[Hub]/) : Traits : Impedance of leg (right) : ← →

chr1:15,752,716-18,132,937

Best TWAS P=1.18e-13 · Best GWAS P=1.01e-09 conditioned to 0.0309

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
60	GTEx	Whole Blood	MST1P2	0.05	0.02	enet	14	0.04	1.8e-04	-5.3	7.4	1.2e-13	-0.59	0.13	0.80	TRUE
2	GTEx	Adipose Subcutaneous	CROCC	0.18	0.15	enet	24	0.19	2.9e-15	-5.9	-6.7	1.6e-11	0.69	0.01	0.99	FALSE
70	The Cancer Genome Atlas	Esophageal Carcinoma	CROCC	0.17	0.05	lasso	4	0.09	7.7e-04	-5.9	-6.5	7.6e-11	0.71	0.01	0.95	FALSE
49	GTEx	Skin Sun Exposed Lower leg	MST1P2	0.24	0.00	enet	29	0.13	8.8e-11	5.0	6.5	9.8e-11	-0.55	0.08	0.91	FALSE
51	GTEx	Skin Sun Exposed Lower leg	NBPF1	0.14	0.04	lasso	7	0.05	2.9e-05	-5.9	-6.5	1.1e-10	0.84	0.02	0.98	FALSE
54	GTEx	Testis	CROCC	0.18	0.03	lasso	4	0.04	1.0e-02	5.3	-6.4	1.7e-10	0.86	0.04	0.69	FALSE
8	GTEx	Artery Tibial	MFAP2	0.15	0.06	enet	20	0.07	2.3e-06	-5.8	6.3	2.2e-10	-0.79	0.01	0.99	FALSE
80	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MST1P9	0.04	0.02	lasso	5	0.02	1.0e-03	-5.8	-6.3	2.3e-10	0.86	0.02	0.92	FALSE
5	GTEx	Adipose Visceral Omentum	MST1L	0.15	0.08	enet	21	0.11	1.7e-06	4.8	-6.3	3.0e-10	0.87	0.02	0.98	FALSE
19	GTEx	Esophagus Mucosa	CROCC	0.14	0.08	enet	18	0.14	9.5e-10	-5.8	-6.3	3.0e-10	0.74	0.06	0.94	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	MST1L	0.31	0.10	lasso	6	0.14	2.2e-05	-5.8	-6.2	4.3e-10	0.84	0.02	0.97	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MFAP2	0.17	0.22	enet	10	0.23	6.8e-26	-6.1	6.2	5.8e-10	-0.95	0.00	1.00	FALSE
78	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ATP13A2	0.06	0.04	blup	54	0.05	7.7e-07	-5.9	6.2	6.1e-10	-0.73	0.02	0.98	FALSE
61	GTEx	Whole Blood	MST1L	0.08	0.02	enet	12	0.04	6.3e-05	-4.6	-6.2	6.4e-10	0.83	0.02	0.98	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	ATP13A2	0.05	0.00	enet	1	0.01	1.6e-02	-6.1	6.1	1.0e-09	-1.00	0.00	0.68	FALSE
9	GTEx	Artery Tibial	MST1L	0.21	0.08	lasso	6	0.12	5.0e-10	-5.9	-6.1	1.3e-09	0.76	0.01	0.99	FALSE
59	GTEx	Thyroid	MST1P2	0.18	0.11	lasso	9	0.13	2.7e-10	5.0	6.0	1.8e-09	-0.81	0.04	0.96	FALSE
68	The Cancer Genome Atlas	Colon Adenocarcinoma	ATP13A2	0.11	0.04	blup	54	0.08	3.4e-05	4.8	6.0	2.0e-09	-0.80	0.02	0.94	FALSE
23	GTEx	Heart Atrial Appendage	CROCC	0.13	0.10	enet	11	0.13	1.5e-06	-4.6	-6.0	2.2e-09	0.73	0.29	0.66	FALSE
28	GTEx	Liver	MST1P2	0.20	0.14	lasso	4	0.10	7.6e-04	5.3	6.0	2.5e-09	-0.92	0.01	0.92	FALSE
