Hub : Genes

SMAD3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1210	0.0460	3.5e-03	0.010	NA	0.038	NA	0.058	5.3e-02	NA	7.1e-04	NA	3.6e-05
2	GTEx	Esophagus Mucosa	0.1820	0.0600	1.8e-03	0.006	NA	0.021	NA	0.014	1.2e-01	NA	1.5e-02	NA	3.5e-02
3	GTEx	Muscle Skeletal	0.1326	0.0479	2.9e-03	0.103	NA	0.101	NA	0.096	2.9e-10	NA	4.2e-10	NA	1.1e-09
4	GTEx	Ovary	0.3220	0.1150	3.5e-03	0.017	NA	0.091	NA	0.070	1.2e-01	NA	3.0e-03	NA	8.5e-03
5	GTEx	Thyroid	0.1880	0.0720	8.9e-03	0.020	NA	0.030	NA	0.022	9.8e-03	NA	2.3e-03	NA	7.5e-03
6	METSIM	Adipose	0.0919	0.0334	2.3e-03	0.009	0.007	0.010	0.007	0.013	1.5e-02	2.6e-02	9.9e-03	0.028	4.1e-03
7	TCGA	Lung Adenocarcinoma	0.0582	0.0255	1.0e-03	0.062	0.042	0.058	NA	0.058	8.3e-08	1.0e-05	2.6e-07	NA	2.5e-07
8	TCGA	Thyroid Carcinoma	0.2230	0.0600	5.6e-09	0.120	0.105	0.112	NA	0.107	9.4e-12	2.2e-10	5.2e-11	NA	1.3e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	0.8	1.3	3.8	-1.9	-1.7	0.4	0.6	1.2	-1.2	0.7	0.6
Bipolar Disorder or Schizophrenia	0.8	2.0	6.5	-2.6	-1.0	1.8	-1.1	0.5	0.2	2.0	-0.1
Depressed Affect (Nagel 2018)	0.4	0.9	2.4	1.4	-0.1	-1.3	0.4	0.3	1.5	-0.9	0.5
Depression (Nagel 2018)	0.3	0.4	2.3	1.5	-0.4	-0.2	0.3	-0.1	0.4	-0.7	-0.2
Intelligence (Savage-Jansen 2018)	1.0	3.2	9.8	0.7	2.3	-3.1	-0.2	-0.5	-1.3	-2.7	-0.6
Neuroticism (Nagel 2018)	0.3	0.8	1.9	0.8	0.4	-1.4	1.0	0.3	1.3	-0.4	0.9
Schizophrenia (2018)	1.0	2.1	4.0	-1.9	0.1	1.9	-1.9	-0.4	1.2	2.0	-0.5
Schizophrenia vs Biploar Disorder	1.0	1.4	5.0	-0.8	0.6	0.8	-2.2	-1.6	0.8	0.5	-0.9
Worry (Nagel 2018)	0.3	0.6	3.2	0.2	-0.1	-1.8	0.8	0.0	0.8	-0.3	0.6
Alzheimer’s Disease (in mother)	1.3	1.6	2.8	0.5	1.4	1.4	1.7	-1.4	-1.3	0.1	-1.3
Alzheimer’s Disease (in father)	0.5	0.5	2.9	-1.7	0.5	-0.2	-0.5	-0.6	-0.2	-0.5	0.4
Alzheimer’s Disease (including proxy)	0.6	0.9	2.1	-0.9	1.0	0.8	-0.2	-1.2	-1.4	-0.7	-0.9
Crohns Disease (2017)	7.4	16.3	59.6	-3.2	1.1	2.0	-1.8	-6.8	0.1	2.2	-7.7
Irritable Bowel Disease (IBD)	7.7	18.2	65.9	-3.7	2.2	0.2	-2.9	-7.1	0.9	1.4	-8.1
Ulcerative Colitis (UC)	4.0	7.6	19.4	-2.2	2.7	-1.7	-2.4	-4.3	1.4	0.3	-4.4
Major Depression (MDD)	0.9	1.1	3.2	1.4	1.0	-0.2	1.8	0.8	1.2	-0.4	0.9
Reaction Time	0.7	1.4	5.8	1.4	0.3	0.6	-0.8	-0.7	2.4	-0.3	-1.1
Verbal and Numeric Reasoning (VNR)	1.8	4.3	16.6	1.1	0.6	-4.1	0.7	-0.8	-1.2	-3.3	-1.6
Breast Cancer	1.2	3.0	6.6	2.6	1.5	-2.3	-1.3	0.3	0.7	-2.4	1.1
Ovarian Cancer	0.5	0.6	3.0	0.6	1.7	0.6	-0.2	0.4	0.3	-0.0	1.1
Prostate Cancer	0.8	1.2	4.3	1.4	-0.8	0.7	2.1	0.8	-0.3	-0.7	-0.9
Age at First Birth	1.3	1.9	11.6	0.2	0.4	-0.0	-3.4	0.1	1.5	0.5	0.9
Bipolar Disorder (2011)	2.1	2.0	5.5	-0.5	-0.3	0.8	2.4	2.3	-0.1	1.4	1.6
Body Mass Index (BMI) (2010)	2.5	3.4	18.4	-4.3	-1.3	-1.1	-1.5	-1.5	-0.9	0.6	-0.0
Coronary Artery Disease (CAD)	1.9	2.2	9.5	-1.0	-1.9	0.0	-0.8	3.1	-0.9	-0.2	1.4
Crohns Disease (2012)	6.2	9.9	39.7	-1.8	1.8	1.7	-1.3	-5.3	0.6	0.8	-6.3
Mean Putamen Volume	0.4	0.4	2.3	0.3	-0.1	0.5	0.2	-0.7	1.5	0.3	0.3
Fasting Glucose	0.6	0.7	2.4	-0.0	-0.5	0.9	1.3	0.1	-1.5	0.5	-0.4
HbA1C	0.9	1.0	3.6	0.5	-0.9	1.9	0.6	0.3	1.1	1.2	0.7
HDL Cholesterol	0.4	0.7	2.5	-0.2	-0.9	-1.6	-0.5	-0.1	0.3	-1.3	0.4
LDL Cholesterol	2.9	4.5	14.6	-0.2	1.7	-2.5	-2.8	-0.7	1.8	-3.8	-1.0
Lupus	0.9	1.4	3.9	1.6	0.4	-1.2	-0.3	-0.3	0.4	-2.0	-1.7
Neuroticism (2016)	0.5	0.7	2.5	1.6	0.2	-0.2	1.0	-1.1	-0.8	-0.1	-0.3
Primary Biliary Cirrhosis	1.3	1.8	6.9	-2.6	-2.2	0.3	-0.8	0.1	-0.5	0.3	-1.3
Rheumatoid Arthritis	2.1	2.9	9.0	-1.2	-0.6	-1.5	0.4	-3.0	0.0	-1.4	-2.9
Schizophrenia (2014)	0.7	1.6	3.4	-1.8	0.1	1.8	-1.8	-0.4	0.0	1.6	-0.7
