Hub : Genes

SMAD3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1210 0.0460 3.5e-03 0.010 NA 0.038 NA 0.058 5.3e-02 NA 7.1e-04 NA 3.6e-05
2 GTEx Esophagus Mucosa 0.1820 0.0600 1.8e-03 0.006 NA 0.021 NA 0.014 1.2e-01 NA 1.5e-02 NA 3.5e-02
3 GTEx Muscle Skeletal 0.1326 0.0479 2.9e-03 0.103 NA 0.101 NA 0.096 2.9e-10 NA 4.2e-10 NA 1.1e-09
4 GTEx Ovary 0.3220 0.1150 3.5e-03 0.017 NA 0.091 NA 0.070 1.2e-01 NA 3.0e-03 NA 8.5e-03
5 GTEx Thyroid 0.1880 0.0720 8.9e-03 0.020 NA 0.030 NA 0.022 9.8e-03 NA 2.3e-03 NA 7.5e-03
6 METSIM Adipose 0.0919 0.0334 2.3e-03 0.009 0.007 0.010 0.007 0.013 1.5e-02 2.6e-02 9.9e-03 0.028 4.1e-03
7 TCGA Lung Adenocarcinoma 0.0582 0.0255 1.0e-03 0.062 0.042 0.058 NA 0.058 8.3e-08 1.0e-05 2.6e-07 NA 2.5e-07
8 TCGA Thyroid Carcinoma 0.2230 0.0600 5.6e-09 0.120 0.105 0.112 NA 0.107 9.4e-12 2.2e-10 5.2e-11 NA 1.3e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.8 1.3 3.8 -1.9 -1.7 0.4 0.6 1.2 -1.2 0.7 0.6
Bipolar Disorder or Schizophrenia 0.8 2.0 6.5 -2.6 -1.0 1.8 -1.1 0.5 0.2 2.0 -0.1
Depressed Affect (Nagel 2018) 0.4 0.9 2.4 1.4 -0.1 -1.3 0.4 0.3 1.5 -0.9 0.5
Depression (Nagel 2018) 0.3 0.4 2.3 1.5 -0.4 -0.2 0.3 -0.1 0.4 -0.7 -0.2
Intelligence (Savage-Jansen 2018) 1.0 3.2 9.8 0.7 2.3 -3.1 -0.2 -0.5 -1.3 -2.7 -0.6
Neuroticism (Nagel 2018) 0.3 0.8 1.9 0.8 0.4 -1.4 1.0 0.3 1.3 -0.4 0.9
Schizophrenia (2018) 1.0 2.1 4.0 -1.9 0.1 1.9 -1.9 -0.4 1.2 2.0 -0.5
Schizophrenia vs Biploar Disorder 1.0 1.4 5.0 -0.8 0.6 0.8 -2.2 -1.6 0.8 0.5 -0.9
Worry (Nagel 2018) 0.3 0.6 3.2 0.2 -0.1 -1.8 0.8 0.0 0.8 -0.3 0.6
Alzheimer’s Disease (in mother) 1.3 1.6 2.8 0.5 1.4 1.4 1.7 -1.4 -1.3 0.1 -1.3
Alzheimer’s Disease (in father) 0.5 0.5 2.9 -1.7 0.5 -0.2 -0.5 -0.6 -0.2 -0.5 0.4
Alzheimer’s Disease (including proxy) 0.6 0.9 2.1 -0.9 1.0 0.8 -0.2 -1.2 -1.4 -0.7 -0.9
Crohns Disease (2017) 7.4 16.3 59.6 -3.2 1.1 2.0 -1.8 -6.8 0.1 2.2 -7.7
Irritable Bowel Disease (IBD) 7.7 18.2 65.9 -3.7 2.2 0.2 -2.9 -7.1 0.9 1.4 -8.1
Ulcerative Colitis (UC) 4.0 7.6 19.4 -2.2 2.7 -1.7 -2.4 -4.3 1.4 0.3 -4.4
Major Depression (MDD) 0.9 1.1 3.2 1.4 1.0 -0.2 1.8 0.8 1.2 -0.4 0.9
Reaction Time 0.7 1.4 5.8 1.4 0.3 0.6 -0.8 -0.7 2.4 -0.3 -1.1
Verbal and Numeric Reasoning (VNR) 1.8 4.3 16.6 1.1 0.6 -4.1 0.7 -0.8 -1.2 -3.3 -1.6
Breast Cancer 1.2 3.0 6.6 2.6 1.5 -2.3 -1.3 0.3 0.7 -2.4 1.1
Ovarian Cancer 0.5 0.6 3.0 0.6 1.7 0.6 -0.2 0.4 0.3 -0.0 1.1
Prostate Cancer 0.8 1.2 4.3 1.4 -0.8 0.7 2.1 0.8 -0.3 -0.7 -0.9
Age at First Birth 1.3 1.9 11.6 0.2 0.4 -0.0 -3.4 0.1 1.5 0.5 0.9
Bipolar Disorder (2011) 2.1 2.0 5.5 -0.5 -0.3 0.8 2.4 2.3 -0.1 1.4 1.6
Body Mass Index (BMI) (2010) 2.5 3.4 18.4 -4.3 -1.3 -1.1 -1.5 -1.5 -0.9 0.6 -0.0
Coronary Artery Disease (CAD) 1.9 2.2 9.5 -1.0 -1.9 0.0 -0.8 3.1 -0.9 -0.2 1.4
Crohns Disease (2012) 6.2 9.9 39.7 -1.8 1.8 1.7 -1.3 -5.3 0.6 0.8 -6.3
Mean Putamen Volume 0.4 0.4 2.3 0.3 -0.1 0.5 0.2 -0.7 1.5 0.3 0.3
Fasting Glucose 0.6 0.7 2.4 -0.0 -0.5 0.9 1.3 0.1 -1.5 0.5 -0.4
HbA1C 0.9 1.0 3.6 0.5 -0.9 1.9 0.6 0.3 1.1 1.2 0.7
HDL Cholesterol 0.4 0.7 2.5 -0.2 -0.9 -1.6 -0.5 -0.1 0.3 -1.3 0.4
LDL Cholesterol 2.9 4.5 14.6 -0.2 1.7 -2.5 -2.8 -0.7 1.8 -3.8 -1.0
Lupus 0.9 1.4 3.9 1.6 0.4 -1.2 -0.3 -0.3 0.4 -2.0 -1.7
Neuroticism (2016) 0.5 0.7 2.5 1.6 0.2 -0.2 1.0 -1.1 -0.8 -0.1 -0.3
Primary Biliary Cirrhosis 1.3 1.8 6.9 -2.6 -2.2 0.3 -0.8 0.1 -0.5 0.3 -1.3
Rheumatoid Arthritis 2.1 2.9 9.0 -1.2 -0.6 -1.5 0.4 -3.0 0.0 -1.4 -2.9
Schizophrenia (2014) 0.7 1.6 3.4 -1.8 0.1 1.8 -1.8 -0.4 0.0 1.6 -0.7