29	GTEx	Lung	MFAP2	0.09	0.08	enet	19	0.06	1.3e-05	-5.6	6.0	2.5e-09	-0.85	0.02	0.97	FALSE
24	GTEx	Heart Atrial Appendage	MST1P2	0.20	0.09	lasso	4	0.09	6.7e-05	-5.4	5.9	3.0e-09	-0.88	0.05	0.92	FALSE
32	GTEx	Muscle Skeletal	CROCC	0.09	0.01	lasso	6	0.02	1.1e-02	-5.1	-5.9	3.3e-09	0.49	0.05	0.82	FALSE
41	GTEx	Ovary	CROCC	0.22	0.05	lasso	4	0.02	1.2e-01	-5.0	-5.9	3.7e-09	0.58	0.08	0.29	FALSE
12	GTEx	Brain Cortex	MST1L	0.38	0.12	enet	26	0.09	1.7e-03	4.8	-5.9	4.1e-09	0.70	0.06	0.67	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	CROCC	0.16	0.12	lasso	7	0.15	9.9e-09	-5.7	-5.9	4.6e-09	0.70	0.03	0.97	FALSE
40	GTEx	Nerve Tibial	RP1-37C10.3	0.07	0.02	lasso	5	0.01	4.3e-02	-5.0	5.8	4.8e-09	-0.55	0.22	0.42	FALSE
72	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MFAP2	0.10	0.05	enet	21	0.07	5.7e-08	-4.8	5.8	4.8e-09	-0.67	0.02	0.98	FALSE
79	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MFAP2	0.04	0.02	blup	38	0.03	1.5e-04	-5.9	5.8	5.1e-09	-0.73	0.01	0.96	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	MST1P9	0.13	0.09	lasso	6	0.11	3.3e-11	5.0	-5.8	5.2e-09	0.85	0.03	0.97	FALSE
71	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ATP13A2	0.05	0.08	enet	5	0.07	2.1e-08	-5.4	5.8	5.3e-09	-0.88	0.04	0.96	FALSE
69	The Cancer Genome Atlas	Colon Adenocarcinoma	MFAP2	0.12	0.06	blup	38	0.07	4.3e-05	-5.3	5.8	6.7e-09	-0.85	0.01	0.98	FALSE
17	GTEx	Cells Transformed fibroblasts	MST1L	0.09	0.02	enet	12	0.03	3.1e-03	-4.6	-5.8	6.8e-09	0.70	0.03	0.92	FALSE
21	GTEx	Esophagus Mucosa	NBPF1	0.17	0.09	enet	27	0.12	1.5e-08	-5.3	-5.8	6.8e-09	0.71	0.24	0.76	FALSE
36	GTEx	Nerve Tibial	MFAP2	0.09	0.06	lasso	3	0.07	9.7e-06	4.8	5.8	6.8e-09	-0.82	0.04	0.96	FALSE
11	GTEx	Brain Cerebellum	MST1P2	0.38	0.04	enet	28	0.21	6.0e-07	-4.6	5.8	7.0e-09	-0.63	0.05	0.79	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATP13A2	0.08	0.06	lasso	5	0.08	6.9e-10	5.0	5.8	7.3e-09	-0.81	0.20	0.80	FALSE
25	GTEx	Heart Atrial Appendage	RP11-108M9.5	0.26	0.10	lasso	12	0.12	5.5e-06	-4.8	-5.8	8.0e-09	0.56	0.04	0.92	FALSE
86	The Cancer Genome Atlas	Soft Tissue Sarcoma	SDHB	0.06	0.03	blup	99	0.02	2.1e-02	-5.8	5.8	8.3e-09	-0.84	0.02	0.66	FALSE
65	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CROCC	0.09	0.04	lasso	4	0.06	1.3e-05	-4.6	-5.8	8.9e-09	0.76	0.06	0.93	FALSE
39	GTEx	Nerve Tibial	MST1L	0.23	0.16	lasso	7	0.22	6.6e-16	-4.6	-5.8	9.0e-09	0.86	0.06	0.94	FALSE
20	GTEx	Esophagus Mucosa	MST1L	0.13	0.07	enet	23	0.07	2.7e-05	5.0	-5.7	9.5e-09	0.71	0.04	0.95	FALSE
