Best TWAS P=1.08e-14 · Best GWAS P=3.2e-15 conditioned to 0.000356
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | LOXL4 | 0.16 | 0.16 | lasso | 3 | 0.15 | 2.4e-09 | -6.6 | 6.7 | 2.1e-11 | 0.49 | 0.87 | 0.13 | FALSE |
| 2 | GTEx | Nerve Tibial | R3HCC1L | 0.06 | 0.07 | enet | 8 | 0.05 | 1.1e-04 | 6.2 | 6.9 | 6.9e-12 | 0.87 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | R3HCC1L | 0.10 | 0.05 | enet | 14 | 0.05 | 3.4e-05 | -6.7 | 7.7 | 1.1e-14 | 0.68 | 0.09 | 0.90 | TRUE |
| 4 | GTEx | Testis | LOXL4 | 0.48 | 0.47 | enet | 8 | 0.46 | 1.0e-22 | -6.8 | 6.7 | 1.6e-11 | 0.48 | 0.84 | 0.16 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | R3HCC1L | 0.03 | 0.04 | lasso | 3 | 0.02 | 1.1e-03 | -6.4 | 6.2 | 4.1e-10 | 0.46 | 0.67 | 0.17 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LOXL4 | 0.08 | 0.00 | blup | 51 | 0.02 | 9.4e-03 | 5.1 | 6.6 | 3.1e-11 | 0.62 | 0.01 | 0.45 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOXL4 | 0.09 | 0.05 | enet | 12 | 0.05 | 3.0e-06 | -5.8 | 6.7 | 2.2e-11 | 0.42 | 0.56 | 0.28 | FALSE |