[Hub]/) : Traits : Impedance of leg (right) :

chr10:101,975,269-105,850,787

Best TWAS P=2.44e-16 · Best GWAS P=4.9e-16 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex USMG5 0.03 0.01 bslmm 352 0.00 7.5e-02 -4.2 5.6 2.0e-08 -0.51 0.16 0.41 FALSE
2 GTEx Adipose Subcutaneous CYP17A1-AS1 0.05 0.02 enet 10 0.03 2.8e-03 -7.1 -5.3 9.7e-08 0.68 0.22 0.42 FALSE
3 GTEx Adipose Subcutaneous RP11-179B2.2 0.15 0.08 lasso 6 0.08 3.2e-07 -5.8 -6.9 4.0e-12 0.01 0.01 0.99 FALSE
4 GTEx Adipose Visceral Omentum RP11-179B2.2 0.13 0.02 lasso 3 0.03 6.5e-03 -7.9 -7.6 2.4e-14 0.04 0.01 0.99 FALSE
5 GTEx Artery Aorta TMEM180 0.25 0.23 enet 37 0.25 7.4e-14 -3.4 -6.2 6.5e-10 0.21 1.00 0.00 TRUE
6 GTEx Artery Aorta ARL3 0.19 0.07 lasso 6 0.06 4.8e-04 -5.6 6.6 3.8e-11 -0.71 0.23 0.62 TRUE
7 GTEx Artery Aorta RP11-179B2.2 0.16 0.11 lasso 2 0.09 7.6e-06 -7.9 -7.6 2.8e-14 0.05 0.01 0.99 FALSE
8 GTEx Artery Tibial RP11-179B2.2 0.11 0.09 lasso 4 0.08 8.8e-07 -7.9 -7.9 2.6e-15 0.02 0.01 0.99 FALSE
9 GTEx Brain Cerebellum TRIM8 0.34 -0.01 enet 25 0.07 4.7e-03 2.5 6.7 1.6e-11 -0.34 0.07 0.37 TRUE
10 GTEx Brain Cerebellum RP11-179B2.2 0.37 0.21 lasso 4 0.20 1.4e-06 -7.9 -8.0 1.3e-15 0.02 0.01 0.99 FALSE
11 GTEx Brain Frontal Cortex BA9 RP11-179B2.2 0.22 0.15 lasso 2 0.11 7.2e-04 -7.9 -7.5 4.4e-14 0.03 0.01 0.95 FALSE
12 GTEx Breast Mammary Tissue SFXN2 0.11 0.00 enet 12 0.03 1.3e-02 -3.6 5.4 8.1e-08 -0.39 0.19 0.05 FALSE
13 GTEx Breast Mammary Tissue RP11-179B2.2 0.11 0.09 lasso 2 0.07 1.8e-04 -7.9 -7.1 1.3e-12 0.04 0.01 0.99 FALSE
14 GTEx Breast Mammary Tissue (Male) RP11-179B2.2 0.16 -0.01 enet 4 -0.01 7.1e-01 7.4 -7.4 1.8e-13 0.00 0.03 0.51 FALSE
15 GTEx Breast Mammary Tissue (Female) CYP17A1-AS1 0.14 0.01 lasso 11 0.00 4.7e-01 -7.6 -6.0 1.7e-09 0.88 0.05 0.42 FALSE
16 GTEx Cells Transformed fibroblasts GBF1 0.07 0.00 enet 2 0.00 1.4e-01 -7.1 -6.7 1.6e-11 0.78 0.05 0.47 FALSE
17 GTEx Cells Transformed fibroblasts SUFU 0.07 0.04 lasso 3 0.04 3.5e-04 -7.6 -7.8 4.9e-15 0.85 0.20 0.55 FALSE
18 GTEx Colon Sigmoid ARL3 0.13 0.10 lasso 6 0.05 5.5e-03 -5.6 5.6 1.8e-08 -0.62 0.15 0.38 FALSE
19 GTEx Esophagus Muscularis RP11-179B2.2 0.15 0.16 lasso 3 0.16 8.1e-10 -8.1 -8.0 8.4e-16 0.01 0.00 1.00 FALSE
20 GTEx Heart Left Ventricle RP11-179B2.2 0.15 0.18 enet 2 0.14 4.8e-08 -7.9 -7.9 2.8e-15 0.04 0.01 0.99 FALSE
21 GTEx Liver ACTR1A 0.15 0.00 lasso 10 0.00 4.6e-01 2.5 5.2 1.8e-07 -0.26 0.07 0.10 FALSE
22 GTEx Lung RP11-179B2.2 0.18 0.12 lasso 3 0.12 1.7e-09 -7.9 -7.5 6.5e-14 0.03 0.01 0.99 FALSE
23 GTEx Muscle Skeletal TMEM180 0.05 0.01 lasso 6 0.01 8.3e-02 -4.3 -5.8 5.7e-09 0.60 0.06 0.53 TRUE
24 GTEx Nerve Tibial RP11-179B2.2 0.15 0.08 lasso 2 0.12 6.4e-09 -8.1 -6.6 3.1e-11 -0.02 0.00 1.00 FALSE
25 GTEx Skin Not Sun Exposed Suprapubic RP11-179B2.2 0.27 0.15 enet 36 0.15 2.0e-08 -7.9 -6.7 2.1e-11 0.00 0.00 1.00 FALSE
26 GTEx Skin Sun Exposed Lower leg RP11-179B2.2 0.12 0.09 lasso 2 0.08 1.7e-07 -5.6 -5.5 3.8e-08 0.03 0.04 0.96 FALSE
