TWAS hub - PPHLN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0210	5.7e-08	0.100	0.070	0.098	0.084	0.097	3.5e-12	6.6e-09	5.7e-12	2.2e-10	6.9e-12
2	GTEx	Adipose Subcutaneous	0.1080	0.0340	1.1e-05	0.112	NA	0.130	NA	0.122	2.1e-09	NA	8.5e-11	NA	3.4e-10
3	GTEx	Adipose Visceral Omentum	0.0960	0.0420	5.7e-03	0.066	NA	0.036	NA	-0.005	2.6e-04	NA	5.6e-03	NA	7.9e-01
4	GTEx	Artery Aorta	0.1220	0.0490	1.6e-03	-0.004	NA	0.020	NA	0.016	6.7e-01	NA	2.6e-02	NA	4.1e-02
5	GTEx	Artery Tibial	0.1182	0.0333	3.5e-07	0.071	NA	0.085	NA	0.088	3.1e-06	NA	3.3e-07	NA	2.3e-07
6	GTEx	Brain Cerebellar Hemisphere	0.2440	0.0980	5.9e-03	-0.001	NA	0.007	NA	0.006	3.3e-01	NA	2.0e-01	NA	2.2e-01
7	GTEx	Brain Cerebellum	0.1950	0.0760	4.3e-03	0.013	NA	0.005	NA	0.049	1.3e-01	NA	2.2e-01	NA	1.4e-02
8	GTEx	Breast Mammary Tissue	0.1130	0.0410	1.0e-03	0.012	NA	0.034	NA	0.024	8.0e-02	NA	7.5e-03	NA	2.2e-02
9	GTEx	Breast Mammary Tissue (Female)	0.1377	0.0730	3.5e-02	-0.007	NA	-0.006	NA	-0.009	5.8e-01	NA	5.3e-01	NA	7.2e-01
10	GTEx	Cells EBV-transformed lymphocytes	0.2200	0.0650	1.4e-04	0.030	NA	0.104	NA	0.084	3.6e-02	NA	2.9e-04	NA	1.1e-03
11	GTEx	Cells Transformed fibroblasts	0.1700	0.0410	2.3e-09	0.103	NA	0.168	NA	0.150	3.7e-08	NA	1.3e-12	NA	2.2e-11
12	GTEx	Lung	0.1416	0.0411	1.3e-06	0.130	NA	0.128	NA	0.130	3.9e-10	NA	5.1e-10	NA	3.5e-10
13	GTEx	Nerve Tibial	0.2089	0.0578	1.5e-07	0.118	NA	0.084	NA	0.095	1.1e-08	NA	1.5e-06	NA	3.2e-07
14	GTEx	Thyroid	0.1040	0.0410	1.1e-03	0.041	NA	0.020	NA	0.014	4.0e-04	NA	1.1e-02	NA	2.5e-02
15	METSIM	Adipose	0.0308	0.0136	1.9e-03	0.022	0.010	0.021	0.014	0.022	2.7e-04	9.3e-03	3.5e-04	3.0e-03	2.5e-04
16	YFS	Blood	0.0612	0.0140	0.0e+00	0.036	0.064	0.071	0.071	0.071	5.9e-12	3.9e-20	4.4e-22	3.6e-22	3.1e-22
17	TCGA	Brain Lower Grade Glioma	0.0270	0.0164	6.8e-03	0.018	0.013	0.020	NA	0.021	3.1e-03	1.1e-02	2.0e-03	NA	1.8e-03
18	TCGA	Pheochromocytoma and Paraganglioma	0.1130	0.0590	2.5e-03	0.077	0.067	0.033	NA	0.041	5.5e-04	1.3e-03	1.8e-02	NA	9.6e-03
19	TCGA	Prostate Adenocarcinoma	0.0264	0.0142	1.2e-03	0.038	0.027	0.030	NA	0.032	7.3e-05	7.4e-04	3.9e-04	NA	2.6e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Primary Biliary Cirrhosis	8.6	12.3	21.4	-3.1	4.0	3.5	3.3	4.2	1.5	-0.3	3.9	2.2	3.0	4.6	4.2	4.0	3.2	4.2	3.1	4.0	3.4	3.9
Rheumatoid Arthritis	6.4	8.8	15.8	-2.6	3.4	4.0	3.0	3.3	2.1	-0.4	2.7	1.8	3.1	3.4	3.0	3.3	4.0	3.2	0.5	3.8	2.5	3.2
Heart disease (mother)	6.2	7.5	13.7	2.0	-2.9	-3.7	-3.0	-2.6	-0.3	0.8	-3.4	-2.8	-2.9	-3.3	-2.7	-2.8	-3.2	-3.2	-0.3	-3.2	-2.9	-2.7
Hand grip strength (right)	4.6	12.6	23.7	-3.6	4.3	3.8	4.3	3.7	1.9	0.5	3.8	3.7	2.0	4.9	4.3	3.9	2.8	3.6	2.4	3.8	3.2	4.0
Hypothyroidism (self reported)	4.1	9.3	17.5	-2.8	3.0	2.8	4.2	4.0	1.4	0.4	3.5	3.2	2.5	3.9	3.2	3.3	2.8	2.8	2.7	3.5	2.7	3.1
Impedance of arm (right)	4.1	19.3	39.6	3.5	-6.3	-4.5	-4.5	-5.3	0.1	0.1	-4.5	-3.8	-4.4	-6.1	-4.9	-4.4	-3.6	-4.9	-3.3	-4.4	-5.2	-4.4
Hand grip strength (left)	4.0	10.6	21.8	-3.0	4.1	3.7	3.7	3.4	0.8	-0.2	3.6	3.4	2.2	4.7	3.7	3.5	3.0	3.5	1.8	3.3	3.1	3.5
Comparative body size at age 10	3.8	10.5	17.6	-3.7	3.7	3.0	3.3	4.2	2.8	1.5	2.2	2.1	2.4	3.8	4.0	4.0	3.6	3.6	2.8	2.9	2.1	4.0
Medication: Allopurinol	3.8	5.1	17.2	-0.9	3.3	3.0	2.4	2.2	-0.3	-1.9	2.3	1.0	1.4	3.0	1.9	1.9	1.9	2.2	0.1	4.1	3.0	1.8
Impedance of arm (left)	3.7	17.1	35.7	3.3	-6.0	-4.0	-4.1	-5.2	0.6	0.0	-4.4	-3.8	-3.9	-5.7	-4.6	-4.2	-3.1	-4.5	-3.4	-4.0	-5.0	-4.1
Impedance of leg (right)	3.6	17.6	32.0	3.8	-5.2	-3.5	-4.1	-5.4	0.2	-0.5	-4.1	-3.3	-3.5	-5.7	-5.2	-4.5	-3.3	-4.7	-5.0	-3.9	-4.5	-4.5
Medication: Levothyroxine sodium	3.6	6.0	12.2	-2.5	1.9	2.1	3.5	3.1	1.2	1.0	3.0	3.0	1.5	3.1	2.7	2.7	2.4	2.4	2.2	2.4	1.7	2.5
Impedance of whole body	3.4	17.3	32.9	3.4	-5.7	-3.6	-4.1	-5.3	0.7	-0.1	-4.3	-3.4	-3.8	-5.7	-4.9	-4.2	-3.1	-4.7	-4.3	-3.9	-4.9	-4.2
Taking other prescription medications	3.3	5.1	19.6	-2.2	1.6	0.5	2.8	2.9	1.1	1.7	2.8	2.7	1.8	2.5	2.7	2.1	0.6	2.2	4.4	1.6	0.8	2.2
Impedance of leg (left)	2.9	13.9	25.0	3.8	-4.0	-2.8	-3.5	-4.7	-0.1	-1.3	-4.1	-3.2	-2.7	-5.0	-4.9	-4.1	-3.1	-4.2	-5.0	-2.8	-3.5	-4.2
Medication: Atenolol	2.7	3.4	6.6	2.4	-0.9	-1.8	-2.0	-2.5	0.4	-1.0	-0.8	-0.7	-1.0	-2.5	-2.4	-2.5	-2.6	-2.6	-1.9	-1.0	-0.3	-2.5
Illnesses of mother	2.7	3.4	8.8	-0.4	2.5	3.0	1.5	1.1	-2.2	-1.6	2.0	1.3	2.1	1.8	1.1	1.2	1.9	1.6	-0.9	2.5	2.7	1.1
Loneliness, isolation	2.7	3.7	9.3	0.5	-2.7	-2.5	-1.4	-1.4	0.7	1.5	-2.7	-2.4	-3.0	-2.0	-1.3	-1.2	-1.1	-1.8	0.3	-2.6	-2.6	-1.2
Medication: Paracetamol	2.7	4.2	11.0	-1.0	3.3	1.7	2.1	2.1	0.4	-1.0	2.7	2.7	2.5	2.0	2.0	1.6	1.0	2.0	1.4	2.3	3.0	1.5
Medication: Paracetamol	2.6	4.2	12.7	-1.0	3.6	1.9	2.0	2.1	0.1	-1.1	2.4	2.7	2.5	2.0	1.9	1.7	1.0	1.7	1.2	2.4	3.2	1.5
Supplements: Glucosamine	2.5	3.2	9.7	1.4	-2.0	-3.1	-1.6	-1.7	0.8	0.3	-2.0	-0.1	-1.9	-2.1	-1.7	-2.0	-2.5	-2.1	0.4	-2.3	-1.3	-1.9
Gout (self-reported)	2.5	3.4	9.1	-0.6	2.9	2.8	1.8	1.5	0.3	-1.7	1.5	0.3	1.5	2.1	1.2	1.5	1.4	1.9	-1.0	3.0	2.9	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	7.8	0.0	-2.0	-2.8	-0.8	-0.4	1.6	2.2	-1.0	0.6	-2.4	-1.9	-0.6	-0.8	-1.6	-2.1	2.2	-2.3	-2.1	-0.8
Tinnitus: Yes, now most or all of the time	2.4	2.8	7.0	-0.2	-2.6	-2.5	-1.2	-0.9	1.3	2.4	-1.8	-1.1	-2.0	-1.4	-0.6	-0.7	-1.1	-0.8	1.6	-2.6	-2.6	-0.6
Had other major operations	2.3	2.8	6.2	-1.9	1.7	0.8	1.7	2.0	1.7	1.1	1.5	2.2	0.6	2.2	2.2	1.8	0.7	1.1	2.5	1.7	0.8	1.9
Diabetes (father)	2.2	2.7	10.6	-1.4	-2.2	-1.9	-0.6	-0.1	2.6	3.3	-0.5	0.8	-1.4	-0.4	0.6	0.4	-0.4	-0.6	2.0	-2.0	-3.2	0.7
Falls in the last year	2.2	2.9	6.3	2.1	-1.2	-2.3	-1.6	-2.0	-1.8	-0.9	-1.6	0.2	-1.9	-1.9	-1.7	-2.3	-2.5	-2.1	-0.3	-0.8	-0.2	-2.3
Hypothyroidism/myxoedema (self-reported)	2.2	4.2	8.1	-1.9	1.8	1.5	2.6	2.6	0.7	0.4	2.6	2.9	1.8	2.6	2.2	2.2	1.5	1.8	2.3	2.3	1.6	2.0
