[Hub]/) : Traits : Impedance of leg (right) :

chr1:8,655,495-12,013,869

Best TWAS P=7.98e-14 · Best GWAS P=1.07e-22 conditioned to 2.18e-14

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex EXOSC10 0.06 0.08 lasso 2 0.07 6.8e-09 -5.9 -5.8 5.7e-09 0.08 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous EXOSC10 0.17 0.00 lasso 3 0.00 1.8e-01 -5.9 -5.3 1.0e-07 0.08 0.05 0.04 FALSE
3 GTEx Adipose Visceral Omentum RP4-635E18.7 0.19 0.08 lasso 6 0.05 9.0e-04 -5.9 -5.7 1.2e-08 0.09 0.44 0.02 FALSE
4 GTEx Brain Cerebellar Hemisphere EXOSC10 0.23 0.10 lasso 3 0.12 6.4e-04 -4.8 -5.2 1.6e-07 0.10 0.19 0.04 FALSE
5 GTEx Brain Cerebellum EXOSC10 0.33 0.16 lasso 6 0.18 3.8e-06 -5.9 -5.4 7.2e-08 0.10 0.78 0.01 FALSE
6 GTEx Brain Cerebellum RP4-635E18.7 0.17 0.17 lasso 5 0.09 1.3e-03 -5.9 -5.8 6.0e-09 0.07 0.38 0.03 FALSE
7 GTEx Brain Cortex RP4-635E18.7 0.17 0.05 lasso 4 0.07 6.4e-03 -5.2 -5.2 2.3e-07 0.08 0.18 0.04 FALSE
8 GTEx Esophagus Mucosa KIF1B 0.10 0.00 enet 17 0.01 1.2e-01 -4.4 -5.8 7.3e-09 0.08 0.22 0.04 TRUE
9 GTEx Lung EXOSC10 0.11 0.07 lasso 4 0.05 1.2e-04 -5.9 -5.8 5.4e-09 0.06 0.88 0.01 FALSE
10 GTEx Muscle Skeletal KIF1B 0.04 0.08 lasso 1 0.07 3.1e-07 -5.3 -5.3 1.4e-07 -0.01 0.98 0.00 FALSE
11 GTEx Thyroid RP4-635E18.7 0.07 0.02 lasso 2 0.01 5.5e-02 -5.9 -7.5 8.0e-14 0.22 0.18 0.03 TRUE
12 METSIM Adipose MTOR 0.04 0.02 bslmm 434 0.02 1.5e-04 -5.2 -5.2 2.4e-07 0.01 0.90 0.01 FALSE
13 NTR Blood SPSB1 0.02 0.00 enet 12 0.01 3.5e-03 -5.3 -5.7 1.6e-08 0.05 0.09 0.14 TRUE
14 ROSMAP Brain Pre-frontal Cortex EXOSC10 0.06 0.06 lasso 2 0.06 4.9e-08 -5.9 -5.9 3.6e-09 0.07 1.00 0.00 FALSE
15 ROSMAP Brain Pre-frontal Cortex MTOR 0.07 0.05 bslmm 423 0.04 2.0e-06 -5.2 -6.1 8.6e-10 0.13 1.00 0.00 FALSE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MTOR 0.02 0.02 blup 54 0.02 5.4e-03 -5.5 -5.3 8.6e-08 0.10 0.06 0.67 FALSE
17 The Cancer Genome Atlas Brain Lower Grade Glioma MTOR 0.03 0.01 blup 54 0.02 5.9e-03 -5.5 -5.3 8.6e-08 0.08 0.03 0.74 FALSE