[Hub]/) : Traits : Impedance of leg (right) : ← →

chr16:52,772,129-54,846,383

Best TWAS P=2.19e-41 · Best GWAS P=2.9e-144 conditioned to 9.31e-75

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	GTEx	Testis	AKTIP	0.19	0.00	enet	26	0.00	1.9e-01	-5.0	-13.5	2.2e-41	0.51	0.03	0.40	TRUE
1	CommonMind	Brain Pre-frontal Cortex	FTO	0.11	0.00	bslmm	739	0.02	1.6e-03	2.3	-10.6	2.5e-26	0.38	0.09	0.55	TRUE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	FTO	0.27	0.16	enet	13	0.14	6.7e-05	1.8	-8.5	2.6e-17	0.33	0.11	0.32	TRUE
16	GTEx	Muscle Skeletal	RBL2	0.11	0.00	lasso	5	0.00	2.9e-01	-6.8	9.6	8.4e-22	-0.10	0.28	0.23	FALSE
32	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RBL2	0.11	0.08	blup	44	0.06	1.5e-03	-6.7	6.8	9.9e-12	-0.03	0.01	0.80	FALSE
8	GTEx	Brain Cortex	RBL2	0.51	0.45	enet	12	0.46	3.5e-14	-5.0	6.7	2.9e-11	0.02	1.00	0.00	FALSE
28	YFS	Blood	AKTIP	0.19	0.27	lasso	13	0.30	3.3e-99	-7.1	-6.6	3.7e-11	-0.01	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RBL2	0.22	0.24	enet	15	0.26	1.8e-31	-5.1	6.3	3.0e-10	0.02	1.00	0.00	FALSE
5	GTEx	Artery Tibial	RBL2	0.16	0.17	enet	11	0.20	2.1e-15	-5.2	6.2	5.0e-10	0.02	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	RBL2	0.34	0.28	enet	18	0.30	1.0e-24	-5.1	6.2	6.2e-10	0.02	1.00	0.00	FALSE
13	GTEx	Esophagus Mucosa	RBL2	0.36	0.36	enet	37	0.37	2.9e-26	-5.1	6.1	1.0e-09	0.00	1.00	0.00	FALSE
23	GTEx	Spleen	RBL2	0.59	0.47	enet	51	0.46	3.2e-13	-5.1	6.0	2.2e-09	-0.06	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	RBL2	0.03	0.06	enet	5	0.05	8.2e-07	-5.0	6.0	2.2e-09	0.04	0.61	0.39	FALSE
12	GTEx	Colon Sigmoid	RBL2	0.38	0.37	lasso	12	0.29	8.4e-11	-5.1	5.8	7.8e-09	0.03	1.00	0.00	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	RBL2	0.35	0.33	enet	16	0.34	2.6e-19	-5.1	5.7	1.0e-08	0.03	1.00	0.00	FALSE
15	GTEx	Lung	RBL2	0.29	0.37	enet	16	0.35	9.1e-28	-5.1	5.6	2.2e-08	0.03	1.00	0.00	FALSE
17	GTEx	Nerve Tibial	RBL2	0.46	0.52	enet	19	0.53	1.6e-43	-5.1	5.5	3.2e-08	0.04	1.00	0.00	FALSE
27	GTEx	Vagina	RBL2	0.41	0.37	enet	13	0.34	1.6e-08	-4.9	5.5	4.6e-08	0.03	0.89	0.01	FALSE
22	GTEx	Skin Sun Exposed Lower leg	RBL2	0.35	0.39	enet	25	0.37	2.9e-32	-5.1	5.4	6.1e-08	0.03	1.00	0.00	FALSE
6	GTEx	Brain Cerebellar Hemisphere	RBL2	0.55	0.55	enet	20	0.46	2.1e-13	-5.1	5.4	8.1e-08	0.04	1.00	0.00	FALSE
7	GTEx	Brain Cerebellum	RBL2	0.66	0.72	enet	16	0.70	5.7e-28	-5.1	5.3	1.1e-07	0.05	1.00	0.00	FALSE
9	GTEx	Breast Mammary Tissue	RBL2	0.36	0.35	lasso	3	0.36	3.0e-19	-5.2	5.3	1.4e-07	0.04	1.00	0.00	FALSE
26	GTEx	Thyroid	RBL2	0.34	0.47	lasso	4	0.45	3.6e-38	-5.1	5.2	1.5e-07	0.04	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Esophageal Carcinoma	RBL2	0.08	0.04	lasso	3	0.03	4.4e-02	-7.1	-5.2	1.7e-07	0.00	0.01	0.81	FALSE
4	GTEx	Artery Aorta	RBL2	0.27	0.21	enet	14	0.19	1.5e-10	-5.1	5.2	1.9e-07	0.04	1.00	0.00	FALSE
10	GTEx	Breast Mammary Tissue (Male)	RBL2	0.40	0.29	lasso	2	0.25	1.4e-06	-5.2	5.2	1.9e-07	0.04	0.60	0.02	FALSE
18	GTEx	Pancreas	RBL2	0.36	0.36	enet	26	0.36	5.9e-16	-5.1	5.2	2.1e-07	0.08	1.00	0.00	FALSE
11	GTEx	Breast Mammary Tissue (Female)	RBL2	0.47	0.27	lasso	7	0.20	1.1e-06	-5.0	5.2	2.5e-07	0.04	0.97	0.00	FALSE
14	GTEx	Esophagus Muscularis	RBL2	0.36	0.38	enet	10	0.41	6.8e-27	-5.1	5.2	2.5e-07	0.05	1.00	0.00	FALSE
20	GTEx	Prostate	RBL2	0.55	0.45	lasso	4	0.45	1.0e-12	-5.1	5.2	2.5e-07	0.04	0.99	0.00	FALSE
19	GTEx	Pituitary	RBL2	0.36	0.39	lasso	6	0.40	4.5e-11	-5.1	-5.1	2.7e-07	-0.04	0.98	0.00	FALSE
24	GTEx	Stomach	RBL2	0.33	0.26	enet	20	0.26	8.7e-13	-5.1	5.1	2.8e-07	0.04	1.00	0.00	FALSE