Health satisfaction	2.2	2.8	4.4	-2.1	1.6	1.4	1.8	1.9	1.1	1.2	1.7	1.6	1.4	1.9	1.9	2.1	1.5	1.9	1.8	1.2	1.1	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	7.2	-1.6	1.4	2.1	0.9	1.8	1.3	0.2	1.0	0.3	1.6	1.9	1.8	2.0	2.7	1.9	0.5	2.1	1.0	2.0
Illnesses of father: Heart disease	2.2	3.0	6.3	1.0	-2.4	-2.0	-1.9	-1.9	0.0	1.2	-1.6	-1.5	-1.8	-2.5	-1.7	-1.6	-1.4	-2.0	-1.0	-2.3	-1.9	-1.6
Age started oral contraceptive pill	2.2	2.7	5.7	1.7	-1.3	-2.1	-1.5	-1.6	-0.4	-0.1	-2.4	-2.3	-0.4	-1.9	-1.8	-1.9	-2.1	-1.4	-0.5	-2.1	-1.0	-2.0
BMI	2.1	12.2	21.7	-3.6	4.1	2.4	3.5	4.3	2.4	1.7	3.7	2.1	3.9	4.3	4.3	3.8	2.5	4.7	4.4	1.3	2.8	3.9
Financial situation satisfaction	2.1	2.7	7.2	-0.7	2.5	2.7	1.2	1.1	-1.6	-1.6	1.9	1.4	1.1	1.6	1.1	1.5	1.8	1.6	-1.2	1.2	2.5	1.2
Medication: Metformin	2.0	2.8	7.5	-1.9	1.2	1.1	1.7	2.0	2.7	1.2	1.6	1.1	1.8	1.5	1.8	1.8	1.2	2.7	1.4	0.2	0.9	1.8
Birth weight of first child	2.0	3.6	6.0	-1.9	2.4	2.4	2.2	2.1	1.2	0.7	1.9	0.7	1.5	2.3	2.2	2.2	2.0	2.4	0.6	1.9	1.7	2.1
Pulse wave reflection index	2.0	2.5	6.9	-2.0	0.9	1.9	1.4	1.9	1.0	1.1	1.7	1.4	0.9	1.4	2.0	2.1	2.6	1.3	0.8	1.1	0.3	2.0
Arm fat-free mass (right)	2.0	10.0	22.7	-2.8	4.8	3.0	2.9	3.7	0.7	0.5	2.6	1.9	3.8	4.3	3.7	3.3	1.9	4.0	2.9	2.8	3.8	3.4
Migraine (self-reported)	2.0	2.4	8.9	2.1	-0.5	-1.7	-0.2	-1.5	-1.0	-1.7	-1.6	-0.3	-0.3	-1.8	-2.1	-2.1	-3.0	-1.9	-1.0	-0.1	0.1	-2.0
Miserableness	2.0	3.4	9.3	1.8	-1.5	-2.7	-1.3	-1.7	-1.1	-0.5	-1.7	-0.5	-2.1	-2.3	-1.9	-2.0	-3.1	-2.6	0.3	-2.2	-1.2	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	4.5	-1.2	1.9	2.1	1.7	1.7	0.7	-0.5	1.0	0.6	1.4	1.5	1.6	1.5	1.7	1.8	0.2	1.8	1.8	1.5
Hair/balding pattern: Pattern 4	1.8	4.4	10.4	-3.2	0.6	1.1	1.1	2.4	2.9	2.7	1.5	0.9	1.8	2.1	2.5	2.7	2.3	2.3	2.3	0.1	-0.7	2.7
Arm predicted mass (right)	1.8	9.1	20.7	-2.6	4.5	2.8	2.6	3.5	0.7	0.5	2.3	1.6	3.7	4.1	3.6	3.1	1.8	3.8	2.9	2.7	3.7	3.2
Medication: Co-codamol	1.6	1.9	5.2	-0.9	1.2	1.6	1.2	1.4	-0.3	-0.6	2.3	0.8	1.4	1.5	1.6	1.3	1.8	1.6	0.5	1.8	1.4	1.2
Sitting height	1.6	11.5	20.1	-4.1	3.6	4.1	2.6	4.0	3.0	1.8	2.1	0.2	3.2	3.8	4.2	4.3	3.7	4.2	2.1	3.0	2.5	4.5
Birth weight	1.6	3.5	8.5	-2.2	1.9	2.0	2.9	1.9	0.5	0.9	1.6	2.1	0.6	2.2	2.2	2.2	2.5	1.3	1.3	1.6	1.2	2.1
Number of full brothers	1.6	2.0	5.9	-1.7	-0.8	0.1	2.4	1.2	1.3	2.0	2.3	2.3	0.6	1.1	1.3	1.3	0.7	0.7	1.9	0.5	-0.5	1.2
Leg fat-free mass (right)	1.6	8.8	16.9	-2.9	4.1	2.4	2.8	3.6	0.7	0.9	2.3	1.6	3.0	3.8	3.7	3.2	1.7	3.8	3.7	2.2	3.4	3.4
Osteoporosis (self-reported)	1.6	2.0	6.4	2.3	-0.5	-1.0	-0.8	-1.4	-2.5	-2.5	-0.4	0.1	-0.6	-1.0	-1.6	-1.9	-1.5	-1.0	-0.7	-0.0	0.7	-1.9
Leg predicted mass (right)	1.6	8.5	15.8	-2.9	4.0	2.3	2.7	3.6	0.7	1.0	2.3	1.5	3.0	3.7	3.6	3.1	1.7	3.7	3.7	2.2	3.3	3.3
Arm fat-free mass (left)	1.6	8.3	21.9	-2.3	4.7	2.7	2.6	3.3	0.1	0.2	2.3	1.5	3.6	3.9	3.3	2.9	1.4	3.6	2.6	2.4	3.9	2.9
Irritability	1.6	2.7	11.3	0.5	-2.4	-2.5	-1.2	-1.0	-1.4	1.4	-1.5	-0.5	-3.4	-1.7	-1.1	-1.1	-1.3	-2.1	1.0	-1.7	-2.0	-0.9
Fractured/broken bones in last 5 years	1.6	2.0	4.8	1.3	-0.8	-1.4	-1.6	-1.4	-2.0	-0.3	-1.4	-0.1	-0.3	-1.6	-1.9	-1.6	-1.6	-1.6	-1.3	-2.2	-0.8	-1.6
Verbal and Numeric Reasoning (VNR)	1.5	3.6	6.9	1.3	-2.6	-2.0	-1.9	-2.1	-0.4	0.4	-2.2	-2.0	-2.6	-1.9	-2.1	-1.8	-1.7	-2.6	-1.1	-1.3	-2.3	-1.7
Type 2 Diabetes (T2D) (2018)	1.5	2.7	6.0	-2.0	1.1	0.6	2.0	1.6	2.3	1.9	1.6	1.9	1.3	1.7	1.9	1.8	0.4	1.9	2.4	0.4	0.4	1.9
Diabetes (self-reported)	1.5	2.3	6.9	-1.7	1.1	0.2	1.2	1.8	1.7	1.4	1.6	2.0	1.6	1.5	1.7	1.6	0.1	1.9	2.6	0.3	0.5	1.7
Whole body fat-free mass	1.5	8.3	19.7	-2.5	4.4	2.6	2.7	3.3	0.1	0.3	2.3	1.6	3.3	3.9	3.4	2.9	1.6	3.5	2.9	2.5	3.8	3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	4.2	1.0	-1.3	-2.0	-0.9	-1.3	-0.1	0.6	-0.9	-0.1	-1.6	-1.3	-1.3	-1.4	-2.1	-1.9	0.3	-1.5	-1.6	-1.2
Whole body water mass	1.5	8.6	20.1	-2.5	4.5	2.7	2.7	3.4	0.1	0.4	2.4	1.6	3.3	3.9	3.5	3.0	1.6	3.6	3.0	2.6	3.8	3.1
Trunk fat-free mass	1.4	7.9	21.9	-1.9	4.7	2.9	2.8	3.0	-0.5	-0.4	2.2	1.4	3.4	3.8	3.0	2.6	1.4	3.3	2.0	3.0	4.2	2.6
Shortness of breath walking on level ground	1.4	1.6	5.1	-1.0	1.1	1.2	1.8	1.5	1.1	0.1	2.3	0.9	1.2	0.9	0.9	1.4	1.4	1.0	0.6	1.8	1.1	1.3
Chest pain or discomfort	1.4	2.1	5.6	0.2	-2.0	-2.1	-1.6	-0.9	1.5	1.8	-1.2	-0.7	-2.4	-1.5	-1.0	-0.7	-1.1	-1.3	0.5	-1.6	-2.3	-0.7
Basal metabolic rate	1.4	7.8	17.4	-2.6	4.2	2.3	2.6	3.3	0.6	0.7	2.2	1.4	3.3	3.7	3.4	2.9	1.4	3.6	3.1	2.1	3.3	3.0
Arm predicted mass (left)	1.4	7.3	18.3	-2.3	4.3	2.3	2.4	3.2	0.0	0.5	2.2	1.6	3.3	3.7	3.2	2.7	1.3	3.3	2.8	2.1	3.4	2.8
Schizophrenia vs Biploar Disorder	1.3	1.7	4.2	-1.4	1.2	1.6	0.7	1.2	-0.1	0.3	2.0	1.9	1.1	1.6	1.2	1.5	1.7	1.4	-0.1	1.0	0.8	1.5
Fasting Glucose	1.3	1.6	5.7	-1.4	0.7	1.4	2.4	1.2	1.2	0.5	1.1	1.5	-0.2	1.6	1.2	1.5	1.7	0.9	0.7	0.8	0.5	1.4
Neuroticism (2016)	1.3	1.9	4.1	1.8	0.9	-0.4	-0.7	-1.3	-0.8	-1.9	-1.8	-1.0	-0.3	-2.0	-1.6	-1.4	-1.2	-1.4	-1.7	-1.1	1.3	-1.6
Lung FVC	1.3	6.5	18.1	0.0	3.7	2.8	2.6	1.6	-3.0	-3.2	2.7	2.8	3.6	2.6	1.4	1.1	1.4	1.9	-0.5	3.1	4.3	1.1
Leg fat-free mass (left)	1.3	7.0	13.3	-2.9	3.3	1.8	2.4	3.2	1.1	1.5	2.1	1.4	2.6	3.3	3.4	2.9	1.5	3.5	3.6	1.4	2.6	3.1
Leg predicted mass (left)	1.3	7.0	13.0	-2.9	3.4	1.9	2.4	3.2	1.0	1.5	2.2	1.3	2.7	3.4	3.4	2.9	1.5	3.6	3.6	1.4	2.6	3.1
Trunk predicted mass	1.3	7.4	21.2	-1.8	4.6	2.8	2.7	2.8	-0.6	-0.5	2.1	1.4	3.3	3.7	2.9	2.4	1.3	3.2	1.9	3.0	4.2	2.4
Forced vital capacity (FVC), Best measure	1.3	4.8	13.6	-0.7	3.4	2.9	2.8	1.6	-2.0	-1.9	1.7	1.6	3.0	2.3	1.4	1.6	1.0	2.1	-0.4	2.7	3.7	1.6
Exposure to tobacco smoke outside home	1.3	1.8	5.6	0.8	-1.6	-2.4	-1.8	-0.7	-0.5	0.6	-0.9	-0.8	-1.5	-1.1	-0.8	-1.2	-1.9	-1.0	1.4	-1.9	-1.5	-1.0
Worry too long after embarrassment	1.3	2.2	5.6	2.2	-0.4	-1.0	-0.9	-1.6	-1.6	-2.4	-1.4	-0.9	-0.1	-1.6	-1.9	-1.8	-1.5	-1.8	-1.6	-0.8	0.5	-2.0
Diabetes diagnosed by doctor	1.3	2.2	6.9	-1.7	0.9	-0.0	1.4	1.6	2.1	1.5	1.5	1.8	1.1	1.4	1.7	1.5	-0.0	1.9	2.6	0.1	0.3	1.6
