2	-0.5	-0.2
Length of working week for main job	0.4	0.5	2.2	0.8	0.9	0.8	0.1	0.6	0.3	0.4	-0.6	0.6	1.5	-0.4	-0.3
Exposure to tobacco smoke at home	3.5	3.9	7.3	1.9	2.7	2.0	-0.1	1.9	2.3	-2.2	-2.1	1.3	2.5	-1.8	-1.8
Breastfed as a baby	0.9	1.2	5.0	-0.8	-0.3	-0.9	1.0	-0.9	-1.0	0.4	1.0	-2.2	-1.2	0.7	1.2
Tense / ‘highly strung’	0.4	0.7	2.4	-0.6	-1.0	-0.6	-1.5	-0.9	-0.7	1.2	0.5	-0.3	-0.1	0.8	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.7	-1.1	-1.3	-0.9	-1.6	-0.1	-0.5	1.1	1.1	-0.3	-0.4	1.2	1.0
Hair/balding pattern: Pattern 4	0.3	0.7	1.5	0.5	0.6	0.8	0.7	0.5	-0.2	-0.9	-1.1	1.2	0.7	-0.9	-1.1
Birth weight of first child	0.4	0.8	1.7	1.3	0.9	1.0	1.0	1.0	0.7	-0.9	-0.4	0.8	1.0	-0.5	-0.3
Peak expiratory flow (PEF)	0.3	0.7	4.3	0.1	0.9	0.4	0.9	2.1	1.2	-0.3	-0.4	0.6	0.8	-0.1	0.1
Pulse wave reflection index	2.3	2.8	5.5	-1.9	-1.7	-2.0	-0.7	0.3	-1.0	1.9	2.1	-1.1	-1.6	2.3	2.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	-0.7	-0.6	-0.9	-0.7	-0.1	-0.6	1.3	0.6	-1.0	-0.3	0.9	0.8
Loud music exposure frequency	0.2	0.2	1.7	0.1	0.1	-0.0	-0.6	-0.5	1.3	-0.3	-0.3	0.1	0.0	-0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	3.6	0.4	0.4	0.6	1.9	0.1	-0.1	-0.6	-0.4	0.8	0.5	-0.4	-0.4
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	5.1	-0.9	-2.0	-1.1	-1.9	-1.9	-1.4	1.4	2.2	-0.2	-1.7	1.1	1.1
Blood clot in the leg (DVT)	0.2	0.2	1.1	0.2	0.6	0.2	0.5	-0.6	0.1	-0.0	-0.2	-1.1	0.5	0.0	0.4
Medication: Paracetamol	0.5	0.9	4.5	-0.9	-0.3	-0.9	-2.1	-0.6	-1.1	0.4	0.5	0.3	-0.6	1.1	0.8
Headache pain in last month	3.8	6.5	9.1	-2.7	-2.4	-2.7	-2.1	-2.5	-2.9	2.2	2.7	-1.5	-2.3	3.0	3.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	-0.5	-0.4	-0.3	0.6	0.1	0.3	0.8	0.4	-0.6	-0.3	0.3	0.4
Glaucoma (self-reported)	0.4	0.4	0.7	-0.2	-0.8	-0.7	-0.6	-0.4	-0.4	0.8	0.7	-0.5	-0.6	0.7	0.8
Gout (self-reported)	0.2	0.3	0.9	0.4	0.9	0.6	-0.1	0.4	0.0	-0.1	-0.6	-0.5	0.8	-0.6	-0.2
Hypothyroidism/myxoedema (self-reported)	2.0	4.0	11.2	-1.8	-1.6	-1.7	-1.6	-3.3	-2.2	1.9	1.8	-2.0	-2.1	1.5	1.8