Triglycerides	0.5	0.9	5.6	0.4	0.2	0.8	-0.3	2.4	-0.6	-0.0	0.4
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.6	-0.9	-1.9	0.6	0.9	1.0	-1.4	1.1	1.3
Ulcerative Colitis	2.7	3.9	13.7	-1.5	1.9	-1.7	-1.0	-2.6	0.7	-0.6	-3.7
Blood Eosinophil Count	5.7	44.2	134.6	-8.7	1.6	-1.4	-5.1	-10.5	-0.0	1.7	-11.6
Blood Platelet Count	0.4	4.5	16.8	-0.8	1.7	-2.4	-1.0	-1.9	1.7	-4.1	-1.6
Blood Red Count	0.3	3.3	14.3	-0.5	-0.9	2.4	0.3	3.8	-1.1	2.0	-0.0
Blood White Count	0.3	2.0	7.8	-0.2	0.3	-0.5	-2.6	-0.5	2.8	0.5	-0.3
Heel T-Score	2.5	19.7	71.2	0.9	-0.3	-8.4	-4.3	-3.6	6.5	-3.0	-1.7
BMI	1.1	6.1	30.2	-5.5	-2.7	-1.1	-0.1	-2.3	-2.0	1.0	0.2
Height	0.8	16.1	43.0	-4.0	3.7	6.1	0.4	-0.7	-4.3	6.6	-0.1
Waist Hip Ratio (WHR)	1.9	8.4	23.8	-2.9	1.4	1.2	-4.9	-3.2	1.8	1.5	-3.9
Systolic Blood Pressure	1.5	7.4	28.5	2.9	-1.7	-2.5	-0.5	5.3	0.3	-1.6	3.2
Smoking Status	0.4	0.9	3.1	-1.5	0.2	-0.3	-1.8	1.0	0.3	0.1	-1.0
Allergy or Eczema	9.4	24.9	95.5	-2.9	2.0	2.9	-2.2	-8.3	0.9	2.7	-9.8
Cardiovascular Disease	1.0	3.4	13.0	-1.4	-0.6	-1.8	-2.7	3.6	-0.0	-0.6	1.0
Hypothyroidism (self reported)	1.0	2.3	5.9	2.4	1.8	2.2	-0.6	0.9	1.4	1.1	-0.3
Respiratory disease	21.0	46.7	169.0	-6.6	0.8	1.8	-4.7	-11.4	-0.5	2.2	-13.0
Type 2 Diabetes (T2D) (2018)	1.6	2.9	7.1	0.2	0.4	1.3	1.5	2.7	-1.1	2.0	2.6
Lung FEV1/FVC ratio	3.2	16.5	45.3	4.4	-1.5	0.9	4.3	6.7	-2.3	0.6	6.3
Lung FVC	2.1	10.7	27.4	-3.0	0.9	-4.9	-3.0	1.2	1.9	-5.2	-3.2
Neuroticism	1.0	2.3	8.8	2.4	-0.4	-1.1	1.2	-0.1	3.0	0.4	0.8
Chronotype (morning person)	0.7	1.6	6.0	-2.5	-1.0	-1.3	-0.3	-0.3	0.1	-1.2	-1.5
Hair Pigment	0.1	2.1	5.2	-1.6	-1.0	-0.1	-1.0	-2.3	-0.8	-0.9	-2.3
Tanning	0.1	1.2	3.4	0.9	-1.2	-0.4	-1.1	1.2	0.5	0.9	1.8
Hand grip strength (left)	2.4	6.4	21.2	1.3	-0.3	-4.6	1.8	3.3	1.5	-2.7	2.0
Number of treatments/medications taken	0.7	1.3	2.9	-1.7	-1.7	0.5	-1.4	0.2	-0.8	-0.3	-1.3
Average weekly spirits intake	1.1	1.3	2.7	0.0	-1.2	-0.1	1.3	1.6	-1.2	1.2	1.4
Sensitivity / hurt feelings	1.8	3.2	11.1	2.6	1.2	-0.7	0.1	-1.4	3.3	-0.4	-1.8
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.2	0.0	-0.9	-1.8	-0.7	-0.8	0.7	-1.7	-1.5
Hearing difficulty/problems: Yes	0.3	0.4	2.2	-0.4	-0.3	-0.2	0.1	-0.8	0.1	0.4	-1.5
Relative age of first facial hair	0.7	1.4	3.6	1.7	1.9	-0.6	1.2	-1.4	0.1	-0.5	-1.0
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.8	-1.5	0.8	-0.4	0.4	-0.4	0.4	-0.7	-1.7
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.6	-0.4	-0.2	-0.0	1.2	1.9	-1.1	0.2	1.9
Ever had hysterectomy (womb removed)	0.6	0.7	2.2	-0.7	-1.5	0.8	-0.1	0.3	-1.1	-0.3	-1.2
Systolic blood pressure, automated reading	1.3	3.9	10.6	0.8	-2.3	-1.2	-1.7	3.2	1.6	-0.5	2.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.3	-0.7	-0.7	-0.4	-0.7	0.7	0.8	1.5	1.1
Angina	2.0	2.7	8.8	1.2	0.4	-1.9	1.1	3.0	-0.3	-1.0	2.3
Medication for hormone replacement therapy	1.0	1.1	3.4	0.0	-0.6	-0.9	0.8	1.7	0.4	-0.6	1.9
Vitamin and mineral supplements	0.9	1.2	5.1	-0.4	-0.1	-1.0	-1.7	-0.3	2.3	-0.7	-0.1
Supplements: Zinc	1.3	1.4	3.0	0.3	1.6	-1.6	1.7	-1.2	-0.2	-0.8	-0.5
Medication: Co-codamol	0.4	0.4	0.8	-0.5	-0.9	-0.4	-0.7	0.8	0.4	0.7	-0.7
Medication: Metformin	1.1	1.5	3.5	-0.0	-0.5	0.4	1.2	1.9	-1.2	1.4	1.9
Diabetes (father)	1.1	1.3	5.0	-1.8	-2.2	0.1	-0.1	0.8	-1.0	0.7	-0.1
Diabetes (mother)	1.8	2.3	7.1	1.5	-0.4	0.6	1.4	2.7	0.2	1.3	2.2
Severe depression (siblings)	0.6	0.7	2.5	-1.1	-0.4	-0.6	-0.7	0.6	-0.5	-1.6	-0.2
Pack years adult smoking proportion	0.4	0.6	1.2	0.7	0.3	1.1	-0.7	-1.1	-0.5	0.6	-0.8