27 GTEx Stomach BTRC 0.12 0.04 enet 10 0.04 4.9e-03 1.9 5.3 9.6e-08 0.05 0.17 0.04 FALSE
28 GTEx Testis NT5C2 0.20 0.03 lasso 8 0.08 2.8e-04 -7.6 -5.6 1.6e-08 0.87 0.08 0.84 FALSE
29 GTEx Testis CYP17A1-AS1 0.14 0.08 enet 5 0.10 2.3e-05 -7.6 7.7 9.3e-15 -0.98 0.03 0.96 FALSE
30 GTEx Thyroid C10orf95 0.10 0.02 enet 28 0.02 6.6e-03 -3.5 -5.8 8.6e-09 0.28 0.21 0.05 TRUE
31 GTEx Thyroid WBP1L 0.26 0.10 enet 9 0.13 2.1e-10 -2.0 5.4 7.9e-08 -0.81 0.19 0.81 FALSE
32 GTEx Thyroid RP11-179B2.2 0.18 0.12 lasso 7 0.11 8.3e-09 -5.8 -6.4 1.4e-10 0.04 0.03 0.97 FALSE
33 METSIM Adipose MRPL43 0.05 0.04 bslmm 422 0.04 1.9e-06 3.6 -5.2 2.0e-07 -0.03 0.94 0.02 FALSE
34 ROSMAP Brain Pre-frontal Cortex ARL3 0.24 0.14 bslmm 368 0.16 3.9e-20 -5.6 6.4 1.9e-10 -0.53 1.00 0.00 FALSE
35 ROSMAP Brain Pre-frontal Cortex CNNM2 0.11 0.08 lasso 3 0.07 2.2e-09 -8.0 -7.9 2.0e-15 1.00 0.02 0.98 TRUE
36 ROSMAP Brain Pre-frontal Cortex USMG5 0.04 0.03 lasso 9 0.03 1.6e-04 -4.2 6.4 1.3e-10 -0.64 0.05 0.92 TRUE
37 YFS Blood NT5C2 0.13 0.10 bslmm 382 0.11 7.3e-35 -7.9 -6.3 2.5e-10 0.94 0.02 0.98 FALSE
38 The Cancer Genome Atlas Bladder Urothelial Carcinoma AS3MT 0.06 0.09 enet 6 0.07 1.3e-06 -5.0 6.2 4.2e-10 -0.69 0.37 0.61 FALSE
39 The Cancer Genome Atlas Breast Invasive Carcinoma CALHM2 0.03 0.02 blup 49 0.02 3.0e-04 -4.5 -5.4 5.1e-08 0.24 0.02 0.82 FALSE
40 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ARL3 0.09 0.02 blup 57 0.05 1.8e-03 -5.6 5.8 7.7e-09 -0.59 0.01 0.60 TRUE
41 The Cancer Genome Atlas Colon Adenocarcinoma MRPL43 0.07 0.02 blup 52 0.00 1.7e-01 -7.7 8.2 2.4e-16 0.02 0.01 0.83 TRUE
42 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MRPL43 0.03 0.02 blup 52 0.03 3.0e-04 3.6 5.3 1.0e-07 0.06 0.10 0.52 FALSE
43 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ARL3 0.03 0.02 lasso 3 0.02 1.1e-03 -5.6 5.5 4.3e-08 -0.63 0.03 0.73 TRUE
44 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SEMA4G 0.04 0.01 blup 52 0.02 1.2e-03 -5.6 -5.6 2.8e-08 -0.02 0.01 0.80 FALSE
45 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TMEM180 0.06 0.03 lasso 5 0.03 3.7e-04 -5.0 -5.4 6.8e-08 0.46 0.01 0.98 FALSE
46 The Cancer Genome Atlas Brain Lower Grade Glioma ACTR1A 0.04 0.01 blup 51 0.02 7.1e-04 -3.5 -5.7 1.0e-08 0.27 0.04 0.17 TRUE
47 The Cancer Genome Atlas Brain Lower Grade Glioma SEMA4G 0.03 0.01 blup 52 0.01 4.2e-02 -8.1 -5.7 1.1e-08 -0.02 0.00 0.90 FALSE
48 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MRPL43 0.06 0.04 blup 51 0.04 7.4e-04 3.6 5.1 2.6e-07 0.03 0.55 0.08 FALSE
49 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma FAM178A 0.14 0.08 lasso 2 0.08 5.9e-04 7.1 6.7 2.6e-11 0.02 0.07 0.14 FALSE
50 The Cancer Genome Atlas Prostate Adenocarcinoma ARL3 0.04 0.02 blup 57 0.03 9.2e-04 -5.6 5.8 6.5e-09 -0.50 0.06 0.56 FALSE
51 The Cancer Genome Atlas Thyroid Carcinoma ARL3 0.06 0.07 lasso 4 0.06 3.5e-06 -5.6 5.3 1.4e-07 -0.57 0.89 0.10 FALSE
52 The Cancer Genome Atlas Thyroid Carcinoma SEMA4G 0.07 0.08 blup 52 0.08 5.1e-08 3.6 -5.2 1.5e-07 -0.03 0.04 0.96 FALSE