Average weekly champagne plus white wine intake	1.3	1.8	4.0	-1.6	1.5	1.6	2.0	1.4	1.0	0.9	1.4	1.7	0.0	1.2	1.8	1.6	1.5	1.3	0.7	0.6	0.8	1.6
Medication for hormone replacement therapy	1.2	1.4	3.7	1.4	-1.2	-1.7	-0.4	-0.7	-1.2	-0.7	-0.6	0.5	-1.9	-0.7	-1.1	-1.5	-1.5	-1.7	0.7	-0.9	-0.2	-1.5
High blood pressure (mother)	1.2	1.7	3.8	1.0	-0.8	-2.0	-0.6	-1.0	1.7	0.1	-1.8	-1.2	-1.0	-1.7	-1.3	-1.3	-1.7	-1.5	-0.1	-1.6	-0.8	-1.3
Body mass index (BMI)	1.2	5.0	17.9	-2.5	2.2	0.3	1.8	2.9	1.3	2.0	2.1	1.4	2.4	2.5	3.0	2.3	0.7	2.8	4.2	-0.1	1.1	2.4
Hair/balding pattern: Pattern 3	1.2	1.8	5.7	2.1	0.2	0.3	0.3	-1.2	-1.9	-2.4	0.1	-0.6	0.1	-0.4	-1.7	-1.5	-1.2	-0.9	-2.4	0.9	1.3	-1.7
Lung cancer (father)	1.2	1.4	3.7	-1.2	0.6	1.0	0.3	1.2	0.8	0.2	1.1	0.2	1.3	1.9	1.5	1.4	1.5	1.8	1.2	0.9	0.9	1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	5.4	-1.1	-1.6	-1.0	-1.4	-0.1	0.6	2.3	-0.5	0.5	-1.7	-0.4	0.1	0.3	0.4	-1.1	0.5	-1.2	-2.1	0.4
Illnesses of father: None of the above (group 1)	1.2	1.5	6.2	0.8	2.1	1.2	-0.0	0.3	-1.1	-2.5	0.6	-0.4	1.5	1.0	-0.0	-0.0	0.2	1.0	-0.7	1.7	2.3	-0.1
Wears glasses or contact lenses	1.2	1.4	3.8	0.3	-1.4	-2.0	-1.7	-0.6	0.0	0.9	-1.8	-1.4	-1.3	-1.5	-0.5	-0.6	-1.3	-1.0	0.8	-0.5	-1.6	-0.4
Alcohol drinker status: Previous	1.2	1.3	6.5	-1.2	0.9	1.3	2.5	1.1	0.7	0.3	0.5	0.2	1.1	1.4	1.2	1.2	0.9	1.5	0.7	1.1	0.8	1.3
Depressed Affect (Nagel 2018)	1.1	2.3	6.4	-0.1	-1.7	-2.5	-1.5	-0.6	0.4	1.9	-1.5	-0.2	-2.3	-1.3	-0.6	-0.6	-1.6	-1.7	1.5	-2.2	-2.3	-0.4
Major Depression (MDD)	1.1	1.3	5.0	0.4	-1.5	-2.1	-0.8	-0.6	0.2	1.1	-0.5	-0.8	-0.9	-1.3	-0.8	-0.9	-1.0	-0.8	1.3	-2.2	-1.4	-0.9
Average weekly spirits intake	1.1	1.3	4.2	0.1	2.0	1.7	0.2	0.5	-0.7	-1.4	1.9	1.5	0.7	1.1	0.5	0.6	1.0	0.3	-0.6	1.9	1.6	0.4
Hearing difficulty/problems: Yes	1.1	1.7	7.2	-0.7	-1.8	-1.4	-0.9	-0.3	1.8	2.5	-0.8	-0.9	-0.7	-1.2	-0.2	0.1	-0.5	-0.7	0.2	-2.7	-2.2	-0.0
Townsend deprivation index at recruitment	1.1	1.6	3.4	1.7	-1.2	-0.6	-1.5	-1.7	-0.7	-1.6	-0.9	-0.6	-0.4	-1.8	-1.4	-1.6	-0.8	-1.2	-1.7	0.1	0.2	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.5	-0.0	-1.6	-1.9	-1.6	-0.4	1.1	1.3	-1.4	-1.3	-0.8	-1.4	-0.2	-0.5	-0.9	-0.4	1.6	-2.1	-1.5	-0.4
Medication: Seretide 50 evohaler	1.1	1.3	3.6	-1.4	0.3	0.5	1.9	0.9	1.3	1.2	1.2	1.8	-0.8	1.3	1.2	1.2	0.6	0.8	1.1	0.5	0.0	1.1
Mood swings	1.1	2.0	4.2	0.4	-1.5	-2.0	-1.8	-0.8	-0.3	1.2	-1.9	-1.4	-2.1	-1.3	-1.0	-0.9	-1.2	-1.7	0.4	-1.9	-1.8	-0.8
Mineral and other dietary supplements	1.1	1.5	2.8	-1.4	1.7	1.7	1.2	1.3	0.7	0.4	1.1	-0.0	1.2	1.5	1.5	1.5	1.1	1.4	0.7	0.8	0.8	1.5
Average weekly beer plus cider intake	1.1	1.6	5.3	1.6	-1.0	-1.0	-0.6	-1.7	-0.4	-1.5	-1.3	-1.2	0.1	-1.0	-1.5	-1.6	-1.0	-0.9	-1.2	-2.3	0.0	-1.5
Blood Eosinophil Count	1.0	7.4	14.7	-2.2	3.8	3.2	2.1	3.2	1.1	-0.7	1.9	1.1	3.0	3.6	3.2	2.9	2.8	3.5	2.0	2.9	2.7	2.8
Respiratory disease	1.0	2.2	4.4	-1.8	1.5	1.2	1.6	1.7	1.1	0.9	0.7	-0.2	1.5	1.9	2.0	1.7	1.0	2.1	2.0	1.0	0.8	1.7
Had menopause	1.0	1.2	2.7	1.4	-0.8	-1.5	-1.6	-1.1	-0.9	-0.7	-0.9	-0.5	-1.1	-1.2	-1.0	-1.4	-1.5	-1.1	-0.6	-0.7	-0.5	-1.3
Weight	1.0	5.1	12.5	-2.4	2.8	1.0	2.0	2.7	1.3	1.5	1.8	1.0	3.0	2.7	2.9	2.4	0.7	3.1	3.5	0.5	1.7	2.5
Exposure to tobacco smoke at home	1.0	1.1	3.5	1.1	-1.2	-1.9	-0.3	-0.9	-0.4	-0.5	-0.5	0.3	-0.8	-0.8	-1.0	-1.4	-1.4	-1.1	0.6	-1.9	-0.8	-1.3
Ever highly irritable/argumentative for 2 days	1.0	1.2	4.0	-0.8	-1.4	-1.3	-0.9	-0.4	1.6	2.0	-0.2	0.2	-1.9	-0.8	-0.0	0.0	-0.3	-1.1	0.9	-0.7	-2.0	0.2
Chronic bronchitis/emphysema (mother)	1.0	1.2	4.4	0.2	-1.6	-1.4	-2.1	-0.8	0.7	1.1	-0.6	-0.2	-0.6	-0.6	-0.9	-0.7	-1.1	-0.5	0.0	-2.1	-1.7	-0.6
Medication: Blood pressure	1.0	1.7	3.5	1.3	-0.9	-1.9	-1.7	-1.5	1.1	-0.6	-1.3	-1.6	-0.9	-1.6	-1.1	-1.5	-1.8	-1.3	-0.1	-0.9	-0.5	-1.4
Alcohol intake frequency.	1.0	2.3	7.4	1.1	-1.9	-1.8	-1.2	-1.4	-2.7	0.0	-1.2	-1.6	-1.3	-1.2	-1.4	-1.4	-1.5	-0.7	-0.0	-2.5	-1.6	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.5	-0.2	-1.7	-1.6	-0.8	-0.4	-1.2	1.6	-0.2	-0.0	-1.4	-1.0	-0.6	-0.4	-0.7	-1.1	0.5	-1.9	-1.8	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.6	0.5	-2.1	-1.8	-1.5	-1.0	1.1	0.8	-1.4	-1.7	-1.1	-1.7	-1.1	-0.8	-0.6	-0.8	-0.1	-1.6	-1.7	-0.8
Mean Putamen Volume	0.9	1.1	4.1	-0.9	1.0	1.7	0.5	1.1	0.0	0.1	0.5	-0.7	0.4	0.8	0.8	1.2	2.0	0.9	-0.6	1.6	1.2	1.0
Number of treatments/medications taken	0.9	1.6	9.4	-1.0	1.0	-0.5	0.9	1.5	1.9	1.1	1.5	1.4	0.9	1.1	1.5	0.9	-0.0	1.0	3.1	0.4	0.5	0.9
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.1	-1.1	1.4	0.7	-0.0	1.1	0.3	0.4	0.6	0.7	1.1	1.1	1.4	1.2	0.1	1.0	1.3	1.5	0.8	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.8	-0.0	-1.2	-2.0	-0.5	-0.4	-0.1	1.7	-1.9	-1.5	-0.7	-1.1	-0.5	-0.5	-1.4	-1.1	1.8	-1.6	-1.2	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	6.0	1.1	0.4	0.1	-0.6	-1.5	-0.7	-1.1	-0.8	-0.2	-0.5	-1.5	-1.2	-1.2	-0.7	-1.0	-2.4	-1.2	0.4	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	5.6	-1.5	-0.3	-0.7	0.1	0.4	2.4	1.9	-0.3	-0.1	-0.3	0.0	1.0	0.8	0.3	0.3	1.2	-1.8	-1.4	0.8
Suffer from ‘nerves’	0.9	1.4	4.3	1.0	-1.2	-0.7	-0.9	-1.6	-0.0	-0.2	-0.5	-0.1	0.1	-1.3	-1.7	-1.2	-0.1	-1.4	-2.0	-2.1	-1.0	-1.3
Ever had bowel cancer screening	0.9	1.0	5.4	-1.3	-0.3	0.3	0.3	0.7	2.3	2.0	0.9	0.0	0.3	0.6	0.8	1.2	1.0	0.7	0.5	1.1	-0.6	1.2
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.8	1.5	0.5	-0.3	-0.7	-0.8	-1.0	-1.7	-1.4	-1.2	-0.3	-1.3	-1.2	-1.1	-1.1	-1.0	-1.3	0.7	1.1	-1.2
Ovarian Cancer	0.8	1.0	4.3	1.6	0.0	-0.1	-0.9	-1.0	-1.1	-2.1	-0.6	-0.6	0.6	-0.6	-1.0	-1.2	-0.9	-1.1	-1.0	0.3	1.2	-1.2
Body Mass Index (BMI) (2010)	0.8	1.1	2.9	-1.1	1.2	0.8	1.4	1.2	0.3	0.3	1.1	0.4	1.4	1.7	1.3	1.1	0.8	1.5	0.9	0.3	0.8	1.1
Blood Platelet Count	0.8	9.1	27.9	1.0	-5.3	-4.1	-2.5	-2.3	0.8	2.4	-3.0	-2.5	-3.1	-3.1	-2.2	-2.1	-1.5	-3.0	0.1	-5.0	-5.0	-2.1