Triglycerides 0.5 0.9 5.6 0.4 0.2 0.8 -0.3 2.4 -0.6 -0.0 0.4
Type 2 Diabetes (T2D) (2012) 1.2 1.4 3.6 -0.9 -1.9 0.6 0.9 1.0 -1.4 1.1 1.3
Ulcerative Colitis 2.7 3.9 13.7 -1.5 1.9 -1.7 -1.0 -2.6 0.7 -0.6 -3.7
Blood Eosinophil Count 5.7 44.2 134.6 -8.7 1.6 -1.4 -5.1 -10.5 -0.0 1.7 -11.6
Blood Platelet Count 0.4 4.5 16.8 -0.8 1.7 -2.4 -1.0 -1.9 1.7 -4.1 -1.6
Blood Red Count 0.3 3.3 14.3 -0.5 -0.9 2.4 0.3 3.8 -1.1 2.0 -0.0
Blood White Count 0.3 2.0 7.8 -0.2 0.3 -0.5 -2.6 -0.5 2.8 0.5 -0.3
Heel T-Score 2.5 19.7 71.2 0.9 -0.3 -8.4 -4.3 -3.6 6.5 -3.0 -1.7
BMI 1.1 6.1 30.2 -5.5 -2.7 -1.1 -0.1 -2.3 -2.0 1.0 0.2
Height 0.8 16.1 43.0 -4.0 3.7 6.1 0.4 -0.7 -4.3 6.6 -0.1
Waist Hip Ratio (WHR) 1.9 8.4 23.8 -2.9 1.4 1.2 -4.9 -3.2 1.8 1.5 -3.9
Systolic Blood Pressure 1.5 7.4 28.5 2.9 -1.7 -2.5 -0.5 5.3 0.3 -1.6 3.2
Smoking Status 0.4 0.9 3.1 -1.5 0.2 -0.3 -1.8 1.0 0.3 0.1 -1.0
Allergy or Eczema 9.4 24.9 95.5 -2.9 2.0 2.9 -2.2 -8.3 0.9 2.7 -9.8
Cardiovascular Disease 1.0 3.4 13.0 -1.4 -0.6 -1.8 -2.7 3.6 -0.0 -0.6 1.0
Hypothyroidism (self reported) 1.0 2.3 5.9 2.4 1.8 2.2 -0.6 0.9 1.4 1.1 -0.3
Respiratory disease 21.0 46.7 169.0 -6.6 0.8 1.8 -4.7 -11.4 -0.5 2.2 -13.0
Type 2 Diabetes (T2D) (2018) 1.6 2.9 7.1 0.2 0.4 1.3 1.5 2.7 -1.1 2.0 2.6
Lung FEV1/FVC ratio 3.2 16.5 45.3 4.4 -1.5 0.9 4.3 6.7 -2.3 0.6 6.3
Lung FVC 2.1 10.7 27.4 -3.0 0.9 -4.9 -3.0 1.2 1.9 -5.2 -3.2
Neuroticism 1.0 2.3 8.8 2.4 -0.4 -1.1 1.2 -0.1 3.0 0.4 0.8
Chronotype (morning person) 0.7 1.6 6.0 -2.5 -1.0 -1.3 -0.3 -0.3 0.1 -1.2 -1.5
Hair Pigment 0.1 2.1 5.2 -1.6 -1.0 -0.1 -1.0 -2.3 -0.8 -0.9 -2.3
Tanning 0.1 1.2 3.4 0.9 -1.2 -0.4 -1.1 1.2 0.5 0.9 1.8
Hand grip strength (left) 2.4 6.4 21.2 1.3 -0.3 -4.6 1.8 3.3 1.5 -2.7 2.0
Number of treatments/medications taken 0.7 1.3 2.9 -1.7 -1.7 0.5 -1.4 0.2 -0.8 -0.3 -1.3
Average weekly spirits intake 1.1 1.3 2.7 0.0 -1.2 -0.1 1.3 1.6 -1.2 1.2 1.4
Sensitivity / hurt feelings 1.8 3.2 11.1 2.6 1.2 -0.7 0.1 -1.4 3.3 -0.4 -1.8
Frequency of depressed mood in last 2 weeks 1.0 1.4 3.2 0.0 -0.9 -1.8 -0.7 -0.8 0.7 -1.7 -1.5
Hearing difficulty/problems: Yes 0.3 0.4 2.2 -0.4 -0.3 -0.2 0.1 -0.8 0.1 0.4 -1.5
Relative age of first facial hair 0.7 1.4 3.6 1.7 1.9 -0.6 1.2 -1.4 0.1 -0.5 -1.0
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.8 -1.5 0.8 -0.4 0.4 -0.4 0.4 -0.7 -1.7
Ever used hormone-replacement therapy (HRT) 1.0 1.2 3.6 -0.4 -0.2 -0.0 1.2 1.9 -1.1 0.2 1.9
Ever had hysterectomy (womb removed) 0.6 0.7 2.2 -0.7 -1.5 0.8 -0.1 0.3 -1.1 -0.3 -1.2
Systolic blood pressure, automated reading 1.3 3.9 10.6 0.8 -2.3 -1.2 -1.7 3.2 1.6 -0.5 2.8
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.3 -0.7 -0.7 -0.4 -0.7 0.7 0.8 1.5 1.1
Angina 2.0 2.7 8.8 1.2 0.4 -1.9 1.1 3.0 -0.3 -1.0 2.3
Medication for hormone replacement therapy 1.0 1.1 3.4 0.0 -0.6 -0.9 0.8 1.7 0.4 -0.6 1.9
Vitamin and mineral supplements 0.9 1.2 5.1 -0.4 -0.1 -1.0 -1.7 -0.3 2.3 -0.7 -0.1
Supplements: Zinc 1.3 1.4 3.0 0.3 1.6 -1.6 1.7 -1.2 -0.2 -0.8 -0.5
Medication: Co-codamol 0.4 0.4 0.8 -0.5 -0.9 -0.4 -0.7 0.8 0.4 0.7 -0.7
Medication: Metformin 1.1 1.5 3.5 -0.0 -0.5 0.4 1.2 1.9 -1.2 1.4 1.9
Diabetes (father) 1.1 1.3 5.0 -1.8 -2.2 0.1 -0.1 0.8 -1.0 0.7 -0.1
Diabetes (mother) 1.8 2.3 7.1 1.5 -0.4 0.6 1.4 2.7 0.2 1.3 2.2
Severe depression (siblings) 0.6 0.7 2.5 -1.1 -0.4 -0.6 -0.7 0.6 -0.5 -1.6 -0.2
Pack years adult smoking proportion 0.4 0.6 1.2 0.7 0.3 1.1 -0.7 -1.1 -0.5 0.6 -0.8