Impedance of leg (right)	1.9	9.1	30.0	0.9	0.6	5.5	-4.1	-2.1	2.7	1.9	-2.9
Leg fat-free mass (left)	0.7	3.7	15.3	-3.9	-0.2	-0.6	1.7	-0.1	-1.8	2.5	1.4
Trunk fat percentage	4.8	19.1	43.8	-6.6	-1.2	6.6	-3.5	-3.5	-0.5	6.3	-0.6
Hand grip strength (right)	1.8	4.8	17.1	1.3	0.1	-4.1	0.8	3.0	1.4	-2.1	1.8
Townsend deprivation index at recruitment	0.7	1.0	2.7	-1.0	-1.6	1.1	-0.3	-0.9	0.5	0.0	-1.5
Current tobacco smoking	0.3	0.5	1.6	0.0	-0.4	0.3	-1.2	-0.2	0.8	0.5	-1.2
Average weekly fortified wine intake	1.6	1.9	5.1	-0.4	0.2	1.8	0.1	0.9	-1.0	2.3	2.2
Maternal smoking around birth	1.1	1.6	3.4	-0.2	1.8	-1.0	-1.6	-1.0	1.0	-1.7	-0.8
Fed-up feelings	0.9	1.7	5.8	0.8	0.4	-0.9	-1.2	-1.1	2.4	-1.5	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.3	-0.0	-0.2	-0.1	0.2	-0.2	0.7	-0.8	-1.1
Relative age voice broke	0.5	0.8	2.3	1.5	1.3	0.1	0.2	0.5	1.0	0.0	1.1
Taking other prescription medications	2.1	3.2	7.3	-2.7	0.2	2.7	-0.5	-0.1	-2.1	1.9	-1.7
Age when periods started (menarche)	1.3	3.1	11.5	3.4	2.6	-0.5	1.4	0.9	0.2	0.0	1.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.8	0.1	-1.4	-0.4	1.2	0.7	-1.0	-1.0	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.0	11.2	-0.8	-1.5	-3.3	-2.2	-1.3	3.3	-0.3	-0.5
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	3.0	-1.2	-0.4	0.2	-0.7	0.4	0.8	1.7	0.0
Qualifications: CSEs or equivalent	1.1	1.4	4.3	-0.8	0.9	-1.7	-0.9	-2.1	0.7	-1.0	-0.9
Serious illness, injury or assault to yourself	1.3	1.6	4.0	-2.0	-1.2	1.5	1.0	0.9	-1.3	1.1	-0.3
High blood pressure	0.9	2.6	10.8	-1.4	-0.3	-1.3	-2.2	3.3	-0.1	-0.5	1.1
Hayfever, allergic rhinitis or eczema	7.4	16.1	68.4	-2.5	1.7	2.1	-1.7	-6.3	0.6	2.0	-8.3
Multivitamins +/- minerals	1.0	1.3	3.5	-1.0	-1.7	0.7	1.0	0.5	-1.9	1.0	0.6
Stomach or abdominal pain in last month	1.8	2.2	5.8	-0.4	0.9	2.4	0.1	-2.0	1.8	1.7	-0.9
Supplements: Glucosamine	1.7	2.2	9.2	-0.8	-1.3	-1.2	-0.4	-1.1	-1.7	-3.0	-0.5
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.2	-1.2	-0.6	-0.5	1.2	-0.4	-0.1	-1.4	-1.5
Medication: Atenolol	1.1	1.3	3.9	-0.0	-0.8	-0.1	-0.3	1.9	1.5	-0.4	2.0
Medication: Levothyroxine sodium	1.2	2.0	7.2	1.1	0.6	2.7	-0.8	1.0	0.6	2.2	-0.7
Sitting height	1.0	6.8	31.2	-2.5	1.7	3.3	-0.2	-0.0	1.2	5.6	1.1
Chronic bronchitis/emphysema (father)	3.5	4.1	11.0	-2.6	0.5	1.0	1.2	-2.5	-2.3	1.0	-3.3
High blood pressure (mother)	1.5	2.1	5.2	0.2	-0.8	-1.6	-1.8	2.3	-0.8	0.2	2.1
Body mass index (BMI)	1.1	4.6	22.1	-4.7	-2.8	0.1	-0.2	-0.7	-0.8	2.1	1.1
Impedance of leg (left)	1.8	8.7	29.4	0.8	0.8	5.4	-4.0	-1.9	2.5	2.3	-2.8
Leg predicted mass (left)	0.7	3.8	15.5	-3.9	-0.2	-0.6	1.7	-0.1	-1.8	2.5	1.4
Trunk fat mass	3.8	16.4	44.9	-6.7	-1.4	5.5	-2.6	-2.8	-0.9	6.2	-0.0
Waist circumference	2.4	9.0	36.6	-6.1	-2.5	2.4	-1.8	-1.5	-1.2	4.1	-0.2
Number of incorrect matches in round	0.5	0.8	3.4	0.2	-0.6	0.8	1.8	0.9	-0.7	0.4	0.9
Past tobacco smoking	0.9	1.6	4.6	2.1	-0.1	1.8	0.8	-0.9	1.0	0.7	1.3
Alcohol usually taken with meals	0.3	0.5	1.9	-0.3	0.9	-0.1	0.9	0.7	-1.4	0.3	0.3
Nervous feelings	0.2	0.5	1.3	0.8	0.4	-0.9	-0.5	-0.8	1.1	-0.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	9.2	-0.6	0.2	-3.0	-0.4	1.5	1.1	-2.0	-0.9
Hearing difficulty/problems with background noise	0.6	0.9	4.2	-0.4	-2.0	0.1	-0.6	0.4	1.1	0.9	-0.9
Hair/balding pattern: Pattern 2	0.3	0.4	2.0	1.4	0.9	-0.6	-0.3	-0.1	0.4	-0.3	0.3
Had menopause	0.8	1.1	2.9	-0.8	-1.1	1.3	0.5	1.2	-1.7	-0.5	0.2
Had other major operations	0.6	0.7	1.8	-1.3	-0.2	-0.2	-1.4	0.2	-0.9	-0.2	-1.0
