TWAS hub - ISLR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.0790	0.0330	2.2e-03	0.003	NA	0.026	NA	0.018	1.8e-01	NA	2.8e-03	NA	0.01100
2	METSIM	Adipose	0.0806	0.0260	2.6e-05	0.012	0.047	0.036	0.047	0.023	5.7e-03	1.1e-07	3.5e-06	1.2e-07	0.00016
3	TCGA	Breast Invasive Carcinoma	0.0170	0.0103	3.1e-03	0.018	0.007	0.006	NA	0.014	9.5e-05	1.4e-02	1.9e-02	NA	0.00062

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Mouth/teeth dental problems: Loose teeth	10.8	12.8	22.5	-4.7	-3.8	-1.3
Impedance of arm (right)	8.4	39.2	70.6	6.7	1.2	8.4
Frequency of tiredness / lethargy in last 2 weeks	8.3	13.4	19.9	-4.2	-1.6	-4.5
Ever taken oral contraceptive pill	7.8	8.7	18.4	-4.3	-2.1	-1.8
Impedance of arm (left)	7.7	35.5	56.4	6.9	1.4	7.5
Exposure to tobacco smoke outside home	6.4	8.5	17.9	-4.2	-1.4	-2.4
Impedance of whole body	6.1	31.1	51.6	6.4	0.9	7.2
Medication: Paracetamol	5.7	8.7	14.7	-3.1	-1.4	-3.8
Cardiovascular Disease	5.6	18.5	34.7	4.3	5.9	1.6
Had major operations	5.5	6.4	11.3	-2.6	-1.0	-3.4
Knee pain experienced in last month	5.3	8.2	11.6	-3.4	-2.6	-2.5
Height	4.9	94.6	156.2	12.5	2.1	11.1
Standing height	4.9	48.7	81.5	9.0	1.9	7.8
Wheeze or whistling in the chest in last year	4.9	8.7	14.8	-3.9	-3.0	-1.5
Osteoarthritis (self-reported)	4.9	6.4	9.9	-2.5	-1.7	-3.1
Hypertension (Self-reported)	4.7	13.1	25.3	3.5	5.0	1.5
Pack years adult smoking proportion	4.6	7.1	17.1	-4.1	-1.9	-0.7
Had other major operations	4.6	5.6	9.7	-2.4	-1.1	-3.1
Number of operations (self-reported)	4.6	6.8	8.2	-2.9	-2.0	-2.9
Mouth/teeth dental problems	4.5	6.9	10.6	3.3	2.6	1.8
Pain experienced in last month	4.5	7.5	11.0	3.3	2.4	2.4
Pack years of smoking	4.4	6.4	15.8	-4.0	-1.6	-0.9
High blood pressure	4.3	11.9	22.0	3.2	4.7	1.8
Hearing difficulty/problems with background noise	4.3	6.9	12.7	-2.6	-1.1	-3.6
Medication: Blood pressure	4.3	8.2	13.1	3.2	3.6	1.1
Prostate Cancer	4.0	5.7	13.4	-1.9	-0.0	-3.7
Vascular/heart problems diagnosed by doctor	4.0	10.9	19.1	-3.2	-4.4	-1.8
Alzheimer’s Disease (in mother)	3.9	4.6	9.3	-1.6	-3.0	1.4
Mouth/teeth dental problems: Bleeding gums	3.9	5.0	7.8	-2.6	-2.8	-0.8
Bipolar Disorder (2018)	3.8	5.9	11.6	-0.9	3.4	-2.3
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.7	7.7	-2.8	-2.0	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	3.6	5.5	11.4	-3.4	0.6	-2.2
Medication: Ibuprofen	3.6	4.3	8.2	-2.9	-1.8	-1.2
Alzheimer’s Disease (including proxy)	3.5	5.1	11.2	-1.9	-3.3	-0.6
Chronic bronchitis/emphysema (mother)	3.5	4.1	9.5	-1.6	-3.1	-0.2
Pulse rate, automated reading	3.5	11.2	21.7	-4.7	-2.0	-2.9
Lupus	3.4	5.1	9.4	2.0	1.3	3.1
Body mass index (BMI)	3.4	14.3	20.7	-4.5	-1.8	-4.3
Forced expiratory volume in 1-second (FEV1), predicted	3.4	7.0	15.9	4.0	0.5	2.2
Comparative height size at age 10	3.3	18.0	34.5	5.9	0.0	4.4