Medication: Amlodipine	0.1	0.2	0.8	0.1	0.5	-0.0	-0.9	-0.5	0.6	0.2	-0.4	-0.6	0.0	-0.2	-0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	2.0	-0.2	0.3	-0.2	-1.4	-0.4	-0.9	0.0	-0.1	0.6	-0.1	0.2	-0.0
Birth weight	1.2	2.7	4.7	-1.7	-1.5	-1.5	1.2	-1.1	-1.8	1.8	1.9	-1.6	-1.3	1.9	2.2
Chronic bronchitis/emphysema (mother)	1.6	1.9	6.6	-1.1	-1.4	-1.1	-2.6	-0.9	-1.9	0.6	1.5	0.7	-0.9	1.4	1.2
High blood pressure (siblings)	0.2	0.3	1.5	-0.4	-0.7	-0.4	-1.2	0.2	0.2	0.0	0.6	-0.4	-0.3	0.6	0.6
Forced vital capacity (FVC), Best measure	0.2	0.6	4.5	0.4	0.6	0.6	2.1	0.9	0.6	-0.1	-0.2	0.4	0.6	-0.3	0.3
Body fat percentage	0.1	0.3	1.4	0.2	0.8	-0.0	-1.2	-0.4	0.5	-0.7	-0.6	-0.3	0.4	0.0	-0.0
Leg fat percentage (right)	0.1	0.2	1.3	-0.2	0.2	-0.3	-1.1	-0.4	0.0	0.1	-0.1	-0.8	0.2	0.4	0.5
Arm fat-free mass (right)	2.1	10.7	18.2	2.8	4.3	3.3	3.4	3.7	3.4	-2.7	-3.6	1.5	4.0	-3.0	-2.7
Exposure to tobacco smoke outside home	1.7	2.2	8.6	-1.2	-1.0	-1.5	-2.9	-1.1	-0.9	1.2	1.5	-0.9	-0.9	1.7	1.7
Comparative body size at age 10	0.4	1.1	3.2	-0.3	-0.7	-0.6	-0.1	-1.8	-0.5	1.6	1.0	-1.8	-0.2	0.7	1.2
Number of full brothers	0.4	0.5	3.2	0.3	-0.3	0.2	-1.8	-0.6	1.1	0.2	0.5	0.3	-0.0	-0.1	-0.1
Worry too long after embarrassment	2.1	3.6	6.8	-1.6	-2.6	-1.7	-0.3	-1.7	-2.0	1.9	2.5	-1.5	-1.8	1.9	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.5	1.1	-1.0	-0.7	-0.9	-0.4	0.1	-0.4	0.5	0.6	-0.3	-0.3	1.1	0.9
Wheeze or whistling in the chest in last year	0.6	1.0	6.6	0.6	0.2	0.6	-2.6	-0.9	0.9	-0.3	-0.1	1.5	0.6	-0.3	-0.5
Number of children fathered	0.4	0.5	1.1	-0.7	-0.7	-0.7	-0.4	0.7	0.6	1.0	0.9	-0.5	-0.7	0.7	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.0	0.9	0.3	0.9	-1.0	0.1	0.5	-0.4	-0.1	0.9	0.4	-0.9	-0.6
Age at first live birth	1.0	1.8	4.2	-1.3	-1.4	-1.6	1.6	-0.2	-1.0	1.6	0.7	-2.1	-1.5	1.0	1.0
Pulse wave peak to peak time	0.6	0.7	1.6	-0.6	-1.2	-0.6	0.5	-0.5	-0.6	1.3	0.9	-1.0	-0.9	0.5	0.7
Health satisfaction	0.8	1.0	2.6	-1.1	-0.5	-1.2	-1.6	-0.9	-0.5	0.5	0.7	-1.6	-0.7	1.1	1.0
Shortness of breath walking on level ground	1.0	1.1	10.0	-0.5	0.6	-0.4	-3.2	-0.9	0.5	-0.4	0.1	0.8	0.4	0.8	0.4
