Best TWAS P=2.61e-09 · Best GWAS P=7.85e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Esophagus Muscularis | ZCRB1 | 0.13 | 0.10 | lasso | 2 | 0.08 | 2.4e-05 | -6.0 | -6.0 | 2.6e-09 | 0.97 | 0.00 | 1.00 | TRUE |
| 7 | GTEx | Thyroid | GXYLT1 | 0.11 | 0.09 | enet | 20 | 0.12 | 2.8e-09 | -4.2 | -5.9 | 2.9e-09 | 0.69 | 0.88 | 0.11 | FALSE |
| 6 | GTEx | Lung | ZCRB1 | 0.10 | 0.14 | enet | 13 | 0.13 | 5.6e-10 | -6.0 | -5.9 | 4.0e-09 | 0.95 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZCRB1 | 0.04 | 0.01 | blup | 34 | 0.01 | 1.8e-02 | -4.4 | -5.8 | 5.0e-09 | 0.93 | 0.00 | 0.32 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | PPHLN1 | 0.17 | 0.10 | enet | 24 | 0.17 | 1.3e-12 | -4.5 | -5.7 | 1.5e-08 | 0.88 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Artery Tibial | PPHLN1 | 0.12 | 0.07 | lasso | 5 | 0.09 | 2.3e-07 | -4.4 | -5.4 | 5.4e-08 | 0.92 | 0.03 | 0.97 | FALSE |
| 1 | GTEx | Adipose Subcutaneous | PPHLN1 | 0.11 | 0.11 | enet | 12 | 0.13 | 8.5e-11 | 4.3 | -5.2 | 1.7e-07 | 0.67 | 0.89 | 0.10 | FALSE |
| 5 | GTEx | Lung | PPHLN1 | 0.14 | 0.13 | lasso | 4 | 0.13 | 3.5e-10 | -4.5 | -5.2 | 1.7e-07 | 0.90 | 0.02 | 0.98 | FALSE |