Hub : Genes

SLC41A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.2690 0.1070 6.9e-03 0.092 NA 0.025 NA 0.081 1.2e-03 NA 6.2e-02 NA 2.1e-03
2 GTEx Esophagus Mucosa 0.1740 0.0460 2.8e-06 0.091 NA 0.125 NA 0.092 1.2e-06 NA 1.1e-08 NA 1.0e-06
3 GTEx Nerve Tibial 0.1210 0.0442 8.5e-04 0.021 NA 0.028 NA 0.048 1.2e-02 NA 4.4e-03 NA 2.5e-04
4 GTEx Pancreas 0.2410 0.0730 6.6e-05 0.212 NA 0.120 NA 0.193 2.4e-09 NA 9.8e-06 NA 1.4e-08
5 GTEx Spleen 0.4180 0.1100 8.3e-04 0.003 NA 0.007 NA 0.037 2.7e-01 NA 2.0e-01 NA 4.0e-02
6 GTEx Thyroid 0.0640 0.0290 6.5e-03 0.002 NA 0.018 NA 0.006 2.2e-01 NA 1.5e-02 NA 1.0e-01
7 GTEx Vagina 0.4550 0.1290 1.6e-03 -0.003 NA 0.083 NA 0.005 3.8e-01 NA 6.1e-03 NA 2.4e-01
8 METSIM Adipose 0.0747 0.0209 3.4e-08 0.076 0.057 0.072 0.066 0.076 1.6e-11 6.8e-09 6.6e-11 3.4e-10 1.9e-11
9 YFS Blood 0.0556 0.0129 4.1e-14 0.051 0.047 0.054 0.047 0.054 2.1e-16 4.6e-15 2.6e-17 5.0e-15 2.6e-17
10 TCGA Breast Invasive Carcinoma 0.0350 0.0162 4.5e-04 0.019 0.012 0.014 NA 0.013 5.8e-05 1.4e-03 6.6e-04 NA 1.0e-03
11 TCGA Testicular Germ Cell Tumors 0.1290 0.0590 1.5e-03 0.032 0.032 0.005 NA 0.025 2.6e-02 2.6e-02 2.0e-01 NA 4.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 1.5 2.3 5.6 2.4 1.7 1.4 2.3 -0.4 1.5 -0.4 0.8 1.3 0.9 -2.0
Bipolar Disorder or Schizophrenia 1.2 2.9 8.4 2.9 2.0 0.6 2.4 -0.4 1.1 -0.2 1.1 2.1 -0.2 -2.6
Depressed Affect (Nagel 2018) 2.8 6.0 16.4 3.7 2.8 1.6 2.3 -0.3 2.8 0.2 1.7 2.9 -0.9 -4.0
Depression (Nagel 2018) 0.7 1.1 3.4 -0.3 0.0 -1.8 -0.3 -1.7 1.3 -0.2 0.0 0.3 -1.3 -1.2
Intelligence (Savage-Jansen 2018) 1.2 3.7 9.6 -1.7 -1.0 -1.6 -2.1 2.0 -2.8 -0.8 -0.7 -2.5 0.7 3.1
Neuroticism (Nagel 2018) 2.8 6.7 15.2 3.7 3.9 1.9 2.3 -0.6 3.0 0.6 1.7 3.1 0.1 -3.6
Schizophrenia (2018) 0.6 1.2 3.3 1.8 1.1 -0.3 1.2 -0.2 0.3 0.0 0.8 1.6 -1.0 -1.6
Schizophrenia vs Biploar Disorder 0.7 1.0 2.6 -0.9 -1.1 -1.6 -1.3 -0.7 -1.5 -0.5 -0.5 -0.6 -0.9 0.6
Worry (Nagel 2018) 3.3 6.9 15.4 3.8 3.9 2.2 2.7 -1.0 2.5 1.0 1.3 3.4 0.8 -3.5
Alzheimer’s Disease (in mother) 0.6 0.7 1.5 0.3 -0.0 1.2 1.2 0.6 1.1 0.9 1.1 1.2 -0.1 -0.0
Alzheimer’s Disease (in father) 2.0 2.1 6.1 2.5 1.1 1.2 2.0 0.4 1.6 0.5 1.6 1.6 -0.1 -1.7
Alzheimer’s Disease (including proxy) 0.8 1.1 2.9 1.3 0.8 0.8 1.7 0.5 1.4 1.0 1.2 1.2 0.3 -0.6
Crohns Disease (2017) 1.0 2.2 5.2 2.3 0.6 1.8 1.8 0.5 1.0 0.8 1.3 2.1 -0.1 -2.0
Irritable Bowel Disease (IBD) 1.8 4.4 10.9 3.3 0.7 2.6 2.8 -0.2 2.0 -0.3 1.9 2.5 1.3 -2.4
Ulcerative Colitis (UC) 2.7 5.0 10.0 3.2 0.6 2.9 3.1 -0.5 2.7 -0.5 2.0 2.3 2.4 -2.0
Major Depression (MDD) 1.4 1.7 3.4 1.1 0.9 0.8 1.0 0.6 1.6 1.6 1.8 1.7 -1.0 -1.4
Reaction Time 7.4 14.1 26.6 3.3 4.3 4.5 5.2 -0.1 3.4 2.5 5.0 4.6 1.6 -3.6
Verbal and Numeric Reasoning (VNR) 1.3 3.0 7.0 -1.4 -0.6 -1.4 -2.1 2.5 -2.0 -0.1 -1.1 -2.7 -0.3 2.3
Breast Cancer 0.5 1.2 4.0 1.5 0.4 2.0 1.2 0.4 1.2 0.4 1.1 0.7 0.6 -0.9
Ovarian Cancer 0.4 0.5 2.3 0.4 0.5 0.3 -0.1 0.6 -0.4 1.5 1.0 0.8 -0.1 -0.8
Prostate Cancer 10.7 15.1 24.3 -4.0 -3.4 -4.9 -4.6 -2.5 -3.2 -4.1 -4.2 -4.9 -0.1 4.3
Age at First Birth 0.2 0.2 1.0 -0.0 -0.4 -0.1 0.4 0.7 -0.2 0.0 1.0 0.5 -0.6 -0.2
Bipolar Disorder (2011) 0.3 0.3 3.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 -1.8
Body Mass Index (BMI) (2010) 6.6 9.1 12.9 -3.0 -3.3 -3.6 -3.5 -1.8 -3.6 -2.8 -3.5 -3.2 -0.0 2.9
Coronary Artery Disease (CAD) 1.8 2.2 5.6 -1.4 -2.2 -1.2 -2.4 0.4 0.5 -0.1 -1.3 -1.8 -2.0 0.7
Crohns Disease (2012) 1.5 2.3 5.4 2.3 1.2 1.7 1.7 0.4 0.8 1.4 1.5 1.9 0.5 -2.0
Mean Putamen Volume 0.8 0.9 2.8 1.3 0.8 0.6 0.7 0.8 1.1 1.7 1.1 0.7 -0.3 -0.6
Fasting Glucose 1.3 1.5 4.4 -1.5 -0.8 -2.1 -1.2 -0.8 -0.9 -0.3 -0.8 -1.3 -2.0 0.3
HbA1C 3.3 3.7 7.2 -2.7 -2.1 -2.7 -2.4 -1.0 -1.4 -1.4 -1.6 -1.7 0.5 2.3
HDL Cholesterol 4.6 7.8 22.1 2.7 2.7 4.7 3.0 0.5 2.2 3.0 2.9 3.2 1.8 -2.1
LDL Cholesterol 0.1 0.2 0.6 -0.1 -0.4 -0.0 -0.3 0.2 0.5 -0.7 -0.3 -0.5 0.5 0.1
Lupus 1.4 2.2 3.9 1.9 0.7 1.4 1.6 -1.9 1.5 1.1 1.0 1.7 2.0 -0.8
Neuroticism (2016) 0.6 0.9 3.5 0.4 0.2 -0.1 0.9 -1.6 -0.1 -0.6 0.7 0.9 -1.1 -1.9
Primary Biliary Cirrhosis 2.0 2.9 6.2 -1.9 -1.6 -1.8 -2.0 -1.1 -2.2 -0.9 -2.5 -1.8 0.0 1.5