7	GTEx	Artery Tibial	CROCC	0.25	0.11	enet	36	0.14	3.6e-11	-5.9	-5.7	9.7e-09	0.57	0.01	0.99	FALSE
26	GTEx	Heart Left Ventricle	CROCC	0.19	0.07	enet	29	0.13	1.8e-07	-5.0	-5.7	1.1e-08	0.65	0.08	0.92	FALSE
43	GTEx	Pancreas	MST1P2	0.17	0.05	enet	23	0.13	5.4e-06	5.0	5.7	1.2e-08	-0.80	0.16	0.76	FALSE
31	GTEx	Lung	RP4-798A10.7	0.11	0.05	lasso	4	0.02	1.0e-02	-5.6	-5.7	1.3e-08	0.68	0.02	0.95	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	SDHB	0.03	0.02	blup	99	0.02	1.3e-03	-5.0	5.7	1.4e-08	-0.80	0.08	0.64	FALSE
15	GTEx	Cells Transformed fibroblasts	CROCC	0.27	0.11	lasso	11	0.16	7.3e-12	-4.6	-5.7	1.5e-08	0.58	0.05	0.95	FALSE
37	GTEx	Nerve Tibial	EPHA2	0.19	0.13	enet	29	0.14	6.7e-10	-5.1	5.7	1.6e-08	-0.01	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	MST1P2	0.12	0.01	enet	20	0.04	2.1e-04	-2.6	5.6	1.8e-08	-0.35	0.07	0.20	FALSE
58	GTEx	Thyroid	EPHA2	0.10	0.05	lasso	9	0.06	1.7e-05	-5.1	5.6	1.8e-08	-0.06	0.01	0.98	FALSE
4	GTEx	Adipose Visceral Omentum	CROCC	0.17	0.12	lasso	5	0.17	3.6e-09	-5.9	-5.6	1.9e-08	0.67	0.02	0.98	FALSE
55	GTEx	Testis	MST1P2	0.44	0.03	enet	33	0.25	2.8e-11	5.3	5.6	1.9e-08	-0.55	0.05	0.79	FALSE
67	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MST1P9	0.11	0.11	blup	38	0.08	1.3e-04	-6.1	-5.6	1.9e-08	0.93	0.00	0.99	FALSE
38	GTEx	Nerve Tibial	ATP13A2	0.05	0.03	lasso	5	0.03	4.8e-03	-5.3	5.6	2.1e-08	-0.67	0.10	0.86	FALSE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	MFAP2	0.02	0.02	lasso	1	0.02	2.4e-03	-5.6	5.6	2.3e-08	-0.64	0.02	0.81	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATP13A2	0.05	0.05	lasso	3	0.07	2.6e-08	-4.8	5.5	2.9e-08	-0.77	0.06	0.94	FALSE
62	METSIM	Adipose	CROCC	0.16	0.12	lasso	3	0.14	1.7e-20	-5.7	-5.5	3.3e-08	0.63	0.02	0.98	FALSE
22	GTEx	Esophagus Muscularis	MFAP2	0.14	0.15	lasso	3	0.12	8.8e-08	-5.3	5.5	3.4e-08	-0.84	0.09	0.91	FALSE
81	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MST1P9	0.08	0.05	blup	38	0.08	4.2e-06	5.0	-5.5	3.8e-08	0.84	0.04	0.90	FALSE
18	GTEx	Colon Transverse	CROCC	0.20	0.14	lasso	2	0.14	2.2e-07	-4.6	-5.5	3.9e-08	0.72	0.58	0.42	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	MST1P2	0.14	0.03	lasso	4	0.01	5.0e-02	5.0	5.5	3.9e-08	-0.77	0.07	0.54	FALSE
85	The Cancer Genome Atlas	Rectum Adenocarcinoma	ATP13A2	0.13	0.06	lasso	3	0.08	6.4e-03	-4.8	5.5	4.5e-08	-0.80	0.02	0.43	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	MST1L	0.15	0.15	lasso	4	0.13	8.2e-08	-4.6	-5.5	4.9e-08	0.80	0.08	0.92	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	MFAP2	0.06	0.04	blup	38	0.05	5.2e-06	4.8	5.4	5.2e-08	-0.67	0.05	0.94	FALSE
