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chr10:101,975,269-105,850,787

Best TWAS P=2.44e-16 · Best GWAS P=4.9e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
41	The Cancer Genome Atlas	Colon Adenocarcinoma	MRPL43	0.07	0.02	blup	52	0.00	1.7e-01	-7.7	8.2	2.4e-16	0.02	0.01	0.83	TRUE
35	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	-8.0	-7.9	2.0e-15	1.00	0.02	0.98	TRUE
9	GTEx	Brain Cerebellum	TRIM8	0.34	-0.01	enet	25	0.07	4.7e-03	2.5	6.7	1.6e-11	-0.34	0.07	0.37	TRUE
6	GTEx	Artery Aorta	ARL3	0.19	0.07	lasso	6	0.06	4.8e-04	-5.6	6.6	3.8e-11	-0.71	0.23	0.62	TRUE
36	ROSMAP	Brain Pre-frontal Cortex	USMG5	0.04	0.03	lasso	9	0.03	1.6e-04	-4.2	6.4	1.3e-10	-0.64	0.05	0.92	TRUE
5	GTEx	Artery Aorta	TMEM180	0.25	0.23	enet	37	0.25	7.4e-14	-3.4	-6.2	6.5e-10	0.21	1.00	0.00	TRUE
23	GTEx	Muscle Skeletal	TMEM180	0.05	0.01	lasso	6	0.01	8.3e-02	-4.3	-5.8	5.7e-09	0.60	0.06	0.53	TRUE
40	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ARL3	0.09	0.02	blup	57	0.05	1.8e-03	-5.6	5.8	7.7e-09	-0.59	0.01	0.60	TRUE
30	GTEx	Thyroid	C10orf95	0.10	0.02	enet	28	0.02	6.6e-03	-3.5	-5.8	8.6e-09	0.28	0.21	0.05	TRUE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACTR1A	0.04	0.01	blup	51	0.02	7.1e-04	-3.5	-5.7	1.0e-08	0.27	0.04	0.17	TRUE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARL3	0.03	0.02	lasso	3	0.02	1.1e-03	-5.6	5.5	4.3e-08	-0.63	0.03	0.73	TRUE
19	GTEx	Esophagus Muscularis	RP11-179B2.2	0.15	0.16	lasso	3	0.16	8.1e-10	-8.1	-8.0	8.4e-16	0.01	0.00	1.00	FALSE
10	GTEx	Brain Cerebellum	RP11-179B2.2	0.37	0.21	lasso	4	0.20	1.4e-06	-7.9	-8.0	1.3e-15	0.02	0.01	0.99	FALSE
8	GTEx	Artery Tibial	RP11-179B2.2	0.11	0.09	lasso	4	0.08	8.8e-07	-7.9	-7.9	2.6e-15	0.02	0.01	0.99	FALSE
20	GTEx	Heart Left Ventricle	RP11-179B2.2	0.15	0.18	enet	2	0.14	4.8e-08	-7.9	-7.9	2.8e-15	0.04	0.01	0.99	FALSE
17	GTEx	Cells Transformed fibroblasts	SUFU	0.07	0.04	lasso	3	0.04	3.5e-04	-7.6	-7.8	4.9e-15	0.85	0.20	0.55	FALSE
29	GTEx	Testis	CYP17A1-AS1	0.14	0.08	enet	5	0.10	2.3e-05	-7.6	7.7	9.3e-15	-0.98	0.03	0.96	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-179B2.2	0.13	0.02	lasso	3	0.03	6.5e-03	-7.9	-7.6	2.4e-14	0.04	0.01	0.99	FALSE
7	GTEx	Artery Aorta	RP11-179B2.2	0.16	0.11	lasso	2	0.09	7.6e-06	-7.9	-7.6	2.8e-14	0.05	0.01	0.99	FALSE
11	GTEx	Brain Frontal Cortex BA9	RP11-179B2.2	0.22	0.15	lasso	2	0.11	7.2e-04	-7.9	-7.5	4.4e-14	0.03	0.01	0.95	FALSE
22	GTEx	Lung	RP11-179B2.2	0.18	0.12	lasso	3	0.12	1.7e-09	-7.9	-7.5	6.5e-14	0.03	0.01	0.99	FALSE
14	GTEx	Breast Mammary Tissue (Male)	RP11-179B2.2	0.16	-0.01	enet	4	-0.01	7.1e-01	7.4	-7.4	1.8e-13	0.00	0.03	0.51	FALSE
13	GTEx	Breast Mammary Tissue	RP11-179B2.2	0.11	0.09	lasso	2	0.07	1.8e-04	-7.9	-7.1	1.3e-12	0.04	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	RP11-179B2.2	0.15	0.08	lasso	6	0.08	3.2e-07	-5.8	-6.9	4.0e-12	0.01	0.01	0.99	FALSE