Rheumatoid Arthritis 0.7 1.0 3.9 2.0 0.8 0.9 1.2 0.0 -0.1 -0.5 0.6 1.4 0.7 -1.1
Schizophrenia (2014) 0.7 1.6 4.8 2.2 1.6 -0.5 1.6 -0.7 0.6 0.3 0.8 1.5 -0.6 -1.9
Triglycerides 0.4 0.7 2.2 -1.4 -0.7 -1.5 -0.8 0.7 -0.1 0.1 0.0 -0.6 -1.1 0.5
Type 2 Diabetes (T2D) (2012) 3.4 3.9 8.5 -1.9 -2.1 -0.7 -2.2 -1.0 -2.9 -1.5 -2.6 -2.7 0.5 1.9
Ulcerative Colitis 1.4 2.1 4.4 2.1 0.3 1.6 2.0 -0.8 2.0 -0.3 1.4 1.0 1.5 -1.4
Blood Eosinophil Count 0.8 6.3 13.1 -1.8 -0.7 -3.6 -2.2 -3.5 -1.0 -3.0 -3.3 -3.4 -0.8 1.4
Blood Platelet Count 0.2 2.1 9.5 0.2 1.1 -3.1 -1.7 -0.8 -1.5 -0.4 -1.5 -1.6 1.2 0.2
Blood Red Count 0.2 1.8 6.5 -1.8 -2.5 1.0 -0.2 0.9 0.4 -2.1 0.2 -0.5 1.2 1.3
Blood White Count 0.5 3.6 13.6 0.6 -0.3 -2.0 0.4 -3.7 0.8 -2.2 -0.3 -0.4 -3.0 -2.6
Heel T-Score 0.2 1.4 3.5 -1.7 -1.4 -1.7 -1.4 0.7 -1.9 -0.3 -0.7 -0.9 -0.4 0.9
BMI 2.2 12.8 26.3 -3.2 -4.1 -4.5 -5.1 -2.9 -2.1 -2.0 -4.1 -4.6 -1.9 3.2
Height 2.5 47.7 123.2 -11.1 -6.2 -8.3 -8.4 -0.3 -6.0 -0.6 -3.8 -8.6 -3.8 9.2
Waist Hip Ratio (WHR) 0.3 1.5 12.0 0.1 0.3 -0.1 0.0 3.5 -1.4 -0.7 0.2 0.1 -1.1 -1.0
Systolic Blood Pressure 0.4 2.0 4.5 1.9 0.1 1.6 1.9 -1.3 1.4 0.6 0.3 2.1 1.3 -1.3
Smoking Status 1.4 3.3 7.0 2.7 2.4 2.3 1.7 0.4 1.8 0.2 1.6 2.0 -0.3 -2.0
Allergy or Eczema 0.6 1.5 5.0 -1.6 -0.8 -0.2 -1.3 1.6 -2.2 -0.2 -0.0 -0.7 -0.7 1.6
Cardiovascular Disease 2.0 6.5 13.8 3.6 1.8 2.5 3.0 -1.2 3.3 1.7 1.4 3.0 0.5 -3.7
Hypothyroidism (self reported) 0.3 0.8 3.4 0.7 0.7 0.9 0.7 0.4 0.6 -0.3 1.9 1.1 0.8 -0.4
Respiratory disease 0.3 0.6 2.0 -0.5 0.2 -0.1 -0.8 1.1 -1.0 1.4 -0.0 -0.7 -0.6 0.9
Type 2 Diabetes (T2D) (2018) 2.2 4.2 16.2 -1.9 -1.1 -2.2 -2.7 0.7 -2.4 0.7 -0.5 -1.4 -4.0 2.1
Lung FEV1/FVC ratio 4.2 21.4 38.2 -5.0 -4.0 -6.2 -5.4 -0.8 -3.9 -4.3 -5.1 -5.9 -3.6 4.4
Lung FVC 1.9 9.4 24.8 4.4 3.8 3.6 2.8 0.5 2.1 1.1 1.1 3.2 5.0 -2.5
Neuroticism 3.6 8.8 22.2 4.3 3.6 2.2 2.9 -1.0 3.0 0.5 1.8 3.9 -1.0 -4.7
Chronotype (morning person) 0.4 0.8 2.4 -0.4 -0.7 -0.1 -0.9 0.6 1.5 -1.3 -1.0 -1.2 0.0 0.7
Hair Pigment 0.8 23.6 44.4 6.7 4.9 6.7 5.6 -1.4 4.1 2.5 3.2 6.5 3.8 -4.9
Tanning 0.0 0.2 0.8 -0.4 0.3 -0.1 0.5 0.2 -0.1 0.1 0.9 -0.7 -0.2 -0.2
Hand grip strength (left) 11.4 30.2 48.7 -7.0 -5.9 -6.5 -6.8 -1.1 -5.9 -2.7 -4.8 -6.8 -2.5 6.5
Number of treatments/medications taken 5.5 9.9 14.2 3.8 3.8 3.8 3.3 0.3 3.2 2.7 2.9 3.8 0.8 -3.8
Average weekly spirits intake 1.1 1.4 5.9 0.2 -1.0 -0.7 -1.0 -1.2 -0.8 -1.9 -2.4 -1.0 -0.0 0.7
Sensitivity / hurt feelings 1.3 2.2 6.3 1.8 1.4 0.4 1.2 -2.5 1.8 -0.5 0.8 1.4 1.7 -1.5
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.9 0.3 1.1 -0.5 0.9 -1.3 1.7 -0.1 0.8 0.9 -0.1 -1.6
Hearing difficulty/problems: Yes 3.1 4.8 10.4 -3.1 -1.6 -2.5 -2.6 0.3 -3.2 -0.6 -2.0 -2.3 -1.5 2.3
Relative age of first facial hair 1.4 2.9 5.4 2.1 2.3 1.8 1.3 -1.1 2.1 2.3 0.7 1.6 0.8 -1.6
Other serious medical condition/disability diagnosed by doctor 3.8 4.9 12.3 2.0 2.1 2.4 2.5 0.2 3.2 0.1 1.6 2.4 3.5 -1.7
Ever used hormone-replacement therapy (HRT) 1.4 1.8 9.9 0.3 -0.3 1.1 0.4 -2.0 0.6 -1.8 -1.1 -0.3 3.1 0.1
Ever had hysterectomy (womb removed) 0.3 0.3 2.2 -0.4 -0.1 0.2 -0.0 0.6 -1.5 0.5 -0.1 -0.1 0.7 0.3
Systolic blood pressure, automated reading 0.5 1.4 4.0 0.5 0.3 1.6 1.7 -1.0 1.3 0.4 0.9 2.0 -0.5 -1.6
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 8.0 0.3 1.2 0.3 -0.1 2.8 -0.9 1.6 1.1 0.5 -1.1 0.1
Angina 0.4 0.5 2.2 0.4 1.3 0.6 0.6 0.5 0.0 0.7 0.2 0.8 -0.0 -1.5
Medication for hormone replacement therapy 0.7 0.8 3.4 0.6 1.4 0.7 0.7 -0.6 0.4 -0.5 0.0 1.0 1.9 -0.5
Vitamin and mineral supplements 4.7 6.4 12.4 -3.5 -1.8 -3.5 -3.4 -1.4 -2.0 -0.8 -2.6 -2.9 -0.8 2.9
Supplements: Zinc 0.5 0.6 2.9 -0.4 -1.4 -0.2 -0.1 -0.1 0.0 -1.7 -0.5 -0.9 -0.0 0.6
Medication: Co-codamol 0.9 1.0 2.0 0.8 0.3 0.9 1.4 -0.7 1.4 0.9 1.2 1.4 0.4 -1.1
Medication: Metformin 1.4 2.0 5.2 -1.8 0.3 -1.0 -1.9 1.2 -0.6 2.3 -0.3 -1.4 -1.4 1.9
Diabetes (father) 0.4 0.5 1.6 -0.3 0.1 0.6 0.4 1.3 0.9 0.7 0.5 0.3 1.2 0.7
Diabetes (mother) 0.6 0.7 2.4 -0.5 -1.3 -0.7 -0.5 0.5 -0.9 -1.5 0.4 0.3 -1.2 0.0
