[Hub]/) : Traits : Impedance of leg (right) :

chr15:76,398,193-78,806,023

Best TWAS P=3.52e-18 · Best GWAS P=3.81e-13 conditioned to 0.807

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous PSTPIP1 0.07 0.05 lasso 3 0.03 1.0e-03 -5.4 -5.1 3.0e-07 -0.30 0.71 0.03 FALSE
2 GTEx Adipose Subcutaneous PEAK1 0.05 0.03 lasso 5 0.02 8.6e-03 -5.9 5.7 9.4e-09 0.32 0.28 0.07 FALSE
3 GTEx Adipose Visceral Omentum RP11-797A18.4 0.06 0.05 lasso 3 0.06 4.1e-04 7.3 -6.8 8.3e-12 -0.97 0.01 0.98 FALSE
4 GTEx Artery Coronary RP11-797A18.3 0.12 0.03 lasso 10 0.01 1.1e-01 -1.9 -5.4 7.4e-08 -0.80 0.03 0.62 FALSE
5 GTEx Artery Tibial TSPAN3 0.14 0.07 lasso 5 0.10 1.6e-08 7.2 -8.7 3.5e-18 -0.85 0.00 1.00 TRUE
6 GTEx Artery Tibial LINGO1 0.08 0.04 lasso 5 0.03 2.7e-03 -6.0 -6.0 2.6e-09 -0.38 0.15 0.47 FALSE
7 GTEx Artery Tibial RP11-797A18.4 0.14 0.03 enet 25 0.09 2.3e-07 7.3 -5.2 2.0e-07 -0.75 0.01 0.99 FALSE
8 GTEx Brain Caudate basal ganglia PSTPIP1 0.22 0.12 lasso 9 0.13 1.4e-04 7.1 6.0 2.0e-09 0.91 0.02 0.95 FALSE
9 GTEx Brain Caudate basal ganglia RP11-797A18.4 0.21 0.14 lasso 5 0.12 2.9e-04 6.8 -5.7 9.5e-09 -0.86 0.03 0.94 FALSE
10 GTEx Brain Cerebellar Hemisphere RP11-797A18.4 0.14 0.12 enet 10 0.12 6.4e-04 4.9 -5.8 5.6e-09 -0.89 0.01 0.91 FALSE
11 GTEx Brain Cerebellum RP11-797A18.4 0.29 0.20 lasso 9 0.25 4.0e-08 7.1 -5.7 9.4e-09 -0.89 0.02 0.98 FALSE
12 GTEx Brain Cortex RP11-797A18.4 0.47 0.28 enet 14 0.34 3.3e-10 7.1 -6.7 2.9e-11 -0.94 0.01 0.99 FALSE
13 GTEx Brain Frontal Cortex BA9 RP11-797A18.4 0.35 0.35 lasso 5 0.35 4.8e-10 7.2 -6.8 8.0e-12 -0.98 0.00 0.99 FALSE
14 GTEx Brain Hippocampus PEAK1 0.23 0.05 lasso 6 0.02 9.9e-02 -5.9 6.1 1.4e-09 0.32 0.13 0.12 FALSE
15 GTEx Brain Hypothalamus RP11-797A18.4 0.21 0.18 lasso 7 0.22 7.6e-06 7.1 -7.4 1.6e-13 -0.96 0.01 0.97 FALSE
16 GTEx Brain Nucleus accumbens basal ganglia PEAK1 0.17 0.12 lasso 4 0.08 2.8e-03 -5.4 5.2 1.6e-07 0.32 0.27 0.06 FALSE
17 GTEx Brain Nucleus accumbens basal ganglia RP11-797A18.4 0.12 0.22 lasso 1 0.17 3.1e-05 7.3 -7.3 3.8e-13 -1.00 0.01 0.97 FALSE
18 GTEx Brain Putamen basal ganglia RP11-797A18.4 0.27 0.06 lasso 5 0.06 1.7e-02 6.8 -5.7 1.2e-08 -0.92 0.02 0.68 FALSE
19 GTEx Cells EBV-transformed lymphocytes PSTPIP1 0.13 0.04 enet 13 0.10 4.0e-04 4.0 -5.9 3.5e-09 -0.71 0.06 0.81 FALSE
20 GTEx Cells EBV-transformed lymphocytes TSPAN3 0.26 0.14 lasso 6 0.12 8.2e-05 -6.7 -7.9 1.9e-15 -0.48 0.06 0.70 FALSE