Forced vital capacity (FVC)	1.2	4.7	11.1	-3.3	0.9	-2.7	-2.8	-0.9	0.0	-1.7	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.9	15.4	-0.3	-0.3	-3.2	-2.7	-2.2	3.9	0.2	-1.1
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	7.3	-0.9	-1.9	-2.7	-1.6	2.7	0.3	-1.9	-0.0
Qualifications: None of the above	0.9	2.0	7.1	-1.0	-0.5	2.7	-0.6	0.8	1.6	2.0	-0.7
Financial difficulties in last 2 years	2.4	3.2	7.7	-1.9	-2.8	0.1	-2.4	-1.6	1.3	0.0	-1.9
Mouth/teeth dental problems	1.1	1.7	5.5	1.2	0.8	-1.4	-1.6	-1.1	0.6	-2.4	-0.2
Heart attack	2.5	3.2	8.1	-0.2	0.6	-2.8	-2.2	2.3	0.7	-1.7	2.0
Allergy	13.4	30.7	121.1	4.6	-1.6	-2.1	3.3	9.0	-0.7	-2.2	11.0
Pain all over the body in last month	1.6	1.7	4.2	-0.4	-0.5	1.0	2.0	1.0	-1.4	2.1	1.1
Diabetes (self-reported)	1.7	2.7	8.1	0.5	-0.7	1.2	1.2	2.8	-0.2	1.8	2.5
Hayfever/allergic rhinitis (self-reported)	6.1	8.1	32.6	-1.3	0.5	1.7	-1.5	-4.7	0.3	1.8	-5.7
Medication: Ramipril	2.2	2.9	6.4	-2.0	0.4	-2.4	-2.2	2.5	-0.0	-0.2	1.4
Medication: Simvastatin	2.3	3.4	12.2	-0.1	-2.9	-0.4	0.0	3.5	-0.8	-0.8	2.3
Fluid intelligence score	1.1	2.3	8.8	1.5	1.0	-3.0	-0.4	-1.2	-0.5	-2.1	-0.6
Illnesses of siblings	1.2	1.7	5.2	-0.2	-1.0	1.2	-0.9	-2.3	1.9	0.4	-1.1
Neuroticism score	1.0	2.1	9.7	1.9	0.2	-1.5	0.3	-0.4	3.1	-0.7	-0.8
Weight	1.4	7.0	29.7	-5.5	-1.2	1.8	-0.1	-1.2	-1.3	4.2	0.9
Impedance of arm (right)	3.6	16.7	64.5	-0.9	3.1	8.0	-3.5	-4.4	-0.2	4.6	-2.6
Arm fat percentage (right)	3.2	12.5	38.7	-6.2	-1.9	4.4	-2.2	-2.8	-1.3	4.8	0.1
Trunk fat-free mass	0.6	3.5	9.6	-2.1	0.4	-2.3	3.1	1.6	-1.5	1.1	1.5
Hip circumference	1.9	8.3	24.0	-4.9	-1.9	2.8	1.1	-0.6	-2.8	4.5	1.1
Time employed in main current job	0.4	0.5	1.3	0.7	-0.2	-0.5	-0.6	0.9	-0.5	-1.2	0.8
Alcohol intake versus 10 years previously	1.6	2.4	6.8	-2.6	-2.2	0.6	-0.9	-1.4	-1.1	1.0	-1.3
Father’s age at death	0.8	1.0	3.9	-0.4	0.9	1.1	1.1	-2.0	-0.7	0.6	0.2
Worrier / anxious feelings	0.6	1.1	2.9	1.1	0.8	-1.7	0.4	-0.4	1.5	-0.5	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.8	-1.3	0.3	0.9	-0.3	0.1	-0.3	1.1	-0.8
Falls in the last year	0.9	1.2	5.2	-0.6	-0.0	1.1	2.3	1.3	-0.5	0.9	0.1
Hair/balding pattern: Pattern 3	0.9	1.3	3.1	-0.9	-0.9	-1.2	0.7	1.8	-0.9	-0.7	1.7
Number of live births	0.3	0.4	2.2	1.5	-0.8	0.3	0.2	0.5	0.2	-0.3	0.2
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	7.6	-1.7	0.5	-2.8	-1.0	1.2	-0.8	-1.3	-0.4
Pulse rate	0.6	1.0	3.7	-0.2	-0.2	0.2	-0.6	-1.9	0.5	0.4	-1.8
Happiness	0.8	0.9	3.6	-0.1	0.2	0.5	0.7	1.6	-1.9	-0.1	0.6
Noisy workplace	0.9	1.1	4.2	0.1	-2.0	0.3	-0.3	1.0	1.4	1.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.8	1.3	0.3	-1.7	0.1	-1.2	0.2	0.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	4.1	-0.0	-2.0	0.3	1.0	0.2	-1.1	0.8	-0.5
Mouth/teeth dental problems: Dentures	1.0	1.6	3.9	0.9	-0.2	1.8	1.0	1.4	1.1	2.0	1.0
Asthma	18.9	37.2	139.4	-6.0	-0.3	1.8	-3.9	-10.0	0.3	2.1	-11.8
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	4.4	-1.1	0.1	-0.5	-1.2	-0.9	1.2	-0.8	-2.1
Medication: Cholesterol lowering	1.9	2.9	12.7	0.7	-0.4	-1.1	-0.5	3.6	0.9	-0.8	2.7
Depression (self-reported)	1.8	2.2	6.1	0.5	0.2	-2.4	0.6	1.9	-0.6	-2.5	1.0
Medication: Lansoprazole	0.4	0.5	1.7	0.7	-0.1	-0.7	-0.7	-0.4	-1.3	-0.6	0.1
Prospective memory result	1.1	1.4	3.9	0.4	0.9	2.0	0.1	0.2	1.9	1.6	0.2
Lung cancer (father)	1.4	1.6	6.3	-1.4	-0.8	2.5	-0.1	-0.3	-1.1	1.6	-0.3
Illnesses of mother	1.0	1.2	3.3	-0.4	0.0	0.1	1.2	-1.8	-0.3	-1.2	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	7.6	-0.4	1.1	-2.8	-1.5	1.0	-0.2	-1.6	-0.4