Severe depression (siblings) 4.6 5.1 9.7 2.2 1.9 2.0 3.1 0.8 2.8 2.4 2.3 2.6 0.2 -2.7
Pack years adult smoking proportion 0.6 0.9 2.6 -0.7 1.1 -1.4 -0.5 -0.8 -1.6 1.0 -0.3 -0.1 -0.9 -0.7
Impedance of leg (right) 3.9 18.7 30.7 5.3 4.6 5.5 5.0 4.0 4.0 3.0 3.6 5.1 1.3 -4.3
Leg fat-free mass (left) 6.2 32.7 57.3 -7.6 -5.9 -7.4 -7.1 -3.4 -4.9 -2.0 -4.7 -7.3 -2.3 6.5
Trunk fat percentage 0.3 1.1 3.5 -0.6 -1.3 -0.9 -1.2 -1.9 0.1 -0.0 -1.0 -0.7 -1.4 -0.6
Hand grip strength (right) 12.7 34.5 58.5 -7.7 -5.5 -6.7 -7.6 -0.4 -6.8 -2.8 -5.2 -7.3 -2.2 7.1
Townsend deprivation index at recruitment 1.8 2.5 4.2 1.7 1.8 1.9 1.7 -0.1 2.0 1.3 1.3 2.0 0.2 -2.0
Current tobacco smoking 0.5 0.9 2.4 1.1 1.1 1.0 0.7 -0.3 0.1 -1.4 0.0 1.1 0.0 -1.6
Average weekly fortified wine intake 2.8 3.3 7.8 2.4 1.1 2.8 2.3 -0.9 0.9 1.4 1.0 1.9 1.8 -2.2
Maternal smoking around birth 0.4 0.6 1.8 0.5 0.7 -0.1 1.3 -0.2 0.6 -0.7 0.8 0.1 0.4 -1.4
Fed-up feelings 0.8 1.4 3.7 1.9 1.6 0.5 0.8 -0.7 0.2 0.6 0.9 1.7 -0.7 -1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.9 10.7 -0.3 -0.9 -1.3 -0.1 -3.3 1.7 -1.2 -1.1 -0.5 1.2 -0.5
Relative age voice broke 0.4 0.6 1.9 0.6 0.2 0.6 0.6 -0.6 1.4 0.9 0.0 0.7 -0.9 -1.2
Taking other prescription medications 2.0 3.1 8.3 1.9 2.9 1.2 1.6 1.4 2.2 1.4 1.9 1.9 0.9 -1.2
Age when periods started (menarche) 5.4 13.0 22.8 4.8 4.6 3.4 3.9 1.8 4.0 2.7 2.6 4.8 0.3 -4.0
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 3.6 -0.4 -0.9 0.1 -0.4 -0.8 -0.8 -0.6 -1.9 -1.0 1.3 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 4.8 -1.6 -0.1 -2.2 -0.8 -0.5 -0.7 0.8 0.1 -0.8 -2.1 0.3
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.7 0.2 -1.4 -0.4 -0.5 -1.0 -0.9 -0.2 -1.1 -1.3 1.6 1.1
Qualifications: CSEs or equivalent 0.5 0.7 2.3 1.1 1.5 0.4 0.9 0.4 0.6 0.2 0.3 0.9 1.3 -0.5
Serious illness, injury or assault to yourself 0.9 1.1 2.7 1.0 1.3 1.0 0.9 0.3 0.6 0.9 0.4 1.6 1.0 -1.6
High blood pressure 1.8 5.0 11.6 3.4 2.0 2.5 2.3 -0.9 2.5 0.9 1.3 2.9 0.7 -3.0
Hayfever, allergic rhinitis or eczema 0.6 1.2 4.1 -1.9 -0.6 0.1 -0.9 2.0 -0.9 0.3 0.4 -0.7 -0.2 1.8
Multivitamins +/- minerals 8.4 10.7 20.1 4.0 2.6 4.5 4.2 1.7 3.0 1.2 3.1 4.1 2.1 -3.5
Stomach or abdominal pain in last month 1.2 1.5 5.4 1.8 2.3 0.5 1.3 -1.3 0.4 -0.4 -0.1 1.2 0.1 -1.7
Supplements: Glucosamine 3.0 3.9 9.2 2.0 0.7 1.9 2.9 -1.2 1.9 0.2 2.6 2.3 0.6 -3.0
Diverticular disease/diverticulitis (self-reported) 1.9 2.3 6.1 1.8 2.5 1.0 1.6 2.1 1.2 1.2 1.4 1.2 0.4 -1.2
Medication: Atenolol 1.9 2.4 6.0 2.0 1.3 2.0 1.6 -0.5 2.4 -0.3 0.9 1.4 0.5 -2.1
Medication: Levothyroxine sodium 1.8 3.0 7.7 1.6 1.8 2.1 2.0 1.5 1.5 0.5 2.8 1.7 1.8 -1.0
Sitting height 7.4 52.8 94.5 -9.7 -7.5 -9.4 -9.2 -3.4 -5.2 -3.0 -5.9 -9.1 -2.8 9.3
Chronic bronchitis/emphysema (father) 0.7 0.9 6.5 0.0 0.7 -0.4 -0.6 -2.5 0.8 -0.4 -0.8 -0.1 -0.7 -0.1
High blood pressure (mother) 1.6 2.2 5.6 1.9 1.8 1.1 1.6 0.2 1.5 1.0 1.4 1.4 -0.7 -2.4
Body mass index (BMI) 0.9 3.9 7.0 -1.8 -2.3 -2.4 -2.6 -2.5 -1.0 -0.8 -2.3 -2.6 -1.4 1.0
Impedance of leg (left) 3.4 16.7 28.0 4.9 4.3 5.3 4.8 3.6 4.0 2.8 3.5 4.9 1.1 -4.1
Leg predicted mass (left) 6.2 32.8 58.1 -7.6 -5.9 -7.4 -7.1 -3.4 -4.9 -2.1 -4.7 -7.3 -2.3 6.5
Trunk fat mass 1.3 5.7 10.7 -3.1 -2.9 -2.9 -3.3 -2.2 -1.3 -0.5 -2.1 -2.9 -1.9 1.6
Waist circumference 1.1 4.2 8.2 -2.6 -2.3 -2.5 -2.9 -0.9 -1.7 -0.4 -1.8 -2.7 -1.3 1.6
Number of incorrect matches in round 5.9 9.7 21.2 4.2 3.3 3.7 4.0 -0.5 2.6 0.7 1.8 4.0 0.9 -4.6
Past tobacco smoking 1.1 2.1 5.7 -2.4 -1.6 -2.2 -1.2 -0.1 -2.0 -1.0 -0.8 -1.1 -1.0 0.8
Alcohol usually taken with meals 0.9 1.4 3.7 1.1 -0.5 1.7 1.9 0.4 0.7 0.2 1.9 1.2 1.4 -0.4
Nervous feelings 3.3 6.1 11.4 3.0 3.4 1.9 2.8 -1.4 2.5 0.4 1.4 3.4 3.0 -2.1
Frequency of tenseness / restlessness in last 2 weeks 1.8 2.7 6.1 2.4 1.3 0.9 1.2 -2.1 2.5 0.1 0.8 2.1 0.2 -2.1
Hearing difficulty/problems with background noise 9.4 15.0 28.8 -5.3 -3.6 -5.4 -4.8 -0.8 -4.0 -1.7 -3.0 -4.0 -3.5 4.0
Hair/balding pattern: Pattern 2 1.0 1.3 3.2 -0.6 -0.2 -1.6 -1.7 1.6 -0.6 0.5 -0.4 -1.1 -0.3 1.8
Had menopause 0.7 0.8 3.0 0.1 -0.7 1.7 0.6 -1.6 1.0 0.9 0.0 0.5 0.5 -0.8