Qualifications: College or University degree	0.3	0.8	2.6	0.9	0.6	0.8	1.0	1.5	-0.4	-0.7	0.1	1.6	1.1	-0.5	-0.4
Eye problems/disorders: None of the above	1.0	1.1	5.9	-0.2	-0.3	-0.2	-2.4	-2.2	-0.2	0.6	1.0	-0.2	-0.7	0.3	0.7
Mouth/teeth dental problems: Loose teeth	1.8	2.1	3.3	1.7	1.5	1.8	1.8	-0.1	0.8	-1.7	-1.2	1.4	1.5	-1.6	-1.3
Emphysema/chronic bronchitis	0.6	0.6	1.2	-1.1	-0.8	-0.8	-0.7	-0.7	-0.2	0.7	0.6	-0.9	-0.7	0.9	1.0
Medication for pain relief, constipation, heartburn	0.5	0.8	6.4	0.7	0.0	0.7	2.5	0.7	0.6	0.3	-0.2	-0.4	0.5	-0.7	-0.5
Neck or shoulder pain in last month	0.2	0.3	0.8	-0.5	-0.9	-0.4	-0.3	-0.1	-0.8	0.9	0.5	0.7	-0.3	0.5	0.1
Medication: Blood pressure	0.2	0.3	2.8	0.1	-0.3	-0.1	-1.7	-0.8	-0.4	-0.2	0.2	0.4	-0.3	0.1	0.0
Angina (self-reported)	0.5	0.6	2.8	0.8	0.3	0.6	-0.8	0.7	-0.2	-0.6	-0.5	1.7	0.9	-0.5	-0.9
Migraine (self-reported)	2.8	3.5	6.3	-2.5	-1.4	-2.3	-0.5	0.7	-2.1	1.8	1.5	-1.9	-1.6	2.5	2.2
Medication: Ibuprofen	0.5	0.6	1.2	-0.7	-0.6	-0.9	-0.8	-0.3	-0.3	0.7	1.0	-0.5	-0.7	1.1	1.1
Medication: Allopurinol	1.3	1.7	2.9	1.3	1.6	1.7	0.8	0.4	0.3	-1.1	-1.6	0.9	1.7	-1.6	-1.4
Medication: Omeprazole	3.1	3.7	8.4	2.0	1.6	1.8	-1.6	0.3	2.3	-2.9	-1.5	2.4	1.1	-1.9	-2.2
Medication: Seretide 50 evohaler	1.6	1.9	4.6	1.2	1.6	1.2	1.2	2.2	1.0	-1.7	-1.2	1.3	1.0	-1.1	-1.4
Mean time to correctly identify matches	0.5	1.0	1.8	-0.7	-0.2	-1.1	-1.1	-1.0	-1.3	0.5	0.9	-1.3	-1.4	0.9	1.0
Heart disease (mother)	0.4	0.5	1.3	1.0	0.8	0.7	1.2	0.0	0.2	-0.4	-0.6	-0.0	0.7	-0.8	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	3.0	-1.2	-1.2	-1.1	-1.4	-0.1	-1.7	0.9	1.3	0.1	-1.3	1.3	1.1
Whole body fat mass	0.7	2.9	6.4	1.7	2.5	1.6	0.5	1.4	1.9	-1.8	-2.1	0.7	2.2	-1.4	-1.3
Leg fat mass (right)	0.7	2.7	5.6	1.6	2.4	1.5	0.2	1.3	2.0	-1.7	-2.0	0.7	2.2	-1.4	-1.3
Arm predicted mass (right)	2.0	10.4	17.5	2.7	4.2	3.2	3.4	3.7	3.4	-2.8	-3.6	1.5	3.9	-2.9	-2.6
Pulse rate, automated reading	0.4	1.4	4.0	1.3	1.5	0.9	-1.0	-1.1	2.0	-1.0	-1.2	0.6	0.7	-1.2	-1.3
Alcohol intake frequency.	0.0	0.1	0.6	0.3	-0.1	0.0	0.2	-0.7	-0.4	-0.3	0.2	-0.5	-0.1	-0.0	0.0
