[Hub]/) : Traits : Impedance of leg (right) : ← →

chr1:204,982,713-206,329,620

Best TWAS P=1.75e-09 · Best GWAS P=2.61e-08 conditioned to 0.894

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	NUCKS1	0.14	0.11	lasso	3	0.08	3.7e-05	4.9	-5.4	6.3e-08	-0.92	0.01	0.98	FALSE
2	GTEx	Brain Cerebellum	SLC41A1	0.27	0.09	lasso	4	0.08	2.1e-03	5.6	5.3	1.4e-07	0.94	0.01	0.91	FALSE
3	GTEx	Esophagus Mucosa	NUCKS1	0.12	0.11	enet	6	0.06	7.2e-05	-5.2	-5.7	1.5e-08	-0.77	0.02	0.98	FALSE
4	GTEx	Esophagus Muscularis	NUCKS1	0.21	0.22	lasso	5	0.20	3.6e-12	5.6	-5.7	1.1e-08	-0.98	0.00	1.00	FALSE
5	GTEx	Heart Atrial Appendage	NUCKS1	0.12	0.14	enet	4	0.08	1.7e-04	-5.2	-5.6	2.7e-08	-0.80	0.01	0.97	FALSE
6	GTEx	Nerve Tibial	NUCKS1	0.25	0.21	enet	16	0.22	7.3e-16	5.5	-5.2	1.6e-07	-0.95	0.01	0.99	FALSE
7	GTEx	Nerve Tibial	RAB7L1	0.35	0.14	enet	68	0.22	1.8e-15	-4.4	5.5	4.1e-08	0.58	0.14	0.86	FALSE
8	GTEx	Nerve Tibial	SLC41A1	0.12	0.02	lasso	4	0.05	2.5e-04	4.9	5.5	3.0e-08	0.81	0.02	0.98	FALSE
9	GTEx	Pancreas	NUCKS1	0.16	0.00	lasso	4	0.00	4.5e-01	-5.1	-5.7	1.3e-08	-0.85	0.02	0.84	FALSE
10	GTEx	Pituitary	NUCKS1	0.26	0.19	lasso	2	0.20	7.6e-06	5.6	-5.7	1.2e-08	-1.00	0.00	0.98	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	NUCKS1	0.20	0.14	lasso	4	0.13	2.0e-07	5.1	-5.3	9.3e-08	-0.98	0.01	0.99	FALSE
12	GTEx	Skin Sun Exposed Lower leg	NUCKS1	0.20	0.26	lasso	5	0.26	1.5e-21	5.1	-5.1	3.1e-07	-0.95	0.01	0.98	FALSE
13	GTEx	Stomach	NUCKS1	0.21	0.11	lasso	8	0.15	1.1e-07	5.6	-6.0	1.7e-09	-0.92	0.01	0.99	TRUE
14	GTEx	Testis	NUCKS1	0.16	0.16	enet	15	0.16	1.3e-07	5.3	-5.7	1.1e-08	-0.89	0.01	0.99	FALSE
15	GTEx	Thyroid	NUCKS1	0.26	0.16	lasso	6	0.19	1.8e-14	5.3	-5.6	1.9e-08	-0.92	0.01	0.99	FALSE
16	METSIM	Adipose	NUCKS1	0.05	0.02	lasso	6	0.01	4.3e-03	5.3	-5.7	1.5e-08	-0.88	0.01	0.98	FALSE
17	YFS	Blood	NUCKS1	0.15	0.24	lasso	4	0.25	1.4e-80	5.1	-5.5	4.8e-08	-0.92	0.02	0.98	FALSE
18	YFS	Blood	RAB7L1	0.06	0.07	lasso	6	0.06	1.1e-19	-5.1	5.5	4.2e-08	0.79	0.03	0.97	FALSE
19	YFS	Blood	SLC41A1	0.06	0.05	enet	15	0.05	2.6e-17	5.1	5.1	2.8e-07	0.90	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	RAB7L1	0.02	0.02	enet	5	0.02	3.1e-04	-4.5	5.2	2.3e-07	0.60	0.06	0.88	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAB7L1	0.09	0.13	lasso	6	0.13	3.6e-14	-4.7	5.3	9.6e-08	0.73	0.10	0.90	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RAB7L1	0.09	0.08	enet	11	0.08	1.7e-09	-5.1	5.3	1.0e-07	0.74	0.02	0.98	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAB7L1	0.09	0.08	lasso	2	0.07	1.1e-08	-5.1	5.1	2.8e-07	0.71	0.02	0.98	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RAB7L1	0.06	0.05	enet	6	0.06	2.6e-07	-4.5	5.1	3.0e-07	0.66	0.18	0.79	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RAB7L1	0.06	0.06	blup	46	0.06	5.2e-05	4.9	5.5	4.7e-08	0.88	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RAB7L1	0.09	0.04	blup	46	0.04	1.2e-02	-5.1	5.6	2.6e-08	0.80	0.01	0.91	FALSE
27	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RAB7L1	0.17	0.13	lasso	2	0.11	4.4e-05	-5.2	5.2	2.4e-07	0.70	0.01	0.94	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUCKS1	0.04	0.05	lasso	2	0.03	1.5e-04	4.9	-5.2	1.8e-07	-0.92	0.01	0.98	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	RAB7L1	0.12	0.12	lasso	2	0.12	3.8e-12	-5.2	5.3	9.2e-08	0.69	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Stomach Adenocarcinoma	RAB7L1	0.07	0.04	blup	46	0.07	1.2e-05	5.1	5.1	2.9e-07	0.74	0.02	0.96	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	RAB7L1	0.13	0.17	enet	15	0.21	3.6e-20	-5.2	5.5	4.5e-08	0.83	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	NUCKS1	0.11	0.02	blup	58	0.09	1.9e-03	-4.4	-5.4	5.2e-08	-0.77	0.02	0.60	FALSE