Hand grip strength (left)	3.2	8.3	18.0	1.7	-2.0	4.2
Medication: Paracetamol	3.2	5.3	7.7	-2.6	-1.2	-2.8
Financial situation satisfaction	3.2	3.9	6.1	-2.5	-1.4	-1.9
Breast Cancer	3.1	7.5	13.6	3.7	2.7	1.2
Impedance of leg (right)	3.1	14.9	26.9	4.2	0.4	5.2
Ever unenthusiastic/disinterested for a whole week	3.1	3.8	5.7	-2.3	-0.5	-2.4
Number of full brothers	3.1	3.9	6.4	-2.2	-2.5	-0.6
Hand grip strength (right)	3.0	8.1	14.9	2.3	-2.1	3.9
Neck or shoulder pain in last month	3.0	4.2	7.0	-2.3	-0.5	-2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.0	3.6	7.7	1.3	-1.2	2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	2.9	3.9	10.0	-3.2	-0.6	-1.1
Financial difficulties in last 2 years	2.9	3.9	9.0	-3.0	-1.6	0.0
Depression (self-reported)	2.9	3.4	7.7	-2.8	-0.7	-1.5
Medication: Amlodipine	2.9	4.0	7.6	2.1	2.8	0.2
Ever depressed for a whole week	2.9	3.5	6.6	-1.9	-0.5	-2.6
Impedance of leg (left)	2.8	13.5	25.6	3.9	0.0	5.1
Miserableness	2.8	4.9	12.7	-3.6	-0.9	-1.1
Alzheimer’s Disease (in father)	2.7	3.0	6.1	-1.5	-0.7	-2.5
Townsend deprivation index at recruitment	2.7	3.7	9.1	-3.0	-1.4	-0.3
Peak expiratory flow (PEF)	2.7	6.3	11.5	2.5	-1.1	3.4
Leg pain on walking	2.6	3.3	4.9	-2.2	-1.6	-1.5
Irritability	2.6	4.3	9.4	-3.1	-1.8	-0.7
Risk taking	2.6	3.8	9.5	-3.1	-1.1	-0.9
Overall health rating	2.5	5.3	9.7	-3.1	-1.8	-1.8
Eye problems/disorders: Glaucoma	2.5	2.9	8.2	-0.5	0.6	-2.9
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	4.9	-2.2	-1.4	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.4	13.8	1.0	-1.2	3.7
Average weekly red wine intake	2.4	3.5	5.8	-2.4	-0.9	-2.0
Systolic Blood Pressure	2.3	11.7	17.4	3.2	4.2	2.7
Serious illness, injury or assault to yourself	2.3	2.8	7.9	-0.6	-0.3	-2.8
Commuting to job workplace: Walk	2.3	2.5	5.7	2.4	1.1	0.8
Medication: Bendroflumethiazide	2.3	3.6	7.4	1.3	2.7	-1.3
Frequency of depressed mood in last 2 weeks	2.2	3.0	8.1	-2.8	-0.4	-0.9
Medication: Co-codamol	2.2	2.6	4.1	-2.0	-1.4	-1.3
Supplements: Glucosamine	2.2	2.9	5.7	-1.6	-2.4	-0.5
Exposure to tobacco smoke at home	2.2	2.4	6.8	-0.0	0.7	-2.6
Major Depression (MDD)	2.1	2.5	6.4	-0.5	1.0	-2.5
Sensitivity / hurt feelings	2.1	3.7	6.2	-2.2	-0.2	-2.5
Illness, injury, bereavement, stress in last 2 years	2.1	2.5	5.5	2.4	0.3	1.4
Wears glasses or contact lenses	2.1	2.4	5.2	0.9	2.3	-1.1
Leg fat percentage (left)	2.1	7.8	10.6	-3.3	-2.3	-2.7
Fractured/broken bones in last 5 years	2.1	2.7	5.9	-1.4	-2.4	-0.4
Stomach or abdominal pain in last month	2.0	2.5	4.6	-2.1	-1.6	-0.5
Waist circumference	2.0	7.1	10.1	-2.9	-1.7	-3.2
Forced vital capacity (FVC)	2.0	7.6	14.3	3.8	-1.3	2.6
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	3.5	-1.9	-1.8	-0.8
Smoking status: Previous	2.0	3.0	5.5	-2.4	-0.9	-1.6
Supplements: Calcium	2.0	2.2	6.5	0.1	0.1	2.5
