TWAS hub - SPSB1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0239	0.0106	0.0130	0.001	0.004	0.006	0.005	0.004	2.0e-01	0.0180	3.5e-03	7.6e-03	2.0e-02
2	YFS	Blood	0.0279	0.0105	0.0015	0.032	0.007	0.023	0.028	0.027	9.4e-11	0.0019	5.1e-08	1.5e-09	2.2e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Waist Hip Ratio (WHR)	9.2	41.4	48.0	-5.9	-6.9
Impedance of arm (right)	7.4	34.6	64.6	-2.1	8.0
Impedance of arm (left)	6.9	32.1	61.5	-1.7	7.8
Medication: Atenolol	6.2	7.8	9.4	-3.1	-2.5
HbA1C	4.8	5.4	8.9	3.0	1.4
Impedance of whole body	4.7	24.1	33.9	-3.8	5.8
Impedance of leg (left)	4.2	20.4	37.5	-6.1	1.8
Had major operations	4.0	4.7	6.2	1.8	2.5
Impedance of leg (right)	3.8	18.2	31.9	-5.7	2.1
Medication: Co-codamol	3.4	3.9	7.8	-2.8	-0.2
Tinnitus: Yes, but not now, but have in the past	3.3	3.5	6.8	0.4	2.6
Ever had prostate specific antigen (PSA) test	3.2	3.7	5.8	1.3	2.4
Illnesses of father: None of the above (group 1)	3.1	3.9	6.1	1.3	2.5
Type 2 Diabetes (T2D) (2012)	3.0	3.5	5.9	-2.4	-1.0
Medication: Allopurinol	2.8	3.7	6.2	-2.5	-1.1
Medication: Gliclazide	2.7	3.0	5.5	-0.7	-2.4
Ever had hysterectomy (womb removed)	2.6	2.9	5.0	-0.9	2.2
Loud music exposure frequency	2.6	2.8	5.3	0.6	2.3
Heel T-Score	2.4	19.2	37.0	-1.2	-6.1
Average weekly fortified wine intake	2.4	2.9	2.9	1.7	1.7
Qualifications: CSEs or equivalent	2.4	3.2	4.4	-1.4	-2.1
Serious illness, injury or assault to yourself	2.2	2.7	4.6	0.9	2.1
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.0	9.7	0.4	-3.1
Happiness	2.2	2.7	3.0	-1.7	1.5
Diabetes diagnosed by doctor	2.2	3.6	5.2	-1.4	-2.3
Age at First Birth	2.1	3.1	6.1	0.4	2.5
Diabetes (self-reported)	2.1	3.2	5.4	-1.0	-2.3
Pack years adult smoking proportion	2.0	3.1	6.2	-0.0	-2.5
Fluid intelligence score	2.0	4.1	8.1	-0.3	2.8
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	3.8	1.9	-1.7
Average weekly champagne plus white wine intake	2.0	2.7	5.3	0.2	2.3
Primary Biliary Cirrhosis	1.9	2.7	4.6	2.1	0.8
Type 2 Diabetes (T2D) (2018)	1.9	3.6	5.5	-1.3	-2.3
Breast cancer (self-reported)	1.9	2.2	3.6	-1.9	-0.9
Crohns Disease (2012)	1.8	2.9	5.8	-0.3	-2.4
Lupus	1.8	2.7	3.6	1.3	1.9
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	4.3	-0.7	-2.1
Mouth/teeth dental problems: Dentures	1.8	3.1	3.1	-1.7	-1.8
Breastfed as a baby	1.8	2.2	4.3	2.1	0.3
Qualifications: College or University degree	1.8	5.8	7.7	2.0	2.8
Medication: Paracetamol	1.8	2.8	5.6	-2.4	-0.1
Pack years of smoking	1.8	2.7	5.4	0.0	-2.3
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	5.3	2.3	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	8.8	1.4	3.0
Forced vital capacity (FVC), Best measure	1.7	6.2	10.0	1.6	3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	6.8	0.7	2.6
Financial situation satisfaction	1.7	2.1	2.2	-1.5	-1.4
Medication: Blood pressure	1.7	3.2	4.7	-1.3	-2.2
Heart disease (siblings)	1.7	2.1	3.8	0.7	-1.9
Height	1.6	30.5	55.8	2.3	7.5