50	GTEx	Skin Sun Exposed Lower leg	MST1L	0.34	0.20	enet	37	0.25	5.6e-21	-4.6	-5.4	7.1e-08	0.78	0.23	0.77	FALSE
52	GTEx	Small Intestine Terminal Ileum	CROCC	0.32	0.07	lasso	14	0.18	7.9e-05	-4.6	-5.4	7.3e-08	0.70	0.04	0.54	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	NBPF1	0.08	0.02	lasso	3	0.00	2.8e-01	-4.9	-5.4	8.0e-08	0.59	0.11	0.44	FALSE
53	GTEx	Stomach	NBPF1	0.09	0.01	lasso	2	0.00	4.0e-01	-5.3	-5.4	8.3e-08	0.57	0.06	0.22	FALSE
27	GTEx	Heart Left Ventricle	MST1L	0.09	0.07	lasso	4	0.07	1.1e-04	-4.6	-5.4	8.4e-08	0.79	0.04	0.93	FALSE
16	GTEx	Cells Transformed fibroblasts	MFAP2	0.29	0.39	enet	6	0.42	1.3e-33	-5.3	5.3	9.4e-08	-0.73	0.14	0.86	FALSE
34	GTEx	Muscle Skeletal	MST1L	0.17	0.12	lasso	9	0.15	3.5e-14	-4.6	-5.3	1.0e-07	0.75	0.27	0.73	FALSE
56	GTEx	Testis	MST1L	0.45	0.20	enet	34	0.25	2.5e-11	-5.8	-5.3	1.0e-07	0.74	0.01	0.99	FALSE
30	GTEx	Lung	MST1P2	0.20	0.10	enet	26	0.10	5.0e-08	5.0	5.3	1.1e-07	-0.76	0.13	0.86	FALSE
82	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ATP13A2	0.14	0.05	blup	54	0.08	2.5e-04	-5.6	5.3	1.1e-07	-0.82	0.01	0.91	FALSE
64	YFS	Blood	CROCC	0.02	0.02	lasso	5	0.01	2.1e-05	-4.6	-5.3	1.2e-07	0.64	0.02	0.98	FALSE
42	GTEx	Ovary	RP11-108M9.5	0.32	0.14	lasso	6	0.09	2.9e-03	-4.6	-5.3	1.3e-07	0.67	0.07	0.54	FALSE
6	GTEx	Adrenal Gland	CROCC	0.16	0.00	lasso	3	0.00	2.1e-01	-4.6	-5.2	1.6e-07	0.72	0.06	0.40	FALSE
35	GTEx	Muscle Skeletal	NBPF1	0.05	0.05	lasso	3	0.05	2.2e-05	-5.1	-5.2	1.6e-07	0.62	0.32	0.59	FALSE
48	GTEx	Skin Sun Exposed Lower leg	CROCC	0.19	0.13	enet	30	0.21	3.4e-17	-4.6	-5.2	1.7e-07	0.70	0.38	0.62	FALSE
13	GTEx	Breast Mammary Tissue	MST1L	0.23	0.14	lasso	4	0.12	8.6e-07	-4.6	-5.2	1.9e-07	0.64	0.02	0.97	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	SDHB	0.04	0.04	lasso	2	0.03	5.4e-05	-5.2	5.2	2.0e-07	-0.78	0.25	0.71	FALSE
57	GTEx	Testis	NBPF1	0.12	-0.01	enet	11	0.00	6.1e-01	-5.0	-5.2	2.2e-07	0.69	0.06	0.25	FALSE
33	GTEx	Muscle Skeletal	PADI2	0.03	0.03	lasso	2	0.03	4.6e-04	-5.0	-5.2	2.6e-07	0.53	0.31	0.59	FALSE
10	GTEx	Brain Caudate basal ganglia	MFAP2	0.14	0.03	enet	20	0.01	2.0e-01	-5.2	5.1	2.9e-07	-0.80	0.07	0.31	FALSE
77	The Cancer Genome Atlas	Lung Adenocarcinoma	ATP13A2	0.07	0.05	lasso	4	0.06	4.8e-07	-5.3	5.1	3.0e-07	-0.74	0.14	0.85	FALSE