[Hub]/) : Traits : Impedance of leg (right) :

chr1:15,752,716-18,132,937

Best TWAS P=1.18e-13 · Best GWAS P=1.01e-09 conditioned to 0.0309

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ATP13A2 0.08 0.06 lasso 5 0.08 6.9e-10 5.0 5.8 7.3e-09 -0.81 0.20 0.80 FALSE
2 GTEx Adipose Subcutaneous CROCC 0.18 0.15 enet 24 0.19 2.9e-15 -5.9 -6.7 1.6e-11 0.69 0.01 0.99 FALSE
3 GTEx Adipose Subcutaneous MST1P2 0.12 0.01 enet 20 0.04 2.1e-04 -2.6 5.6 1.8e-08 -0.35 0.07 0.20 FALSE
4 GTEx Adipose Visceral Omentum CROCC 0.17 0.12 lasso 5 0.17 3.6e-09 -5.9 -5.6 1.9e-08 0.67 0.02 0.98 FALSE
5 GTEx Adipose Visceral Omentum MST1L 0.15 0.08 enet 21 0.11 1.7e-06 4.8 -6.3 3.0e-10 0.87 0.02 0.98 FALSE
6 GTEx Adrenal Gland CROCC 0.16 0.00 lasso 3 0.00 2.1e-01 -4.6 -5.2 1.6e-07 0.72 0.06 0.40 FALSE
7 GTEx Artery Tibial CROCC 0.25 0.11 enet 36 0.14 3.6e-11 -5.9 -5.7 9.7e-09 0.57 0.01 0.99 FALSE
8 GTEx Artery Tibial MFAP2 0.15 0.06 enet 20 0.07 2.3e-06 -5.8 6.3 2.2e-10 -0.79 0.01 0.99 FALSE
9 GTEx Artery Tibial MST1L 0.21 0.08 lasso 6 0.12 5.0e-10 -5.9 -6.1 1.3e-09 0.76 0.01 0.99 FALSE
10 GTEx Brain Caudate basal ganglia MFAP2 0.14 0.03 enet 20 0.01 2.0e-01 -5.2 5.1 2.9e-07 -0.80 0.07 0.31 FALSE
11 GTEx Brain Cerebellum MST1P2 0.38 0.04 enet 28 0.21 6.0e-07 -4.6 5.8 7.0e-09 -0.63 0.05 0.79 FALSE
12 GTEx Brain Cortex MST1L 0.38 0.12 enet 26 0.09 1.7e-03 4.8 -5.9 4.1e-09 0.70 0.06 0.67 FALSE
13 GTEx Breast Mammary Tissue MST1L 0.23 0.14 lasso 4 0.12 8.6e-07 -4.6 -5.2 1.9e-07 0.64 0.02 0.97 FALSE
14 GTEx Cells EBV-transformed lymphocytes MST1L 0.31 0.10 lasso 6 0.14 2.2e-05 -5.8 -6.2 4.3e-10 0.84 0.02 0.97 FALSE
15 GTEx Cells Transformed fibroblasts CROCC 0.27 0.11 lasso 11 0.16 7.3e-12 -4.6 -5.7 1.5e-08 0.58 0.05 0.95 FALSE
16 GTEx Cells Transformed fibroblasts MFAP2 0.29 0.39 enet 6 0.42 1.3e-33 -5.3 5.3 9.4e-08 -0.73 0.14 0.86 FALSE
17 GTEx Cells Transformed fibroblasts MST1L 0.09 0.02 enet 12 0.03 3.1e-03 -4.6 -5.8 6.8e-09 0.70 0.03 0.92 FALSE
18 GTEx Colon Transverse CROCC 0.20 0.14 lasso 2 0.14 2.2e-07 -4.6 -5.5 3.9e-08 0.72 0.58 0.42 FALSE
19 GTEx Esophagus Mucosa CROCC 0.14 0.08 enet 18 0.14 9.5e-10 -5.8 -6.3 3.0e-10 0.74 0.06 0.94 FALSE
20 GTEx Esophagus Mucosa MST1L 0.13 0.07 enet 23 0.07 2.7e-05 5.0 -5.7 9.5e-09 0.71 0.04 0.95 FALSE
21 GTEx Esophagus Mucosa NBPF1 0.17 0.09 enet 27 0.12 1.5e-08 -5.3 -5.8 6.8e-09 0.71 0.24 0.76 FALSE