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	6.0	1.1	-2.5
Number of incorrect matches in round	1.6	2.7	4.6	-2.1	-0.9
Medication: Ramipril	1.6	2.0	2.6	-1.2	-1.6
Standing height	1.6	15.7	30.8	0.8	5.5
Pulse wave reflection index	1.6	1.9	3.0	0.9	1.7
Heart disease (mother)	1.6	1.9	3.5	-0.6	-1.9
Alcohol drinker status: Never	1.6	1.9	3.4	-0.6	-1.8
Systolic Blood Pressure	1.5	7.6	13.1	-1.5	-3.6
Systolic blood pressure, automated reading	1.5	4.2	8.1	-0.6	-2.8
Severe depression (siblings)	1.5	1.6	2.9	-0.6	1.7
Number of live births	1.5	2.1	2.4	-1.4	1.5
Medication: Cholesterol lowering	1.5	2.3	3.6	-1.0	-1.9
Supplements: Vitamin C	1.5	1.7	1.8	1.4	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	3.5	-1.9	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.5	-0.8	1.6
Basal cell carcinoma (self-reported)	1.5	1.8	2.2	-1.5	1.2
Diabetes (mother)	1.4	1.8	3.6	0.1	-1.9
Length of working week for main job	1.4	1.6	2.1	-1.0	-1.4
Hair/balding pattern: Pattern 4	1.4	3.3	6.0	0.8	-2.4
Angina (self-reported)	1.4	1.8	2.8	1.7	0.9
Chest pain or discomfort	1.4	2.1	2.8	1.7	1.2
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.4	0.1	-1.8
Commuting to job workplace: Walk	1.4	1.5	2.7	0.5	1.6
Number of self-reported non-cancer illnesses	1.4	2.5	4.9	-0.2	-2.2
Medication: Bendroflumethiazide	1.4	2.1	4.2	0.1	-2.0
Supplements: Calcium	1.4	1.6	2.8	-1.7	-0.6
Leg predicted mass (left)	1.3	6.7	12.9	3.6	0.7
Medication: Paracetamol	1.3	2.2	2.5	-1.6	1.4
Emphysema/chronic bronchitis	1.3	1.4	2.9	-0.0	1.7
Age at last live birth	1.3	1.8	3.5	0.3	1.9
Leg fat-free mass (right)	1.3	7.0	13.7	3.7	0.6
Leg predicted mass (right)	1.3	6.8	13.4	3.7	0.5
Commuting to job workplace: Cycle	1.3	1.6	2.1	-1.0	-1.4
Intelligence (Savage-Jansen 2018)	1.2	3.7	6.9	0.7	2.6
Verbal and Numeric Reasoning (VNR)	1.2	2.8	4.8	0.9	2.2
Leg fat-free mass (left)	1.2	6.5	12.4	3.5	0.8
Forced vital capacity (FVC)	1.2	4.5	8.3	0.8	2.9
Qualifications: None of the above	1.2	2.6	4.0	-1.1	-2.0
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	7.9	0.7	2.8
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.0	0.2	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	1.5	-1.2	-1.2
Crohns Disease (2017)	1.1	2.5	4.1	-0.9	-2.0
Mean Putamen Volume	1.1	1.3	2.5	1.6	-0.3
Schizophrenia (2014)	1.1	2.3	4.3	-0.6	-2.1
Blood Red Count	1.1	10.4	20.3	-0.7	-4.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.2	1.5	-0.9
Maternal smoking around birth	1.1	1.5	2.2	-1.0	-1.5
Alcohol usually taken with meals	1.1	1.8	2.0	1.2	1.4
Hip circumference	1.1	4.8	7.2	1.6	2.7
Asthma	1.1	2.2	3.6	-0.9	-1.9
Peak expiratory flow (PEF)	1.1	2.6	4.2	1.0	2.0
Family relationship satisfaction	1.1	1.3	2.6	-1.6	0.2
Asthma (self-reported)	1.1	2.1	3.7	-0.7	-1.9
Wears glasses or contact lenses	1.1	1.3	2.6	0.2	1.6
Leg fat percentage (left)	1.1	3.9	5.1	-2.3	-1.6
Irritability	1.1	1.9	3.8	1.9	-0.3
Age started oral contraceptive pill	1.1	1.4	1.5	-1.2	-1.1
Myopia	1.1	1.5	1.7	-1.2	1.3