Pain all over the body in last month	1.9	2.0	4.9	-1.1	-2.2	-0.0
Falls in the last year	1.9	2.6	6.0	-2.5	-0.5	-1.2
Number of live births	1.9	2.7	4.0	1.3	2.0	1.6
Gout (self-reported)	1.9	2.6	5.1	2.3	1.6	0.2
Forced vital capacity (FVC), Best measure	1.9	7.0	10.9	3.3	-2.0	2.5
Medication: Aspirin	1.9	2.4	3.1	1.8	1.6	1.2
Illnesses of father: High blood pressure	1.9	2.4	4.9	-2.2	0.5	-1.4
Eye problems/disorders: Diabetes related eye disease	1.8	1.9	4.3	1.1	2.1	-0.6
Supplements: Zinc	1.8	1.9	2.4	-1.6	-1.1	1.5
Maternal smoking around birth	1.8	2.6	5.1	-2.3	-0.6	-1.5
Hair/balding pattern: Pattern 3	1.8	2.8	3.2	1.8	1.4	1.8
Leg fat percentage (right)	1.8	6.4	9.2	-3.0	-2.1	-2.4
Medication: Allopurinol	1.8	2.3	5.0	2.2	1.0	1.0
Age at last live birth	1.8	2.6	5.4	1.4	2.3	0.7
Hearing aid user	1.8	2.1	4.3	2.1	1.3	-0.6
Bipolar Disorder or Schizophrenia	1.7	4.1	6.4	-0.2	2.4	-2.5
Age at First Birth	1.7	2.5	4.6	2.1	0.3	1.6
Coronary Artery Disease (CAD)	1.7	2.1	4.3	-0.8	-1.1	-2.1
Ulcerative Colitis	1.7	2.5	4.2	-2.0	-1.1	-1.4
Waist Hip Ratio (WHR)	1.7	7.5	10.3	-3.2	-3.0	-1.8
Average weekly spirits intake	1.7	2.1	3.0	-1.6	-1.7	-0.9
Diabetes (father)	1.7	2.1	2.2	1.5	1.4	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	9.2	0.5	-1.5	3.0
Medication: Ramipril	1.7	2.2	3.5	1.8	1.9	-0.2
Loud music exposure frequency	1.7	1.8	2.1	-1.3	-1.3	-1.4
Worry too long after embarrassment	1.7	2.8	4.4	-2.1	-0.3	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	4.6	-2.1	-0.8	-1.2
Long-standing illness, disability or infirmity	1.7	2.6	3.5	-1.9	-1.7	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	3.2	-1.8	-0.5	-1.4
Illnesses of father: None of the above (group 1)	1.7	2.1	3.6	1.7	0.2	1.9
Age started oral contraceptive pill	1.7	2.2	4.8	2.2	0.8	1.0
Commuting to job workplace: Cycle	1.7	2.0	6.1	2.5	0.1	-0.1
Glaucoma (self-reported)	1.6	1.8	4.6	-0.9	0.3	-2.2
High cholesterol (Self-reported)	1.6	2.9	4.6	1.3	1.5	2.1
Ever smoked	1.6	2.8	7.6	-2.8	-0.9	-0.3
BMI	1.5	8.4	15.1	-3.2	-0.4	-3.9
Number of incorrect matches in round	1.5	2.5	4.0	0.3	1.8	-2.0
Medication for pain relief, constipation, heartburn	1.5	2.6	5.4	2.3	1.1	1.1
Medication: Aspirin	1.5	2.0	2.5	1.6	1.2	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	3.2	-1.3	0.5	-1.8
Blood Red Count	1.4	13.3	16.1	3.6	4.0	3.3
Alcohol intake versus 10 years previously	1.4	2.1	3.2	-0.7	-1.6	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.3	5.7	2.4	-1.9	1.9
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	3.5	-1.5	-1.9	-1.2
High blood pressure (siblings)	1.4	2.0	3.3	1.3	1.8	-1.0
Comparative body size at age 10	1.4	3.7	8.6	-1.6	-0.3	-2.9
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.2	-0.2	1.8	-1.3
Pulse wave peak to peak time	1.4	1.6	4.4	2.1	0.7	0.2
Health satisfaction	1.4	1.8	2.8	-1.7	-0.4	-1.6