Waist Hip Ratio (WHR)	0.8	3.7	7.5	1.9	-2.1	-1.8	-1.3	-2.6	-0.5	-0.0	-2.0	-1.1	-2.0	-2.5	-2.3	-2.0	-2.2	-2.7	-1.7	-1.6	-1.8	-2.2
Lung FEV1/FVC ratio	0.8	4.1	8.8	2.5	-1.6	-1.0	-2.2	-3.0	-0.3	-1.6	-1.3	-1.8	-1.3	-2.9	-2.6	-2.4	-1.7	-1.9	-3.0	-1.4	-0.8	-2.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.1	1.2	0.0	-0.9	-0.8	-0.9	0.3	-0.7	-1.0	-0.4	-0.3	-0.9	-1.2	-1.3	-1.4	-1.5	-0.9	-0.7	0.2	-1.4
Relative age voice broke	0.8	1.2	5.4	1.3	0.1	0.3	-0.4	-0.9	-2.3	-1.6	-0.6	-1.7	0.8	-1.1	-1.2	-1.0	-0.3	-0.4	-1.6	0.2	0.8	-1.0
Pain all over the body in last month	0.8	0.8	2.0	1.1	-0.9	-0.3	-0.9	-1.4	-1.2	-0.6	-0.6	-0.4	0.6	-0.6	-1.3	-1.1	-0.7	-0.9	-1.4	-0.4	-0.4	-1.1
Mouth/teeth dental problems: Dentures	0.8	1.4	2.9	-0.6	1.2	1.1	1.0	1.4	-1.7	-0.3	1.6	1.3	1.3	1.5	1.4	1.1	0.9	1.5	0.8	1.3	0.4	1.0
Length of working week for main job	0.8	0.9	1.8	1.1	-0.9	-0.7	-1.0	-1.3	-0.6	-0.1	-0.5	-0.7	-0.6	-1.2	-1.3	-1.2	-0.6	-1.1	-1.2	-0.7	-0.3	-1.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	5.0	-0.5	1.4	1.8	1.1	1.0	-2.2	-0.7	0.3	0.9	0.8	1.5	0.6	1.0	1.4	1.0	-0.6	1.6	1.1	0.9
High blood pressure (siblings)	0.8	1.2	5.0	-0.8	-0.7	-0.3	-1.3	-0.1	2.2	1.7	-1.7	-2.0	-0.8	-0.7	0.3	0.5	0.5	0.5	-0.4	-1.4	-0.9	0.6
Wheeze or whistling in the chest in last year	0.8	1.4	4.1	-0.7	1.7	1.0	1.1	1.0	-0.4	-0.7	1.6	1.0	0.0	1.6	1.2	1.0	0.7	1.1	0.9	2.0	1.3	1.1
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.5	1.6	-0.8	-1.3	-1.4	-1.0	-1.2	-0.9	-0.4	-0.1	-0.5	-1.2	-1.3	-1.3	-1.0	-1.1	-0.6	-0.1	-0.1	-1.4
Number of operations (self-reported)	0.8	1.2	5.5	-1.5	0.1	-0.1	0.6	0.9	1.1	1.7	0.2	0.3	0.1	1.8	1.4	1.1	0.5	0.9	2.3	0.7	-0.6	1.2
Ever depressed for a whole week	0.8	1.0	4.1	0.7	-1.3	-2.0	-0.5	-0.5	-1.3	0.2	-0.6	0.1	-0.4	-1.1	-1.1	-0.9	-1.0	-1.1	1.4	-1.0	-1.3	-0.8
Unable to work because of sickness or disability	0.8	1.1	6.2	0.9	-1.2	-1.6	-1.0	-0.6	-2.5	-0.3	-0.3	-0.4	-0.7	-1.0	-0.7	-1.1	-1.2	-0.5	0.5	-0.9	-0.2	-1.0
Supplements: Calcium	0.8	0.9	2.8	0.8	-1.7	-1.1	-1.0	-0.9	-0.5	-0.1	-1.0	-0.7	-1.5	-1.4	-0.8	-1.0	-0.5	-0.8	-0.2	-0.5	-1.1	-1.0
Alzheimer’s Disease (in father)	0.7	0.8	6.4	1.1	0.2	-0.9	-0.3	-0.2	-2.5	-0.9	-0.4	0.4	-0.6	-0.2	-0.8	-0.7	-1.1	-0.8	0.6	0.8	0.6	-0.7
Bipolar Disorder (2011)	0.7	0.7	2.0	0.1	1.2	1.3	0.3	0.4	-0.8	-1.0	0.5	-0.4	1.2	0.8	0.4	0.5	0.1	1.4	-0.3	1.2	1.2	0.4
HDL Cholesterol	0.7	1.1	2.8	1.1	-0.7	-1.5	-1.5	-0.9	-0.9	-0.4	-0.1	0.4	-1.3	-1.3	-1.1	-1.1	-0.9	-1.2	-0.3	-1.7	-0.6	-1.2
Chronotype (morning person)	0.7	1.6	6.0	-1.1	1.2	1.8	2.1	1.2	0.3	0.3	1.3	0.6	-0.3	2.0	1.0	1.3	2.4	1.2	-0.0	1.1	0.9	1.1
Relative age of first facial hair	0.7	1.4	6.7	1.8	0.0	-0.4	-0.4	-1.2	-2.6	-1.8	-0.6	-0.4	-0.3	-1.6	-1.3	-1.4	-1.1	-1.1	-0.7	0.4	0.7	-1.5
Severe depression (siblings)	0.7	0.8	2.5	0.6	-0.1	-1.2	-1.3	-0.5	-0.4	-0.0	-1.6	-0.6	-0.8	-1.2	-0.7	-0.8	-1.4	-1.4	0.2	-0.6	-0.3	-0.6
Pack years adult smoking proportion	0.7	1.1	3.2	0.6	-1.0	-1.8	-1.2	-0.5	-1.1	0.8	-1.1	-0.5	-1.0	-1.0	-0.8	-0.8	-1.3	-1.1	0.9	-1.2	-1.1	-0.9
Hearing difficulty/problems with background noise	0.7	1.1	5.9	-0.1	-0.5	-1.0	-1.0	-0.6	0.5	1.2	-1.6	-1.6	-0.2	-1.4	-0.7	-0.3	-0.6	-0.5	-0.8	-2.4	-1.1	-0.3
Forced vital capacity (FVC)	0.7	2.7	9.9	-0.1	2.9	2.1	2.0	1.0	-1.8	-2.0	0.5	0.6	2.2	1.5	0.7	0.9	0.6	1.0	-0.7	2.1	3.1	0.9
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	4.5	0.1	-1.4	-1.3	-0.1	-0.4	-0.5	0.6	-1.3	-0.2	-2.1	-0.5	-0.4	-0.3	-0.3	-1.1	1.0	-0.3	-1.5	-0.3
Number of live births	0.7	0.9	2.7	-1.0	0.9	0.9	0.1	1.2	-0.4	0.0	1.3	1.6	0.4	1.6	1.3	1.1	1.0	0.8	0.4	0.7	0.2	1.0
Peak expiratory flow (PEF)	0.7	1.6	6.6	-0.6	2.1	1.6	1.7	1.0	0.2	-0.9	0.8	0.0	1.3	1.3	1.0	1.1	0.9	0.8	0.1	2.6	2.0	1.1
Medication: Amlodipine	0.7	1.0	2.2	-0.9	1.2	0.7	0.4	1.5	0.9	0.1	0.8	0.1	1.4	1.1	1.4	1.0	1.0	1.4	1.2	0.8	1.2	1.0
Age at last live birth	0.7	1.0	3.8	-0.9	1.1	1.1	0.7	0.7	1.2	0.0	1.2	2.0	-0.2	0.7	0.9	1.1	0.8	0.1	0.1	1.5	0.9	1.0
Family relationship satisfaction	0.7	0.9	2.2	1.2	-1.5	-0.5	-0.3	-1.3	-0.5	-1.1	-1.1	-1.2	-0.6	-0.9	-1.3	-1.1	-0.0	-0.5	-1.5	0.4	-0.2	-1.2
Average weekly red wine intake	0.7	1.0	4.0	0.3	-1.0	-1.0	-0.9	-0.6	0.3	0.7	-2.0	-1.7	-1.3	-1.2	-0.8	-0.6	-0.8	-1.3	-0.1	-0.3	-1.3	-0.6
Medication for cholesterol	0.7	1.1	3.0	-0.9	0.7	1.5	1.4	0.8	-0.3	-0.2	0.8	-0.2	1.2	1.5	0.9	1.1	1.7	1.4	-0.1	1.2	0.8	1.2
Asthma (self-reported)	0.7	1.3	3.3	-1.2	1.2	0.9	1.7	1.3	1.0	0.3	0.7	-0.2	0.9	1.5	1.5	1.2	0.7	1.8	1.5	0.5	1.0	1.1
Arm fat mass (left)	0.7	3.0	13.8	-2.0	1.6	-0.2	0.9	2.1	1.5	2.0	0.9	0.3	2.1	1.6	2.3	1.7	0.0	2.2	3.7	-0.7	0.5	1.8
Guilty feelings	0.7	1.1	4.5	-1.1	-0.1	-0.6	-0.0	0.9	2.1	1.4	-1.4	-1.8	-0.7	-0.0	0.8	0.8	0.3	0.4	1.4	-1.4	-0.4	0.7
Medication: Lisinopril	0.7	0.9	5.0	-0.5	-0.4	-1.5	-1.2	-0.0	0.6	1.5	-0.7	-0.6	-0.8	-0.1	0.4	-0.1	-0.9	-0.2	2.2	-1.4	-0.8	0.1
Myopia	0.7	1.0	3.4	0.7	-1.1	-0.1	-0.5	-0.9	1.8	-0.6	-0.7	-1.2	0.0	-1.4	-1.1	-0.6	-0.1	-0.6	-1.8	-0.5	-1.0	-0.8
Heart disease (siblings)	0.7	0.8	2.5	1.1	-0.2	-0.6	-0.7	-0.9	-0.3	-0.8	0.3	1.6	0.1	-0.9	-1.2	-1.1	-0.9	-1.0	-1.4	-0.9	0.0	-1.2
Depression (Nagel 2018)	0.6	0.9	3.3	-0.9	-0.7	-0.9	-0.7	0.5	1.4	1.8	0.1	0.3	-0.7	-0.3	0.7	0.5	-0.2	0.0	1.8	-1.6	-1.3	0.6
LDL Cholesterol	0.6	0.9	1.8	1.0	-0.6	-1.0	-0.6	-1.3	-0.1	-0.9	-1.0	0.0	-1.2	-1.2	-1.1	-1.3	-1.1	-1.2	-1.1	-0.3	-0.6	-1.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.9	1.0	-1.2	-1.4	-1.0	-0.8	-0.6	-0.2	-0.1	0.5	-0.5	-0.5	-0.8	-1.2	-1.3	-1.2	0.2	-0.4	-0.7	-1.1
Qualifications: CSEs or equivalent	0.6	0.7	3.8	-0.3	-1.2	-0.1	-1.2	-0.3	1.9	0.9	-0.7	-1.3	-0.8	-0.5	-0.2	0.1	0.5	-0.3	-0.3	-1.4	-0.9	-0.0
Serious illness, injury or assault to yourself	0.6	0.7	1.7	-0.8	1.3	0.3	1.0	0.9	0.9	0.3	0.5	0.4	1.0	1.2	0.8	0.8	-0.2	1.1	1.3	0.3	0.9	0.9