Impedance of leg (right) 1.9 9.1 30.0 0.9 0.6 5.5 -4.1 -2.1 2.7 1.9 -2.9
Leg fat-free mass (left) 0.7 3.7 15.3 -3.9 -0.2 -0.6 1.7 -0.1 -1.8 2.5 1.4
Trunk fat percentage 4.8 19.1 43.8 -6.6 -1.2 6.6 -3.5 -3.5 -0.5 6.3 -0.6
Hand grip strength (right) 1.8 4.8 17.1 1.3 0.1 -4.1 0.8 3.0 1.4 -2.1 1.8
Townsend deprivation index at recruitment 0.7 1.0 2.7 -1.0 -1.6 1.1 -0.3 -0.9 0.5 0.0 -1.5
Current tobacco smoking 0.3 0.5 1.6 0.0 -0.4 0.3 -1.2 -0.2 0.8 0.5 -1.2
Average weekly fortified wine intake 1.6 1.9 5.1 -0.4 0.2 1.8 0.1 0.9 -1.0 2.3 2.2
Maternal smoking around birth 1.1 1.6 3.4 -0.2 1.8 -1.0 -1.6 -1.0 1.0 -1.7 -0.8
Fed-up feelings 0.9 1.7 5.8 0.8 0.4 -0.9 -1.2 -1.1 2.4 -1.5 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.3 -0.0 -0.2 -0.1 0.2 -0.2 0.7 -0.8 -1.1
Relative age voice broke 0.5 0.8 2.3 1.5 1.3 0.1 0.2 0.5 1.0 0.0 1.1
Taking other prescription medications 2.1 3.2 7.3 -2.7 0.2 2.7 -0.5 -0.1 -2.1 1.9 -1.7
Age when periods started (menarche) 1.3 3.1 11.5 3.4 2.6 -0.5 1.4 0.9 0.2 0.0 1.9
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.8 0.1 -1.4 -0.4 1.2 0.7 -1.0 -1.0 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.0 11.2 -0.8 -1.5 -3.3 -2.2 -1.3 3.3 -0.3 -0.5
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 3.0 -1.2 -0.4 0.2 -0.7 0.4 0.8 1.7 0.0
Qualifications: CSEs or equivalent 1.1 1.4 4.3 -0.8 0.9 -1.7 -0.9 -2.1 0.7 -1.0 -0.9
Serious illness, injury or assault to yourself 1.3 1.6 4.0 -2.0 -1.2 1.5 1.0 0.9 -1.3 1.1 -0.3
High blood pressure 0.9 2.6 10.8 -1.4 -0.3 -1.3 -2.2 3.3 -0.1 -0.5 1.1
Hayfever, allergic rhinitis or eczema 7.4 16.1 68.4 -2.5 1.7 2.1 -1.7 -6.3 0.6 2.0 -8.3
Multivitamins +/- minerals 1.0 1.3 3.5 -1.0 -1.7 0.7 1.0 0.5 -1.9 1.0 0.6
Stomach or abdominal pain in last month 1.8 2.2 5.8 -0.4 0.9 2.4 0.1 -2.0 1.8 1.7 -0.9
Supplements: Glucosamine 1.7 2.2 9.2 -0.8 -1.3 -1.2 -0.4 -1.1 -1.7 -3.0 -0.5
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.2 -1.2 -0.6 -0.5 1.2 -0.4 -0.1 -1.4 -1.5
Medication: Atenolol 1.1 1.3 3.9 -0.0 -0.8 -0.1 -0.3 1.9 1.5 -0.4 2.0
Medication: Levothyroxine sodium 1.2 2.0 7.2 1.1 0.6 2.7 -0.8 1.0 0.6 2.2 -0.7
Sitting height 1.0 6.8 31.2 -2.5 1.7 3.3 -0.2 -0.0 1.2 5.6 1.1
Chronic bronchitis/emphysema (father) 3.5 4.1 11.0 -2.6 0.5 1.0 1.2 -2.5 -2.3 1.0 -3.3
High blood pressure (mother) 1.5 2.1 5.2 0.2 -0.8 -1.6 -1.8 2.3 -0.8 0.2 2.1
Body mass index (BMI) 1.1 4.6 22.1 -4.7 -2.8 0.1 -0.2 -0.7 -0.8 2.1 1.1
Impedance of leg (left) 1.8 8.7 29.4 0.8 0.8 5.4 -4.0 -1.9 2.5 2.3 -2.8
Leg predicted mass (left) 0.7 3.8 15.5 -3.9 -0.2 -0.6 1.7 -0.1 -1.8 2.5 1.4
Trunk fat mass 3.8 16.4 44.9 -6.7 -1.4 5.5 -2.6 -2.8 -0.9 6.2 -0.0
Waist circumference 2.4 9.0 36.6 -6.1 -2.5 2.4 -1.8 -1.5 -1.2 4.1 -0.2
Number of incorrect matches in round 0.5 0.8 3.4 0.2 -0.6 0.8 1.8 0.9 -0.7 0.4 0.9
Past tobacco smoking 0.9 1.6 4.6 2.1 -0.1 1.8 0.8 -0.9 1.0 0.7 1.3
Alcohol usually taken with meals 0.3 0.5 1.9 -0.3 0.9 -0.1 0.9 0.7 -1.4 0.3 0.3
Nervous feelings 0.2 0.5 1.3 0.8 0.4 -0.9 -0.5 -0.8 1.1 -0.1 0.2
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.2 9.2 -0.6 0.2 -3.0 -0.4 1.5 1.1 -2.0 -0.9
Hearing difficulty/problems with background noise 0.6 0.9 4.2 -0.4 -2.0 0.1 -0.6 0.4 1.1 0.9 -0.9
Hair/balding pattern: Pattern 2 0.3 0.4 2.0 1.4 0.9 -0.6 -0.3 -0.1 0.4 -0.3 0.3
Had menopause 0.8 1.1 2.9 -0.8 -1.1 1.3 0.5 1.2 -1.7 -0.5 0.2
Had other major operations 0.6 0.7 1.8 -1.3 -0.2 -0.2 -1.4 0.2 -0.9 -0.2 -1.0