22 GTEx Esophagus Muscularis MFAP2 0.14 0.15 lasso 3 0.12 8.8e-08 -5.3 5.5 3.4e-08 -0.84 0.09 0.91 FALSE
23 GTEx Heart Atrial Appendage CROCC 0.13 0.10 enet 11 0.13 1.5e-06 -4.6 -6.0 2.2e-09 0.73 0.29 0.66 FALSE
24 GTEx Heart Atrial Appendage MST1P2 0.20 0.09 lasso 4 0.09 6.7e-05 -5.4 5.9 3.0e-09 -0.88 0.05 0.92 FALSE
25 GTEx Heart Atrial Appendage RP11-108M9.5 0.26 0.10 lasso 12 0.12 5.5e-06 -4.8 -5.8 8.0e-09 0.56 0.04 0.92 FALSE
26 GTEx Heart Left Ventricle CROCC 0.19 0.07 enet 29 0.13 1.8e-07 -5.0 -5.7 1.1e-08 0.65 0.08 0.92 FALSE
27 GTEx Heart Left Ventricle MST1L 0.09 0.07 lasso 4 0.07 1.1e-04 -4.6 -5.4 8.4e-08 0.79 0.04 0.93 FALSE
28 GTEx Liver MST1P2 0.20 0.14 lasso 4 0.10 7.6e-04 5.3 6.0 2.5e-09 -0.92 0.01 0.92 FALSE
29 GTEx Lung MFAP2 0.09 0.08 enet 19 0.06 1.3e-05 -5.6 6.0 2.5e-09 -0.85 0.02 0.97 FALSE
30 GTEx Lung MST1P2 0.20 0.10 enet 26 0.10 5.0e-08 5.0 5.3 1.1e-07 -0.76 0.13 0.86 FALSE
31 GTEx Lung RP4-798A10.7 0.11 0.05 lasso 4 0.02 1.0e-02 -5.6 -5.7 1.3e-08 0.68 0.02 0.95 FALSE
32 GTEx Muscle Skeletal CROCC 0.09 0.01 lasso 6 0.02 1.1e-02 -5.1 -5.9 3.3e-09 0.49 0.05 0.82 FALSE
33 GTEx Muscle Skeletal PADI2 0.03 0.03 lasso 2 0.03 4.6e-04 -5.0 -5.2 2.6e-07 0.53 0.31 0.59 FALSE
34 GTEx Muscle Skeletal MST1L 0.17 0.12 lasso 9 0.15 3.5e-14 -4.6 -5.3 1.0e-07 0.75 0.27 0.73 FALSE
35 GTEx Muscle Skeletal NBPF1 0.05 0.05 lasso 3 0.05 2.2e-05 -5.1 -5.2 1.6e-07 0.62 0.32 0.59 FALSE
36 GTEx Nerve Tibial MFAP2 0.09 0.06 lasso 3 0.07 9.7e-06 4.8 5.8 6.8e-09 -0.82 0.04 0.96 FALSE
37 GTEx Nerve Tibial EPHA2 0.19 0.13 enet 29 0.14 6.7e-10 -5.1 5.7 1.6e-08 -0.01 0.01 0.99 FALSE
38 GTEx Nerve Tibial ATP13A2 0.05 0.03 lasso 5 0.03 4.8e-03 -5.3 5.6 2.1e-08 -0.67 0.10 0.86 FALSE
39 GTEx Nerve Tibial MST1L 0.23 0.16 lasso 7 0.22 6.6e-16 -4.6 -5.8 9.0e-09 0.86 0.06 0.94 FALSE
40 GTEx Nerve Tibial RP1-37C10.3 0.07 0.02 lasso 5 0.01 4.3e-02 -5.0 5.8 4.8e-09 -0.55 0.22 0.42 FALSE
41 GTEx Ovary CROCC 0.22 0.05 lasso 4 0.02 1.2e-01 -5.0 -5.9 3.7e-09 0.58 0.08 0.29 FALSE
42 GTEx Ovary RP11-108M9.5 0.32 0.14 lasso 6 0.09 2.9e-03 -4.6 -5.3 1.3e-07 0.67 0.07 0.54 FALSE
43 GTEx Pancreas MST1P2 0.17 0.05 enet 23 0.13 5.4e-06 5.0 5.7 1.2e-08 -0.80 0.16 0.76 FALSE
44 GTEx Skin Not Sun Exposed Suprapubic CROCC 0.16 0.12 lasso 7 0.15 9.9e-09 -5.7 -5.9 4.6e-09 0.70 0.03 0.97 FALSE
45 GTEx Skin Not Sun Exposed Suprapubic MST1P2 0.14 0.03 lasso 4 0.01 5.0e-02 5.0 5.5 3.9e-08 -0.77 0.07 0.54 FALSE