Pulse wave Arterial Stiffness index	1.3	1.5	5.3	-2.3	-2.0	-0.4	-1.3	-0.1	-0.6	0.6	-0.3
Impedance of arm (left)	3.4	15.8	58.2	-0.8	3.2	7.6	-3.4	-4.3	0.0	4.8	-2.1
Arm fat mass (right)	2.2	8.9	35.2	-5.9	-1.7	2.8	-1.3	-2.1	-0.9	4.3	0.3
Trunk predicted mass	0.6	3.4	9.1	-2.2	0.4	-2.4	3.0	1.4	-1.5	1.1	1.4
Standing height	0.8	7.9	26.8	-2.6	3.2	4.1	0.3	-1.0	-1.2	5.2	-0.5
Length of working week for main job	0.9	1.0	4.1	0.3	-0.6	-1.7	0.8	0.2	0.6	-2.0	-0.1
Exposure to tobacco smoke at home	0.2	0.3	0.9	-0.3	0.0	-1.0	0.5	0.1	0.7	-0.2	-0.5
Breastfed as a baby	1.2	1.4	3.5	-0.7	0.6	1.9	0.5	-1.7	-0.3	1.1	-1.6
Tense / ‘highly strung’	0.4	0.7	2.9	-0.7	-0.5	-0.4	0.7	0.9	1.7	-0.7	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.3	-0.8	0.6	0.3	-1.1	0.5	-0.4	0.4	0.0
Hair/balding pattern: Pattern 4	1.6	3.9	12.5	3.5	0.7	-2.9	1.6	0.6	1.6	-1.6	1.3
Birth weight of first child	3.3	5.9	13.9	-3.6	-0.5	0.1	-1.5	-3.6	-2.3	0.2	-3.7
Peak expiratory flow (PEF)	1.0	2.4	14.9	0.7	0.9	-3.9	0.2	0.7	-1.2	-0.7	0.9
Pulse wave reflection index	0.5	0.6	2.0	-1.4	-0.6	0.2	0.2	-0.1	-1.3	0.7	-0.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.6	0.2	-1.9	-0.4	0.4	1.7	-0.6	-0.2	-1.4
Loud music exposure frequency	1.7	1.9	4.9	0.4	-1.7	1.3	-0.8	1.9	0.1	2.2	1.0
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	5.5	2.3	0.2	-1.6	2.1	-0.3	-1.6	-1.3	0.4
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	5.0	-2.2	-1.7	-0.7	0.9	0.8	-1.8	1.1	0.1
Blood clot in the leg (DVT)	0.5	0.6	1.9	-0.1	-0.6	0.5	1.3	0.8	-0.4	-0.2	1.4
Medication: Paracetamol	0.5	0.9	3.4	0.7	0.9	-0.3	-0.3	-1.3	1.9	0.5	-0.7
Headache pain in last month	1.7	2.9	9.6	1.3	0.7	0.6	-1.7	-3.1	2.1	1.3	-1.5
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	10.5	-0.0	0.2	0.5	0.8	-3.2	0.5	-0.0	-2.0
Glaucoma (self-reported)	1.7	2.0	4.1	1.5	0.1	2.0	-1.1	0.5	1.8	1.5	1.7
Gout (self-reported)	1.0	1.3	3.9	-0.9	-1.4	2.0	-0.9	0.2	-0.8	1.3	-0.7
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.2	1.5	1.8	1.3	-1.0	1.1	1.3	0.9	-0.1
Medication: Amlodipine	0.8	1.1	3.2	0.7	-1.8	-0.6	0.8	1.2	-1.3	-0.8	0.4
Medication: Ventolin 100micrograms inhaler	7.6	9.8	33.3	-3.5	-0.8	1.7	-2.8	-4.5	0.7	1.0	-5.8
Birth weight	1.6	3.6	12.5	-0.6	0.6	-1.0	1.6	-2.8	-1.5	-1.3	-3.5
Chronic bronchitis/emphysema (mother)	2.3	2.7	7.5	-2.1	1.0	0.1	-1.4	-2.2	-0.2	-1.2	-2.7
High blood pressure (siblings)	0.6	0.9	2.4	0.6	0.5	-0.6	1.0	1.5	-1.5	-0.3	0.5
Forced vital capacity (FVC), Best measure	1.4	5.1	10.1	-2.0	1.5	-2.9	-3.2	-1.7	0.3	-1.7	-3.1
Body fat percentage	4.1	16.4	41.9	-6.5	-2.1	5.8	-3.2	-3.0	-0.4	5.6	-0.3
Leg fat percentage (right)	2.3	8.4	25.6	-5.1	-3.1	3.4	-2.5	-2.0	0.1	3.1	-0.3
Arm fat-free mass (right)	0.6	2.8	7.2	-2.7	-0.9	-2.1	2.0	1.5	-0.8	1.2	1.4
Exposure to tobacco smoke outside home	0.3	0.4	1.1	-0.1	0.6	1.0	-0.4	-1.1	0.6	0.2	0.0
Comparative body size at age 10	1.8	4.9	22.5	-4.7	-1.3	-3.5	-1.3	-0.4	0.6	-0.6	-0.6
Number of full brothers	0.4	0.5	2.6	-0.5	-1.6	-0.3	-0.3	-0.2	0.5	0.8	-0.0
Worry too long after embarrassment	0.7	1.2	2.4	1.6	-1.5	-0.8	1.2	-0.6	1.3	-0.6	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.6	0.7	-0.3	0.2	0.8	-0.4	-0.9	-0.2
Wheeze or whistling in the chest in last year	8.6	15.3	54.6	-4.2	-0.6	1.4	-2.8	-6.2	-0.3	1.3	-7.4
Number of children fathered	1.4	1.6	5.9	0.7	-0.6	-0.9	-0.9	2.4	0.0	0.1	2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.3	-0.5	0.4	-1.1	0.1	0.9	0.2	-0.9	-0.3
Age at first live birth	0.7	1.3	4.4	-0.1	-0.8	-1.5	-2.1	-1.4	0.4	-0.8	0.3