Forced vital capacity (FVC) 1.2 4.7 11.1 -3.3 0.9 -2.7 -2.8 -0.9 0.0 -1.7 -2.6
Heel bone mineral density (BMD) T-score, automated (right) 2.1 4.9 15.4 -0.3 -0.3 -3.2 -2.7 -2.2 3.9 0.2 -1.1
Ever unenthusiastic/disinterested for a whole week 2.6 3.2 7.3 -0.9 -1.9 -2.7 -1.6 2.7 0.3 -1.9 -0.0
Qualifications: None of the above 0.9 2.0 7.1 -1.0 -0.5 2.7 -0.6 0.8 1.6 2.0 -0.7
Financial difficulties in last 2 years 2.4 3.2 7.7 -1.9 -2.8 0.1 -2.4 -1.6 1.3 0.0 -1.9
Mouth/teeth dental problems 1.1 1.7 5.5 1.2 0.8 -1.4 -1.6 -1.1 0.6 -2.4 -0.2
Heart attack 2.5 3.2 8.1 -0.2 0.6 -2.8 -2.2 2.3 0.7 -1.7 2.0
Allergy 13.4 30.7 121.1 4.6 -1.6 -2.1 3.3 9.0 -0.7 -2.2 11.0
Pain all over the body in last month 1.6 1.7 4.2 -0.4 -0.5 1.0 2.0 1.0 -1.4 2.1 1.1
Diabetes (self-reported) 1.7 2.7 8.1 0.5 -0.7 1.2 1.2 2.8 -0.2 1.8 2.5
Hayfever/allergic rhinitis (self-reported) 6.1 8.1 32.6 -1.3 0.5 1.7 -1.5 -4.7 0.3 1.8 -5.7
Medication: Ramipril 2.2 2.9 6.4 -2.0 0.4 -2.4 -2.2 2.5 -0.0 -0.2 1.4
Medication: Simvastatin 2.3 3.4 12.2 -0.1 -2.9 -0.4 0.0 3.5 -0.8 -0.8 2.3
Fluid intelligence score 1.1 2.3 8.8 1.5 1.0 -3.0 -0.4 -1.2 -0.5 -2.1 -0.6
Illnesses of siblings 1.2 1.7 5.2 -0.2 -1.0 1.2 -0.9 -2.3 1.9 0.4 -1.1
Neuroticism score 1.0 2.1 9.7 1.9 0.2 -1.5 0.3 -0.4 3.1 -0.7 -0.8
Weight 1.4 7.0 29.7 -5.5 -1.2 1.8 -0.1 -1.2 -1.3 4.2 0.9
Impedance of arm (right) 3.6 16.7 64.5 -0.9 3.1 8.0 -3.5 -4.4 -0.2 4.6 -2.6
Arm fat percentage (right) 3.2 12.5 38.7 -6.2 -1.9 4.4 -2.2 -2.8 -1.3 4.8 0.1
Trunk fat-free mass 0.6 3.5 9.6 -2.1 0.4 -2.3 3.1 1.6 -1.5 1.1 1.5
Hip circumference 1.9 8.3 24.0 -4.9 -1.9 2.8 1.1 -0.6 -2.8 4.5 1.1
Time employed in main current job 0.4 0.5 1.3 0.7 -0.2 -0.5 -0.6 0.9 -0.5 -1.2 0.8
Alcohol intake versus 10 years previously 1.6 2.4 6.8 -2.6 -2.2 0.6 -0.9 -1.4 -1.1 1.0 -1.3
Father’s age at death 0.8 1.0 3.9 -0.4 0.9 1.1 1.1 -2.0 -0.7 0.6 0.2
Worrier / anxious feelings 0.6 1.1 2.9 1.1 0.8 -1.7 0.4 -0.4 1.5 -0.5 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.8 -1.3 0.3 0.9 -0.3 0.1 -0.3 1.1 -0.8
Falls in the last year 0.9 1.2 5.2 -0.6 -0.0 1.1 2.3 1.3 -0.5 0.9 0.1
Hair/balding pattern: Pattern 3 0.9 1.3 3.1 -0.9 -0.9 -1.2 0.7 1.8 -0.9 -0.7 1.7
Number of live births 0.3 0.4 2.2 1.5 -0.8 0.3 0.2 0.5 0.2 -0.3 0.2
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 7.6 -1.7 0.5 -2.8 -1.0 1.2 -0.8 -1.3 -0.4
Pulse rate 0.6 1.0 3.7 -0.2 -0.2 0.2 -0.6 -1.9 0.5 0.4 -1.8
Happiness 0.8 0.9 3.6 -0.1 0.2 0.5 0.7 1.6 -1.9 -0.1 0.6
Noisy workplace 0.9 1.1 4.2 0.1 -2.0 0.3 -0.3 1.0 1.4 1.2 -0.1
Qualifications: A levels/AS levels or equivalent 0.4 0.8 2.8 1.3 0.3 -1.7 0.1 -1.2 0.2 0.2 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 4.1 -0.0 -2.0 0.3 1.0 0.2 -1.1 0.8 -0.5
Mouth/teeth dental problems: Dentures 1.0 1.6 3.9 0.9 -0.2 1.8 1.0 1.4 1.1 2.0 1.0
Asthma 18.9 37.2 139.4 -6.0 -0.3 1.8 -3.9 -10.0 0.3 2.1 -11.8
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 4.4 -1.1 0.1 -0.5 -1.2 -0.9 1.2 -0.8 -2.1
Medication: Cholesterol lowering 1.9 2.9 12.7 0.7 -0.4 -1.1 -0.5 3.6 0.9 -0.8 2.7
Depression (self-reported) 1.8 2.2 6.1 0.5 0.2 -2.4 0.6 1.9 -0.6 -2.5 1.0
Medication: Lansoprazole 0.4 0.5 1.7 0.7 -0.1 -0.7 -0.7 -0.4 -1.3 -0.6 0.1
Prospective memory result 1.1 1.4 3.9 0.4 0.9 2.0 0.1 0.2 1.9 1.6 0.2
Lung cancer (father) 1.4 1.6 6.3 -1.4 -0.8 2.5 -0.1 -0.3 -1.1 1.6 -0.3
Illnesses of mother 1.0 1.2 3.3 -0.4 0.0 0.1 1.2 -1.8 -0.3 -1.2 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 7.6 -0.4 1.1 -2.8 -1.5 1.0 -0.2 -1.6 -0.4