Irritable Bowel Disease (IBD)	1.0	2.4	3.6	-1.1	-1.9
LDL Cholesterol	1.0	1.5	3.1	-0.1	-1.8
Hearing difficulty/problems: Yes	1.0	1.6	2.9	0.4	-1.7
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.2	-0.3	-1.5
Glaucoma (self-reported)	1.0	1.1	1.1	-1.1	-1.1
Birth weight	1.0	2.2	2.7	1.6	1.3
Comparative height size at age 10	1.0	5.8	11.5	0.1	3.4
Osteoporosis (self-reported)	1.0	1.2	2.4	0.2	1.6
Rheumatoid Arthritis	0.9	1.2	2.3	-1.5	0.1
Chronotype (morning person)	0.9	2.1	2.4	-1.6	-1.3
Number of treatments/medications taken	0.9	1.7	2.1	-1.4	-1.1
Chronic bronchitis/emphysema (father)	0.9	1.1	2.0	0.4	-1.4
Illnesses of mother	0.9	1.1	1.8	-0.7	1.3
Leg fat percentage (right)	0.9	3.2	4.2	-2.0	-1.5
Arm fat-free mass (right)	0.9	4.6	4.8	2.1	-2.2
Medication: Blood pressure	0.9	1.5	3.0	0.2	-1.7
Medication: Seretide 50 evohaler	0.9	1.0	1.5	0.8	-1.2
Arm predicted mass (right)	0.9	4.5	5.0	2.0	-2.2
Medication: Aspirin	0.9	1.1	2.0	0.5	1.4
Medication for cholesterol	0.9	1.4	2.0	0.9	1.4
Ever taken oral contraceptive pill	0.9	1.0	2.0	0.2	1.4
Commuting to job workplace: Public transport	0.9	1.1	1.6	-1.3	-0.7
Average weekly beer plus cider intake	0.9	1.4	2.7	-1.6	-0.0
Respiratory disease	0.8	1.8	2.4	1.2	-1.5
Lung FEV1/FVC ratio	0.8	3.9	7.7	-2.8	-0.0
Average weekly spirits intake	0.8	1.0	1.9	0.1	-1.4
Trunk fat percentage	0.8	3.4	5.8	-1.0	2.4
Body mass index (BMI)	0.8	3.2	6.0	0.7	-2.4
Waist circumference	0.8	2.9	4.3	-1.2	-2.1
Falls in the last year	0.8	1.1	1.9	0.5	-1.4
Prospective memory result	0.8	0.9	1.5	1.2	-0.6
Tense / ‘highly strung’	0.8	1.3	1.5	1.0	-1.2
Shortness of breath walking on level ground	0.8	1.0	1.8	1.3	0.4
Eye problems/disorders: None of the above	0.8	0.9	1.8	-0.1	1.3
Medication for pain relief, constipation, heartburn	0.8	1.3	2.6	1.6	-0.2
Migraine (self-reported)	0.8	0.9	1.9	0.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.1	-0.0	1.8
Smoking status: Current	0.8	1.3	1.6	-1.0	-1.3
Eye problems/disorders: Glaucoma	0.8	1.0	1.8	-0.4	-1.3
Schizophrenia (2018)	0.7	1.5	2.3	-0.8	-1.5
Prostate Cancer	0.7	1.0	2.0	-1.4	-0.3
Ulcerative Colitis	0.7	1.1	2.0	0.3	-1.4
Blood White Count	0.7	5.2	9.1	-1.1	-3.0
Smoking Status	0.7	1.6	2.8	-1.7	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.4	0.7	-1.2
Relative age voice broke	0.7	1.1	1.9	-0.5	1.4
Hearing difficulty/problems with background noise	0.7	1.2	1.4	1.0	-1.2
Had menopause	0.7	0.9	1.4	-1.2	-0.7
Illnesses of siblings	0.7	1.0	1.3	-1.2	0.8
Hair/balding pattern: Pattern 3	0.7	1.0	1.7	0.6	-1.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.0	1.0	-0.9
Age at first live birth	0.7	1.3	1.4	1.2	1.1
Mean time to correctly identify matches	0.7	1.3	2.3	-0.6	1.5
Overall health rating	0.7	1.5	2.9	0.1	-1.7
Mood swings	0.7	1.3	1.7	1.3	-1.0
Friendships satisfaction	0.7	0.8	1.3	-0.5	1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.2	1.1	1.0
Whole body water mass	0.7	3.8	7.0	2.6	-0.8