Medication: Blood pressure	1.4	2.5	5.3	1.5	2.3	0.4
Mother’s age at death	1.4	1.8	3.1	1.3	1.8	0.8
Myopia	1.4	2.0	4.3	1.2	0.5	2.1
Depression (Nagel 2018)	1.3	2.0	3.9	-2.0	0.5	-1.3
Heel T-Score	1.3	10.2	24.0	1.1	-2.4	4.9
Ever had hysterectomy (womb removed)	1.3	1.5	2.6	1.6	1.0	0.9
Past tobacco smoking	1.3	2.4	5.2	2.3	0.9	1.0
Noisy workplace	1.3	1.7	2.7	-1.6	-1.3	-0.8
Number of children fathered	1.3	1.5	2.5	-1.6	-1.4	-0.3
Family relationship satisfaction	1.3	1.6	3.8	-0.3	-1.0	1.9
Loneliness, isolation	1.3	1.8	4.5	-2.1	0.5	0.8
Back pain experienced in last month	1.3	1.9	3.0	-1.7	-1.0	-1.3
Osteoporosis (self-reported)	1.3	1.6	4.2	0.7	-0.1	2.0
Ulcerative Colitis (UC)	1.2	2.3	3.8	-1.2	-1.9	1.4
Neuroticism score	1.2	2.5	5.8	-2.4	0.5	-1.2
Length of working week for main job	1.2	1.4	3.4	-0.8	-1.9	-0.0
Alcohol intake frequency.	1.2	2.8	4.8	2.2	1.1	1.6
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.3	-1.5	-1.2	0.7
Eye problems/disorders: Cataract	1.2	1.4	2.3	1.5	1.1	0.7
Medication: Lisinopril	1.2	1.6	2.0	1.0	1.4	1.3
Neuroticism (Nagel 2018)	1.1	2.5	5.2	-2.3	0.8	-1.3
Smoking Status	1.1	2.7	6.1	-2.5	-0.7	-1.3
Hypothyroidism (self reported)	1.1	2.6	4.3	1.4	1.2	-2.1
Relative age voice broke	1.1	1.7	2.3	1.3	1.1	1.5
Medication: Atenolol	1.1	1.4	3.6	0.8	1.9	-0.0
Medication: Simvastatin	1.1	1.6	2.9	1.0	1.0	1.7
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	5.9	2.4	-1.4	1.7
Qualifications: A levels/AS levels or equivalent	1.1	2.5	2.9	-1.7	-1.3	-1.6
Age at first live birth	1.1	2.0	3.6	1.4	1.9	0.7
Average weekly beer plus cider intake	1.1	1.6	4.5	0.4	0.3	2.1
Leg fat mass (left)	1.1	4.1	5.1	-2.3	-2.1	-1.7
Depressed Affect (Nagel 2018)	1.0	2.1	3.8	-1.9	0.5	-1.5
LDL Cholesterol	1.0	1.6	2.3	-1.5	-1.1	-1.2
Blood Platelet Count	1.0	11.4	20.0	-3.7	-0.8	-4.5
Neuroticism	1.0	2.4	2.8	-1.5	1.5	-1.7
Sitting height	1.0	7.1	11.2	3.4	2.2	2.3
Had menopause	1.0	1.3	2.2	1.3	1.5	0.2
Medication: Cholesterol lowering	1.0	1.6	2.6	0.6	1.3	1.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.2	-1.5	0.1	-1.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.1	-1.8	-0.8	-1.0
Leg fat mass (right)	1.0	4.0	5.3	-2.3	-2.1	-1.6
Medication for cholesterol	1.0	1.4	2.2	-1.5	-1.3	-0.7
Average weekly champagne plus white wine intake	1.0	1.4	2.6	-1.0	-0.7	-1.6
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.5	-1.0	-0.6	-1.6
Diastolic blood pressure, automated reading	1.0	3.1	9.2	0.0	3.0	-0.0
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.3	-0.9	-1.8	0.0
Worry (Nagel 2018)	0.9	1.8	4.9	-0.6	2.2	-0.4
Multivitamins +/- minerals	0.9	1.1	1.4	-1.2	-0.9	-1.0
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.2	-0.9	-1.5	-0.4
Illnesses of siblings	0.9	1.3	2.6	-1.1	-1.6	-0.1
Lung cancer (father)	0.9	1.0	2.7	-0.3	0.4	1.7