Had other major operations 0.6 0.7 4.0 -0.3 1.3 0.2 0.1 -0.2 -0.8 -0.8 -0.5 -0.1 2.0 -0.4
Forced vital capacity (FVC) 0.5 2.0 4.5 -1.0 -0.0 -1.2 -1.9 0.2 -1.3 0.4 -1.9 -1.3 2.1 2.1
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.2 7.8 -2.4 -0.9 -2.8 -1.9 -1.4 -1.8 1.1 -1.0 -1.7 -2.1 1.5
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.3 1.0 1.1 0.1 0.6 -0.2 -0.6 -0.2 0.2 0.4 0.7 -0.8
Qualifications: None of the above 1.7 3.6 9.1 2.6 0.9 1.3 1.6 -3.0 2.9 0.8 -0.3 1.6 1.2 -2.2
Financial difficulties in last 2 years 0.5 0.6 5.3 -0.2 -0.5 0.1 -0.1 -0.2 -2.3 0.2 0.0 0.1 1.0 0.3
Mouth/teeth dental problems 1.9 2.9 5.1 -0.8 -2.2 -1.5 -2.2 1.7 -1.8 -2.0 -1.6 -1.5 -0.6 2.3
Heart attack 1.0 1.3 4.1 1.7 2.0 0.6 0.8 -0.5 1.4 0.2 0.5 0.8 -0.8 -1.5
Allergy 0.6 1.4 3.9 2.0 -0.2 0.5 1.1 -1.9 1.4 -0.1 0.2 1.2 -0.1 -1.9
Pain all over the body in last month 0.8 0.9 2.7 -1.2 -0.1 -1.2 -0.6 -1.1 -0.2 -1.6 0.1 -0.3 1.0 1.2
Diabetes (self-reported) 1.5 2.3 7.3 -1.7 0.2 -1.1 -1.7 1.5 -1.2 2.0 -0.0 -0.8 -2.7 1.7
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 4.2 -0.2 0.7 -0.5 -0.6 0.6 -0.3 -0.6 -0.8 -1.0 2.1 2.0
Medication: Ramipril 1.6 2.0 5.2 1.8 1.0 1.4 1.1 -0.7 2.3 1.2 0.3 1.5 -0.7 -2.2
Medication: Simvastatin 1.5 2.2 5.3 1.5 1.4 1.8 1.1 0.2 1.9 2.3 1.7 1.4 0.3 -1.3
Fluid intelligence score 1.1 2.2 6.7 -1.2 -0.4 -0.7 -1.8 2.6 -1.7 -0.1 -1.0 -2.1 0.2 2.0
Illnesses of siblings 0.3 0.4 1.3 -0.1 0.5 -0.5 -0.3 0.7 -0.3 -0.2 0.5 -0.6 1.1 1.1
Neuroticism score 4.2 8.8 20.3 4.1 3.4 2.5 3.1 -1.4 3.1 0.6 2.0 4.1 0.3 -4.5
Weight 3.9 19.0 33.9 -5.8 -4.8 -5.3 -5.6 -3.0 -3.2 -1.3 -3.8 -5.6 -2.0 4.7
Impedance of arm (right) 3.0 14.1 24.2 4.8 3.9 4.2 4.7 2.3 3.1 1.8 3.6 4.9 1.1 -4.4
Arm fat percentage (right) 0.3 1.1 2.7 -0.2 -1.0 -1.0 -1.1 -1.6 0.4 0.1 -1.1 -0.9 -1.6 -1.0
Trunk fat-free mass 6.0 34.3 73.4 -8.6 -5.9 -7.1 -7.2 -1.8 -5.0 -1.4 -4.1 -7.6 -2.4 7.5
Hip circumference 1.7 7.2 12.1 -3.4 -3.1 -3.2 -3.5 -2.4 -1.9 -0.4 -2.0 -3.4 -1.9 2.6
Time employed in main current job 0.2 0.3 1.0 0.4 -0.1 0.4 0.5 -0.1 1.0 0.1 0.7 0.6 -0.6 -0.7
Alcohol intake versus 10 years previously 0.4 0.6 2.2 0.2 0.2 -0.2 -0.1 -1.5 0.4 -1.1 -1.1 -0.9 0.6 0.1
Father’s age at death 0.6 0.8 3.2 0.0 -1.8 0.7 0.0 1.0 -1.6 -0.9 0.4 0.6 0.5 0.0
Worrier / anxious feelings 3.0 5.6 13.3 2.8 3.2 1.7 2.5 -1.6 2.6 0.9 1.4 3.1 0.4 -3.6
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 3.7 0.1 0.8 -1.9 -0.8 -1.9 0.6 -0.8 -0.6 -0.7 -0.9 -0.2
Falls in the last year 2.2 2.9 5.0 -2.2 -1.8 -1.6 -2.2 -0.4 -1.3 -1.4 -2.0 -1.9 0.5 2.2
Hair/balding pattern: Pattern 3 2.6 3.8 9.4 2.1 2.9 1.3 2.5 0.2 1.8 0.8 1.9 1.7 -1.0 -3.1
Number of live births 1.6 2.3 6.3 2.5 2.1 1.7 1.8 -0.1 0.3 0.7 1.2 1.4 0.2 -2.1
Forced expiratory volume in 1-second (FEV1) 1.7 5.9 11.3 -2.4 -1.3 -3.0 -3.3 0.2 -2.5 -0.5 -3.4 -3.0 1.0 3.1
Pulse rate 1.0 1.6 5.0 -0.5 0.0 -1.2 -1.9 -2.2 -0.5 -0.1 -2.2 -1.2 0.1 1.2
Happiness 0.2 0.2 0.6 -0.1 0.5 0.6 0.8 0.0 -0.0 -0.2 0.6 0.4 0.1 -0.6
Noisy workplace 0.4 0.5 2.0 0.8 -0.7 0.1 0.6 -1.1 -0.0 -0.3 -0.2 0.9 -0.4 -1.4
Qualifications: A levels/AS levels or equivalent 1.0 2.3 6.1 -2.5 -1.3 -1.5 -1.5 0.7 -2.0 -0.2 -0.1 -1.0 -1.9 1.9
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 4.8 0.1 0.3 1.5 1.3 2.2 -0.4 0.7 1.4 1.0 1.2 -0.1
Mouth/teeth dental problems: Dentures 0.7 1.2 5.1 0.1 0.8 -0.3 0.8 -2.3 1.5 -0.7 -0.3 0.3 0.7 -1.7
Asthma 0.4 0.9 3.6 0.7 1.7 0.4 0.5 1.0 0.2 1.9 1.0 -0.0 -0.6 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 3.9 1.3 1.0 2.0 0.6 0.1 0.4 0.7 1.2 1.7 -0.0 -1.0
Medication: Cholesterol lowering 1.3 2.0 4.3 1.8 1.8 1.3 0.9 0.5 2.1 1.7 0.7 1.2 0.3 -1.8
Depression (self-reported) 2.4 2.8 5.8 1.0 2.4 1.5 1.9 1.0 1.4 1.6 1.9 2.2 0.6 -2.1
Medication: Lansoprazole 0.2 0.3 1.5 -0.1 0.1 0.6 -0.0 -0.5 0.3 0.5 -0.1 0.5 1.2 -0.0
Prospective memory result 0.6 0.8 2.2 1.2 -0.4 0.1 1.1 -0.6 1.0 -0.5 0.6 1.0 -0.8 -1.5
Lung cancer (father) 0.7 0.8 3.5 0.0 -1.2 -1.1 -0.3 -1.9 -0.6 0.1 -0.9 -0.4 -0.8 -0.5