21 GTEx Cells Transformed fibroblasts TSPAN3 0.17 0.16 lasso 3 0.17 1.7e-12 7.2 -6.5 7.5e-11 -0.89 0.00 1.00 FALSE
22 GTEx Cells Transformed fibroblasts RP11-797A18.4 0.12 0.11 lasso 8 0.12 4.0e-09 6.8 -7.4 1.0e-13 -0.98 0.01 0.99 FALSE
23 GTEx Cells Transformed fibroblasts RP11-797A18.6 0.07 0.06 lasso 4 0.06 2.2e-05 7.2 -6.0 2.6e-09 -0.82 0.01 0.99 FALSE
24 GTEx Esophagus Gastroesophageal Junction RP11-797A18.4 0.14 0.11 enet 10 0.15 6.0e-06 4.9 -5.3 1.0e-07 -0.81 0.02 0.96 FALSE
25 GTEx Esophagus Muscularis RP11-797A18.4 0.07 0.09 lasso 3 0.09 6.3e-06 7.2 -7.2 5.0e-13 -0.96 0.01 0.99 FALSE
26 GTEx Heart Left Ventricle RP11-797A18.4 0.16 0.09 enet 12 0.08 3.3e-05 7.2 -7.5 7.7e-14 -0.95 0.01 0.99 FALSE
27 GTEx Lung RP11-797A18.4 0.19 0.09 enet 21 0.17 3.5e-13 7.3 -5.7 9.5e-09 -0.81 0.00 1.00 FALSE
28 GTEx Muscle Skeletal RP11-797A18.4 0.14 0.14 lasso 6 0.18 6.6e-17 6.8 -6.3 3.0e-10 -0.92 0.04 0.96 FALSE
29 GTEx Nerve Tibial TSPAN3 0.13 0.08 lasso 2 0.07 9.0e-06 7.2 -7.3 3.6e-13 -0.98 0.00 0.99 FALSE
30 GTEx Skin Sun Exposed Lower leg TSPAN3 0.11 0.03 enet 8 0.10 2.5e-08 -6.7 -8.1 6.0e-16 -0.71 0.01 0.97 FALSE
31 GTEx Skin Sun Exposed Lower leg RP11-797A18.4 0.16 0.08 enet 23 0.09 1.3e-07 6.8 -6.2 6.0e-10 -0.78 0.02 0.98 FALSE
32 GTEx Testis PSTPIP1 0.10 0.03 lasso 3 0.02 4.1e-02 7.1 -7.1 9.8e-13 -0.99 0.01 0.96 FALSE
33 GTEx Testis TSPAN3 0.19 0.05 lasso 7 0.06 1.6e-03 7.3 -6.5 5.9e-11 -0.86 0.01 0.96 FALSE
34 GTEx Whole Blood TSPAN3 0.05 0.04 lasso 2 0.03 1.8e-03 -6.7 -6.5 6.3e-11 -0.44 0.06 0.68 FALSE
35 METSIM Adipose PSTPIP1 0.04 0.04 lasso 3 0.04 2.3e-06 -5.3 -5.8 6.2e-09 -0.49 0.79 0.19 FALSE
36 NTR Blood TSPAN3 0.07 0.08 lasso 9 0.09 5.1e-27 7.3 -6.4 1.4e-10 -0.94 0.00 1.00 FALSE
37 YFS Blood TSPAN3 0.18 0.14 bslmm 256 0.18 5.9e-57 -5.5 -7.9 2.3e-15 -0.55 1.00 0.00 FALSE
38 The Cancer Genome Atlas Bladder Urothelial Carcinoma TSPAN3 0.05 0.00 enet 7 0.02 9.7e-03 7.3 -5.8 8.6e-09 -0.79 0.01 0.80 FALSE
39 The Cancer Genome Atlas Breast Invasive Carcinoma TSPAN3 0.03 0.01 blup 43 0.01 8.2e-03 3.3 -5.7 9.4e-09 -0.78 0.04 0.58 FALSE
40 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TSPAN3 0.05 0.01 blup 43 0.01 1.5e-02 6.8 -7.8 6.0e-15 -0.76 0.01 0.42 FALSE
41 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SCAPER 0.06 0.00 enet 5 0.00 3.4e-01 5.4 -5.3 1.3e-07 -0.37 0.01 0.51 FALSE