Illnesses of mother	0.9	1.1	2.8	0.3	0.5	-1.7
Irritable Bowel Disease (IBD)	0.8	1.9	3.4	-1.8	-1.5	0.4
Bipolar Disorder (2011)	0.8	0.8	2.4	-1.6	-0.1	0.0
Lung FVC	0.8	4.2	12.1	0.3	-3.5	0.5
Allergy	0.8	1.8	3.4	1.4	1.8	0.3
Time employed in main current job	0.8	1.0	1.3	-0.8	-1.1	-1.0
Mouth/teeth dental problems: Dentures	0.8	1.4	1.5	-1.1	-1.2	-1.1
Pulse wave Arterial Stiffness index	0.8	0.9	2.3	-1.5	-0.6	0.1
Illnesses of siblings: Diabetes	0.8	1.0	1.7	1.0	0.7	1.3
Reaction Time	0.7	1.2	1.8	1.3	0.9	-1.1
Crohns Disease (2012)	0.7	1.1	2.7	-1.6	0.2	-0.8
Schizophrenia (2014)	0.7	1.5	2.9	-0.6	1.1	-1.7
Triglycerides	0.7	1.1	2.5	0.6	-0.7	1.6
Ever used hormone-replacement therapy (HRT)	0.7	0.8	1.8	1.3	0.4	0.8
Systolic blood pressure, automated reading	0.7	2.1	4.4	1.0	2.1	0.9
Average weekly fortified wine intake	0.7	0.8	1.4	0.9	1.2	-0.2
Medication: Levothyroxine sodium	0.7	1.2	3.3	0.2	0.5	-1.8
High blood pressure (mother)	0.7	1.0	2.4	-0.3	1.5	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.5	-1.6	-0.6	-0.6
Worrier / anxious feelings	0.7	1.4	1.7	-0.9	1.3	-1.3
Breastfed as a baby	0.7	0.9	1.2	-1.1	-1.0	-0.6
Blood clot in the leg (DVT)	0.7	0.9	2.3	-0.7	-1.5	0.0
Eye problems/disorders: None of the above	0.7	0.8	1.6	-0.4	-0.7	1.3
Heart disease (mother)	0.7	0.8	2.4	0.2	0.1	1.6
Ever had bowel cancer screening	0.7	0.8	1.4	-0.7	-0.7	1.2
Friendships satisfaction	0.7	0.9	2.0	0.4	-0.7	1.4
Breast cancer (self-reported)	0.7	0.9	2.1	0.7	0.4	-1.4
Guilty feelings	0.7	1.1	3.0	-1.7	0.3	0.5
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.2	-0.6	-0.9	-1.1
Alcohol drinker status: Previous	0.7	0.7	1.3	-0.0	1.2	-0.9
Schizophrenia vs Biploar Disorder	0.6	0.8	1.1	1.1	-0.6	0.9
Rheumatoid Arthritis	0.6	0.9	2.4	-1.6	-0.0	-0.5
Severe depression (siblings)	0.6	0.7	1.9	-1.4	0.4	-0.1
Age when periods started (menarche)	0.6	1.5	2.5	0.3	1.4	-1.6
Alcohol usually taken with meals	0.6	0.9	2.0	0.3	1.4	-0.8
Fluid intelligence score	0.6	1.3	2.5	1.0	0.6	1.6
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.7	0.3	0.8	-1.3
Emphysema/chronic bronchitis	0.6	0.7	1.9	-0.4	-1.4	0.0
Mean time to correctly identify matches	0.6	1.2	1.4	1.2	0.9	-1.2
Arm fat percentage (left)	0.6	2.3	3.3	-1.8	-1.2	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.2	-0.5	-1.8	0.0
Heart disease (siblings)	0.6	0.7	2.0	0.2	-0.5	1.4
Neuroticism (2016)	0.5	0.8	1.3	-1.2	0.9	-0.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.4	-0.2	1.6	-0.8
Number of treatments/medications taken	0.5	0.9	1.5	-1.1	0.2	-1.2
Nervous feelings	0.5	0.9	2.3	-0.1	1.5	-0.6
Hair/balding pattern: Pattern 2	0.5	0.6	1.7	-0.4	-1.3	0.1
Father’s age at death	0.5	0.6	1.2	-0.0	0.8	-1.1
Prospective memory result	0.5	0.6	1.3	1.2	0.0	0.7
Birth weight	0.5	1.0	2.9	0.2	-0.1	-1.7
Number of full sisters	0.5	0.6	1.1	-1.0	-0.8	-0.4