Illnesses of mother 1.0 1.2 2.5 -0.8 -0.3 -1.3 -1.4 1.2 -1.5 0.4 -0.8 -1.4 0.1 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 6.4 -1.2 -0.9 -2.5 -2.3 0.5 -1.6 0.4 -2.5 -2.1 1.0 2.4
Pulse wave Arterial Stiffness index 1.6 1.9 4.6 1.5 0.5 1.2 1.7 -0.1 0.8 0.7 1.7 2.1 -1.4 -1.8
Impedance of arm (left) 2.2 10.1 18.0 3.9 3.6 3.8 4.0 2.0 2.6 0.5 2.9 4.2 1.3 -3.6
Arm fat mass (right) 1.6 6.6 11.7 -3.2 -3.0 -3.2 -3.4 -2.2 -1.5 -0.8 -2.4 -3.4 -2.0 1.7
Trunk predicted mass 6.1 35.1 74.5 -8.6 -6.0 -7.2 -7.3 -1.9 -5.0 -1.5 -4.2 -7.7 -2.4 7.6
Standing height 3.6 36.0 87.0 -9.3 -6.0 -6.9 -7.1 -1.1 -5.2 -1.6 -3.8 -7.5 -1.7 8.4
Length of working week for main job 0.8 0.9 1.8 0.6 -1.3 0.1 -0.8 1.4 -0.7 -1.2 -0.9 -0.7 0.6 1.2
Exposure to tobacco smoke at home 0.5 0.5 2.2 -0.3 -0.0 0.1 0.6 -0.5 1.2 1.5 0.1 0.5 -0.4 -1.0
Breastfed as a baby 4.1 5.1 14.3 2.2 2.1 3.8 2.9 1.9 2.1 0.4 2.1 2.4 1.7 -1.7
Tense / ‘highly strung’ 7.1 11.7 20.2 4.2 3.9 4.0 4.0 -0.5 3.7 1.5 3.5 4.5 1.6 -3.7
Seen doctor (GP) for nerves, anxiety, tension or depression 5.6 8.6 18.5 3.4 4.3 2.8 3.5 1.0 2.4 1.9 2.6 3.8 1.7 -3.2
Hair/balding pattern: Pattern 4 0.8 1.9 4.5 -1.7 -2.1 -1.2 -1.2 -1.5 -0.8 -1.4 -1.8 -1.0 0.6 0.9
Birth weight of first child 2.1 3.9 9.8 -3.1 -2.1 -2.1 -2.6 0.2 -1.9 -0.3 -1.5 -1.9 -0.1 2.8
Peak expiratory flow (PEF) 14.8 34.4 51.3 -6.7 -6.2 -6.4 -7.2 -1.3 -6.6 -4.2 -6.7 -7.1 -1.3 6.5
Pulse wave reflection index 5.4 6.7 12.9 2.4 1.6 3.0 3.4 1.9 2.6 2.1 3.6 3.1 -0.6 -2.6
Ever highly irritable/argumentative for 2 days 1.0 1.2 5.2 1.7 0.8 -0.1 -0.1 -2.3 -0.1 -0.2 -1.3 0.4 1.1 -1.2
Loud music exposure frequency 0.7 0.8 1.8 -0.3 -1.1 -1.0 -1.2 -0.6 -0.8 -0.6 -0.3 -0.9 -0.7 1.4
Qualifications: O levels/GCSEs or equivalent 2.7 4.4 11.2 -3.3 -1.4 -1.9 -2.0 1.3 -2.6 -1.2 -0.9 -2.4 -1.7 2.8
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 6.7 0.2 -0.0 1.1 0.7 -1.2 1.1 2.6 1.6 0.7 -0.2 0.1
Blood clot in the leg (DVT) 1.1 1.4 5.3 -2.0 -1.1 -0.3 -0.6 0.0 -0.4 -2.3 -1.1 -1.3 0.8 1.1
Medication: Paracetamol 2.0 3.3 7.6 2.5 2.6 2.0 1.6 1.2 1.1 1.3 0.8 2.1 -0.1 -2.8
Headache pain in last month 2.1 3.7 7.5 2.7 2.1 2.4 2.0 0.7 1.1 1.0 2.2 2.4 0.3 -2.4
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 6.1 -2.1 -1.5 -0.8 -0.6 0.5 -1.9 -1.8 -0.5 -1.7 0.4 2.5
Glaucoma (self-reported) 1.1 1.2 3.2 1.4 0.8 0.8 1.2 -0.0 -0.4 1.8 -0.1 1.1 -1.2 -1.7
Gout (self-reported) 1.0 1.4 3.5 -1.1 -1.4 -1.2 -1.8 0.3 -1.4 -0.4 -0.9 -0.8 -0.3 1.9
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 4.1 1.0 1.0 1.4 1.1 1.0 0.5 -0.0 2.0 1.3 1.0 -0.5
Medication: Amlodipine 0.7 1.0 2.8 0.7 0.5 1.3 0.8 -0.4 1.1 0.6 1.7 1.5 -0.3 -1.0
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.9 0.5 0.5 0.3 -0.4 -0.5 0.2 0.6 -0.4 -0.3 0.9 -0.2
Birth weight 5.5 11.9 28.4 -5.3 -3.5 -3.3 -4.2 1.2 -4.0 -1.0 -1.6 -4.2 -1.9 4.5
Chronic bronchitis/emphysema (mother) 0.9 1.0 5.3 -0.7 -0.0 -0.0 1.1 -2.3 1.5 -1.0 -0.4 -0.0 0.3 -0.7
High blood pressure (siblings) 0.8 1.1 3.9 1.0 0.5 0.7 1.2 -1.4 0.9 0.3 -0.0 0.9 -1.3 -2.0
Forced vital capacity (FVC), Best measure 0.3 1.2 4.4 -0.1 -0.1 -1.1 -1.1 0.8 -0.4 1.1 -1.2 -0.5 2.1 1.6
Body fat percentage 0.2 0.9 3.3 -0.2 -1.1 -0.7 -1.1 -1.8 0.5 0.3 -1.0 -0.7 -1.3 -0.9
Leg fat percentage (right) 0.2 0.7 2.4 1.0 -0.0 0.6 -0.1 -1.0 1.5 0.7 -0.4 0.2 -0.4 -1.5
Arm fat-free mass (right) 6.7 34.5 68.4 -8.3 -6.0 -6.8 -7.4 -2.4 -5.0 -2.0 -4.6 -7.6 -2.0 7.4
Exposure to tobacco smoke outside home 0.5 0.7 1.8 0.6 1.2 0.3 0.6 0.4 -0.2 1.2 0.2 1.1 1.3 -0.7
Comparative body size at age 10 8.1 22.5 36.4 -4.5 -5.0 -5.7 -6.0 -3.2 -4.3 -4.0 -5.6 -5.7 -1.3 4.7
Number of full brothers 0.2 0.3 1.5 0.1 1.2 -0.8 -0.2 0.0 -0.3 -0.6 -0.1 0.3 0.6 0.3
Worry too long after embarrassment 0.3 0.5 2.2 -0.2 1.5 0.4 0.4 0.4 0.9 0.7 0.5 0.9 0.1 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 7.8 10.2 17.0 3.4 4.1 3.0 4.1 -0.7 3.5 1.4 3.3 4.1 2.2 -3.4
Wheeze or whistling in the chest in last year 0.2 0.4 2.2 0.5 0.2 0.2 -0.4 -1.5 -0.1 0.0 -0.9 -0.9 -0.5 -0.2
Number of children fathered 2.7 3.1 9.5 3.1 1.2 2.2 1.2 -0.3 1.8 0.7 1.0 1.2 3.0 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 5.2 1.0 -0.6 -0.7 0.1 0.3 2.3 -1.2 -1.0 -0.2 0.1 -0.6