Comparative height size at age 10	0.2	1.2	4.4	-1.4	0.0	-1.3	0.3	-1.0	-0.8	1.0	0.4	-2.1	-0.8	1.1	1.2
Number of full sisters	1.5	1.8	4.4	-1.3	-1.7	-1.6	-0.7	0.2	-0.4	0.9	1.9	-1.1	-2.1	1.5	1.4
Suffer from ‘nerves’	0.4	0.7	2.4	-0.9	-0.8	-1.0	0.1	0.3	-0.4	1.1	0.5	-1.5	-0.7	0.8	0.7
Overall health rating	0.3	0.7	3.6	-0.9	-0.2	-1.0	-1.9	-0.1	-0.1	0.2	0.5	-0.2	-0.2	1.2	0.8
Chest pain or discomfort	2.5	3.7	6.9	-1.7	-2.6	-1.7	-1.9	-1.4	-2.2	2.2	2.2	-0.7	-2.2	1.8	1.6
Had major operations	0.3	0.4	1.3	0.6	-0.4	0.5	-1.1	-0.2	0.8	0.5	0.0	1.1	0.3	-0.3	-0.5
Age at last live birth	1.2	1.8	2.5	-1.3	-1.6	-1.4	1.0	-0.3	-1.4	1.4	1.4	-1.6	-1.4	1.2	1.4
Family relationship satisfaction	1.3	1.6	3.6	0.8	1.2	1.1	0.8	1.2	0.5	-1.9	-1.5	1.8	1.1	-1.2	-1.5
Leg pain on walking	0.1	0.1	0.5	-0.0	-0.1	-0.2	-0.7	-0.2	-0.1	-0.4	0.1	0.3	0.1	0.3	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.9	0.6	0.6	0.8	0.2	-0.1	0.1	-0.7	-0.9	0.9	0.8	-0.8	-0.7
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.7	-1.2	-0.5	-0.9	-0.2	0.1	-0.4	1.3	-0.1	-1.3	-0.3	0.9	0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.2	0.8	0.5	0.7	1.0	1.5	0.9	-0.5	-0.7	0.1	0.7	-0.9	-1.0
Medication: Aspirin	0.1	0.1	0.5	-0.3	-0.2	-0.1	-0.7	-0.1	0.2	0.0	0.0	-0.0	0.2	0.1	0.2
Supplements: Vitamin C	1.6	1.9	3.3	1.8	1.4	1.6	1.1	0.9	1.8	-0.7	-1.3	0.8	1.4	-1.7	-1.6
Knee pain experienced in last month	4.8	7.5	14.4	2.9	2.3	3.0	0.7	1.5	2.9	-3.1	-2.7	3.8	2.5	-2.9	-3.2
Hypertension (Self-reported)	0.2	0.4	3.3	0.4	0.2	-0.1	-1.8	-1.0	-0.3	-0.1	0.2	-0.6	-0.4	-0.2	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	4.3	1.1	0.7	1.1	-1.7	0.2	1.9	-1.8	-1.4	2.1	0.8	-1.5	-1.9
Illnesses of father: Heart disease	1.4	2.0	5.4	-1.4	-1.3	-1.1	1.7	-1.2	-2.3	1.1	1.2	-1.3	-1.1	1.2	1.6
Illnesses of siblings: Diabetes	0.2	0.3	1.5	0.3	0.0	0.1	-0.6	-1.2	-0.2	-0.3	0.3	-1.1	-0.1	-0.2	0.1
Smoking status: Previous	0.6	0.8	2.2	1.0	0.7	1.1	-0.2	0.5	1.0	-0.8	-0.5	1.5	1.2	-0.8	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.9	1.1	1.2	0.9	1.7	1.6	0.6	-0.3	-0.7	0.7	1.7	-0.5	-0.3