Pulse wave peak to peak time	1.4	1.6	6.2	2.1	2.5	0.5	1.1	-0.0	0.7	-0.4	0.3
Health satisfaction	0.9	1.2	3.8	-2.0	-1.4	0.3	-0.3	0.2	-1.8	0.7	-0.1
Shortness of breath walking on level ground	1.7	2.1	4.4	-1.9	0.0	-1.1	-1.5	-2.1	1.4	-0.4	-1.8
Qualifications: College or University degree	0.3	1.0	3.8	-0.2	1.2	-1.2	-0.8	-2.0	-0.2	-0.6	-0.3
Eye problems/disorders: None of the above	1.7	1.9	6.3	-2.5	0.1	-1.6	-1.6	-1.0	0.6	-1.3	-1.0
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.8	-0.6	-1.4	1.1	0.5	1.5	-0.3	1.7	1.0
Emphysema/chronic bronchitis	2.6	2.9	10.0	-2.5	0.4	-1.7	-3.2	0.5	-0.3	-1.8	-0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.3	0.1	0.6	0.2	1.1	-0.5	-1.0	1.1	0.5
Neck or shoulder pain in last month	0.5	0.8	4.6	0.1	0.5	-2.1	0.7	0.2	0.6	-0.6	0.0
Medication: Blood pressure	0.9	1.5	5.6	-0.6	-1.2	-0.8	-1.2	2.4	-0.4	0.7	1.5
Angina (self-reported)	2.1	2.7	8.2	1.3	0.6	-1.9	1.0	2.9	-0.6	-1.2	2.2
Migraine (self-reported)	1.1	1.4	3.6	-1.4	-0.7	1.5	-0.1	-0.9	0.6	1.9	-1.2
Medication: Ibuprofen	0.8	0.9	3.0	-0.3	-0.3	-0.8	-0.6	-1.2	1.1	-0.4	-1.7
Medication: Allopurinol	0.8	1.1	2.5	-1.1	-1.6	1.4	-0.4	-0.2	-0.4	1.0	-1.2
Medication: Omeprazole	0.6	0.7	2.5	-0.0	0.4	0.6	1.1	1.6	-0.2	-0.5	1.1
Medication: Seretide 50 evohaler	7.3	8.4	23.7	-4.2	-0.6	1.5	-3.3	-3.3	0.9	0.8	-4.9
Mean time to correctly identify matches	0.5	1.0	2.8	1.5	1.1	1.7	0.4	0.0	1.4	-0.0	-0.5
Heart disease (mother)	2.4	2.9	9.3	1.1	0.1	-2.0	-0.5	3.0	1.5	-1.3	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	4.6	-0.4	-2.1	-1.6	0.8	0.9	-1.2	-1.0	0.9
Whole body fat mass	3.2	13.2	42.5	-6.5	-2.0	4.4	-2.0	-2.4	-0.7	5.4	0.0
Leg fat mass (right)	2.5	9.5	35.8	-6.0	-3.0	2.9	-1.7	-1.7	-0.7	4.0	0.5
Arm predicted mass (right)	0.6	3.2	6.3	-2.5	-0.8	-2.3	2.2	1.9	-0.6	1.2	1.8
Pulse rate, automated reading	1.0	3.2	11.2	-1.8	1.3	-0.5	-1.6	-2.4	-0.1	-0.8	-3.3
Alcohol intake frequency.	1.5	3.4	9.1	0.2	1.6	2.8	1.8	-1.8	-0.5	3.0	-0.8
Comparative height size at age 10	1.3	7.0	19.1	-4.4	0.7	3.4	0.1	0.5	-2.5	4.2	-0.4
Number of full sisters	0.6	0.7	2.3	-0.5	-0.1	0.3	0.8	0.9	0.7	-1.5	-1.0
Suffer from ‘nerves’	0.5	0.7	2.2	0.7	0.9	-1.3	-0.5	-0.0	1.5	-0.6	-0.5
Overall health rating	0.7	1.4	3.8	-1.8	-0.6	-0.3	-1.2	-1.3	1.0	-0.1	-2.0
Chest pain or discomfort	0.5	0.7	2.9	0.5	0.3	-0.5	0.3	-0.3	-0.3	-1.7	-1.3
Had major operations	1.8	2.1	8.9	-1.5	-0.5	-0.7	1.6	0.4	-3.0	-1.3	-0.7
Age at last live birth	0.7	1.0	3.8	0.9	-1.9	-1.0	-0.8	-0.6	-0.4	-0.8	0.5
Family relationship satisfaction	0.8	1.0	4.7	-0.6	-0.1	1.2	0.2	-0.3	-2.2	0.0	-1.1
Leg pain on walking	0.6	0.8	2.9	-0.9	-1.2	-0.2	-1.7	-0.3	-0.0	0.9	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.8	0.1	-0.5	1.3	0.1	0.9	0.4	1.7	1.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.1	0.8	0.4	-0.3	0.4	1.1	1.7	0.4	1.2
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	7.3	2.7	1.6	-0.0	1.3	0.4	-0.0	-0.4	1.4
Medication: Aspirin	1.8	2.4	10.4	0.4	-1.3	-0.7	-1.5	3.2	-0.0	-1.7	1.1
Supplements: Vitamin C	1.0	1.2	3.5	0.9	1.9	0.3	-0.7	-0.2	1.5	-1.2	-1.0
Knee pain experienced in last month	0.8	1.3	4.9	-0.3	-1.2	0.3	-0.6	-1.0	1.2	-0.9	-2.2
Hypertension (Self-reported)	0.8	2.2	10.9	-1.4	-0.4	-0.9	-1.5	3.3	-0.1	-0.5	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	0.3	-0.0	0.6	0.6	-0.3	0.6	0.8	-1.1
Illnesses of father: Heart disease	4.2	5.8	20.7	0.7	-0.0	-2.6	-1.5	4.6	0.7	-2.5	3.0
Illnesses of siblings: Diabetes	0.8	0.9	2.6	1.1	-0.7	0.4	1.2	1.6	-0.6	0.7	0.9