Age at first live birth 0.6 1.0 3.8 -0.7 -2.0 -0.9 -1.1 1.3 -0.1 -0.5 0.2 -0.4 -1.2 1.1
Pulse wave peak to peak time 2.6 3.1 6.9 -2.2 -0.7 -1.7 -2.1 0.1 -1.3 -0.7 -1.9 -2.6 1.5 2.5
Health satisfaction 0.9 1.1 4.8 1.0 0.3 0.5 0.3 -2.2 -0.5 -1.1 -1.5 0.6 1.2 -0.8
Shortness of breath walking on level ground 0.8 0.9 3.1 0.1 -0.8 -0.1 0.1 -1.3 1.8 -0.6 -1.0 -0.1 1.8 0.8
Qualifications: College or University degree 1.1 3.4 11.2 -1.2 -1.1 -1.3 -2.0 3.4 -3.2 -0.8 0.3 -1.0 -1.8 1.6
Eye problems/disorders: None of the above 2.2 2.5 5.6 -1.8 -1.8 -1.7 -1.7 -2.4 -0.7 -0.4 -1.4 -1.6 1.0 1.9
Mouth/teeth dental problems: Loose teeth 0.4 0.4 2.5 -0.1 0.3 -0.3 0.3 -1.6 0.1 -0.8 -0.1 0.3 -0.4 -0.9
Emphysema/chronic bronchitis 0.5 0.6 4.2 -0.3 -0.2 -0.3 -0.4 -0.4 0.4 -0.8 -0.3 -0.4 2.0 0.9
Medication for pain relief, constipation, heartburn 4.3 7.4 13.8 -3.3 -3.7 -3.7 -2.7 0.1 -2.5 -1.6 -1.8 -3.4 -0.7 3.5
Neck or shoulder pain in last month 1.5 2.1 5.0 -0.5 -0.9 -2.0 -1.7 -1.8 -1.2 -1.3 -2.2 -1.1 -1.7 0.3
Medication: Blood pressure 1.5 2.6 6.7 2.3 1.6 0.7 1.0 -0.6 1.8 1.4 1.0 2.3 -1.2 -2.6
Angina (self-reported) 0.6 0.7 2.8 0.8 1.4 0.8 0.7 0.2 0.3 0.6 0.2 0.9 0.1 -1.7
Migraine (self-reported) 0.3 0.3 1.5 1.2 0.1 0.2 -0.4 -0.7 0.5 0.4 -0.6 -0.0 -0.0 -0.7
Medication: Ibuprofen 1.0 1.2 3.4 1.6 0.6 1.8 1.0 0.3 0.4 -0.1 1.2 1.5 0.7 -1.1
Medication: Allopurinol 0.4 0.5 1.8 -0.5 -0.3 -0.8 -1.0 1.0 -0.9 0.2 -0.1 -0.2 -0.4 1.3
Medication: Omeprazole 0.2 0.3 0.7 -0.8 0.8 0.1 0.0 0.9 0.5 0.7 0.3 -0.2 0.3 0.5
Medication: Seretide 50 evohaler 0.4 0.5 1.8 0.1 0.5 0.5 0.0 -1.0 1.3 0.0 0.5 -0.4 1.0 0.8
Mean time to correctly identify matches 9.8 18.7 36.5 3.3 4.8 5.2 6.0 0.5 3.9 2.5 6.0 5.4 1.5 -4.2
Heart disease (mother) 0.6 0.7 2.2 0.8 1.5 1.0 0.5 0.3 0.9 0.4 0.7 1.0 -0.3 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.2 0.9 0.6 0.6 0.2 1.1 -0.3 1.1 1.0 0.8 0.0 -0.1
Whole body fat mass 1.5 6.2 11.9 -3.1 -2.9 -3.0 -3.4 -2.4 -1.2 -0.6 -2.4 -3.2 -1.9 1.7
Leg fat mass (right) 1.2 4.5 9.0 -2.4 -2.5 -2.6 -3.0 -2.0 -0.6 -0.2 -2.2 -2.9 -1.3 1.4
Arm predicted mass (right) 6.7 34.5 69.1 -8.3 -6.1 -6.8 -7.4 -2.6 -4.8 -1.9 -4.8 -7.6 -1.9 7.4
Pulse rate, automated reading 2.9 9.5 23.6 -3.8 -2.3 -3.5 -4.9 -1.7 -1.9 -1.4 -3.3 -3.7 -1.2 3.8
Alcohol intake frequency. 0.3 0.7 2.0 -0.0 0.3 -1.4 -0.6 -1.4 -0.0 -1.0 -1.0 -0.8 0.7 0.4
Comparative height size at age 10 6.5 35.9 85.4 -9.2 -5.9 -6.5 -6.9 -2.2 -5.3 -2.2 -4.5 -7.2 -1.1 8.5
Number of full sisters 0.3 0.4 2.1 0.2 0.8 -0.3 -0.4 -0.5 -0.8 -0.3 -1.4 -0.2 0.7 0.3
Suffer from ‘nerves’ 0.9 1.5 4.6 1.1 1.3 0.2 0.8 -1.9 -0.3 -1.1 -1.3 0.8 2.1 -1.0
Overall health rating 0.8 1.8 6.0 1.3 2.5 -0.3 0.9 -2.2 1.1 0.3 0.3 1.3 0.9 -1.4
Chest pain or discomfort 0.4 0.5 1.9 0.0 0.8 -0.7 -0.2 -0.5 -1.4 -1.1 -0.3 0.0 -1.2 0.1
Had major operations 1.0 1.2 7.5 0.5 0.2 0.6 0.8 -0.3 1.1 -1.5 -0.1 1.0 2.7 -0.4
Age at last live birth 0.8 1.1 2.6 -0.5 -1.5 -1.1 -1.0 1.6 -0.8 -0.8 0.4 -0.3 -1.4 1.1
Family relationship satisfaction 0.5 0.6 1.9 0.7 -0.1 0.0 0.8 -0.2 0.6 -1.0 0.3 0.6 -1.4 -1.3
Leg pain on walking 0.5 0.6 2.5 0.2 0.2 -1.1 0.2 -1.6 0.5 -0.7 -0.7 0.6 -0.2 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.2 -0.4 -0.3 -0.1 -0.2 -1.5 1.1 -1.1 -0.9 -0.4 1.1 0.2
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.5 0.2 -1.2 -0.3 -0.9 -1.1 0.3 0.9 -0.6 -0.7 0.3 0.6
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 3.9 -0.1 0.4 -0.5 -1.1 -1.3 2.0 0.3 -0.9 -0.7 -1.9 0.1
Medication: Aspirin 2.2 2.9 4.9 1.9 1.7 2.2 1.7 -1.3 1.6 1.4 1.2 2.1 0.7 -2.1
Supplements: Vitamin C 0.6 0.7 2.4 1.3 -0.4 0.8 0.6 0.6 0.5 -0.3 -0.6 0.2 -1.6 -1.3
Knee pain experienced in last month 1.5 2.4 6.8 2.4 0.2 0.6 1.2 -2.6 0.6 -1.7 -0.5 1.5 0.9 -2.3
Hypertension (Self-reported) 1.5 4.1 9.6 3.1 1.8 2.3 2.1 -0.6 2.2 0.7 1.2 2.7 0.6 -2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.2 3.8 0.6 1.3 1.1 1.4 0.8 -0.5 0.6 1.0 1.4 2.0 -0.5
Illnesses of father: Heart disease 2.5 3.5 7.1 2.0 1.4 2.6 2.7 1.6 1.6 0.3 1.8 1.9 0.8 -2.4