Number of operations (self-reported)	0.7	1.0	1.5	-0.7	1.2
Ovarian Cancer	0.6	0.8	1.2	-1.1	-0.6
Blood Eosinophil Count	0.6	4.7	6.7	2.6	1.6
BMI	0.6	3.6	7.2	0.1	-2.7
Hypothyroidism (self reported)	0.6	1.3	2.6	-0.2	-1.6
Angina	0.6	0.8	1.6	1.2	0.3
Current tobacco smoking	0.6	1.0	1.1	-1.1	-0.9
Multivitamins +/- minerals	0.6	0.8	1.3	0.5	1.1
Financial difficulties in last 2 years	0.6	0.8	1.2	-1.1	0.5
Mouth/teeth dental problems	0.6	0.8	1.1	1.1	0.7
Medication: Lansoprazole	0.6	0.6	1.2	-1.1	0.3
Headache pain in last month	0.6	1.0	2.0	-0.1	1.4
High blood pressure (siblings)	0.6	0.8	1.6	1.3	-0.3
Comparative body size at age 10	0.6	1.7	3.3	0.3	-1.8
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.2	1.1	0.4
Medication: Omeprazole	0.6	0.7	1.3	0.4	1.1
Alcohol intake frequency.	0.6	1.4	2.1	-0.8	-1.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	0.9	1.0	-0.6
Whole body fat-free mass	0.6	3.6	6.9	2.6	-0.6
Medication: Aspirin	0.6	0.8	1.1	0.7	1.0
Hearing aid user	0.6	0.6	1.1	-1.0	0.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.3	1.1	-0.5
Arm fat-free mass (left)	0.6	2.9	4.2	1.2	-2.0
Unable to work because of sickness or disability	0.6	0.8	1.6	-0.1	1.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.6	1.2	-0.2
Depression (Nagel 2018)	0.5	0.7	1.2	1.1	-0.5
Blood Platelet Count	0.5	5.6	9.9	-3.1	1.1
Supplements: Zinc	0.5	0.5	0.8	-0.9	-0.4
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.1	1.1	-0.9
Allergy	0.5	1.3	2.4	-0.4	1.5
Medication: Simvastatin	0.5	0.8	1.3	-1.1	-0.5
Trunk fat-free mass	0.5	2.7	3.8	1.9	-1.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.7	0.7	1.3
Lung cancer (father)	0.5	0.6	1.0	-1.0	0.5
Trunk predicted mass	0.5	2.7	3.8	2.0	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.3	0.3	1.1
Hypertension (Self-reported)	0.5	1.3	2.5	-0.4	-1.6
Average weekly red wine intake	0.5	0.7	1.3	1.1	-0.3
Qualifications: nursing, teaching	0.5	0.8	1.4	1.2	-0.2
Medication: Atorvastatin	0.5	0.7	1.3	-0.3	-1.1
Basal metabolic rate	0.5	2.6	5.2	2.3	-0.3
Risk taking	0.5	0.7	1.3	-1.2	0.3
Fractured/broken bones in last 5 years	0.5	0.7	1.0	-0.6	1.0
Arm predicted mass (left)	0.5	2.7	3.6	1.3	-1.9
Bipolar Disorder or Schizophrenia	0.4	1.0	2.0	-0.2	-1.4
Alzheimer’s Disease (in father)	0.4	0.5	0.9	0.3	-0.9
Neuroticism (2016)	0.4	0.5	1.0	1.0	0.1
Sensitivity / hurt feelings	0.4	0.7	1.0	1.0	0.7
Medication: Metformin	0.4	0.6	1.0	-1.0	-0.3
Taking other prescription medications	0.4	0.6	1.1	0.2	-1.1
Age when periods started (menarche)	0.4	0.9	1.7	-1.3	-0.0
High blood pressure	0.4	1.1	2.0	-0.5	-1.4
High blood pressure (mother)	0.4	0.6	1.2	1.1	0.2
Trunk fat mass	0.4	1.5	3.0	-0.3	1.7
Past tobacco smoking	0.4	0.7	0.9	0.9	-0.7
Time employed in main current job	0.4	0.5	0.5	0.7	-0.7
Worrier / anxious feelings	0.4	0.8	1.5	1.2	0.2
Pulse wave Arterial Stiffness index	0.4	0.4	0.8	-0.1	0.9
Exposure to tobacco smoke at home	0.4	0.5	0.7	0.8	-0.5
Body fat percentage	0.4	1.5	1.7	-1.3	1.1