Pulse wave Arterial Stiffness index 1.3 1.5 5.3 -2.3 -2.0 -0.4 -1.3 -0.1 -0.6 0.6 -0.3
Impedance of arm (left) 3.4 15.8 58.2 -0.8 3.2 7.6 -3.4 -4.3 0.0 4.8 -2.1
Arm fat mass (right) 2.2 8.9 35.2 -5.9 -1.7 2.8 -1.3 -2.1 -0.9 4.3 0.3
Trunk predicted mass 0.6 3.4 9.1 -2.2 0.4 -2.4 3.0 1.4 -1.5 1.1 1.4
Standing height 0.8 7.9 26.8 -2.6 3.2 4.1 0.3 -1.0 -1.2 5.2 -0.5
Length of working week for main job 0.9 1.0 4.1 0.3 -0.6 -1.7 0.8 0.2 0.6 -2.0 -0.1
Exposure to tobacco smoke at home 0.2 0.3 0.9 -0.3 0.0 -1.0 0.5 0.1 0.7 -0.2 -0.5
Breastfed as a baby 1.2 1.4 3.5 -0.7 0.6 1.9 0.5 -1.7 -0.3 1.1 -1.6
Tense / ‘highly strung’ 0.4 0.7 2.9 -0.7 -0.5 -0.4 0.7 0.9 1.7 -0.7 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.3 -0.8 0.6 0.3 -1.1 0.5 -0.4 0.4 0.0
Hair/balding pattern: Pattern 4 1.6 3.9 12.5 3.5 0.7 -2.9 1.6 0.6 1.6 -1.6 1.3
Birth weight of first child 3.3 5.9 13.9 -3.6 -0.5 0.1 -1.5 -3.6 -2.3 0.2 -3.7
Peak expiratory flow (PEF) 1.0 2.4 14.9 0.7 0.9 -3.9 0.2 0.7 -1.2 -0.7 0.9
Pulse wave reflection index 0.5 0.6 2.0 -1.4 -0.6 0.2 0.2 -0.1 -1.3 0.7 -0.6
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.6 0.2 -1.9 -0.4 0.4 1.7 -0.6 -0.2 -1.4
Loud music exposure frequency 1.7 1.9 4.9 0.4 -1.7 1.3 -0.8 1.9 0.1 2.2 1.0
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 5.5 2.3 0.2 -1.6 2.1 -0.3 -1.6 -1.3 0.4
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 5.0 -2.2 -1.7 -0.7 0.9 0.8 -1.8 1.1 0.1
Blood clot in the leg (DVT) 0.5 0.6 1.9 -0.1 -0.6 0.5 1.3 0.8 -0.4 -0.2 1.4
Medication: Paracetamol 0.5 0.9 3.4 0.7 0.9 -0.3 -0.3 -1.3 1.9 0.5 -0.7
Headache pain in last month 1.7 2.9 9.6 1.3 0.7 0.6 -1.7 -3.1 2.1 1.3 -1.5
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 10.5 -0.0 0.2 0.5 0.8 -3.2 0.5 -0.0 -2.0
Glaucoma (self-reported) 1.7 2.0 4.1 1.5 0.1 2.0 -1.1 0.5 1.8 1.5 1.7
Gout (self-reported) 1.0 1.3 3.9 -0.9 -1.4 2.0 -0.9 0.2 -0.8 1.3 -0.7
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 3.2 1.5 1.8 1.3 -1.0 1.1 1.3 0.9 -0.1
Medication: Amlodipine 0.8 1.1 3.2 0.7 -1.8 -0.6 0.8 1.2 -1.3 -0.8 0.4
Medication: Ventolin 100micrograms inhaler 7.6 9.8 33.3 -3.5 -0.8 1.7 -2.8 -4.5 0.7 1.0 -5.8
Birth weight 1.6 3.6 12.5 -0.6 0.6 -1.0 1.6 -2.8 -1.5 -1.3 -3.5
Chronic bronchitis/emphysema (mother) 2.3 2.7 7.5 -2.1 1.0 0.1 -1.4 -2.2 -0.2 -1.2 -2.7
High blood pressure (siblings) 0.6 0.9 2.4 0.6 0.5 -0.6 1.0 1.5 -1.5 -0.3 0.5
Forced vital capacity (FVC), Best measure 1.4 5.1 10.1 -2.0 1.5 -2.9 -3.2 -1.7 0.3 -1.7 -3.1
Body fat percentage 4.1 16.4 41.9 -6.5 -2.1 5.8 -3.2 -3.0 -0.4 5.6 -0.3
Leg fat percentage (right) 2.3 8.4 25.6 -5.1 -3.1 3.4 -2.5 -2.0 0.1 3.1 -0.3
Arm fat-free mass (right) 0.6 2.8 7.2 -2.7 -0.9 -2.1 2.0 1.5 -0.8 1.2 1.4
Exposure to tobacco smoke outside home 0.3 0.4 1.1 -0.1 0.6 1.0 -0.4 -1.1 0.6 0.2 0.0
Comparative body size at age 10 1.8 4.9 22.5 -4.7 -1.3 -3.5 -1.3 -0.4 0.6 -0.6 -0.6
Number of full brothers 0.4 0.5 2.6 -0.5 -1.6 -0.3 -0.3 -0.2 0.5 0.8 -0.0
Worry too long after embarrassment 0.7 1.2 2.4 1.6 -1.5 -0.8 1.2 -0.6 1.3 -0.6 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.8 -0.6 0.7 -0.3 0.2 0.8 -0.4 -0.9 -0.2
Wheeze or whistling in the chest in last year 8.6 15.3 54.6 -4.2 -0.6 1.4 -2.8 -6.2 -0.3 1.3 -7.4
Number of children fathered 1.4 1.6 5.9 0.7 -0.6 -0.9 -0.9 2.4 0.0 0.1 2.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.3 -0.5 0.4 -1.1 0.1 0.9 0.2 -0.9 -0.3
Age at first live birth 0.7 1.3 4.4 -0.1 -0.8 -1.5 -2.1 -1.4 0.4 -0.8 0.3