Hair/balding pattern: Pattern 2	0.6	0.8	2.2	-1.3	0.0	0.0	1.1	1.1	0.7	1.4	0.2	0.4	-0.5	0.7	1.1	1.1	0.7	0.8	1.5	-0.1	-0.4	1.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.7	1.2	-0.1	-0.2	-0.4	-1.1	-0.9	-1.3	-0.6	0.0	-1.1	-1.2	-1.2	-1.0	-0.8	-1.1	-1.3	-0.3	0.2	-1.2
Illnesses of siblings	0.6	0.8	3.5	0.3	1.1	1.0	0.9	0.4	-1.8	-1.3	0.8	0.3	0.3	1.0	0.3	0.1	-0.0	0.1	0.1	1.9	1.2	0.1
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.4	0.8	-0.5	-0.7	-0.3	-1.6	0.7	0.2	-2.1	-0.3	-1.0	-1.4	-1.3	-1.2	-1.7	-1.7	-1.4	-0.7	-0.3	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	5.7	-0.6	2.2	2.0	2.0	0.9	-1.1	-1.0	1.0	1.0	2.0	1.3	0.9	1.1	0.7	1.3	-0.4	1.6	2.4	1.2
Arm fat mass (right)	0.6	2.6	12.5	-1.8	1.4	-0.3	0.7	1.9	1.3	1.8	1.0	0.2	2.0	1.4	2.1	1.5	-0.1	2.0	3.5	-0.9	0.5	1.6
Age at first live birth	0.6	1.1	4.2	-1.1	1.0	1.2	1.3	0.8	2.1	0.4	0.7	1.1	-0.3	1.0	0.8	1.0	1.0	0.2	0.1	1.6	0.9	1.1
Medication for pain relief, constipation, heartburn	0.6	1.0	4.1	0.2	-1.8	-0.8	-0.9	-0.5	-0.7	0.8	-1.5	-2.0	-0.9	-0.2	-0.7	-0.5	-0.2	-0.5	-0.3	-1.1	-1.7	-0.4
Medication: Omeprazole	0.6	0.7	2.6	-0.1	-0.8	-1.2	-0.2	-0.1	0.9	1.0	0.3	0.6	-1.6	-0.4	-0.0	-0.1	-0.1	-0.7	1.3	-1.3	-1.2	-0.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.4	0.9	-0.6	-0.5	-0.2	-0.8	-0.4	-0.3	-0.5	0.2	-1.2	-0.6	-0.8	-1.0	-1.2	-1.5	-1.1	0.4	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.8	-0.9	2.0	1.6	0.7	0.9	0.8	-0.3	0.8	0.5	1.9	0.9	1.1	1.1	0.5	1.6	0.3	1.1	1.6	1.2
Qualifications: nursing, teaching	0.6	0.9	5.6	-0.7	-1.0	-0.6	0.9	-0.3	2.4	1.7	-0.2	0.0	-0.6	-0.4	-0.2	0.1	-0.6	-0.5	0.2	-0.7	-1.8	0.3
Commuting to job workplace: Walk	0.6	0.6	2.4	-0.9	-0.8	-0.2	-0.2	0.2	1.0	1.5	-1.2	-1.1	-0.4	-0.2	0.4	0.5	0.6	0.3	0.8	-0.8	-1.3	0.5
Smoking status: Current	0.6	0.9	2.6	-0.2	0.7	1.2	1.6	0.6	-1.1	-1.1	1.4	1.4	0.5	0.7	0.4	0.6	1.0	0.8	-0.3	1.2	1.1	0.5
Pain experienced in last month	0.6	1.1	4.1	0.5	-2.0	-1.3	-1.5	-1.2	0.1	0.5	-0.3	-0.3	-1.2	-0.8	-0.7	-0.9	-0.9	-0.6	-0.4	-1.4	-1.7	-0.8
Pack years of smoking	0.6	0.9	2.9	0.6	-0.7	-1.7	-1.2	-0.4	-1.1	0.7	-0.9	-0.2	-1.0	-0.9	-0.6	-0.7	-1.4	-0.8	1.0	-1.1	-0.9	-0.8
Leg fat mass (left)	0.6	2.3	9.1	-1.6	1.6	-0.2	0.9	1.8	1.4	1.6	0.8	0.1	2.2	1.4	1.8	1.4	-0.2	2.1	3.0	-0.9	0.6	1.5
Neuroticism (Nagel 2018)	0.5	1.2	3.4	-0.3	-1.1	-1.7	-1.1	-0.5	0.6	1.5	-1.2	-0.4	-1.4	-0.9	-0.4	-0.2	-0.9	-1.2	0.9	-1.7	-1.9	-0.1
Schizophrenia (2018)	0.5	1.0	4.0	-0.2	-0.5	-1.2	-2.0	-0.4	-0.6	1.4	-1.2	-1.0	-2.0	-1.0	-0.3	-0.3	-1.2	-0.4	-0.0	-0.8	-1.3	-0.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	3.0	-0.1	-0.7	0.2	-0.6	0.4	0.4	0.1	-0.7	-0.5	-1.7	0.7	0.8	-0.0	0.2	-0.8	0.7	1.5	-1.2	-0.1
Tanning	0.5	6.5	10.4	-2.7	2.5	2.2	2.6	3.2	1.2	0.3	3.2	2.6	2.8	2.9	3.0	2.9	2.6	2.7	2.5	1.9	1.8	2.9
Frequency of depressed mood in last 2 weeks	0.5	0.7	3.1	-1.1	-0.2	-0.2	0.2	0.7	1.8	1.5	0.0	-0.3	-0.7	0.0	1.1	0.8	0.5	0.5	1.4	-0.9	-0.3	0.7
Supplements: Zinc	0.5	0.5	2.3	-0.5	-1.3	-0.9	-1.0	-0.2	0.4	1.2	-0.7	-0.1	-0.5	-0.3	0.3	-0.0	-0.4	-0.1	0.9	-0.2	-1.5	0.0
Average weekly fortified wine intake	0.5	0.6	2.6	1.0	0.5	-0.7	-0.4	-0.5	-1.6	-1.2	0.0	0.1	-0.6	-0.6	-0.6	-0.8	-1.5	-0.7	0.1	-0.3	0.4	-0.8
Age when periods started (menarche)	0.5	1.1	4.5	0.5	-1.4	-0.4	-0.7	-1.3	0.3	0.0	-1.7	-1.0	-2.1	-0.8	-0.8	-0.8	0.1	-1.3	-1.2	-0.9	-1.4	-0.8
Multivitamins +/- minerals	0.5	0.6	2.0	-0.2	0.6	0.9	1.0	0.7	-0.1	-0.3	1.1	1.4	1.4	0.6	0.0	0.5	0.4	0.6	-0.4	1.4	0.6	0.4
Qualifications: None of the above	0.5	1.1	2.9	-0.3	1.0	1.0	0.6	1.0	-0.9	-1.2	1.7	1.3	1.2	0.9	0.9	0.8	1.2	1.4	0.5	1.1	1.1	0.8
Mouth/teeth dental problems	0.5	0.8	1.8	1.1	-0.7	-0.9	-0.9	-1.4	-0.9	-0.4	-1.0	-0.5	-0.3	-0.7	-1.1	-1.3	-1.2	-1.0	-0.7	-0.4	0.0	-1.2
Heart attack	0.5	0.6	1.6	-0.9	-0.2	0.6	0.4	0.9	0.1	1.2	1.0	-0.2	-0.1	0.8	1.1	0.9	1.1	0.8	1.0	-0.1	-0.3	0.9
Medication: Ramipril	0.5	0.6	2.0	0.7	-0.3	-1.0	-1.4	-0.8	0.4	0.0	-0.9	-0.9	-0.6	-1.1	-0.8	-0.7	-1.3	-0.9	-0.2	0.2	-0.2	-0.7
Medication: Simvastatin	0.5	0.7	2.5	0.8	-0.7	-1.1	-0.4	-0.5	-0.5	-0.0	0.5	0.8	-0.9	-1.2	-0.6	-0.9	-1.1	-1.1	0.4	-1.6	-0.4	-0.9
Arm fat percentage (right)	0.5	1.8	11.3	-1.3	-0.1	-1.6	-0.1	1.0	1.6	2.2	0.3	-0.1	1.0	0.2	1.2	0.7	-0.7	0.9	3.4	-2.1	-1.0	0.8
Noisy workplace	0.5	0.6	3.7	0.5	-0.8	-0.2	-0.7	-1.1	-0.5	-0.1	-0.5	-0.4	-0.7	-0.9	-0.8	-0.7	0.2	-1.2	-1.9	-0.4	-0.6	-0.6
Asthma	0.5	0.9	2.7	-1.0	0.7	0.5	1.5	1.0	1.3	0.4	0.3	-0.4	0.4	1.2	1.3	0.9	0.4	1.4	1.6	0.3	0.5	0.9
Pulse wave Arterial Stiffness index	0.5	0.6	1.6	-0.4	1.2	1.1	1.1	0.9	0.1	0.1	1.2	1.1	1.3	0.4	0.6	0.6	1.2	0.4	-0.1	-0.1	0.4	0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.8	0.5	-0.8	-0.5	-0.3	-0.9	0.8	-0.3	-0.7	0.1	-1.7	-0.9	-0.8	-0.7	-0.7	-1.3	-0.7	-1.1	-0.8	-0.6
Number of children fathered	0.5	0.6	2.9	-0.3	0.7	0.7	0.4	0.8	-1.2	-0.2	0.6	0.5	0.9	0.8	0.4	0.7	0.7	0.4	0.0	1.7	0.9	0.6
Pulse wave peak to peak time	0.5	0.6	1.6	0.6	-1.1	-0.9	-1.1	-1.1	-0.3	-0.3	-1.2	-0.9	-1.2	-0.4	-0.7	-0.7	-1.2	-0.5	-0.2	0.2	-0.4	-0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.1	0.7	-0.9	-0.1	-0.7	-1.1	0.4	-0.2	-0.0	-0.5	-0.7	-1.4	-0.8	-0.7	-0.2	-0.9	-1.5	-1.1	-0.7	-0.8
Neck or shoulder pain in last month	0.5	0.7	2.7	-0.8	1.2	0.5	1.3	1.1	1.7	0.2	0.4	-0.3	-0.0	0.2	0.5	0.9	0.7	0.8	0.4	0.4	0.9	0.9
Medication: Ibuprofen	0.5	0.6	1.9	0.8	0.3	-0.2	-0.3	-1.1	-0.1	-0.5	-0.1	0.5	-0.6	-1.1	-0.8	-0.9	-0.8	-0.8	-1.4	-1.1	0.0	-0.8
Whole body fat mass	0.5	2.2	10.0	-1.7	1.1	-0.5	0.5	1.5	1.7	1.9	0.6	0.0	2.1	1.1	1.8	1.3	-0.2	2.0	3.2	-1.1	0.0	1.5
Leg fat mass (right)	0.5	1.8	8.1	-1.4	1.1	-0.6	0.6	1.4	1.5	1.9	0.6	-0.0	1.8	1.1	1.6	1.1	-0.3	1.8	2.8	-1.3	0.1	1.2
Illnesses of siblings: Diabetes	0.5	0.6	2.2	0.7	-0.5	-0.9	-0.6	-1.0	0.1	0.1	-1.0	-0.6	0.2	-1.1	-0.9	-0.8	-0.8	-0.4	-0.4	-1.5	-0.6	-0.8
Arm fat percentage (left)	0.5	1.9	11.1	-1.4	0.1	-1.3	-0.0	1.1	1.9	2.2	0.3	-0.2	1.3	0.4	1.4	0.9	-0.5	1.2	3.3	-1.9	-0.9	1.0
