[Hub]/) : Traits : Impedance of leg (right) : ← →

chr16:66,737,479-71,513,034

Best TWAS P=1.2e-08 · Best GWAS P=4.13e-10 conditioned to 0.145

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
32	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NFATC3	0.23	0.05	enet	17	0.06	1.5e-03	-3.3	5.7	1.2e-08	0.03	0.01	0.07	TRUE
8	GTEx	Brain Nucleus accumbens basal ganglia	RP11-296I10.6	0.15	0.11	lasso	3	0.08	3.0e-03	4.6	5.5	3.8e-08	0.38	0.08	0.41	TRUE
20	METSIM	Adipose	NOB1	0.03	0.03	lasso	2	0.03	2.8e-05	-5.1	5.3	9.0e-08	0.76	0.07	0.92	TRUE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HYDIN	0.02	0.00	blup	61	0.02	2.6e-03	4.5	5.2	2.2e-07	0.05	0.02	0.70	TRUE
14	GTEx	Skin Sun Exposed Lower leg	NFATC3	0.06	0.04	enet	9	0.05	6.6e-05	-5.0	5.6	1.9e-08	-0.09	0.05	0.85	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZDHHC1	0.02	0.01	lasso	1	0.01	2.4e-03	-5.5	5.5	3.2e-08	0.02	0.01	0.84	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	PRMT7	0.19	0.14	enet	5	0.15	6.9e-17	5.0	5.5	3.2e-08	0.01	0.06	0.94	FALSE
17	GTEx	Whole Blood	ATP6V0D1	0.08	0.00	enet	13	0.00	3.6e-01	-4.6	5.5	3.4e-08	0.02	0.04	0.84	FALSE
19	METSIM	Adipose	NFATC3	0.03	0.00	blup	298	0.00	3.4e-01	3.3	5.5	4.5e-08	-0.02	0.06	0.18	FALSE
24	YFS	Blood	ATP6V0D1	0.14	0.18	lasso	15	0.20	1.8e-63	-5.3	5.5	4.6e-08	0.02	0.02	0.98	FALSE
5	GTEx	Brain Cerebellar Hemisphere	EXOSC6	0.51	0.15	lasso	11	0.26	2.9e-07	4.7	5.5	4.8e-08	0.40	0.41	0.37	FALSE
22	NTR	Blood	ATP6V0D1	0.02	0.01	bslmm	220	0.01	1.6e-04	-4.6	5.5	4.8e-08	0.00	0.11	0.79	FALSE
33	The Cancer Genome Atlas	Rectum Adenocarcinoma	LRRC36	0.13	0.12	lasso	14	0.11	1.4e-03	-5.4	-5.5	5.0e-08	-0.03	0.01	0.66	FALSE
16	GTEx	Thyroid	ZDHHC1	0.07	0.03	lasso	6	0.02	1.6e-02	-5.3	-5.4	5.2e-08	-0.02	0.02	0.95	FALSE
6	GTEx	Brain Hippocampus	EXOSC6	0.17	0.06	lasso	4	0.03	6.7e-02	4.6	5.4	5.7e-08	0.25	0.05	0.09	FALSE
25	YFS	Blood	PDPR	0.02	0.00	enet	20	0.01	1.8e-05	1.3	-5.4	5.7e-08	-0.47	0.05	0.08	FALSE
26	YFS	Blood	ZDHHC1	0.05	0.05	enet	26	0.05	1.8e-16	-5.3	-5.4	5.7e-08	-0.02	0.02	0.98	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	EXOSC6	0.22	0.12	enet	12	0.12	3.3e-04	4.6	5.4	7.5e-08	0.37	0.24	0.23	FALSE
21	METSIM	Adipose	RLTPR	0.04	0.00	bslmm	211	0.00	1.1e-01	-5.4	-5.4	8.5e-08	-0.06	0.03	0.80	FALSE
13	GTEx	Pituitary	ZDHHC1	0.23	0.13	lasso	4	0.08	4.0e-03	-4.2	-5.3	9.0e-08	-0.05	0.05	0.42	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	LRRC36	0.04	0.04	lasso	3	0.04	1.5e-04	-5.3	-5.3	1.0e-07	-0.02	0.01	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATP6V0D1	0.10	0.12	lasso	8	0.11	2.4e-13	-4.6	5.3	1.1e-07	0.01	0.07	0.92	FALSE
4	GTEx	Brain Cerebellar Hemisphere	PDXDC2P	0.33	0.16	enet	11	0.27	1.4e-07	4.7	5.3	1.2e-07	0.45	0.54	0.18	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	ZDHHC1	0.07	0.06	enet	7	0.07	2.9e-07	-5.3	-5.3	1.2e-07	-0.03	0.02	0.98	FALSE
15	GTEx	Testis	NFATC3	0.23	0.16	lasso	7	0.17	6.0e-08	3.7	5.3	1.3e-07	0.02	0.85	0.08	FALSE
23	NTR	Blood	EXOSC6	0.06	0.07	bslmm	195	0.07	2.7e-22	4.6	5.3	1.3e-07	0.32	0.56	0.44	FALSE
12	GTEx	Nerve Tibial	RP11-296I10.6	0.32	0.40	enet	23	0.43	5.1e-33	4.6	5.2	1.5e-07	0.26	0.60	0.39	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	ATP6V0D1	0.04	0.02	blup	33	0.03	4.7e-04	-4.6	5.2	1.5e-07	0.02	0.02	0.96	FALSE
11	GTEx	Muscle Skeletal	RP11-296I10.6	0.11	0.15	enet	16	0.15	1.8e-14	4.6	5.2	1.9e-07	0.29	0.59	0.40	FALSE
2	CommonMind	Brain Pre-frontal Cortex	EXOSC6	0.24	0.25	enet	14	0.24	1.5e-29	4.7	5.2	2.3e-07	0.28	0.55	0.45	FALSE
18	GTEx	Whole Blood	RP11-296I10.6	0.08	0.07	enet	16	0.09	2.3e-08	4.7	5.2	2.3e-07	0.23	0.52	0.47	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TPPP3	0.03	0.02	blup	31	0.04	2.1e-05	-5.2	5.2	2.3e-07	0.03	0.02	0.97	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PRMT7	0.23	0.19	bslmm	319	0.19	2.2e-22	4.9	5.2	2.4e-07	-0.01	0.06	0.93	FALSE
9	GTEx	Breast Mammary Tissue (Female)	EXOSC6	0.52	0.26	enet	21	0.27	1.4e-08	4.6	5.2	2.4e-07	0.36	0.49	0.39	FALSE
10	GTEx	Lung	NFATC3	0.04	0.01	lasso	4	0.01	4.1e-02	-4.7	5.2	2.4e-07	-0.09	0.03	0.90	FALSE