Pulse wave peak to peak time 1.4 1.6 6.2 2.1 2.5 0.5 1.1 -0.0 0.7 -0.4 0.3
Health satisfaction 0.9 1.2 3.8 -2.0 -1.4 0.3 -0.3 0.2 -1.8 0.7 -0.1
Shortness of breath walking on level ground 1.7 2.1 4.4 -1.9 0.0 -1.1 -1.5 -2.1 1.4 -0.4 -1.8
Qualifications: College or University degree 0.3 1.0 3.8 -0.2 1.2 -1.2 -0.8 -2.0 -0.2 -0.6 -0.3
Eye problems/disorders: None of the above 1.7 1.9 6.3 -2.5 0.1 -1.6 -1.6 -1.0 0.6 -1.3 -1.0
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.8 -0.6 -1.4 1.1 0.5 1.5 -0.3 1.7 1.0
Emphysema/chronic bronchitis 2.6 2.9 10.0 -2.5 0.4 -1.7 -3.2 0.5 -0.3 -1.8 -0.6
Medication for pain relief, constipation, heartburn 0.3 0.5 1.3 0.1 0.6 0.2 1.1 -0.5 -1.0 1.1 0.5
Neck or shoulder pain in last month 0.5 0.8 4.6 0.1 0.5 -2.1 0.7 0.2 0.6 -0.6 0.0
Medication: Blood pressure 0.9 1.5 5.6 -0.6 -1.2 -0.8 -1.2 2.4 -0.4 0.7 1.5
Angina (self-reported) 2.1 2.7 8.2 1.3 0.6 -1.9 1.0 2.9 -0.6 -1.2 2.2
Migraine (self-reported) 1.1 1.4 3.6 -1.4 -0.7 1.5 -0.1 -0.9 0.6 1.9 -1.2
Medication: Ibuprofen 0.8 0.9 3.0 -0.3 -0.3 -0.8 -0.6 -1.2 1.1 -0.4 -1.7
Medication: Allopurinol 0.8 1.1 2.5 -1.1 -1.6 1.4 -0.4 -0.2 -0.4 1.0 -1.2
Medication: Omeprazole 0.6 0.7 2.5 -0.0 0.4 0.6 1.1 1.6 -0.2 -0.5 1.1
Medication: Seretide 50 evohaler 7.3 8.4 23.7 -4.2 -0.6 1.5 -3.3 -3.3 0.9 0.8 -4.9
Mean time to correctly identify matches 0.5 1.0 2.8 1.5 1.1 1.7 0.4 0.0 1.4 -0.0 -0.5
Heart disease (mother) 2.4 2.9 9.3 1.1 0.1 -2.0 -0.5 3.0 1.5 -1.3 2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 4.6 -0.4 -2.1 -1.6 0.8 0.9 -1.2 -1.0 0.9
Whole body fat mass 3.2 13.2 42.5 -6.5 -2.0 4.4 -2.0 -2.4 -0.7 5.4 0.0
Leg fat mass (right) 2.5 9.5 35.8 -6.0 -3.0 2.9 -1.7 -1.7 -0.7 4.0 0.5
Arm predicted mass (right) 0.6 3.2 6.3 -2.5 -0.8 -2.3 2.2 1.9 -0.6 1.2 1.8
Pulse rate, automated reading 1.0 3.2 11.2 -1.8 1.3 -0.5 -1.6 -2.4 -0.1 -0.8 -3.3
Alcohol intake frequency. 1.5 3.4 9.1 0.2 1.6 2.8 1.8 -1.8 -0.5 3.0 -0.8
Comparative height size at age 10 1.3 7.0 19.1 -4.4 0.7 3.4 0.1 0.5 -2.5 4.2 -0.4
Number of full sisters 0.6 0.7 2.3 -0.5 -0.1 0.3 0.8 0.9 0.7 -1.5 -1.0
Suffer from ‘nerves’ 0.5 0.7 2.2 0.7 0.9 -1.3 -0.5 -0.0 1.5 -0.6 -0.5
Overall health rating 0.7 1.4 3.8 -1.8 -0.6 -0.3 -1.2 -1.3 1.0 -0.1 -2.0
Chest pain or discomfort 0.5 0.7 2.9 0.5 0.3 -0.5 0.3 -0.3 -0.3 -1.7 -1.3
Had major operations 1.8 2.1 8.9 -1.5 -0.5 -0.7 1.6 0.4 -3.0 -1.3 -0.7
Age at last live birth 0.7 1.0 3.8 0.9 -1.9 -1.0 -0.8 -0.6 -0.4 -0.8 0.5
Family relationship satisfaction 0.8 1.0 4.7 -0.6 -0.1 1.2 0.2 -0.3 -2.2 0.0 -1.1
Leg pain on walking 0.6 0.8 2.9 -0.9 -1.2 -0.2 -1.7 -0.3 -0.0 0.9 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.8 0.1 -0.5 1.3 0.1 0.9 0.4 1.7 1.0
Commuting to job workplace: Car/motor vehicle 0.8 0.9 3.1 0.8 0.4 -0.3 0.4 1.1 1.7 0.4 1.2
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 7.3 2.7 1.6 -0.0 1.3 0.4 -0.0 -0.4 1.4
Medication: Aspirin 1.8 2.4 10.4 0.4 -1.3 -0.7 -1.5 3.2 -0.0 -1.7 1.1
Supplements: Vitamin C 1.0 1.2 3.5 0.9 1.9 0.3 -0.7 -0.2 1.5 -1.2 -1.0
Knee pain experienced in last month 0.8 1.3 4.9 -0.3 -1.2 0.3 -0.6 -1.0 1.2 -0.9 -2.2
Hypertension (Self-reported) 0.8 2.2 10.9 -1.4 -0.4 -0.9 -1.5 3.3 -0.1 -0.5 1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.2 0.3 -0.0 0.6 0.6 -0.3 0.6 0.8 -1.1
Illnesses of father: Heart disease 4.2 5.8 20.7 0.7 -0.0 -2.6 -1.5 4.6 0.7 -2.5 3.0
Illnesses of siblings: Diabetes 0.8 0.9 2.6 1.1 -0.7 0.4 1.2 1.6 -0.6 0.7 0.9
