TWAS hub - MAPK10

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.147	0.0520	8.8e-04	0.168	NA	0.168	NA	0.165	1.4e-09	NA	1.4e-09	NA	2.1e-09
2	GTEx	Colon Sigmoid	0.248	0.0730	1.6e-04	0.107	NA	0.060	NA	0.072	1.3e-04	NA	3.6e-03	NA	1.6e-03
3	GTEx	Nerve Tibial	0.085	0.0336	1.9e-03	0.007	NA	0.034	NA	0.010	9.1e-02	NA	1.7e-03	NA	5.6e-02
4	GTEx	Prostate	0.300	0.0970	1.3e-03	0.070	NA	0.017	NA	0.183	8.1e-03	NA	1.2e-01	NA	2.4e-05
5	ROSMAP	Brain Pre-frontal Cortex	0.345	0.0541	4.4e-16	0.121	0.161	0.203	0.201	0.209	2.6e-15	3.4e-20	1.8e-25	2.6e-25	2.9e-26
6	TCGA	Pancreatic Adenocarcinoma	0.175	0.0700	4.4e-03	-0.006	0.082	0.018	NA	-0.007	7.6e-01	2.6e-04	5.9e-02	NA	9.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hypothyroidism (self reported)	6.7	15.5	33.9	-5.8	-5.1	-5.1	0.8	-0.1	-2.5
Triglycerides	4.4	7.3	21.3	-3.0	-2.3	-4.6	-1.5	2.3	0.6
Impedance of arm (right)	4.3	20.0	39.8	6.2	6.3	6.3	0.7	-0.2	1.2
Arm predicted mass (right)	4.3	21.9	49.1	-6.5	-7.0	-5.9	2.0	1.3	-0.1
Illness, injury, bereavement, stress in last 2 years	4.2	5.2	11.0	3.3	3.1	2.3	0.5	-1.5	1.7
Hypothyroidism/myxoedema (self-reported)	4.0	7.8	16.2	-3.9	-3.5	-4.0	0.4	-0.2	-1.8
Bipolar Disorder (2011)	3.8	3.6	13.5	-0.0	-1.4	-2.5	0.2	3.7	-0.6
Arm fat-free mass (right)	3.8	19.6	46.1	-6.1	-6.8	-5.5	2.0	0.7	-0.1
Arm predicted mass (left)	3.5	17.7	41.3	-5.8	-6.4	-5.0	2.4	0.6	-0.1
Impedance of leg (right)	3.4	16.7	34.6	5.9	5.8	5.1	-1.4	1.8	1.2
Arm fat-free mass (left)	3.4	17.2	40.4	-5.8	-6.4	-4.9	2.2	0.5	0.2
Trunk fat-free mass	3.3	18.7	42.9	-6.2	-6.5	-4.9	2.6	-0.0	-0.6
Qualifications: NVQ or HND or HNC or equivalent	3.3	4.0	8.5	-2.9	-2.4	-2.5	1.6	-0.2	-0.8
Whole body water mass	3.3	18.6	42.5	-6.1	-6.5	-5.0	2.7	-0.1	-0.2
HDL Cholesterol	3.2	5.3	10.1	2.6	2.2	3.2	0.5	-3.2	0.2
Impedance of arm (left)	3.2	15.0	31.5	5.6	5.4	5.1	0.5	0.6	1.6
Trunk predicted mass	3.2	18.3	42.1	-6.1	-6.5	-4.8	2.6	-0.0	-0.5
Whole body fat-free mass	3.2	18.4	41.6	-6.1	-6.5	-5.0	2.6	-0.1	-0.3
Impedance of whole body	3.2	16.4	34.5	5.9	5.7	5.2	-0.5	1.6	1.3
Leg fat-free mass (right)	3.1	16.4	35.9	-5.7	-6.0	-4.9	2.5	-0.4	-0.1
Leg predicted mass (right)	3.1	16.6	36.1	-5.7	-6.0	-4.9	2.5	-0.5	-0.0
Basal metabolic rate	3.0	16.5	37.5	-5.6	-6.1	-4.8	2.5	0.1	0.1
Major Depression (MDD)	2.9	3.5	15.4	-0.6	-1.4	-0.8	-0.6	3.9	-1.6