Number of full brothers	0.4	0.5	0.8	-0.4	-0.9
Number of children fathered	0.4	0.4	0.7	0.9	0.4
Smoking status: Previous	0.4	0.7	0.7	-0.8	0.8
Ever had bowel cancer screening	0.4	0.5	0.8	-0.9	-0.4
Osteoarthritis (self-reported)	0.4	0.5	1.0	-1.0	-0.3
Alcohol drinker status: Previous	0.4	0.5	0.6	-0.8	-0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.4	0.7	0.5
Diabetes (father)	0.3	0.4	0.4	-0.6	0.6
Stomach or abdominal pain in last month	0.3	0.3	0.6	0.2	0.8
Medication: Levothyroxine sodium	0.3	0.4	0.4	-0.6	-0.7
Nervous feelings	0.3	0.5	0.6	0.8	-0.6
Hair/balding pattern: Pattern 2	0.3	0.4	0.4	-0.7	0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.6	0.4	0.8
Neuroticism score	0.3	0.5	1.0	1.0	0.4
Father’s age at death	0.3	0.4	0.7	-0.2	-0.8
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	-0.9	-0.3
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.9	-0.3
Gout (self-reported)	0.3	0.4	0.6	-0.8	0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.0	-0.1	-1.0
Wheeze or whistling in the chest in last year	0.3	0.6	0.8	0.6	-0.9
Pulse rate, automated reading	0.3	1.0	1.0	-1.0	1.0
Suffer from ‘nerves’	0.3	0.4	0.6	-0.5	-0.8
Illnesses of siblings: Diabetes	0.3	0.4	0.7	-0.4	-0.8
Eye problems/disorders: Cataract	0.3	0.3	0.3	0.6	-0.5
Back pain experienced in last month	0.3	0.4	0.6	0.8	0.5
Mother’s age at death	0.3	0.4	0.4	0.7	0.6
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.8	-0.0	1.3
Bipolar Disorder (2018)	0.2	0.3	0.5	0.7	-0.4
Schizophrenia vs Biploar Disorder	0.2	0.3	0.3	-0.5	-0.5
Worry (Nagel 2018)	0.2	0.4	0.8	-0.2	-0.9
Alzheimer’s Disease (including proxy)	0.2	0.2	0.4	-0.1	-0.7
Ulcerative Colitis (UC)	0.2	0.3	0.4	-0.4	-0.7
Reaction Time	0.2	0.4	0.6	-0.7	0.5
Breast Cancer	0.2	0.4	0.7	-0.4	0.8
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	0.7	0.1
Fasting Glucose	0.2	0.2	0.3	0.4	0.5
HDL Cholesterol	0.2	0.4	0.7	-0.8	0.3
Allergy or Eczema	0.2	0.6	0.9	1.0	-0.6
Hand grip strength (left)	0.2	0.5	1.1	-0.1	-1.0
Hand grip strength (right)	0.2	0.6	1.0	0.4	-1.0
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.7	-0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.2	0.6
Had other major operations	0.2	0.3	0.6	-0.8	0.1
Heart attack	0.2	0.2	0.3	0.5	0.3
Pain all over the body in last month	0.2	0.2	0.3	0.2	0.5
Arm fat percentage (right)	0.2	0.8	1.6	0.1	1.3
Noisy workplace	0.2	0.2	0.3	-0.4	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.2	0.6
Medication: Amlodipine	0.2	0.3	0.4	-0.6	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.3	0.5	-0.5
Health satisfaction	0.2	0.2	0.4	-0.1	-0.6
Medication: Ibuprofen	0.2	0.2	0.3	-0.6	0.2
Leg fat mass (right)	0.2	0.7	1.3	-0.4	-1.1
Number of full sisters	0.2	0.2	0.2	0.4	0.5
Leg pain on walking	0.2	0.3	0.5	0.7	-0.2
Illnesses of father: Heart disease	0.2	0.3	0.3	0.6	-0.6
Arm fat percentage (left)	0.2	0.6	1.2	0.2	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.5	0.4