Whole body fat-free mass	2.2	12.9	21.5	3.0	4.6	3.5	3.9	4.2	3.8	-3.1	-3.9	1.6	4.3	-3.2	-2.9
Leg fat-free mass (right)	2.6	14.1	22.7	3.3	4.8	3.7	3.4	4.2	4.3	-3.6	-4.0	2.2	4.4	-3.4	-3.1
Arm fat percentage (left)	0.4	1.6	3.2	1.4	1.8	1.2	-0.2	0.5	1.7	-1.4	-1.4	0.6	1.7	-1.0	-1.0
Average weekly red wine intake	0.4	0.6	1.3	-0.5	-0.8	-0.6	0.3	-0.6	-0.9	1.1	1.2	-0.9	-0.7	0.6	0.8
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.7	-1.2	-0.5	-1.2	-0.7	-0.1	-0.4	0.5	0.5	-1.3	-1.0	1.2	1.1
Mood swings	1.0	1.8	4.3	-0.6	-1.4	-1.0	-1.5	-0.2	-1.1	2.1	1.8	-0.0	-0.1	1.9	1.9
Loneliness, isolation	1.0	1.4	2.6	-1.4	-1.5	-1.3	-0.2	-0.9	-1.6	1.0	1.2	-0.8	-1.1	1.3	1.2
Long-standing illness, disability or infirmity	0.2	0.3	1.2	-0.1	0.4	-0.0	-1.1	0.5	0.0	-0.4	0.2	0.7	0.6	0.6	0.4
Ever had bowel cancer screening	1.1	1.3	2.4	-0.8	-1.0	-1.3	-0.9	-0.3	-1.2	1.0	1.3	-1.5	-1.5	1.1	1.1
Diabetes diagnosed by doctor	4.6	7.5	10.7	2.9	2.5	2.8	1.9	2.1	3.0	-2.7	-3.2	2.1	2.9	-3.0	-3.3
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.9	1.2	1.0	1.2	-1.6	1.1	1.8	-0.9	-0.5	2.0	1.4	-0.9	-1.0
Friendships satisfaction	0.3	0.4	1.1	-0.7	-0.4	-0.1	-0.8	-0.9	-0.8	-1.1	-0.2	0.7	-0.5	-0.1	-0.4
Qualifications: nursing, teaching	2.6	4.0	7.7	-2.8	-2.0	-2.5	-0.8	-1.4	-1.7	1.4	1.6	-2.3	-2.5	2.0	2.0
Commuting to job workplace: Walk	0.8	0.8	1.6	1.2	0.2	1.0	1.3	1.2	-0.0	-0.8	-0.4	1.1	0.5	-1.0	-1.0
Eye problems/disorders: Cataract	1.6	1.8	4.4	0.8	1.6	1.0	2.1	1.9	0.8	-1.2	-1.7	0.6	1.5	-1.0	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	7.7	0.1	-0.9	0.3	0.3	-2.8	-1.4	0.5	0.6	-0.1	-0.5	-0.2	0.3
Medication for cholesterol	0.2	0.3	0.7	-0.7	-0.8	-0.5	0.4	-0.1	-0.2	0.1	0.6	0.1	-0.6	0.7	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.7	-1.0	-0.2	-1.1	-0.3	-0.8	-1.1	1.2	0.9	-0.9	-0.8	1.3	1.3
Back pain experienced in last month	0.3	0.4	1.2	-0.7	-1.1	-0.7	-0.9	-0.0	0.3	0.4	0.7	0.0	-1.1	0.6	0.3
Mineral and other dietary supplements	2.3	3.1	5.2	2.1	2.1	1.7	-0.4	0.9	1.9	-1.9	-1.7	2.3	1.9	-1.5	-1.8
Breast cancer (self-reported)	0.6	0.7	1.7	-0.9	-0.1	-0.8	0.1	-0.6	-1.3	1.1	0.7	-0.9	-0.2	1.2	1.1
