[Hub]/) : Traits : Impedance of leg (right) :

chr10:99,204,526-100,718,107

Best TWAS P=1.08e-14 · Best GWAS P=3.2e-15 conditioned to 0.000356

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Esophagus Muscularis LOXL4 0.16 0.16 lasso 3 0.15 2.4e-09 -6.6 6.7 2.1e-11 0.49 0.87 0.13 FALSE
2 GTEx Nerve Tibial R3HCC1L 0.06 0.07 enet 8 0.05 1.1e-04 6.2 6.9 6.9e-12 0.87 0.02 0.98 FALSE
3 GTEx Skin Sun Exposed Lower leg R3HCC1L 0.10 0.05 enet 14 0.05 3.4e-05 -6.7 7.7 1.1e-14 0.68 0.09 0.90 TRUE
4 GTEx Testis LOXL4 0.48 0.47 enet 8 0.46 1.0e-22 -6.8 6.7 1.6e-11 0.48 0.84 0.16 FALSE
5 ROSMAP Brain Pre-frontal Cortex R3HCC1L 0.03 0.04 lasso 3 0.02 1.1e-03 -6.4 6.2 4.1e-10 0.46 0.67 0.17 FALSE
6 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma LOXL4 0.08 0.00 blup 51 0.02 9.4e-03 5.1 6.6 3.1e-11 0.62 0.01 0.45 FALSE
7 The Cancer Genome Atlas Prostate Adenocarcinoma LOXL4 0.09 0.05 enet 12 0.05 3.0e-06 -5.8 6.7 2.2e-11 0.42 0.56 0.28 FALSE