46 GTEx Skin Not Sun Exposed Suprapubic MST1L 0.15 0.15 lasso 4 0.13 8.2e-08 -4.6 -5.5 4.9e-08 0.80 0.08 0.92 FALSE
47 GTEx Skin Not Sun Exposed Suprapubic NBPF1 0.08 0.02 lasso 3 0.00 2.8e-01 -4.9 -5.4 8.0e-08 0.59 0.11 0.44 FALSE
48 GTEx Skin Sun Exposed Lower leg CROCC 0.19 0.13 enet 30 0.21 3.4e-17 -4.6 -5.2 1.7e-07 0.70 0.38 0.62 FALSE
49 GTEx Skin Sun Exposed Lower leg MST1P2 0.24 0.00 enet 29 0.13 8.8e-11 5.0 6.5 9.8e-11 -0.55 0.08 0.91 FALSE
50 GTEx Skin Sun Exposed Lower leg MST1L 0.34 0.20 enet 37 0.25 5.6e-21 -4.6 -5.4 7.1e-08 0.78 0.23 0.77 FALSE
51 GTEx Skin Sun Exposed Lower leg NBPF1 0.14 0.04 lasso 7 0.05 2.9e-05 -5.9 -6.5 1.1e-10 0.84 0.02 0.98 FALSE
52 GTEx Small Intestine Terminal Ileum CROCC 0.32 0.07 lasso 14 0.18 7.9e-05 -4.6 -5.4 7.3e-08 0.70 0.04 0.54 FALSE
53 GTEx Stomach NBPF1 0.09 0.01 lasso 2 0.00 4.0e-01 -5.3 -5.4 8.3e-08 0.57 0.06 0.22 FALSE
54 GTEx Testis CROCC 0.18 0.03 lasso 4 0.04 1.0e-02 5.3 -6.4 1.7e-10 0.86 0.04 0.69 FALSE
55 GTEx Testis MST1P2 0.44 0.03 enet 33 0.25 2.8e-11 5.3 5.6 1.9e-08 -0.55 0.05 0.79 FALSE
56 GTEx Testis MST1L 0.45 0.20 enet 34 0.25 2.5e-11 -5.8 -5.3 1.0e-07 0.74 0.01 0.99 FALSE
57 GTEx Testis NBPF1 0.12 -0.01 enet 11 0.00 6.1e-01 -5.0 -5.2 2.2e-07 0.69 0.06 0.25 FALSE
58 GTEx Thyroid EPHA2 0.10 0.05 lasso 9 0.06 1.7e-05 -5.1 5.6 1.8e-08 -0.06 0.01 0.98 FALSE
59 GTEx Thyroid MST1P2 0.18 0.11 lasso 9 0.13 2.7e-10 5.0 6.0 1.8e-09 -0.81 0.04 0.96 FALSE
60 GTEx Whole Blood MST1P2 0.05 0.02 enet 14 0.04 1.8e-04 -5.3 7.4 1.2e-13 -0.59 0.13 0.80 TRUE
61 GTEx Whole Blood MST1L 0.08 0.02 enet 12 0.04 6.3e-05 -4.6 -6.2 6.4e-10 0.83 0.02 0.98 FALSE
62 METSIM Adipose CROCC 0.16 0.12 lasso 3 0.14 1.7e-20 -5.7 -5.5 3.3e-08 0.63 0.02 0.98 FALSE
63 ROSMAP Brain Pre-frontal Cortex SDHB 0.04 0.04 lasso 2 0.03 5.4e-05 -5.2 5.2 2.0e-07 -0.78 0.25 0.71 FALSE
64 YFS Blood CROCC 0.02 0.02 lasso 5 0.01 2.1e-05 -4.6 -5.3 1.2e-07 0.64 0.02 0.98 FALSE
65 The Cancer Genome Atlas Bladder Urothelial Carcinoma CROCC 0.09 0.04 lasso 4 0.06 1.3e-05 -4.6 -5.8 8.9e-09 0.76 0.06 0.93 FALSE
66 The Cancer Genome Atlas Breast Invasive Carcinoma ATP13A2 0.05 0.00 enet 1 0.01 1.6e-02 -6.1 6.1 1.0e-09 -1.00 0.00 0.68 FALSE
67 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma MST1P9 0.11 0.11 blup 38 0.08 1.3e-04 -6.1 -5.6 1.9e-08 0.93 0.00 0.99 FALSE