Miserableness	0.2	0.3	0.4	0.5	-0.6
Guilty feelings	0.2	0.3	0.4	-0.5	0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	-0.2	0.7
Medication: Lisinopril	0.2	0.2	0.4	0.6	-0.2
Ever smoked	0.2	0.3	0.7	-0.1	0.8
Cholesterol lowering medication	0.2	0.3	0.4	-0.3	-0.7
Leg fat mass (left)	0.2	0.8	1.1	-0.7	-1.1
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	0.2	0.5
Alzheimer’s Disease (in mother)	0.1	0.2	0.3	0.6	-0.0
Triglycerides	0.1	0.2	0.2	0.4	-0.5
Cardiovascular Disease	0.1	0.5	0.9	-0.2	-0.9
Lung FVC	0.1	0.5	0.8	0.9	0.5
Neuroticism	0.1	0.2	0.4	0.0	0.6
Hair Pigment	0.1	1.7	2.5	-1.0	1.6
Tanning	0.1	1.4	2.0	-0.9	-1.4
Relative age of first facial hair	0.1	0.3	0.5	-0.2	0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.3	-0.4
Fed-up feelings	0.1	0.1	0.2	-0.1	0.5
Sitting height	0.1	0.5	0.6	0.8	0.7
Weight	0.1	0.6	1.2	1.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.4	0.2
Depression (self-reported)	0.1	0.1	0.2	0.4	0.2
Birth weight of first child	0.1	0.2	0.4	-0.0	0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.1	0.4	0.2
Exposure to tobacco smoke outside home	0.1	0.2	0.3	-0.2	-0.5
Worry too long after embarrassment	0.1	0.1	0.2	0.4	0.3
Neck or shoulder pain in last month	0.1	0.1	0.2	0.4	-0.3
Whole body fat mass	0.1	0.4	0.5	-0.5	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.5	-0.1
Knee pain experienced in last month	0.1	0.2	0.3	0.6	0.0
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	0.2	0.4
Loneliness, isolation	0.1	0.1	0.1	-0.3	0.2
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.4	-0.3
Mineral and other dietary supplements	0.1	0.2	0.3	-0.2	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.4	-0.1
Diastolic blood pressure, automated reading	0.1	0.4	0.6	-0.4	0.8
Ever depressed for a whole week	0.1	0.1	0.3	0.5	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.2	0.5
Neuroticism (Nagel 2018)	0.0	0.1	0.1	0.3	0.4
Major Depression (MDD)	0.0	0.0	0.1	0.0	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	-0.2	-0.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.2	-0.2
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.2	-0.0
Vitamin and mineral supplements	0.0	0.0	0.0	-0.2	0.0
Supplements: Glucosamine	0.0	0.0	0.0	-0.2	-0.0
Alcohol intake versus 10 years previously	0.0	0.0	0.1	-0.0	-0.2
Pulse rate	0.0	0.0	0.1	-0.0	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	-0.1	0.2
Arm fat mass (right)	0.0	0.1	0.1	0.4	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.0	-0.1
Chronic bronchitis/emphysema (mother)	0.0	0.1	0.1	-0.3	0.1
Pulse wave peak to peak time	0.0	0.0	0.1	0.3	-0.1
Arm fat mass (left)	0.0	0.1	0.1	0.4	-0.1
High cholesterol (Self-reported)	0.0	0.0	0.1	-0.2	0.1
Illnesses of father: High blood pressure	0.0	0.0	0.0	-0.1	-0.1
Pain experienced in last month	0.0	0.1	0.1	-0.3	-0.1
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	0.3	0.1

Hub : Genes

SPSB1

Models

Trait associations