Smoking status: Previous	0.6	0.9	2.5	-1.6	-0.5	-1.4	0.1	1.0	-1.0	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.7	-0.7	1.0	0.4	-1.1	-1.5	0.9	1.7	-1.2
Whole body fat-free mass	0.6	3.3	8.1	-2.9	0.0	-1.9	2.6	1.0	-1.7	1.5	1.4
Leg fat-free mass (right)	0.7	3.7	12.4	-3.5	0.2	-1.1	2.1	0.2	-2.0	2.3	1.6
Arm fat percentage (left)	3.0	12.1	37.2	-6.1	-1.7	4.2	-2.0	-2.8	-1.1	5.1	0.4
Average weekly red wine intake	0.5	0.7	3.7	-1.9	0.1	-0.9	-0.5	-0.1	-0.7	-0.7	-0.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.0	1.7	0.2	0.5	0.8	-1.2	1.0	-0.7	-1.5
Mood swings	0.6	1.1	5.2	0.4	0.2	-1.4	-0.5	-0.4	2.3	-1.0	-0.3
Loneliness, isolation	0.3	0.5	1.3	-0.3	-1.2	0.2	1.0	0.3	0.3	0.7	0.9
Long-standing illness, disability or infirmity	1.6	2.4	7.9	-2.8	-0.2	-1.7	-0.2	0.3	-1.2	-1.0	-2.4
Ever had bowel cancer screening	0.9	1.0	5.2	-2.3	-0.4	-1.3	-0.3	0.0	-0.5	-1.0	-0.1
Diabetes diagnosed by doctor	2.3	3.8	13.0	0.5	-0.8	1.3	0.6	3.6	0.2	2.5	2.9
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.9	1.5	-0.1	-1.4	-0.6	1.3	0.1	-1.7	0.0
Friendships satisfaction	0.6	0.8	4.8	0.4	0.4	0.5	0.7	0.4	-2.2	-0.5	0.1
Qualifications: nursing, teaching	1.0	1.5	3.5	1.6	1.6	-1.5	0.4	0.4	-0.2	-1.9	0.8
Commuting to job workplace: Walk	1.0	1.1	4.1	-1.4	-0.6	-0.8	-0.6	-2.0	-0.3	-0.9	-0.8
Eye problems/disorders: Cataract	4.5	5.2	13.2	3.5	2.1	0.3	3.6	1.1	-2.4	1.2	1.8
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	5.8	0.2	0.0	2.0	2.4	0.9	-1.6	1.8	0.7
Medication for cholesterol	1.4	2.2	8.8	-0.3	2.0	0.8	0.0	-3.0	0.9	1.2	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.2	-0.4	-1.3	-0.3	0.3	1.5	-0.3	-1.4	0.8
Back pain experienced in last month	4.9	7.2	27.6	-0.8	-0.4	-5.3	0.7	-1.0	1.0	-4.7	-2.2
Mineral and other dietary supplements	0.9	1.3	3.6	-0.5	1.0	0.1	0.7	0.9	1.6	1.9	1.2
Breast cancer (self-reported)	0.4	0.5	1.8	0.1	0.3	0.8	0.5	0.8	-1.3	0.5	0.0
Asthma (self-reported)	18.7	37.3	139.2	-6.2	-0.1	1.6	-4.0	-9.9	-0.1	2.2	-11.8
Osteoporosis (self-reported)	2.4	3.0	9.4	-1.2	-0.0	3.1	-0.8	-1.6	-1.3	2.6	-1.2
Osteoarthritis (self-reported)	1.6	2.0	10.3	-0.4	-0.4	-1.7	-0.5	0.3	0.5	-3.2	-1.5
Medication: Aspirin	2.0	2.6	11.6	0.1	-1.0	-0.6	-1.6	3.4	-0.4	-1.8	1.4
Medication: Gliclazide	1.8	2.0	5.2	-1.4	-0.2	0.4	0.8	1.9	-0.8	2.3	1.9
Illnesses of father: None of the above (group 1)	2.8	3.4	16.9	0.0	-0.1	1.3	-0.4	-4.1	0.6	1.5	-2.5
Smoking status: Current	0.3	0.6	2.0	-0.3	-0.0	-0.1	-1.3	0.1	0.7	0.0	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.2	8.0	-0.6	-1.0	-2.1	0.3	1.5	-1.1	-2.8	-0.4
Whole body water mass	0.6	3.3	7.7	-2.8	-0.2	-1.9	2.5	1.3	-1.6	1.4	1.5
Leg predicted mass (right)	0.7	3.8	12.3	-3.5	0.2	-1.1	2.2	0.3	-2.0	2.2	1.7
Arm fat mass (left)	2.3	9.5	38.6	-6.2	-1.8	2.8	-1.3	-2.0	-1.1	4.4	0.6
Number of self-reported non-cancer illnesses	1.7	3.0	10.0	-3.1	0.3	0.4	-1.5	-0.4	-1.3	0.4	-3.2
Average weekly champagne plus white wine intake	1.3	1.7	6.0	1.3	1.9	-0.9	-0.5	-2.4	0.3	-1.0	-0.8
Miserableness	0.9	1.5	5.4	1.7	0.2	-0.8	0.1	1.1	2.3	-1.5	-0.3
Guilty feelings	0.9	1.4	5.2	1.7	0.7	0.3	0.4	-1.0	2.3	0.4	-1.1
Wears glasses or contact lenses	1.3	1.5	4.9	1.4	-1.2	-0.6	0.8	2.2	-1.1	-0.8	0.6
Ever taken oral contraceptive pill	1.2	1.3	3.3	-0.9	-0.8	1.5	-0.9	0.9	0.4	1.8	1.3
Hearing aid user	0.5	0.6	2.0	-0.5	-1.4	0.5	0.6	-0.3	-0.9	0.6	-0.6
Mother’s age at death	0.6	0.8	3.8	0.9	0.6	0.8	-0.2	-2.0	-0.1	0.7	0.4
Financial situation satisfaction	0.3	0.4	1.4	-0.8	-1.2	-0.3	-0.9	0.4	0.2	-0.0	-0.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.8	0.5	-1.0	-0.2	-1.3	-0.8	1.7	-0.5	-0.8