Illnesses of siblings: Diabetes 1.1 1.4 3.6 -1.9 -1.5 -0.8 -1.6 -0.8 -1.1 -0.1 -1.1 -1.2 -1.1 0.7
Smoking status: Previous 1.1 1.6 5.0 1.6 0.7 1.8 1.3 0.2 2.2 1.1 1.2 0.6 1.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.1 -2.0 -1.2 -1.1 -1.4 1.4 -0.9 0.4 0.0 -1.7 -0.9 1.9
Whole body fat-free mass 6.4 36.8 71.7 -8.5 -6.2 -7.6 -7.5 -2.5 -5.2 -1.8 -4.6 -7.8 -2.5 7.4
Leg fat-free mass (right) 6.7 35.6 63.4 -8.0 -6.2 -7.7 -7.4 -3.4 -5.1 -2.2 -4.8 -7.6 -2.4 6.9
Arm fat percentage (left) 0.3 1.3 3.6 -0.5 -1.1 -1.2 -1.5 -1.9 0.0 -0.5 -1.4 -1.2 -1.4 -0.6
Average weekly red wine intake 1.0 1.5 3.5 1.8 0.6 1.5 1.4 0.6 0.6 0.7 1.0 1.9 0.4 -1.6
Handedness (chirality/laterality): Left-handed 0.9 1.1 3.1 1.8 -0.2 0.8 1.4 -0.6 1.2 -0.8 0.3 1.3 0.1 -1.4
Mood swings 7.8 14.0 31.6 5.1 4.1 3.3 4.3 0.2 4.1 1.3 3.0 4.9 -0.0 -5.6
Loneliness, isolation 1.0 1.4 4.6 1.8 1.1 0.4 1.2 -0.9 0.9 0.3 0.7 1.6 -0.1 -2.1
Long-standing illness, disability or infirmity 1.7 2.7 6.7 1.5 2.6 0.6 1.0 0.5 1.5 2.5 1.8 2.2 -0.4 -1.3
Ever had bowel cancer screening 0.2 0.3 0.8 -0.6 0.4 0.3 0.6 -0.5 -0.1 -0.5 0.5 0.6 0.9 0.1
Diabetes diagnosed by doctor 1.7 2.7 5.6 -2.1 -0.3 -1.3 -2.1 1.2 -2.0 1.6 -0.2 -1.1 -2.4 2.2
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 2.8 1.5 0.6 1.7 0.7 -0.1 -0.5 -0.7 0.9 1.0 1.6 -0.4
Friendships satisfaction 0.2 0.2 0.9 -0.2 0.5 -0.4 0.7 -0.9 -0.1 -0.2 -0.3 0.3 0.0 -0.5
Qualifications: nursing, teaching 0.5 0.8 4.1 -0.5 -0.2 0.4 0.2 1.4 -0.8 0.3 2.0 0.4 0.7 0.7
Commuting to job workplace: Walk 0.5 0.6 1.7 -0.7 0.7 -0.8 -0.1 1.3 -0.3 0.9 0.7 -0.2 -1.2 -0.3
Eye problems/disorders: Cataract 1.2 1.3 3.0 0.7 1.7 1.0 1.4 1.5 0.4 -0.5 1.4 1.3 -0.8 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.7 0.8 0.7 1.3 1.3 -0.8 0.3 1.0 0.5 0.5 1.2 -0.7
Medication for cholesterol 1.3 2.0 4.0 -2.0 -1.3 -1.9 -1.6 1.0 -1.7 -0.6 -0.3 -1.3 -1.7 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.2 -1.0 0.0 -0.0 0.5 0.3 0.1 -0.6 0.7 0.0 1.1 0.1
Back pain experienced in last month 2.3 3.4 9.8 -0.8 -1.2 -2.2 -2.0 -1.5 -2.2 -2.1 -3.1 -2.0 0.0 1.0
Mineral and other dietary supplements 4.4 5.9 12.7 -3.2 -1.0 -3.6 -3.4 0.1 -1.8 -0.4 -2.9 -3.0 -1.5 2.5
Breast cancer (self-reported) 0.5 0.6 1.4 -0.9 -0.8 0.1 -0.7 0.8 -0.3 -0.2 -0.9 -1.2 0.9 1.0
Asthma (self-reported) 0.4 0.8 3.5 0.6 1.4 0.3 0.5 0.9 0.0 1.9 1.0 -0.0 -0.8 0.2
Osteoporosis (self-reported) 0.8 0.9 2.6 -0.2 1.0 1.3 0.1 1.5 -0.4 1.2 1.6 0.8 -0.8 0.5
Osteoarthritis (self-reported) 3.2 4.1 10.6 3.2 2.1 1.6 2.6 -1.3 1.7 -0.0 1.7 2.2 1.8 -2.3
Medication: Aspirin 2.3 3.0 6.5 2.2 1.8 2.0 1.8 -1.3 1.7 1.0 0.9 2.1 0.4 -2.6
Medication: Gliclazide 1.6 1.8 5.7 0.8 2.4 0.7 -0.3 1.9 -0.4 2.3 -0.1 0.3 -2.0 -0.4
Illnesses of father: None of the above (group 1) 7.4 9.1 17.1 -3.7 -2.9 -3.9 -4.1 -1.0 -3.2 -1.1 -3.1 -3.5 -1.1 3.3
Smoking status: Current 0.5 0.7 2.1 1.0 1.1 0.9 0.3 -0.4 -0.0 -1.3 -0.1 1.0 -0.4 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.8 0.7 0.5 0.0 -0.8 1.0 -0.5 -0.8 -1.2 -0.1 1.3 0.2
Whole body water mass 6.4 36.7 71.1 -8.4 -6.2 -7.5 -7.5 -2.6 -5.2 -1.7 -4.7 -7.8 -2.5 7.4
Leg predicted mass (right) 6.6 35.3 63.2 -8.0 -6.2 -7.7 -7.3 -3.5 -5.0 -2.2 -4.8 -7.6 -2.4 6.8
Arm fat mass (left) 1.7 7.1 13.4 -3.3 -3.0 -3.2 -3.7 -2.2 -1.6 -1.2 -2.7 -3.6 -1.6 2.0
Number of self-reported non-cancer illnesses 2.7 4.6 11.2 2.7 3.4 2.0 2.3 -0.0 2.2 0.8 1.5 2.4 2.4 -2.0
Average weekly champagne plus white wine intake 0.7 1.0 4.5 0.2 0.1 0.2 0.1 2.1 -1.6 0.7 1.7 0.7 -0.4 -0.1
Miserableness 1.2 2.0 6.2 1.7 1.5 1.0 1.0 0.0 1.3 0.7 1.6 1.9 -0.8 -2.5
Guilty feelings 1.2 1.9 4.0 1.4 1.8 1.5 1.5 -1.0 1.6 -0.3 0.8 1.2 1.1 -2.0
Wears glasses or contact lenses 0.2 0.3 1.3 -0.2 -0.2 1.1 0.1 0.3 0.7 -0.2 -0.1 0.5 0.4 -0.7
Ever taken oral contraceptive pill 1.5 1.7 4.5 0.7 1.3 2.0 1.0 0.8 -0.7 2.1 1.0 1.2 -1.1 -1.2
Hearing aid user 0.7 0.8 3.8 -1.1 -2.0 -0.5 -0.5 0.5 0.2 -1.2 -0.6 -0.9 0.7 0.5
Mother’s age at death 4.4 5.5 11.9 -2.0 -2.6 -2.5 -2.8 0.1 -2.1 -2.4 -2.1 -3.5 0.5 3.0
Financial situation satisfaction 2.4 3.0 7.7 -2.8 -0.8 -1.6 -1.7 -0.1 -2.2 -1.3 -2.1 -2.2 -0.1 1.8