68 The Cancer Genome Atlas Colon Adenocarcinoma ATP13A2 0.11 0.04 blup 54 0.08 3.4e-05 4.8 6.0 2.0e-09 -0.80 0.02 0.94 FALSE
69 The Cancer Genome Atlas Colon Adenocarcinoma MFAP2 0.12 0.06 blup 38 0.07 4.3e-05 -5.3 5.8 6.7e-09 -0.85 0.01 0.98 FALSE
70 The Cancer Genome Atlas Esophageal Carcinoma CROCC 0.17 0.05 lasso 4 0.09 7.7e-04 -5.9 -6.5 7.6e-11 0.71 0.01 0.95 FALSE
71 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ATP13A2 0.05 0.08 enet 5 0.07 2.1e-08 -5.4 5.8 5.3e-09 -0.88 0.04 0.96 FALSE
72 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MFAP2 0.10 0.05 enet 21 0.07 5.7e-08 -4.8 5.8 4.8e-09 -0.67 0.02 0.98 FALSE
73 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MFAP2 0.17 0.22 enet 10 0.23 6.8e-26 -6.1 6.2 5.8e-10 -0.95 0.00 1.00 FALSE
74 The Cancer Genome Atlas Brain Lower Grade Glioma ATP13A2 0.05 0.05 lasso 3 0.07 2.6e-08 -4.8 5.5 2.9e-08 -0.77 0.06 0.94 FALSE
75 The Cancer Genome Atlas Brain Lower Grade Glioma MFAP2 0.02 0.02 lasso 1 0.02 2.4e-03 -5.6 5.6 2.3e-08 -0.64 0.02 0.81 FALSE
76 The Cancer Genome Atlas Brain Lower Grade Glioma SDHB 0.03 0.02 blup 99 0.02 1.3e-03 -5.0 5.7 1.4e-08 -0.80 0.08 0.64 FALSE
77 The Cancer Genome Atlas Lung Adenocarcinoma ATP13A2 0.07 0.05 lasso 4 0.06 4.8e-07 -5.3 5.1 3.0e-07 -0.74 0.14 0.85 FALSE
78 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ATP13A2 0.06 0.04 blup 54 0.05 7.7e-07 -5.9 6.2 6.1e-10 -0.73 0.02 0.98 FALSE
79 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MFAP2 0.04 0.02 blup 38 0.03 1.5e-04 -5.9 5.8 5.1e-09 -0.73 0.01 0.96 FALSE
80 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MST1P9 0.04 0.02 lasso 5 0.02 1.0e-03 -5.8 -6.3 2.3e-10 0.86 0.02 0.92 FALSE
81 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MST1P9 0.08 0.05 blup 38 0.08 4.2e-06 5.0 -5.5 3.8e-08 0.84 0.04 0.90 FALSE
82 The Cancer Genome Atlas Pancreatic Adenocarcinoma ATP13A2 0.14 0.05 blup 54 0.08 2.5e-04 -5.6 5.3 1.1e-07 -0.82 0.01 0.91 FALSE
83 The Cancer Genome Atlas Prostate Adenocarcinoma MFAP2 0.06 0.04 blup 38 0.05 5.2e-06 4.8 5.4 5.2e-08 -0.67 0.05 0.94 FALSE
84 The Cancer Genome Atlas Prostate Adenocarcinoma MST1P9 0.13 0.09 lasso 6 0.11 3.3e-11 5.0 -5.8 5.2e-09 0.85 0.03 0.97 FALSE
85 The Cancer Genome Atlas Rectum Adenocarcinoma ATP13A2 0.13 0.06 lasso 3 0.08 6.4e-03 -4.8 5.5 4.5e-08 -0.80 0.02 0.43 FALSE
86 The Cancer Genome Atlas Soft Tissue Sarcoma SDHB 0.06 0.03 blup 99 0.02 2.1e-02 -5.8 5.8 8.3e-09 -0.84 0.02 0.66 FALSE