Asthma (self-reported)	0.4	0.9	5.3	0.4	0.0	0.3	-2.1	-0.2	0.1	-0.7	-0.3	2.3	0.1	-0.1	-0.6
Osteoporosis (self-reported)	1.5	1.8	3.3	-1.1	-1.8	-1.1	-1.3	-0.6	-1.6	1.4	1.8	-0.4	-1.0	1.6	1.6
Osteoarthritis (self-reported)	1.9	2.5	3.9	1.7	1.8	1.9	0.8	0.8	1.7	-1.2	-1.7	1.2	2.0	-1.8	-1.7
Medication: Aspirin	0.0	0.1	0.2	-0.3	0.0	-0.0	-0.4	0.3	0.2	-0.4	-0.3	0.1	0.3	0.0	0.0
Medication: Gliclazide	1.5	1.7	2.7	1.3	1.4	1.5	0.7	1.4	0.8	-1.4	-1.5	0.9	1.6	-1.4	-1.3
Illnesses of father: None of the above (group 1)	0.9	1.1	4.3	0.7	0.9	0.6	-0.7	2.1	1.8	-0.7	-0.5	0.7	0.5	-0.7	-1.0
Smoking status: Current	1.2	1.8	3.7	1.4	1.1	1.3	-0.1	1.9	1.9	-0.6	-1.2	1.6	1.5	-1.1	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.8	-0.5	0.0	-0.5	0.2	0.9	0.6	-0.3	-0.2	-0.3	-0.6	0.2	0.1
Whole body water mass	2.3	13.0	21.5	3.0	4.6	3.5	4.0	4.3	3.8	-3.1	-3.9	1.5	4.3	-3.2	-2.9
Leg predicted mass (right)	2.7	14.4	23.0	3.4	4.8	3.7	3.5	4.2	4.4	-3.6	-4.0	2.2	4.4	-3.4	-3.2
Arm fat mass (left)	1.0	4.2	8.2	2.0	2.9	2.0	1.2	1.8	2.5	-2.1	-2.4	0.9	2.7	-1.8	-1.6
Number of self-reported non-cancer illnesses	0.7	1.1	2.3	1.5	0.9	1.0	-1.0	0.2	0.9	-1.4	-0.7	1.5	0.6	-1.0	-1.3
Average weekly champagne plus white wine intake	0.5	0.7	1.7	0.8	0.7	1.2	0.6	-0.9	-0.6	-0.3	-0.5	0.8	1.3	-0.9	-0.2
Miserableness	1.2	2.0	4.2	-1.5	-1.9	-1.3	-0.8	-0.1	-1.7	1.6	1.7	0.1	-0.6	2.0	1.8
Guilty feelings	3.8	5.7	8.3	-2.0	-2.7	-2.4	-1.5	-1.9	-2.7	2.8	2.9	-2.0	-2.0	2.7	2.6
Wears glasses or contact lenses	0.5	0.6	2.6	-1.1	-0.2	-1.0	-0.8	1.6	-0.1	0.5	0.1	-0.0	-0.4	0.9	0.3
Ever taken oral contraceptive pill	0.6	0.6	1.1	0.8	0.9	0.8	1.1	0.4	0.3	-0.8	-1.0	0.4	0.8	-1.0	-0.8
Hearing aid user	0.5	0.5	1.1	1.0	-0.3	1.1	-0.4	-0.8	0.6	0.7	-0.4	0.5	0.7	-1.0	-0.7
Mother’s age at death	0.3	0.4	1.5	-0.4	-0.8	-0.4	0.1	-0.2	-1.0	0.3	1.0	-0.1	-1.2	0.4	0.5
Financial situation satisfaction	0.3	0.4	1.9	-0.9	0.2	-0.6	-1.4	-0.7	-0.0	-0.4	-0.3	-0.3	-0.1	0.5	0.3
Tinnitus: Yes, now most or all of the time	1.8	2.1	3.7	-0.8	-1.6	-1.4	-0.3	-1.6	-0.7	1.7	1.6	-1.9	-1.6	1.3	1.7
