TWAS
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Models
Genes
Traits
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Traits
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Impedance of leg (right)
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chr16:74,578,110-75,998,656
Best TWAS P=1.63e-15 · Best GWAS P=3.09e-18 conditioned to 0.052
74.6M
74.8M
75M
75.2M
75.4M
75.6M
75.8M
76M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Brain Lower Grade Glioma
BCAR1
0.06
0.03
enet
4
0.04
1.4e-05
-8.5
-8.0
1.6e-15
0.47
0.01
0.97
TRUE
1
GTEx
Nerve Tibial
BCAR1
0.23
0.12
lasso
6
0.13
1.4e-09
-4.3
5.4
7.3e-08
-0.76
0.76
0.24
TRUE
3
The Cancer Genome Atlas
Lung Adenocarcinoma
BCAR1
0.04
0.02
enet
8
0.03
5.1e-04
7.7
-6.7
2.8e-11
0.29
0.03
0.36
FALSE