Arm fat mass (left)	0.5	2.0	2.3	-1.5	-1.2	-1.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	0.5	-0.4	1.2
Commuting to job workplace: Public transport	0.5	0.6	0.8	0.9	0.3	-0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.8	-0.1	-1.4	0.3
Ovarian Cancer	0.4	0.5	0.7	0.8	-0.3	0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.2	0.4	1.1	-0.4
Lung FEV1/FVC ratio	0.4	1.9	3.9	-1.4	2.0	-0.0
Hearing difficulty/problems: Yes	0.4	0.5	1.3	-0.1	0.5	-1.2
Relative age of first facial hair	0.4	0.8	1.3	0.6	-0.8	1.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	-0.8	-0.2	-0.7
Qualifications: CSEs or equivalent	0.4	0.5	1.3	-0.4	-1.1	0.1
Chronic bronchitis/emphysema (father)	0.4	0.4	0.7	-0.1	-0.8	-0.8
Heart attack	0.4	0.5	1.5	-0.1	-1.2	0.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.3	0.2	-1.2	-0.6
Arm fat percentage (right)	0.4	1.7	2.9	-1.7	-1.1	-1.0
Pulse rate	0.4	0.8	1.4	-1.2	0.2	-0.9
Happiness	0.4	0.5	1.0	-1.0	-0.1	0.6
Arm fat mass (right)	0.4	1.5	2.0	-1.3	-0.9	-1.4
Tense / ‘highly strung’	0.4	0.7	2.2	-1.5	0.1	0.2
Medication: Omeprazole	0.4	0.4	0.7	-0.4	0.9	0.6
Mood swings	0.4	0.7	1.9	-1.4	-0.5	0.0
Mineral and other dietary supplements	0.4	0.6	1.1	1.0	0.8	0.1
Medication: Atorvastatin	0.4	0.4	0.8	0.7	0.9	0.2
Schizophrenia (2018)	0.3	0.7	1.8	0.4	0.3	-1.4
Crohns Disease (2017)	0.3	0.7	2.0	-1.4	-0.1	-0.1
HbA1C	0.3	0.3	0.6	0.6	0.8	0.1
Allergy or Eczema	0.3	0.7	1.8	-0.5	-0.2	-1.3
Chronotype (morning person)	0.3	0.7	0.9	0.8	-0.7	0.9
Angina	0.3	0.4	1.0	0.4	1.0	-0.4
Medication for hormone replacement therapy	0.3	0.3	0.5	0.7	0.0	0.6
Medication: Metformin	0.3	0.4	1.2	-0.3	1.1	0.1
Trunk fat percentage	0.3	1.0	2.4	0.0	-1.6	0.8
Current tobacco smoking	0.3	0.5	1.5	-1.2	0.1	-0.2
Fed-up feelings	0.3	0.6	0.9	-0.8	0.3	-0.9
Taking other prescription medications	0.3	0.5	1.2	-0.4	-0.2	-1.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	-0.8	-0.3	-1.2
Diabetes (self-reported)	0.3	0.5	1.4	-0.1	1.2	-0.3
Asthma	0.3	0.5	0.9	-0.9	-0.8	0.2
Hair/balding pattern: Pattern 4	0.3	0.8	2.1	-0.2	1.5	-0.4
Birth weight of first child	0.3	0.5	1.1	-0.5	-1.1	-0.4
Headache pain in last month	0.3	0.6	0.8	-0.9	0.8	-0.6
Body fat percentage	0.3	1.2	2.7	-1.0	-1.6	-0.2
Angina (self-reported)	0.3	0.4	0.9	0.5	0.9	-0.3
Suffer from ‘nerves’	0.3	0.5	0.8	-0.8	0.9	-0.1
Chest pain or discomfort	0.3	0.5	0.9	-0.9	-0.7	-0.1
Diabetes diagnosed by doctor	0.3	0.6	1.7	-0.2	1.3	0.1
Qualifications: nursing, teaching	0.3	0.4	1.2	-0.2	0.1	-1.1
Smoking status: Current	0.3	0.4	1.1	-1.1	0.1	-0.3
Alcohol drinker status: Never	0.3	0.3	0.7	-0.6	-0.8	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.5	-0.7	0.3	0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	0.4	0.8	0.7
Body Mass Index (BMI) (2010)	0.2	0.2	0.3	-0.0	-0.6	-0.6
HDL Cholesterol	0.2	0.3	0.8	-0.9	-0.2	0.1