Commuting to job workplace: Public transport	0.4	0.5	1.3	-0.9	-0.3	-0.9	-0.5	-0.4	-0.6	0.3	1.0	-0.3	-0.5	1.1	1.1
Eye problems/disorders: Glaucoma	0.4	0.4	1.5	0.1	-1.2	-0.5	-1.0	-0.7	-0.2	0.7	0.7	0.1	-0.8	0.4	0.3
Medication: Blood pressure	0.2	0.5	1.2	0.6	1.1	0.5	-0.4	0.5	-0.2	-0.9	-0.8	0.6	0.5	-0.7	-0.8
Pain type(s) experienced in last month: Hip pain	0.5	0.6	3.0	0.2	0.6	0.3	0.7	1.7	0.1	-0.7	-0.9	1.1	0.7	-0.2	-0.8
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.2	-1.7	-1.5	-1.5	-0.5	-1.2	-1.6	1.3	1.1	-2.0	-1.6	1.1	1.2
High cholesterol (Self-reported)	0.1	0.2	0.7	-0.4	-0.5	-0.2	0.8	0.1	-0.5	-0.3	0.1	-0.1	-0.6	0.1	-0.1
Medication: Bendroflumethiazide	1.8	2.7	5.5	1.7	1.5	1.7	1.1	0.5	1.1	-1.8	-2.0	1.7	1.0	-2.2	-2.3
Medication: Paracetamol	0.6	1.0	3.6	-0.8	-0.3	-0.8	-1.9	-1.1	-1.4	0.6	0.9	0.0	-0.5	1.1	1.0
Medication: Lisinopril	0.7	0.8	2.0	1.1	1.4	1.2	-0.1	0.4	0.6	-0.4	-1.0	0.7	1.1	-1.2	-0.9
Medication: Atorvastatin	1.7	2.1	3.3	1.4	1.8	1.6	1.7	0.3	0.7	-1.6	-1.8	0.6	1.7	-1.6	-1.5
Illnesses of father: High blood pressure	0.5	0.6	2.2	-0.7	-0.8	-0.5	1.1	-0.3	-1.5	0.6	0.6	-0.8	-0.7	0.6	0.8
Alcohol drinker status: Never	0.4	0.5	1.1	0.8	0.5	0.7	-0.8	-0.5	0.1	-1.1	-0.3	0.9	0.3	-0.8	-0.7
Ever smoked	2.3	4.0	8.2	2.1	1.6	2.5	0.0	1.6	2.4	-1.3	-1.5	2.7	2.9	-1.9	-1.8
Basal metabolic rate	2.1	11.4	19.8	2.8	4.4	3.3	3.6	4.0	3.6	-2.9	-3.6	1.4	4.1	-2.9	-2.6
Leg fat percentage (left)	0.1	0.2	1.4	0.2	0.4	0.0	-1.2	-0.5	0.3	-0.3	-0.4	-0.6	0.4	-0.0	0.0
Arm fat-free mass (left)	1.7	8.5	15.5	2.3	3.9	2.8	3.4	3.6	2.9	-2.4	-3.3	0.8	3.6	-2.5	-2.2
Number of operations (self-reported)	2.2	3.3	7.3	2.1	1.3	2.0	-0.2	1.6	2.0	-1.6	-1.4	2.7	1.7	-1.8	-2.0
Average weekly beer plus cider intake	0.2	0.2	1.3	-0.1	-0.4	0.2	1.1	0.7	0.1	-0.0	-0.0	0.9	0.0	-0.1	-0.1
Irritability	0.2	0.4	1.9	0.4	0.1	0.6	0.2	0.6	0.5	-0.2	-0.3	1.4	1.1	-0.3	-0.5
Risk taking	0.5	0.8	4.4	-0.2	0.3	-0.0	-2.1	-0.8	-0.5	-0.3	1.0	1.2	0.3	0.6	0.8
Ever had prostate specific antigen (PSA) test	7.1	8.2	11.1	-2.8	-2.8	-3.0	-1.7	-2.9	-2.7	3.0	2.8	-3.2	-3.3	2.8	2.9