Commuting to job workplace: Public transport	0.7	0.9	2.7	-0.1	-1.1	-0.3	0.1	-1.0	-0.9	-1.6	-1.1
Eye problems/disorders: Glaucoma	1.5	1.8	4.0	1.8	-0.2	2.0	-0.2	0.3	1.9	1.5	1.0
Medication: Blood pressure	0.2	0.4	1.8	-0.2	-0.3	0.1	-0.7	1.4	-0.1	-0.5	0.5
Pain type(s) experienced in last month: Hip pain	1.1	1.3	3.8	-0.9	-0.9	-1.9	-0.5	-0.2	0.5	-1.8	-1.3
Supplements: Fish oil (including cod liver oil)	0.9	1.2	4.1	1.1	-0.7	-0.2	0.8	-0.2	-2.0	-1.7	-0.2
High cholesterol (Self-reported)	1.9	3.4	13.5	-0.3	-1.8	-1.7	-0.8	3.7	0.6	-2.1	1.4
Medication: Bendroflumethiazide	0.4	0.6	2.2	-0.5	0.4	-1.5	-0.9	0.1	0.5	-0.2	0.8
Medication: Paracetamol	1.0	1.5	3.6	0.6	1.9	-0.8	-0.5	-1.6	1.9	0.9	-0.7
Medication: Lisinopril	1.7	2.2	4.4	2.1	0.4	2.0	-0.1	0.9	-1.2	1.6	2.0
Medication: Atorvastatin	1.1	1.3	4.7	0.3	0.5	-0.1	-2.2	1.5	1.6	0.6	-0.6
Illnesses of father: High blood pressure	2.2	2.7	10.9	1.7	-0.4	-1.5	1.7	3.3	0.0	-1.0	1.3
Alcohol drinker status: Never	2.4	2.9	8.1	1.5	1.7	2.8	2.6	-0.3	-0.3	1.6	0.2
Ever smoked	0.6	1.0	1.9	-1.4	0.0	-1.3	-0.9	0.2	-1.1	-0.3	-1.4
Basal metabolic rate	0.6	3.2	12.8	-3.6	-0.3	-0.9	1.8	0.4	-1.4	2.3	1.2
Leg fat percentage (left)	2.2	7.8	25.1	-5.0	-2.8	3.2	-2.3	-1.7	0.1	3.3	-0.3
Arm fat-free mass (left)	0.5	2.5	7.8	-2.8	-1.1	-1.4	2.0	1.2	-0.6	1.4	1.1
Number of operations (self-reported)	1.9	2.9	8.1	-2.9	-0.6	-0.1	1.2	0.7	-2.3	-0.8	-2.6
Average weekly beer plus cider intake	0.7	1.1	2.6	0.6	1.0	-1.6	-0.3	1.4	1.0	-1.2	0.5
Irritability	0.7	1.1	4.7	-0.6	0.4	-0.9	-0.6	2.2	1.1	-1.1	0.3
Risk taking	1.2	1.8	6.8	-0.7	-2.6	1.4	-1.0	0.1	-0.5	1.9	0.7
Ever had prostate specific antigen (PSA) test	1.6	1.8	5.4	-0.7	-0.8	-2.3	0.5	0.9	-1.8	-1.9	0.2
Fractured/broken bones in last 5 years	1.6	2.0	9.1	-1.2	0.8	3.0	0.7	1.6	-1.0	0.8	-0.4
Age started oral contraceptive pill	0.7	0.9	2.3	0.9	1.1	0.9	1.2	0.6	-0.2	-0.4	1.5
Diastolic blood pressure, automated reading	1.2	3.8	13.0	-3.6	-1.7	1.2	-3.3	1.2	-0.4	0.2	-0.6
Ever depressed for a whole week	1.4	1.8	5.6	-0.8	-1.9	-1.3	0.3	2.4	-1.3	-0.4	1.0
Unable to work because of sickness or disability	0.4	0.5	2.5	-0.1	-0.6	-0.7	1.6	0.5	0.3	-0.1	-0.2
Commuting to job workplace: Cycle	1.3	1.5	5.6	-1.2	-1.5	-0.5	0.2	1.4	-2.4	-0.6	-0.3
Myopia	0.8	1.2	5.4	0.2	0.8	-2.3	-0.9	-0.2	0.1	-1.7	0.1
Vascular/heart problems diagnosed by doctor	1.4	3.7	17.0	1.8	0.9	1.5	2.1	-4.1	0.3	0.9	-1.2
Cholesterol lowering medication	1.7	2.5	8.1	0.0	-1.8	-1.2	-0.7	2.8	-1.6	-2.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.3	-0.4	0.4	0.8	0.7	1.1	0.3	-0.4	0.2
Pain experienced in last month	1.3	2.2	5.2	1.4	1.9	2.3	-0.3	1.3	-0.5	1.0	1.9
Supplements: Calcium	0.7	0.8	3.2	-0.9	0.6	0.9	0.7	-0.2	-1.8	0.8	0.3
Basal cell carcinoma (self-reported)	1.8	2.1	7.0	-0.5	1.5	-2.6	-0.4	-0.5	0.1	-2.6	-0.7
Heart attack/myocardial infarction (self-reported)	2.4	3.2	6.7	-0.1	0.5	-2.6	-2.2	2.5	0.9	-1.6	2.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.6	-0.1	-0.8	0.5	1.1	0.9	-0.2	0.0	1.6
Heart disease (siblings)	3.7	4.6	15.5	0.9	0.5	-1.5	1.4	3.7	-1.5	-0.5	3.9
Alcohol drinker status: Previous	1.3	1.4	8.0	0.6	2.8	0.5	0.4	-0.5	0.9	1.2	0.5
Pack years of smoking	0.5	0.8	2.4	1.0	0.3	1.6	-0.4	-1.1	-0.5	0.6	-0.7
Impedance of whole body	2.8	14.2	52.9	-0.1	2.3	7.3	-4.3	-3.6	1.5	3.7	-2.8
Leg fat mass (left)	2.3	8.9	34.4	-5.9	-2.7	2.8	-1.5	-1.5	-0.8	4.1	0.5
Arm predicted mass (left)	0.5	2.6	6.8	-2.6	-1.1	-1.7	2.1	1.6	-0.7	1.0	1.2