Smoking status: Previous 0.6 0.9 2.5 -1.6 -0.5 -1.4 0.1 1.0 -1.0 -0.5 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 2.7 -0.7 1.0 0.4 -1.1 -1.5 0.9 1.7 -1.2
Whole body fat-free mass 0.6 3.3 8.1 -2.9 0.0 -1.9 2.6 1.0 -1.7 1.5 1.4
Leg fat-free mass (right) 0.7 3.7 12.4 -3.5 0.2 -1.1 2.1 0.2 -2.0 2.3 1.6
Arm fat percentage (left) 3.0 12.1 37.2 -6.1 -1.7 4.2 -2.0 -2.8 -1.1 5.1 0.4
Average weekly red wine intake 0.5 0.7 3.7 -1.9 0.1 -0.9 -0.5 -0.1 -0.7 -0.7 -0.0
Handedness (chirality/laterality): Left-handed 0.9 1.1 3.0 1.7 0.2 0.5 0.8 -1.2 1.0 -0.7 -1.5
Mood swings 0.6 1.1 5.2 0.4 0.2 -1.4 -0.5 -0.4 2.3 -1.0 -0.3
Loneliness, isolation 0.3 0.5 1.3 -0.3 -1.2 0.2 1.0 0.3 0.3 0.7 0.9
Long-standing illness, disability or infirmity 1.6 2.4 7.9 -2.8 -0.2 -1.7 -0.2 0.3 -1.2 -1.0 -2.4
Ever had bowel cancer screening 0.9 1.0 5.2 -2.3 -0.4 -1.3 -0.3 0.0 -0.5 -1.0 -0.1
Diabetes diagnosed by doctor 2.3 3.8 13.0 0.5 -0.8 1.3 0.6 3.6 0.2 2.5 2.9
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.9 1.5 -0.1 -1.4 -0.6 1.3 0.1 -1.7 0.0
Friendships satisfaction 0.6 0.8 4.8 0.4 0.4 0.5 0.7 0.4 -2.2 -0.5 0.1
Qualifications: nursing, teaching 1.0 1.5 3.5 1.6 1.6 -1.5 0.4 0.4 -0.2 -1.9 0.8
Commuting to job workplace: Walk 1.0 1.1 4.1 -1.4 -0.6 -0.8 -0.6 -2.0 -0.3 -0.9 -0.8
Eye problems/disorders: Cataract 4.5 5.2 13.2 3.5 2.1 0.3 3.6 1.1 -2.4 1.2 1.8
Mouth/teeth dental problems: Mouth ulcers 1.3 2.1 5.8 0.2 0.0 2.0 2.4 0.9 -1.6 1.8 0.7
Medication for cholesterol 1.4 2.2 8.8 -0.3 2.0 0.8 0.0 -3.0 0.9 1.2 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 2.2 -0.4 -1.3 -0.3 0.3 1.5 -0.3 -1.4 0.8
Back pain experienced in last month 4.9 7.2 27.6 -0.8 -0.4 -5.3 0.7 -1.0 1.0 -4.7 -2.2
Mineral and other dietary supplements 0.9 1.3 3.6 -0.5 1.0 0.1 0.7 0.9 1.6 1.9 1.2
Breast cancer (self-reported) 0.4 0.5 1.8 0.1 0.3 0.8 0.5 0.8 -1.3 0.5 0.0
Asthma (self-reported) 18.7 37.3 139.2 -6.2 -0.1 1.6 -4.0 -9.9 -0.1 2.2 -11.8
Osteoporosis (self-reported) 2.4 3.0 9.4 -1.2 -0.0 3.1 -0.8 -1.6 -1.3 2.6 -1.2
Osteoarthritis (self-reported) 1.6 2.0 10.3 -0.4 -0.4 -1.7 -0.5 0.3 0.5 -3.2 -1.5
Medication: Aspirin 2.0 2.6 11.6 0.1 -1.0 -0.6 -1.6 3.4 -0.4 -1.8 1.4
Medication: Gliclazide 1.8 2.0 5.2 -1.4 -0.2 0.4 0.8 1.9 -0.8 2.3 1.9
Illnesses of father: None of the above (group 1) 2.8 3.4 16.9 0.0 -0.1 1.3 -0.4 -4.1 0.6 1.5 -2.5
Smoking status: Current 0.3 0.6 2.0 -0.3 -0.0 -0.1 -1.3 0.1 0.7 0.0 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.2 8.0 -0.6 -1.0 -2.1 0.3 1.5 -1.1 -2.8 -0.4
Whole body water mass 0.6 3.3 7.7 -2.8 -0.2 -1.9 2.5 1.3 -1.6 1.4 1.5
Leg predicted mass (right) 0.7 3.8 12.3 -3.5 0.2 -1.1 2.2 0.3 -2.0 2.2 1.7
Arm fat mass (left) 2.3 9.5 38.6 -6.2 -1.8 2.8 -1.3 -2.0 -1.1 4.4 0.6
Number of self-reported non-cancer illnesses 1.7 3.0 10.0 -3.1 0.3 0.4 -1.5 -0.4 -1.3 0.4 -3.2
Average weekly champagne plus white wine intake 1.3 1.7 6.0 1.3 1.9 -0.9 -0.5 -2.4 0.3 -1.0 -0.8
Miserableness 0.9 1.5 5.4 1.7 0.2 -0.8 0.1 1.1 2.3 -1.5 -0.3
Guilty feelings 0.9 1.4 5.2 1.7 0.7 0.3 0.4 -1.0 2.3 0.4 -1.1
Wears glasses or contact lenses 1.3 1.5 4.9 1.4 -1.2 -0.6 0.8 2.2 -1.1 -0.8 0.6
Ever taken oral contraceptive pill 1.2 1.3 3.3 -0.9 -0.8 1.5 -0.9 0.9 0.4 1.8 1.3
Hearing aid user 0.5 0.6 2.0 -0.5 -1.4 0.5 0.6 -0.3 -0.9 0.6 -0.6
Mother’s age at death 0.6 0.8 3.8 0.9 0.6 0.8 -0.2 -2.0 -0.1 0.7 0.4
Financial situation satisfaction 0.3 0.4 1.4 -0.8 -1.2 -0.3 -0.9 0.4 0.2 -0.0 -0.6
