TWAS
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Traits
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Traits
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Impedance of leg (right)
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chr15:73,524,629-74,915,888
Best TWAS P=1.65e-09 · Best GWAS P=2.74e-11 conditioned to 0.00387
73.6M
73.8M
74M
74.2M
74.4M
74.6M
74.8M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Testis
LOXL1-AS1
0.36
0.15
lasso
10
0.13
2.4e-06
-5.9
-6.0
1.7e-09
0.60
0.12
0.79
TRUE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
ISLR
0.02
0.02
lasso
2
0.01
6.2e-04
-5.1
5.2
2.1e-07
-0.15
0.01
0.95
TRUE
1
GTEx
Cells Transformed fibroblasts
LOXL1-AS1
0.28
0.09
lasso
6
0.17
1.7e-12
3.2
5.3
9.0e-08
-0.64
0.84
0.15
FALSE