Tinnitus: Yes, now most or all of the time 3.2 3.8 6.6 -1.8 -2.5 -2.6 -1.9 -1.5 -1.5 -1.9 -1.9 -2.6 -1.1 1.7
Commuting to job workplace: Public transport 0.6 0.7 3.2 0.1 -0.7 0.8 0.9 1.2 -0.0 -1.8 0.9 0.7 0.1 -0.6
Eye problems/disorders: Glaucoma 0.6 0.7 3.1 1.8 0.6 0.8 0.9 0.6 0.2 0.7 -0.2 0.8 -0.7 -1.1
Medication: Blood pressure 1.9 3.6 6.8 2.6 1.7 2.5 2.3 -1.2 2.1 0.9 1.3 2.2 1.8 -1.6
Pain type(s) experienced in last month: Hip pain 0.9 1.1 3.6 1.4 0.2 0.1 0.5 -1.8 -0.6 -0.3 -1.0 0.7 0.9 -1.9
Supplements: Fish oil (including cod liver oil) 2.4 3.2 6.8 2.6 0.3 2.5 2.6 -0.1 1.6 1.0 2.0 2.0 1.1 -1.5
High cholesterol (Self-reported) 1.5 2.6 9.5 1.6 0.7 1.7 1.7 -1.1 3.1 1.5 0.7 1.2 0.8 -2.1
Medication: Bendroflumethiazide 2.0 3.0 7.6 2.8 1.1 1.7 1.8 -1.1 1.6 1.1 1.1 2.3 1.8 -1.9
Medication: Paracetamol 3.6 5.5 11.2 3.3 3.4 2.4 2.2 1.7 1.2 1.9 1.6 2.8 -0.2 -3.1
Medication: Lisinopril 0.6 0.8 4.8 0.1 -0.1 0.8 -0.1 0.4 0.3 0.9 0.5 0.1 2.2 1.4
Medication: Atorvastatin 0.5 0.6 3.0 -0.1 -0.6 0.1 -0.2 -0.7 -0.2 -0.6 -1.4 -0.5 1.7 0.1
Illnesses of father: High blood pressure 3.2 3.9 7.1 1.8 2.7 1.8 2.4 2.0 1.7 1.8 2.3 1.9 -0.3 -2.1
Alcohol drinker status: Never 1.1 1.4 2.4 1.4 1.5 1.3 0.7 1.2 0.2 -0.1 1.6 1.5 1.3 -0.8
Ever smoked 1.6 2.8 6.2 2.5 1.8 2.5 1.3 1.6 1.9 1.6 1.1 1.4 0.6 -1.1
Basal metabolic rate 6.0 33.5 63.5 -8.0 -5.9 -7.3 -7.2 -2.7 -4.8 -1.7 -4.6 -7.5 -2.5 6.9
Leg fat percentage (left) 0.2 0.6 1.9 0.6 -0.2 0.3 -0.3 -1.3 1.3 0.6 -0.5 0.0 -0.7 -1.4
Arm fat-free mass (left) 5.7 29.1 57.0 -7.5 -5.8 -6.5 -6.7 -2.2 -4.3 -1.3 -4.1 -7.1 -2.2 6.8
Number of operations (self-reported) 1.1 1.6 8.5 0.8 1.5 1.1 0.9 -1.4 -0.0 -1.4 0.2 0.7 2.9 -0.3
Average weekly beer plus cider intake 5.6 8.1 14.1 3.6 3.7 3.3 2.5 2.1 3.8 2.1 2.5 2.9 1.0 -2.6
Irritability 0.8 1.3 3.2 1.5 1.1 0.7 0.6 -1.2 1.8 0.1 0.2 1.1 -1.1 -1.8
Risk taking 2.4 3.5 6.8 2.6 1.0 2.4 2.2 1.3 1.9 1.3 1.5 2.1 -0.1 -2.4
Ever had prostate specific antigen (PSA) test 4.5 5.2 9.9 -3.1 -2.6 -2.5 -2.6 -2.1 -0.8 -2.2 -2.2 -2.2 1.7 2.2
Fractured/broken bones in last 5 years 0.4 0.5 1.6 -1.0 -0.9 -0.8 -0.0 -0.8 -0.2 -1.3 0.1 -0.5 -0.5 0.7
Age started oral contraceptive pill 0.9 1.2 3.8 -0.6 -0.3 2.0 1.2 1.7 -0.1 0.7 1.8 0.7 0.2 0.0
Diastolic blood pressure, automated reading 0.3 0.8 2.6 0.5 -0.3 0.8 0.7 -0.9 1.6 0.6 0.5 1.0 -1.2 -1.0
Ever depressed for a whole week 0.3 0.4 1.6 0.7 0.5 -0.1 0.6 -1.3 -0.4 -0.1 -0.1 0.1 1.2 -0.3
Unable to work because of sickness or disability 0.2 0.3 0.9 0.7 0.5 -0.9 0.0 -0.2 0.3 0.2 -0.3 0.8 0.7 -0.5
Commuting to job workplace: Cycle 0.5 0.6 2.7 1.6 0.9 0.8 0.7 -0.1 -0.3 -0.8 0.1 0.7 -0.1 -1.0
Myopia 0.3 0.4 1.4 -0.9 0.6 -0.1 -0.6 -0.2 -0.3 1.2 -0.0 0.2 0.6 1.1
Vascular/heart problems diagnosed by doctor 1.8 4.8 10.4 -3.2 -2.0 -2.4 -2.3 0.6 -2.6 -0.9 -1.2 -2.8 -0.4 3.2
Cholesterol lowering medication 0.5 0.7 2.2 0.5 -0.6 1.1 0.8 -1.5 0.7 0.8 0.7 0.7 0.9 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.6 -1.1 -0.2 -0.8 -1.1 0.1 -0.6 -0.4 -0.7 -1.2 -0.2 1.2
Pain experienced in last month 0.6 1.1 3.0 -1.7 -1.0 0.5 0.3 1.4 0.3 0.4 1.0 -0.9 0.6 1.6
Supplements: Calcium 1.0 1.1 2.5 0.7 1.3 1.2 1.6 -0.2 1.5 0.1 1.3 1.1 0.8 -0.7
Basal cell carcinoma (self-reported) 1.3 1.5 4.0 0.9 0.9 0.9 1.3 1.1 1.0 0.5 2.0 1.7 -1.3 -1.3
Heart attack/myocardial infarction (self-reported) 0.8 1.0 3.8 1.5 2.0 0.4 0.5 -0.5 1.2 0.1 0.3 0.7 -0.8 -1.3
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 4.4 -2.0 -1.0 -0.4 -0.7 0.4 -0.4 -2.1 -0.9 -1.4 0.5 1.2
Heart disease (siblings) 0.3 0.4 1.4 0.3 0.4 0.1 0.5 1.2 0.1 1.0 0.5 0.4 0.4 -0.7
Alcohol drinker status: Previous 0.7 0.8 3.8 -0.2 1.0 -0.7 0.2 0.1 1.4 0.7 0.5 -0.1 -2.0 -0.7
Pack years of smoking 0.6 0.8 2.4 -0.8 0.9 -1.4 -0.5 -1.0 -1.6 0.6 -0.6 -0.3 -0.9 -0.7
Impedance of whole body 2.8 14.5 23.3 4.6 4.2 4.8 4.7 2.9 3.5 1.6 3.5 4.8 1.1 -4.0
Leg fat mass (left) 1.3 5.2 10.0 -2.7 -2.7 -2.8 -3.2 -2.4 -0.8 -0.3 -2.4 -3.1 -1.3 1.5
Arm predicted mass (left) 5.8 29.5 57.3 -7.6 -5.7 -6.6 -6.8 -2.3 -4.3 -1.3 -4.3 -7.2 -2.0 6.8