Breast cancer (self-reported)	0.5	0.6	1.8	-0.7	0.6	1.3	0.3	1.0	0.6	0.3	0.2	0.1	0.0	0.6	1.2	0.8	1.2	0.9	0.4	1.3	0.3	0.8
Risk taking	0.5	0.7	1.5	0.6	-0.9	-0.6	-0.4	-0.9	-0.8	0.5	-0.4	-1.1	-0.9	-1.1	-1.1	-0.7	-0.8	-1.0	-1.2	-0.7	-0.5	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	3.0	-0.1	-0.9	-1.0	-0.6	-0.4	0.5	1.0	0.3	0.2	-1.7	-0.7	-0.2	-0.2	-0.2	-0.7	0.5	-1.5	-1.3	-0.2
Bipolar Disorder or Schizophrenia	0.4	1.0	3.3	-0.1	-0.4	-1.0	-1.8	-0.5	-0.5	1.1	-1.3	-1.4	-1.8	-1.1	-0.2	-0.2	-1.3	-0.3	-0.2	-0.9	-1.2	-0.1
Alzheimer’s Disease (in mother)	0.4	0.5	1.5	0.3	-0.9	-0.3	-1.1	-0.8	0.2	0.1	-1.0	-0.5	-0.6	-0.8	-0.7	-0.5	0.0	-0.8	-0.9	-1.2	-0.8	-0.6
Crohns Disease (2017)	0.4	0.9	4.5	-0.7	0.5	-0.3	0.3	0.9	0.6	0.7	1.3	1.6	-0.9	0.6	1.1	0.7	-0.2	0.9	2.1	0.8	-0.2	0.7
Crohns Disease (2012)	0.4	0.6	5.2	0.0	1.0	0.3	0.5	0.5	-0.2	-0.5	1.0	2.3	-1.1	0.4	0.6	0.2	0.2	0.5	0.5	0.9	0.5	0.1
Blood White Count	0.4	2.7	6.8	2.4	-0.4	-0.5	-0.5	-2.1	-2.6	-2.4	-0.8	-0.8	-0.2	-1.6	-2.1	-2.1	-1.6	-1.2	-2.4	-0.5	0.9	-2.2
Trunk fat percentage	0.4	1.7	6.1	-0.9	-0.6	-1.6	-0.9	0.3	2.0	2.0	-0.4	-0.7	1.0	-0.4	0.7	0.4	-1.0	0.8	2.5	-2.3	-1.6	0.5
Fed-up feelings	0.4	0.7	2.8	-1.0	-0.3	-1.1	-0.4	0.6	1.1	1.6	-0.5	-0.3	-0.2	-0.5	0.5	0.6	-0.4	-0.1	1.7	-0.9	-0.7	0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.7	1.0	0.7	0.1	-0.1	-0.2	-1.1	-1.3	0.1	0.5	0.8	0.1	-0.3	-0.6	-0.6	-0.2	-0.2	0.4	0.9	-0.7
Trunk fat mass	0.4	1.9	8.4	-1.5	0.8	-0.6	0.2	1.3	1.9	1.9	0.4	-0.2	2.0	0.8	1.6	1.2	-0.4	1.8	2.9	-1.2	-0.3	1.3
Waist circumference	0.4	1.3	7.7	-0.9	1.2	-0.7	0.6	1.2	1.0	1.2	0.8	0.5	1.6	0.9	1.3	0.8	-0.8	1.4	2.8	-0.8	0.6	0.8
Past tobacco smoking	0.4	0.7	4.8	-1.1	0.0	0.9	0.2	0.4	2.2	1.3	0.4	-0.2	-0.4	0.5	0.6	0.9	1.2	0.4	-0.2	-0.3	-0.4	0.8
Financial difficulties in last 2 years	0.4	0.6	3.1	-1.0	-0.5	-0.7	0.5	0.8	0.2	0.8	-0.6	-0.3	-0.6	0.2	0.8	0.7	-0.0	0.4	1.8	-1.2	-0.6	0.7
Neuroticism score	0.4	0.8	2.5	0.3	-0.4	-1.4	-0.6	-0.4	-0.2	0.4	-1.6	-0.6	-1.2	-0.9	-0.8	-0.5	-0.8	-1.4	0.4	-1.6	-0.7	-0.6
Hip circumference	0.4	1.8	12.0	-1.2	1.2	-0.8	0.1	1.4	0.4	1.6	0.7	0.3	1.8	1.2	1.6	0.9	-0.8	1.6	3.5	-0.9	0.6	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	2.3	-0.8	0.0	0.2	0.8	0.4	1.5	1.0	-0.0	0.7	0.2	-0.0	0.5	0.5	0.6	0.6	0.1	-1.2	-0.2	0.5
Medication: Lansoprazole	0.4	0.5	2.5	0.2	-0.7	-1.2	-0.7	-0.5	0.5	0.8	-0.1	0.2	-0.3	-0.5	-0.3	-0.4	-1.1	-0.5	1.6	-0.8	-0.9	-0.4
Prospective memory result	0.4	0.6	2.2	-1.1	-0.4	0.4	1.5	0.6	0.9	1.0	0.3	-0.1	-0.3	0.5	0.7	0.8	1.2	0.8	0.3	-0.3	-0.6	0.8
Glaucoma (self-reported)	0.4	0.5	1.5	-0.1	1.2	0.3	1.0	0.4	1.0	-0.6	1.0	1.1	0.8	0.6	0.5	0.3	-0.0	0.0	0.5	0.8	0.9	0.2
Body fat percentage	0.4	1.5	6.3	-0.9	-0.4	-1.6	-0.6	0.5	1.8	2.0	-0.1	-0.5	1.2	-0.2	0.7	0.4	-1.0	0.8	2.5	-2.3	-1.4	0.5
Angina (self-reported)	0.4	0.6	2.3	0.7	-0.3	-0.8	-1.5	-0.4	-1.0	0.1	-0.3	-0.5	-1.5	-0.7	-0.6	-0.5	-0.8	-1.1	-0.3	-0.3	-0.6	-0.6
Mean time to correctly identify matches	0.4	0.8	5.3	0.8	0.6	1.0	-0.1	-0.6	-0.8	-1.8	-0.2	-0.8	0.9	-0.4	-0.6	-0.5	0.4	0.4	-2.3	0.3	1.2	-0.7
Smoking status: Previous	0.4	0.5	4.0	0.8	0.1	-1.2	-0.2	-0.1	-2.0	-0.5	-0.2	0.0	0.3	-0.3	-0.4	-0.7	-1.4	-0.4	0.8	0.3	0.2	-0.6
Eye problems/disorders: Cataract	0.4	0.4	1.3	-0.7	1.0	0.1	0.6	0.8	0.9	0.4	-0.4	-0.3	0.7	0.8	0.7	0.6	-0.2	0.5	1.2	0.3	0.4	0.6
Back pain experienced in last month	0.4	0.6	1.9	-0.9	0.3	0.6	0.9	0.7	0.8	0.6	-0.1	-1.4	0.8	0.3	0.7	0.9	1.4	0.4	0.1	0.1	0.4	0.8
Mother’s age at death	0.4	0.5	2.9	-0.0	-0.6	-1.0	0.1	-0.2	0.0	0.7	-1.0	-0.4	-0.4	-0.5	-0.1	-0.3	-0.9	-0.4	0.4	-1.7	-1.2	-0.3
High cholesterol (Self-reported)	0.4	0.8	2.7	0.8	-0.7	-1.3	-0.5	-0.7	0.3	0.2	0.5	0.3	-0.1	-1.4	-0.9	-1.0	-1.4	-1.0	0.1	-1.6	-0.6	-1.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.7	0.1	-0.7	-0.9	-1.1	-0.6	-0.6	0.8	-0.5	0.0	-1.3	-0.3	-0.5	-0.2	-0.4	-1.0	-0.0	0.2	-1.2	-0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.6	-0.9	-0.2	0.5	0.2	0.8	0.5	1.3	0.8	-0.3	-0.1	0.6	1.0	0.8	1.0	0.7	0.9	-0.2	-0.5	0.8
Reaction Time	0.3	0.5	1.8	0.6	0.3	0.4	0.3	-0.6	-0.6	-1.2	-0.7	-1.0	0.2	-0.5	-0.6	-0.6	-0.1	0.2	-1.3	-0.6	0.9	-0.7
Age at First Birth	0.3	0.5	1.9	-0.3	-0.1	-0.7	-0.3	-0.2	0.8	0.9	-1.2	-0.6	-1.4	-0.7	-0.3	-0.1	-0.9	-0.7	-0.1	-1.1	-0.4	0.0
Lupus	0.3	0.4	1.2	-0.6	-0.2	-0.0	1.0	0.5	0.6	0.6	1.1	1.0	-0.4	0.6	0.3	0.5	0.4	0.8	0.3	-0.6	-0.9	0.5
Schizophrenia (2014)	0.3	0.6	2.3	-0.3	-0.3	-0.6	-1.4	-0.2	-0.7	1.2	-0.5	-1.1	-1.5	-0.7	-0.1	0.0	-0.8	-0.1	-0.3	-0.4	-1.0	0.2
Heel T-Score	0.3	2.7	6.1	-2.0	1.9	1.6	2.5	2.3	0.3	1.4	1.0	1.4	0.0	2.2	1.8	2.1	2.1	1.0	1.2	0.9	0.4	2.0
Smoking Status	0.3	0.6	6.0	0.8	-0.0	-0.2	0.7	-0.2	-2.4	-1.2	0.4	0.4	0.3	-0.3	-0.6	-0.5	-0.3	-0.3	-0.3	0.8	0.6	-0.6
Cardiovascular Disease	0.3	1.0	9.2	-0.4	-0.0	-1.5	-0.6	0.3	3.0	1.3	-0.3	0.5	-0.4	-0.6	0.2	0.1	-1.0	-0.2	1.5	-1.0	-0.6	0.3
Angina	0.3	0.4	1.9	0.7	-0.0	-0.5	-1.3	-0.3	-1.0	-0.1	-0.1	-0.3	-1.4	-0.6	-0.5	-0.4	-0.8	-1.0	-0.3	-0.0	-0.3	-0.5
Current tobacco smoking	0.3	0.5	1.9	0.1	0.2	0.8	1.3	0.2	-1.0	-1.0	1.2	1.4	0.3	0.3	-0.0	0.2	0.7	0.3	-0.4	0.8	0.7	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.5	-1.1	0.2	0.0	1.6	0.8	1.3	1.3	0.0	0.9	-0.4	0.6	0.8	0.8	0.4	-0.1	1.3	-0.1	-0.3	0.9
High blood pressure	0.3	0.7	5.3	-0.3	0.2	-1.2	-1.2	0.2	2.3	0.7	-0.8	-0.2	0.0	-0.6	0.5	0.1	-0.7	0.2	1.5	-0.5	0.0	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.5	-0.1	0.9	0.2	0.7	0.5	0.9	-0.0	1.1	1.2	0.3	0.6	0.6	0.3	0.1	-0.0	0.8	0.6	0.5	0.3
Number of incorrect matches in round	0.3	0.5	2.7	0.7	0.2	0.8	0.0	-0.4	-1.2	-1.0	1.1	0.7	-0.4	-0.1	-0.5	-0.2	0.3	-0.0	-1.6	-0.0	0.4	-0.3
Alcohol usually taken with meals	0.3	0.4	2.2	-0.3	-0.7	-0.5	-0.4	-0.2	0.7	1.4	-0.2	0.3	-0.9	-0.8	-0.1	-0.1	-0.0	-0.6	-0.4	-0.9	-1.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.2	-0.7	-0.0	-0.6	-0.4	0.5	0.1	1.2	-1.1	-0.9	-0.5	0.1	0.7	0.5	-0.1	0.6	1.5	-0.6	-0.2	0.6