Primary Biliary Cirrhosis	0.2	0.3	0.8	0.9	0.4	0.1
Blood Eosinophil Count	0.2	1.4	4.1	2.0	0.5	-0.0
Respiratory disease	0.2	0.4	0.7	-0.7	-0.8	-0.2
Tanning	0.2	3.0	5.2	-2.3	-0.8	-1.7
Trunk fat mass	0.2	0.7	2.0	0.2	-1.4	0.4
Pulse wave reflection index	0.2	0.3	0.5	-0.5	-0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	1.0	0.4	-0.4
Arm fat-free mass (right)	0.2	1.1	2.8	-0.5	-0.5	-1.7
Migraine (self-reported)	0.2	0.2	0.5	0.0	0.7	0.3
Medication: Seretide 50 evohaler	0.2	0.3	0.4	-0.4	-0.5	0.6
Whole body fat mass	0.2	0.7	1.8	-0.4	-1.3	-0.2
Arm predicted mass (right)	0.2	1.0	2.6	-0.2	-0.5	-1.6
Supplements: Vitamin C	0.2	0.3	0.4	-0.5	0.6	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.5	-0.7	-0.3	-0.5
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	-0.3	-0.9	-0.1
Asthma (self-reported)	0.2	0.4	0.8	-0.9	-0.7	-0.0
Medication: Gliclazide	0.2	0.2	0.4	-0.6	-0.2	0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.6	-0.2	0.8	-0.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	0.4	-0.4	0.5
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	-0.8	0.1	-0.5
Mean Putamen Volume	0.1	0.2	0.3	0.5	0.3	0.3
Blood White Count	0.1	0.9	1.3	-1.1	0.4	-1.1
Hair Pigment	0.1	3.8	10.2	-0.7	-0.9	-3.2
Vitamin and mineral supplements	0.1	0.1	0.2	0.5	0.1	-0.3
Diabetes (mother)	0.1	0.1	0.3	-0.0	0.5	0.1
Qualifications: None of the above	0.1	0.3	0.8	0.9	-0.2	0.2
Weight	0.1	0.5	0.8	-0.3	-0.9	-0.7
Trunk fat-free mass	0.1	0.3	0.9	1.0	0.2	-0.2
Hip circumference	0.1	0.4	1.2	-0.0	0.3	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	0.2	0.2	-0.5
Medication: Lansoprazole	0.1	0.2	0.4	-0.3	-0.6	0.1
Trunk predicted mass	0.1	0.3	0.8	0.9	0.2	-0.2
Shortness of breath walking on level ground	0.1	0.1	0.1	-0.3	0.1	-0.3
Qualifications: College or University degree	0.1	0.2	0.4	-0.3	0.6	0.0
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.5	0.5	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	0.3	0.5	0.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.6	0.5	0.3
Arm fat-free mass (left)	0.1	0.7	1.9	-0.2	-0.4	-1.4
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.4	0.1	0.4
Cholesterol lowering medication	0.1	0.1	0.1	0.3	0.4	0.2
Arm predicted mass (left)	0.1	0.5	1.2	-0.2	-0.5	-1.1
Fasting Glucose	0.0	0.0	0.1	-0.3	-0.0	-0.1
Leg fat-free mass (left)	0.0	0.2	0.4	0.6	-0.3	-0.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.1	0.1	-0.0	0.3	-0.3
Leg predicted mass (left)	0.0	0.1	0.3	0.6	-0.3	-0.2
Whole body fat-free mass	0.0	0.2	0.2	0.5	-0.2	-0.4
Leg fat-free mass (right)	0.0	0.2	0.2	0.3	-0.5	-0.4
Whole body water mass	0.0	0.2	0.3	0.5	-0.1	-0.5
Leg predicted mass (right)	0.0	0.2	0.2	0.2	-0.5	-0.5
Basal metabolic rate	0.0	0.2	0.3	0.4	-0.3	-0.5

Hub : Genes

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Trait associations