Fractured/broken bones in last 5 years	0.5	0.7	2.5	-0.5	-0.6	-0.6	-0.7	-0.5	-0.9	1.6	0.9	-1.1	-0.4	0.5	0.7
Age started oral contraceptive pill	0.5	0.6	3.1	0.9	0.3	0.4	0.2	-1.8	-1.3	-0.2	0.1	-0.4	-0.7	-0.8	-0.5
Diastolic blood pressure, automated reading	1.0	3.2	7.7	-1.9	-0.9	-1.9	-0.9	-1.7	-2.8	1.1	1.7	-1.9	-1.6	2.0	2.1
Ever depressed for a whole week	0.2	0.2	0.6	-0.4	-0.1	0.1	-0.8	-0.6	-0.2	-0.2	-0.5	-0.7	0.1	-0.6	-0.5
Unable to work because of sickness or disability	1.1	1.4	2.3	1.5	0.4	1.5	-0.4	-0.1	1.1	-0.7	-1.3	1.4	1.5	-1.4	-1.5
Commuting to job workplace: Cycle	1.6	1.9	4.7	1.6	0.8	2.2	1.9	0.8	0.4	-0.6	-0.7	1.8	1.5	-1.6	-1.2
Myopia	0.4	0.6	2.0	-0.4	-0.3	-0.8	-0.5	-0.9	-0.6	0.7	0.7	-1.4	-1.0	0.6	0.7
Vascular/heart problems diagnosed by doctor	0.1	0.2	1.2	-0.6	-0.5	-0.1	1.1	0.2	0.4	0.2	0.0	0.3	0.2	0.3	0.3
Cholesterol lowering medication	0.3	0.4	1.6	0.2	0.9	0.2	1.3	-0.1	0.2	0.0	-0.5	-1.2	0.6	-0.4	-0.2
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	7.5	1.6	1.0	1.6	-1.0	0.3	2.1	-2.7	-1.4	2.4	0.5	-1.9	-2.2
Pain experienced in last month	0.2	0.3	1.3	0.2	0.6	0.2	0.5	-0.1	0.4	0.1	-0.6	-1.1	0.3	-0.6	-0.3
Supplements: Calcium	0.7	0.8	3.3	-0.2	0.3	0.1	0.9	1.8	1.2	-0.9	-1.2	0.2	0.4	-0.4	-0.9
Basal cell carcinoma (self-reported)	1.4	1.6	2.2	-1.0	-1.3	-1.1	-1.3	-1.4	-1.1	1.4	1.5	-1.1	-1.1	1.3	1.4
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.6	0.6	1.2	0.8	-0.6	0.4	1.3	-1.6	-1.2	1.1	0.9	-1.0	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.0	0.3	0.8	0.3	0.8	-0.2	0.3	-0.2	-0.3	-1.0	0.7	-0.1	0.3
Heart disease (siblings)	0.3	0.3	1.3	0.7	0.2	0.3	-0.2	-1.1	0.4	0.6	-0.2	-0.9	0.8	-0.3	-0.1
Alcohol drinker status: Previous	0.2	0.3	0.6	-0.1	-0.5	-0.4	0.6	0.2	-0.8	0.4	0.8	-0.1	-0.3	0.6	0.5
Pack years of smoking	0.2	0.3	0.9	0.5	0.1	0.6	-0.5	0.3	-0.0	-0.5	-0.3	0.8	1.0	-0.3	-0.3
Impedance of whole body	3.6	18.2	25.0	-4.5	-4.8	-4.7	-3.1	-4.2	-5.0	3.9	4.2	-2.9	-5.0	4.4	4.1
Leg fat mass (left)	0.7	2.7	5.5	1.6	2.3	1.5	0.1	1.1	2.0	-1.8	-2.0	0.6	2.1	-1.5	-1.3
Arm predicted mass (left)	1.6	8.0	14.8	2.3	3.9	2.7	3.1	3.4	2.9	-2.3	-3.1	0.7	3.5	-2.4	-2.0