16	GTEx	Cells Transformed fibroblasts	GBF1	0.07	0.00	enet	2	0.00	1.4e-01	-7.1	-6.7	1.6e-11	0.78	0.05	0.47	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	RP11-179B2.2	0.27	0.15	enet	36	0.15	2.0e-08	-7.9	-6.7	2.1e-11	0.00	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FAM178A	0.14	0.08	lasso	2	0.08	5.9e-04	7.1	6.7	2.6e-11	0.02	0.07	0.14	FALSE
24	GTEx	Nerve Tibial	RP11-179B2.2	0.15	0.08	lasso	2	0.12	6.4e-09	-8.1	-6.6	3.1e-11	-0.02	0.00	1.00	FALSE
32	GTEx	Thyroid	RP11-179B2.2	0.18	0.12	lasso	7	0.11	8.3e-09	-5.8	-6.4	1.4e-10	0.04	0.03	0.97	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	ARL3	0.24	0.14	bslmm	368	0.16	3.9e-20	-5.6	6.4	1.9e-10	-0.53	1.00	0.00	FALSE
37	YFS	Blood	NT5C2	0.13	0.10	bslmm	382	0.11	7.3e-35	-7.9	-6.3	2.5e-10	0.94	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	-5.0	6.2	4.2e-10	-0.69	0.37	0.61	FALSE
15	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	-7.6	-6.0	1.7e-09	0.88	0.05	0.42	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARL3	0.04	0.02	blup	57	0.03	9.2e-04	-5.6	5.8	6.5e-09	-0.50	0.06	0.56	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEMA4G	0.03	0.01	blup	52	0.01	4.2e-02	-8.1	-5.7	1.1e-08	-0.02	0.00	0.90	FALSE
28	GTEx	Testis	NT5C2	0.20	0.03	lasso	8	0.08	2.8e-04	-7.6	-5.6	1.6e-08	0.87	0.08	0.84	FALSE
18	GTEx	Colon Sigmoid	ARL3	0.13	0.10	lasso	6	0.05	5.5e-03	-5.6	5.6	1.8e-08	-0.62	0.15	0.38	FALSE
1	CommonMind	Brain Pre-frontal Cortex	USMG5	0.03	0.01	bslmm	352	0.00	7.5e-02	-4.2	5.6	2.0e-08	-0.51	0.16	0.41	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEMA4G	0.04	0.01	blup	52	0.02	1.2e-03	-5.6	-5.6	2.8e-08	-0.02	0.01	0.80	FALSE
26	GTEx	Skin Sun Exposed Lower leg	RP11-179B2.2	0.12	0.09	lasso	2	0.08	1.7e-07	-5.6	-5.5	3.8e-08	0.03	0.04	0.96	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	CALHM2	0.03	0.02	blup	49	0.02	3.0e-04	-4.5	-5.4	5.1e-08	0.24	0.02	0.82	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM180	0.06	0.03	lasso	5	0.03	3.7e-04	-5.0	-5.4	6.8e-08	0.46	0.01	0.98	FALSE
31	GTEx	Thyroid	WBP1L	0.26	0.10	enet	9	0.13	2.1e-10	-2.0	5.4	7.9e-08	-0.81	0.19	0.81	FALSE
12	GTEx	Breast Mammary Tissue	SFXN2	0.11	0.00	enet	12	0.03	1.3e-02	-3.6	5.4	8.1e-08	-0.39	0.19	0.05	FALSE
27	GTEx	Stomach	BTRC	0.12	0.04	enet	10	0.04	4.9e-03	1.9	5.3	9.6e-08	0.05	0.17	0.04	FALSE
2	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	-7.1	-5.3	9.7e-08	0.68	0.22	0.42	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MRPL43	0.03	0.02	blup	52	0.03	3.0e-04	3.6	5.3	1.0e-07	0.06	0.10	0.52	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	ARL3	0.06	0.07	lasso	4	0.06	3.5e-06	-5.6	5.3	1.4e-07	-0.57	0.89	0.10	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	SEMA4G	0.07	0.08	blup	52	0.08	5.1e-08	3.6	-5.2	1.5e-07	-0.03	0.04	0.96	FALSE
21	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	2.5	5.2	1.8e-07	-0.26	0.07	0.10	FALSE
33	METSIM	Adipose	MRPL43	0.05	0.04	bslmm	422	0.04	1.9e-06	3.6	-5.2	2.0e-07	-0.03	0.94	0.02	FALSE
48	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MRPL43	0.06	0.04	blup	51	0.04	7.4e-04	3.6	5.1	2.6e-07	0.03	0.55	0.08	FALSE