Best TWAS P=7.65e-09 · Best GWAS P=7.18e-12 conditioned to 0.0084
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | GTEx | Nerve Tibial | PIAS1 | 0.20 | 0.10 | lasso | 8 | 0.14 | 3.0e-10 | 5.2 | -5.8 | 7.7e-09 | -0.22 | 0.85 | 0.15 | TRUE |
| 4 | GTEx | Muscle Skeletal | SMAD3 | 0.13 | 0.10 | enet | 8 | 0.10 | 4.2e-10 | 5.6 | 5.5 | 4.3e-08 | -0.03 | 0.26 | 0.74 | TRUE |
| 6 | METSIM | Adipose | MAP2K5 | 0.07 | 0.05 | enet | 19 | 0.06 | 2.8e-09 | 5.0 | -5.3 | 1.3e-07 | -0.84 | 0.16 | 0.84 | TRUE |
| 3 | GTEx | Muscle Skeletal | MAP2K5 | 0.08 | 0.03 | lasso | 6 | 0.05 | 1.9e-05 | -4.7 | -5.2 | 2.1e-07 | -0.69 | 0.75 | 0.24 | FALSE |
| 2 | GTEx | Artery Tibial | PIAS1 | 0.14 | 0.02 | enet | 26 | 0.08 | 1.6e-06 | 2.0 | -5.2 | 2.4e-07 | -0.18 | 0.68 | 0.22 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAP2K5 | 0.03 | 0.03 | blup | 142 | 0.02 | 1.6e-03 | 3.2 | -5.2 | 2.7e-07 | -0.90 | 0.05 | 0.92 | FALSE |
| 1 | GTEx | Artery Aorta | PIAS1 | 0.26 | 0.12 | enet | 22 | 0.10 | 3.4e-06 | 5.3 | -5.1 | 3.0e-07 | -0.18 | 0.94 | 0.02 | FALSE |