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.8 0.5 -1.0 -0.2 -1.3 -0.8 1.7 -0.5 -0.8
Commuting to job workplace: Public transport 0.7 0.9 2.7 -0.1 -1.1 -0.3 0.1 -1.0 -0.9 -1.6 -1.1
Eye problems/disorders: Glaucoma 1.5 1.8 4.0 1.8 -0.2 2.0 -0.2 0.3 1.9 1.5 1.0
Medication: Blood pressure 0.2 0.4 1.8 -0.2 -0.3 0.1 -0.7 1.4 -0.1 -0.5 0.5
Pain type(s) experienced in last month: Hip pain 1.1 1.3 3.8 -0.9 -0.9 -1.9 -0.5 -0.2 0.5 -1.8 -1.3
Supplements: Fish oil (including cod liver oil) 0.9 1.2 4.1 1.1 -0.7 -0.2 0.8 -0.2 -2.0 -1.7 -0.2
High cholesterol (Self-reported) 1.9 3.4 13.5 -0.3 -1.8 -1.7 -0.8 3.7 0.6 -2.1 1.4
Medication: Bendroflumethiazide 0.4 0.6 2.2 -0.5 0.4 -1.5 -0.9 0.1 0.5 -0.2 0.8
Medication: Paracetamol 1.0 1.5 3.6 0.6 1.9 -0.8 -0.5 -1.6 1.9 0.9 -0.7
Medication: Lisinopril 1.7 2.2 4.4 2.1 0.4 2.0 -0.1 0.9 -1.2 1.6 2.0
Medication: Atorvastatin 1.1 1.3 4.7 0.3 0.5 -0.1 -2.2 1.5 1.6 0.6 -0.6
Illnesses of father: High blood pressure 2.2 2.7 10.9 1.7 -0.4 -1.5 1.7 3.3 0.0 -1.0 1.3
Alcohol drinker status: Never 2.4 2.9 8.1 1.5 1.7 2.8 2.6 -0.3 -0.3 1.6 0.2
Ever smoked 0.6 1.0 1.9 -1.4 0.0 -1.3 -0.9 0.2 -1.1 -0.3 -1.4
Basal metabolic rate 0.6 3.2 12.8 -3.6 -0.3 -0.9 1.8 0.4 -1.4 2.3 1.2
Leg fat percentage (left) 2.2 7.8 25.1 -5.0 -2.8 3.2 -2.3 -1.7 0.1 3.3 -0.3
Arm fat-free mass (left) 0.5 2.5 7.8 -2.8 -1.1 -1.4 2.0 1.2 -0.6 1.4 1.1
Number of operations (self-reported) 1.9 2.9 8.1 -2.9 -0.6 -0.1 1.2 0.7 -2.3 -0.8 -2.6
Average weekly beer plus cider intake 0.7 1.1 2.6 0.6 1.0 -1.6 -0.3 1.4 1.0 -1.2 0.5
Irritability 0.7 1.1 4.7 -0.6 0.4 -0.9 -0.6 2.2 1.1 -1.1 0.3
Risk taking 1.2 1.8 6.8 -0.7 -2.6 1.4 -1.0 0.1 -0.5 1.9 0.7
Ever had prostate specific antigen (PSA) test 1.6 1.8 5.4 -0.7 -0.8 -2.3 0.5 0.9 -1.8 -1.9 0.2
Fractured/broken bones in last 5 years 1.6 2.0 9.1 -1.2 0.8 3.0 0.7 1.6 -1.0 0.8 -0.4
Age started oral contraceptive pill 0.7 0.9 2.3 0.9 1.1 0.9 1.2 0.6 -0.2 -0.4 1.5
Diastolic blood pressure, automated reading 1.2 3.8 13.0 -3.6 -1.7 1.2 -3.3 1.2 -0.4 0.2 -0.6
Ever depressed for a whole week 1.4 1.8 5.6 -0.8 -1.9 -1.3 0.3 2.4 -1.3 -0.4 1.0
Unable to work because of sickness or disability 0.4 0.5 2.5 -0.1 -0.6 -0.7 1.6 0.5 0.3 -0.1 -0.2
Commuting to job workplace: Cycle 1.3 1.5 5.6 -1.2 -1.5 -0.5 0.2 1.4 -2.4 -0.6 -0.3
Myopia 0.8 1.2 5.4 0.2 0.8 -2.3 -0.9 -0.2 0.1 -1.7 0.1
Vascular/heart problems diagnosed by doctor 1.4 3.7 17.0 1.8 0.9 1.5 2.1 -4.1 0.3 0.9 -1.2
Cholesterol lowering medication 1.7 2.5 8.1 0.0 -1.8 -1.2 -0.7 2.8 -1.6 -2.1 0.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.3 -0.4 0.4 0.8 0.7 1.1 0.3 -0.4 0.2
Pain experienced in last month 1.3 2.2 5.2 1.4 1.9 2.3 -0.3 1.3 -0.5 1.0 1.9
Supplements: Calcium 0.7 0.8 3.2 -0.9 0.6 0.9 0.7 -0.2 -1.8 0.8 0.3
Basal cell carcinoma (self-reported) 1.8 2.1 7.0 -0.5 1.5 -2.6 -0.4 -0.5 0.1 -2.6 -0.7
Heart attack/myocardial infarction (self-reported) 2.4 3.2 6.7 -0.1 0.5 -2.6 -2.2 2.5 0.9 -1.6 2.0
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 2.6 -0.1 -0.8 0.5 1.1 0.9 -0.2 0.0 1.6
Heart disease (siblings) 3.7 4.6 15.5 0.9 0.5 -1.5 1.4 3.7 -1.5 -0.5 3.9
Alcohol drinker status: Previous 1.3 1.4 8.0 0.6 2.8 0.5 0.4 -0.5 0.9 1.2 0.5
Pack years of smoking 0.5 0.8 2.4 1.0 0.3 1.6 -0.4 -1.1 -0.5 0.6 -0.7
Impedance of whole body 2.8 14.2 52.9 -0.1 2.3 7.3 -4.3 -3.6 1.5 3.7 -2.8
Leg fat mass (left) 2.3 8.9 34.4 -5.9 -2.7 2.8 -1.5 -1.5 -0.8 4.1 0.5
Arm predicted mass (left) 0.5 2.6 6.8 -2.6 -1.1 -1.7 2.1 1.6 -0.7 1.0 1.2