Medication: Cholesterol lowering	0.3	0.5	2.0	0.1	-0.8	-1.0	-1.1	-0.3	0.7	0.5	0.1	-0.4	-0.4	-1.0	-0.1	-0.4	-0.8	-0.6	1.0	-1.4	-0.7	-0.4
Depression (self-reported)	0.3	0.3	1.5	0.2	1.0	0.5	0.5	0.2	-1.0	-1.1	0.2	-0.2	0.3	0.3	0.1	-0.0	0.1	0.5	-0.3	0.1	1.2	-0.1
Breastfed as a baby	0.3	0.4	2.2	-0.2	-0.3	-0.4	-0.3	0.4	0.8	0.6	-1.5	-1.4	-1.0	-0.2	0.2	0.1	-0.3	-0.5	0.0	0.4	-0.3	-0.0
Tense / ‘highly strung’	0.3	0.5	1.3	-0.9	1.1	0.7	1.1	0.7	0.4	0.4	0.5	0.7	0.0	0.5	0.8	0.9	0.8	0.5	0.5	0.2	0.7	0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	3.8	-0.6	-0.4	-0.0	0.9	-0.2	2.0	0.8	-1.2	-0.5	-0.8	-0.0	0.2	0.1	0.0	-0.5	-0.2	0.2	-0.6	0.1
Leg fat percentage (right)	0.3	1.0	4.9	-0.5	-0.2	-1.4	-0.2	0.4	1.2	1.7	0.3	-0.1	1.1	-0.0	0.4	0.1	-1.0	0.7	1.8	-2.2	-1.0	0.1
Number of full sisters	0.3	0.3	2.2	0.0	-0.7	-0.3	0.1	-0.4	1.5	0.4	-0.4	-0.1	-0.4	-0.4	-0.5	-0.4	-0.1	-0.0	-0.6	-1.1	-0.5	-0.4
Had major operations	0.3	0.4	1.3	-0.7	0.1	0.3	0.8	0.2	-0.3	0.6	-0.6	-0.9	-1.1	0.5	0.6	0.6	0.5	0.3	0.5	0.8	-0.6	0.7
Leg pain on walking	0.3	0.4	1.3	-0.5	0.6	0.2	0.4	0.6	-0.8	0.2	1.1	0.9	0.7	0.6	0.6	0.6	0.3	0.7	0.9	0.8	0.6	0.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.7	0.7	-0.3	0.6	-0.6	-0.6	-1.0	-0.3	0.1	-0.6	-0.1	0.0	-0.5	-0.3	0.2	-0.5	-1.3	1.3	0.0	-0.4
Friendships satisfaction	0.3	0.4	1.3	0.8	0.2	-0.5	0.3	-0.5	-0.5	-1.2	-0.7	-0.2	-0.3	-0.3	-0.6	-0.6	-1.0	-0.7	-0.0	0.8	1.0	-0.7
Medication: Aspirin	0.3	0.4	2.6	0.6	-0.2	-1.1	-0.4	-0.4	1.6	-0.2	-0.3	0.3	-0.1	-0.8	-0.4	-0.7	-1.0	-0.4	0.7	0.3	-0.1	-0.7
Medication: Gliclazide	0.3	0.3	1.3	0.1	1.0	0.6	0.3	0.2	0.8	-1.0	0.0	0.3	0.9	0.2	0.2	0.2	-0.3	0.7	-0.0	0.5	1.2	0.1
Ever taken oral contraceptive pill	0.3	0.4	1.2	-0.5	-0.6	-0.7	0.6	0.6	-1.0	0.9	0.6	0.6	0.5	0.5	0.1	0.3	0.1	0.3	1.1	-1.0	-0.2	0.2
Alcohol drinker status: Never	0.3	0.4	4.2	0.4	0.1	-0.7	0.4	-0.1	-2.0	-0.4	0.2	0.2	-0.8	0.1	-0.4	-0.4	-0.3	-0.1	0.2	-0.4	0.4	-0.5
Leg fat percentage (left)	0.3	0.9	4.2	-0.6	0.7	-1.0	0.3	0.9	0.9	1.1	0.5	0.2	1.7	0.5	0.7	0.4	-0.8	1.0	2.0	-1.4	-0.2	0.5
Diastolic blood pressure, automated reading	0.3	1.0	3.7	-0.3	-0.6	-1.8	-1.3	0.1	1.4	1.6	-0.9	-0.6	0.6	-0.4	0.0	-0.1	-0.7	0.2	1.9	-1.4	-1.1	-0.0
Vascular/heart problems diagnosed by doctor	0.3	0.9	7.7	0.8	-0.3	1.0	1.0	-0.7	-2.8	-1.3	0.3	-0.2	-0.3	0.2	-0.9	-0.5	0.2	-0.5	-1.8	0.4	0.3	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.5	0.8	-0.6	-0.3	-0.1	-0.9	-0.4	-0.7	-1.0	-1.2	-0.5	-0.2	-1.1	-0.7	-0.6	-0.9	-0.5	0.1	-0.2	-0.8
Irritable Bowel Disease (IBD)	0.2	0.6	2.0	-0.7	0.1	-0.2	0.4	0.7	0.4	0.8	1.2	1.0	-1.0	0.4	1.0	0.7	0.1	0.6	1.4	0.8	-0.4	0.6
HbA1C	0.2	0.3	1.3	-0.2	-0.3	-0.9	-0.6	0.3	0.1	0.4	-0.9	0.3	-0.8	-0.3	0.4	0.1	-0.6	-0.2	1.1	-0.2	0.4	-0.1
Triglycerides	0.2	0.4	1.0	0.9	0.6	0.2	0.0	-0.6	-0.6	-1.0	-0.3	0.2	0.3	0.3	-0.8	-0.7	-0.5	-0.6	-0.9	0.9	0.5	-0.7
Systolic Blood Pressure	0.2	1.2	3.1	1.1	-0.4	-1.4	-1.0	-1.1	0.5	-0.3	-1.8	-0.5	0.3	-1.6	-1.4	-1.2	-1.3	-1.5	-0.3	-0.9	-0.4	-1.4
Neuroticism	0.2	0.6	2.3	0.2	-0.6	-1.5	-0.4	-0.3	-0.6	0.5	-0.8	-0.3	-0.9	-0.5	-0.6	-0.4	-0.8	-1.2	0.9	-1.5	-0.7	-0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.4	0.3	0.6	0.2	1.2	-0.0	0.7	-0.8	0.4	0.5	0.2	-0.0	-0.2	-0.1	-0.1	-0.3	0.1	0.8	0.8	-0.2
Systolic blood pressure, automated reading	0.2	0.4	1.5	0.9	0.7	-0.4	-0.4	-0.2	0.1	-1.0	-0.8	-0.6	1.2	-0.9	-0.7	-0.7	-0.6	-0.2	-0.3	-0.1	0.7	-0.7
Diabetes (mother)	0.2	0.3	1.3	0.3	-0.3	-0.5	-0.4	-0.5	1.2	-0.0	-0.6	-0.8	-0.4	-0.7	-0.6	-0.4	-0.5	-0.3	-0.6	-0.6	-0.6	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.4	-0.9	0.4	1.2	0.3	0.3	1.0	0.1	0.1	-0.6	0.1	-0.1	0.7	0.8	1.0	1.1	-0.4	0.5	0.3	0.8
Stomach or abdominal pain in last month	0.2	0.3	1.1	0.8	0.3	0.0	-0.3	-0.7	-0.7	-0.1	0.4	0.3	0.1	-0.3	-0.6	-0.7	-1.1	-0.7	-0.3	0.0	0.4	-0.8
Nervous feelings	0.2	0.3	1.6	-0.3	0.9	0.7	0.6	0.1	1.3	-0.3	-0.1	-0.5	0.9	0.2	0.1	0.5	0.8	0.3	-0.7	-0.1	0.3	0.3
Fluid intelligence score	0.2	0.4	1.9	-0.0	-0.7	-0.5	-0.4	-0.4	-0.5	0.7	-0.9	-1.4	-1.3	0.1	-0.3	-0.2	-0.4	-0.5	0.3	0.0	-0.8	-0.1
Time employed in main current job	0.2	0.2	1.0	0.2	0.1	-0.3	-0.9	-0.4	-0.1	0.1	-0.5	0.5	-0.2	-0.4	0.1	-0.2	-0.4	-0.8	0.3	1.0	-0.2	-0.1
Alcohol intake versus 10 years previously	0.2	0.3	1.2	0.2	-1.1	-0.4	-1.0	-0.4	-0.7	0.0	-0.5	-1.1	-0.1	-0.2	-0.2	-0.2	-0.1	0.1	0.2	-1.0	-0.5	-0.1
Father’s age at death	0.2	0.3	1.3	-0.9	-0.1	-0.4	0.5	0.6	0.9	1.1	-0.3	0.1	-0.6	-0.2	0.6	0.6	-0.1	0.0	0.6	-0.3	-0.6	0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	3.6	-0.1	1.7	1.3	1.2	0.2	-0.9	-1.1	-0.2	-0.2	1.1	0.4	0.1	0.4	0.4	0.2	-1.0	1.2	1.9	0.5
Pulse rate	0.2	0.3	1.4	0.7	0.4	0.3	-0.1	-0.5	-1.2	-0.4	0.2	0.1	0.1	0.2	-0.5	-0.5	0.1	-0.1	-1.2	-0.5	0.2	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	2.1	-0.5	0.3	-0.6	0.4	0.6	-0.1	0.6	0.4	0.9	-0.0	0.3	0.5	0.4	0.1	0.3	1.5	-0.8	-0.2	0.4
Loud music exposure frequency	0.2	0.2	1.0	0.3	0.5	0.6	0.7	-0.3	-0.5	-1.0	0.1	-0.2	0.5	-0.2	-0.2	-0.0	-0.4	0.2	-0.8	0.4	0.8	-0.1
Eye problems/disorders: None of the above	0.2	0.3	1.4	0.1	-0.5	0.6	0.6	-0.1	-0.7	-0.2	0.7	0.6	-0.9	-0.2	-0.1	0.1	0.8	0.0	-1.2	-0.1	0.2	0.1
Emphysema/chronic bronchitis	0.2	0.2	1.6	-0.1	0.2	0.1	0.3	0.1	-0.4	-0.1	1.1	1.2	0.3	0.3	0.2	0.3	-0.1	-0.1	-0.3	0.3	-0.3	0.2
Comparative height size at age 10	0.2	1.1	3.2	1.4	0.9	0.0	-0.1	-1.2	-1.6	-1.8	-0.6	-0.4	1.3	-0.1	-0.9	-1.1	-1.5	0.2	-1.0	-0.1	1.7	-1.0
Overall health rating	0.2	0.4	1.6	-0.2	-0.3	-1.3	-1.0	-0.2	-0.1	0.8	-0.1	-0.1	-0.9	-0.6	-0.1	-0.1	-1.0	-0.3	1.0	-1.0	-0.2	-0.1
Medication: Aspirin	0.2	0.2	1.1	0.6	0.2	-0.4	-0.0	-0.2	1.1	-0.7	0.2	0.7	0.0	-0.6	-0.2	-0.5	-0.7	-0.0	0.3	0.6	0.4	-0.5
Supplements: Vitamin C	0.2	0.2	1.4	-0.5	-0.2	0.6	-0.1	0.3	0.9	0.2	0.4	0.1	0.2	-0.0	0.5	0.5	1.2	0.2	0.2	0.5	-0.3	0.4
Hypertension (Self-reported)	0.2	0.7	4.5	-0.2	0.3	-1.2	-1.4	0.2	2.1	0.5	-0.9	-0.6	-0.0	-0.6	0.5	-0.0	-0.8	0.2	1.4	-0.5	0.1	0.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.5	-0.5	-0.1	0.3	-0.1	0.1	-0.5	0.8	0.1	-0.3	0.1	0.1	0.0	0.4	0.9	0.7	-0.7	-1.2	-0.4	0.3
Long-standing illness, disability or infirmity	0.2	0.2	1.3	-0.5	-0.1	-0.6	0.3	0.0	1.0	1.1	0.5	0.1	-0.7	-0.1	0.2	0.2	-0.4	0.0	0.7	-0.2	-0.4	0.3
Osteoarthritis (self-reported)	0.2	0.2	0.8	0.7	0.2	-0.0	-0.4	-0.3	-0.8	-0.6	0.1	-0.4	0.9	-0.0	-0.1	-0.4	-0.5	-0.2	0.0	0.5	0.7	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	2.3	-0.3	1.5	0.7	0.5	0.3	-0.5	-0.4	0.6	0.2	1.2	0.5	0.6	0.5	-0.2	0.8	-0.1	0.3	1.5	0.7
Number of self-reported non-cancer illnesses	0.2	0.4	2.5	-0.3	0.8	-0.9	0.4	0.4	1.2	0.5	-0.3	0.0	0.3	-0.1	0.3	0.0	-0.8	0.1	1.6	-0.3	0.6	0.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	0.6	0.3	-0.5	0.2	0.0	-0.2	-0.5	0.4	0.6	0.4	0.4	-0.1	-0.4	-0.6	-0.6	0.7	0.2	0.2	-0.5
Medication: Bendroflumethiazide	0.2	0.3	1.2	0.6	0.1	0.2	-0.7	-0.8	0.7	-1.1	-0.5	-0.5	0.1	-0.4	-0.4	-0.4	-0.0	-0.3	-1.1	0.4	-0.2	-0.3
Illnesses of father: High blood pressure	0.2	0.3	1.7	0.5	0.3	0.3	0.6	-0.1	-0.6	-1.3	-0.1	0.7	-0.4	-0.4	-0.1	-0.1	0.4	-0.3	-0.2	0.1	0.8	-0.3
Ever smoked	0.2	0.4	4.3	0.6	-0.2	0.0	-0.3	-0.2	-2.1	-1.1	-0.0	0.6	0.7	-0.0	-0.3	-0.4	-0.3	-0.0	-0.4	0.4	0.1	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.9	-0.5	-0.5	-0.3	-0.6	0.2	-0.0	0.9	-0.6	-0.1	0.3	-0.1	0.0	0.3	0.1	-0.1	0.4	-0.1	-1.0	0.3
Commuting to job workplace: Cycle	0.2	0.3	1.3	-0.5	-0.5	0.6	0.7	-0.1	0.6	0.3	0.1	-0.0	-0.4	0.0	0.2	0.5	1.1	-0.0	-0.7	0.3	-0.8	0.3
Bipolar Disorder (2018)	0.1	0.1	1.1	0.0	-0.1	-0.1	-0.3	-0.2	-0.0	0.0	-0.7	-1.0	-0.4	-0.5	0.0	0.0	-0.5	0.1	-0.3	-0.4	-0.3	-0.1
Worry (Nagel 2018)	0.1	0.2	0.7	-0.5	0.8	0.3	0.3	0.2	0.2	-0.1	0.0	-0.1	0.7	0.7	0.2	0.6	0.5	0.4	-0.0	0.2	0.3	0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.8	0.0	-0.0	-0.1	-0.5	0.1	-0.9	-0.2	-0.5	0.1	0.0	0.2	-0.1	0.1	0.2	-0.2	0.2	-0.1	0.3	-0.0
Ulcerative Colitis (UC)	0.1	0.1	1.5	0.1	-0.3	-0.1	-0.1	-0.2	-0.3	0.1	0.4	0.1	-1.2	-0.3	0.1	-0.1	-0.2	-0.3	-0.3	0.5	-0.4	-0.2
Coronary Artery Disease (CAD)	0.1	0.2	0.9	-0.1	0.5	-0.2	-0.5	-0.3	0.7	-0.4	-0.0	0.9	-0.1	-0.3	0.3	-0.1	-0.5	-0.3	-0.2	-0.1	0.3	0.1
Ulcerative Colitis	0.1	0.2	0.7	-0.7	-0.3	0.2	0.4	0.4	0.2	0.5	0.5	0.4	-0.3	0.0	0.8	0.5	0.6	0.3	0.2	0.1	-0.6	0.5
Blood Red Count	0.1	0.5	1.7	0.3	0.9	0.5	-0.1	0.4	-0.7	-1.3	-0.4	-1.3	1.0	0.5	0.4	0.2	-0.0	0.8	-0.6	0.6	1.3	0.2
Height	0.1	1.5	10.5	1.2	1.1	1.1	-0.7	-1.4	-0.3	-1.6	-1.1	-0.9	0.2	-1.0	-1.3	-0.7	-1.1	-0.3	-3.2	0.3	1.2	-0.7
Allergy or Eczema	0.1	0.2	0.7	-0.3	-0.4	0.3	-0.6	-0.3	0.9	0.2	-0.1	-0.2	-0.3	-0.5	0.1	0.1	0.5	0.4	-0.5	-0.2	-0.4	0.2
Hair Pigment	0.1	2.3	8.2	0.2	-2.5	-2.3	-1.3	-1.4	0.1	2.0	-0.3	0.3	-0.7	-0.8	-1.2	-1.1	-1.5	-1.4	0.2	-2.9	-2.5	-1.0
Sensitivity / hurt feelings	0.1	0.3	1.0	0.1	0.4	-0.8	-0.8	-0.2	0.5	-0.0	-0.2	0.6	-0.2	-0.5	0.1	-0.2	-0.6	-0.6	0.5	-1.0	-0.3	-0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.6	0.2	0.7	-0.4	-0.4	-0.1	-0.0	-0.3	-0.1	0.7	-0.5	0.2	0.0	-0.2	-0.5	-0.2	0.4	0.1	0.3	-0.2
Vitamin and mineral supplements	0.1	0.2	0.7	-0.4	0.1	-0.5	-0.3	-0.1	0.4	0.6	-0.5	-0.4	-0.7	-0.1	0.2	0.1	-0.5	-0.0	0.2	-0.8	-0.4	0.2
Maternal smoking around birth	0.1	0.2	0.6	-0.2	-0.8	-0.4	-0.4	0.0	0.6	0.6	0.4	-0.4	-0.4	0.2	0.0	0.1	0.5	-0.1	0.7	0.0	-0.1	0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.5	0.0	0.2	-0.2	0.0	0.2	0.2	0.3	-0.1	0.7	0.5	-0.3	0.1	-0.1	-0.4	-0.0	0.0	-0.5	-0.0	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	1.0	-0.3	-0.1	-0.1	0.9	0.3	0.3	0.5	-0.1	1.0	-0.7	0.2	0.2	0.1	0.3	-0.7	0.6	0.3	-0.0	0.2
Allergy	0.1	0.3	1.1	0.6	-0.3	-0.7	-0.7	-0.1	-1.1	0.1	0.3	1.0	-0.1	0.1	-0.5	-0.4	-0.4	-1.0	-0.1	-0.4	-0.5	-0.4
Worrier / anxious feelings	0.1	0.1	0.5	0.3	0.5	-0.7	-0.2	0.0	-0.4	-0.5	-0.2	0.5	0.2	0.3	-0.2	-0.1	-0.4	-0.3	0.6	-0.4	0.2	-0.3
Happiness	0.1	0.2	0.5	0.1	0.7	0.7	0.3	-0.2	-0.6	-0.3	0.4	0.2	0.3	0.1	0.1	0.2	0.0	-0.0	-0.6	0.7	0.6	-0.0
Standing height	0.1	0.8	2.4	-0.1	1.5	1.6	0.4	-0.1	0.0	-0.7	-0.4	-0.7	1.4	0.7	0.2	0.4	-0.1	0.8	-1.1	1.3	1.4	0.5
Blood clot in the leg (DVT)	0.1	0.2	0.6	-0.2	-0.2	-0.4	-0.5	-0.3	0.4	0.8	-0.4	-0.2	-0.4	-0.5	-0.4	-0.0	0.6	-0.0	-0.3	-0.5	-0.8	-0.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.5	-0.1	0.6	0.1	0.6	0.3	-0.2	-0.4	0.0	0.2	-0.5	0.4	0.4	0.1	0.1	0.2	0.4	0.7	0.6	0.1
Qualifications: College or University degree	0.1	0.4	1.2	0.5	-0.4	-0.1	0.9	-0.9	-0.0	-0.2	-1.1	-0.8	-0.7	-0.8	-0.5	-0.6	-1.0	-0.4	-0.7	0.1	-0.0	-0.5
Pulse rate, automated reading	0.1	0.3	1.5	-0.5	-0.4	-0.4	0.4	0.2	-0.4	0.8	0.6	1.2	-0.7	0.2	0.3	0.4	0.3	0.1	0.7	-0.4	-0.8	0.3
Knee pain experienced in last month	0.1	0.2	1.0	0.0	0.5	0.2	0.0	0.3	0.2	-0.5	0.5	1.0	0.6	0.4	0.5	0.1	-0.3	0.4	0.6	0.7	0.7	0.2
Hearing aid user	0.1	0.1	0.7	0.1	-0.2	-0.2	-0.3	-0.4	0.1	0.1	0.3	0.1	0.8	0.1	-0.1	-0.1	-0.2	0.5	-0.3	-0.4	-0.3	-0.0
Commuting to job workplace: Public transport	0.1	0.1	0.6	0.3	0.4	0.1	-0.0	-0.1	-0.3	-0.5	0.2	0.1	0.3	-0.3	-0.0	-0.1	-0.2	0.2	0.1	-0.0	0.8	-0.2
Medication: Blood pressure	0.1	0.2	1.2	-0.2	0.2	-0.4	-1.1	0.2	1.0	0.2	-0.3	0.1	0.5	-0.2	0.4	0.1	-0.3	0.1	0.9	-0.1	-0.0	0.1
Medication: Atorvastatin	0.1	0.2	0.6	-0.4	0.0	-0.2	-0.8	-0.1	0.7	0.8	-0.2	-0.5	-0.4	-0.2	-0.1	0.1	0.2	-0.5	0.3	-0.4	-0.5	0.1
Cholesterol lowering medication	0.1	0.2	0.7	0.1	-0.1	-0.3	-0.7	-0.1	0.4	0.4	0.2	0.3	-0.8	-0.9	-0.3	-0.2	-0.1	-0.6	-0.4	-0.6	-0.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.8	-0.3	-0.1	-0.4	-0.4	-0.2	0.5	0.9	-0.2	0.1	-0.4	-0.4	-0.2	0.1	0.6	0.2	-0.1	-0.6	-0.6	0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Headache pain in last month	0.0	0.1	0.3	-0.1	0.5	0.0	0.2	0.1	0.5	0.2	-0.1	-0.3	-0.3	-0.4	0.1	0.1	0.1	-0.1	0.3	-0.3	0.1	-0.0

Hub : Genes

PPHLN1

Models

Trait associations