Leg fat-free mass (left)	2.9	15.5	35.2	-5.5	-5.9	-4.6	2.5	-0.4	0.2
Impedance of leg (left)	2.9	14.3	29.4	5.4	5.4	4.6	-1.3	2.0	0.8
Leg predicted mass (left)	2.9	15.3	34.7	-5.4	-5.9	-4.7	2.5	-0.4	0.2
Sensitivity / hurt feelings	2.8	4.7	8.7	-1.8	-2.0	-2.7	-1.4	3.0	-1.8
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	7.0	-2.2	-2.3	-2.7	0.6	0.0	-1.0
Bipolar Disorder (2018)	2.5	3.9	13.0	0.5	-0.3	-1.8	-2.0	3.6	-1.6
Coronary Artery Disease (CAD)	2.4	2.9	9.3	-0.3	-1.0	-1.9	-1.0	3.1	-1.5
Chronic bronchitis/emphysema (father)	2.4	2.9	4.7	2.0	2.2	1.6	0.2	-1.4	1.9
Alzheimer’s Disease (in mother)	2.3	2.7	5.9	-1.5	-1.5	-1.6	-0.1	1.8	-2.4
Mean Putamen Volume	2.3	2.7	4.6	-1.7	-1.9	-2.2	2.0	1.0	0.3
Birth weight of first child	2.3	4.2	8.9	-2.2	-2.6	-0.8	3.0	-1.0	1.8
Alcohol intake versus 10 years previously	2.2	3.4	7.2	0.0	0.6	1.9	2.7	-2.7	1.3
Age at first live birth	2.2	4.0	6.1	2.4	2.5	2.2	-0.3	-1.7	2.1
Angina (self-reported)	2.2	2.8	7.4	2.2	2.0	2.7	-0.4	-0.3	0.7
Loud music exposure frequency	2.1	2.3	5.4	-2.3	-1.4	-2.2	-0.1	-0.9	0.9
Medication: Ibuprofen	2.1	2.5	5.1	1.9	1.5	0.7	1.3	-1.5	2.3
Family relationship satisfaction	2.1	2.6	7.7	1.1	1.5	2.0	0.3	-2.8	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	13.3	-1.4	-1.6	-2.6	-3.6	1.6	0.5
Length of working week for main job	2.0	2.2	5.1	-0.5	-1.1	-1.1	2.2	2.3	0.6
Suffer from ‘nerves’	2.0	3.1	8.3	-1.5	-1.6	-2.9	-0.5	2.2	0.5
Loneliness, isolation	2.0	2.8	5.1	-2.0	-2.0	-1.9	0.3	2.3	0.2
Ever had prostate specific antigen (PSA) test	2.0	2.3	5.7	1.5	1.0	1.7	-0.9	2.4	-1.1
Heart attack/myocardial infarction (self-reported)	2.0	2.6	9.5	-0.9	-0.4	-0.1	3.1	-1.9	1.3
Blood Platelet Count	1.9	22.6	47.9	6.9	5.9	5.0	-2.9	-0.5	4.3
Financial difficulties in last 2 years	1.9	2.5	7.1	-2.7	-2.0	-1.2	-1.3	-0.2	-0.9
Heart attack	1.9	2.4	8.6	-0.8	-0.4	-0.0	2.9	-1.8	1.4
Depression (self-reported)	1.9	2.2	5.7	-1.4	-1.9	-1.4	0.2	2.4	-0.1
Medication: Ramipril	1.8	2.3	8.0	0.2	0.1	-0.4	2.4	0.3	2.8
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	6.8	-2.2	-2.6	-2.4	1.5	0.8	-1.6
Average weekly red wine intake	1.8	2.6	8.4	2.9	1.8	1.3	-0.8	1.1	-0.9
Ovarian Cancer	1.7	2.3	3.9	2.0	1.9	1.7	-0.1	-1.2	1.4
Heel T-Score	1.7	13.7	42.4	-0.7	-0.4	-5.4	-6.5	2.8	1.6
Hand grip strength (left)	1.7	4.5	12.7	-3.6	-3.0	-1.8	-1.1	0.2	-0.9
Angina	1.7	2.3	5.4	2.0	1.8	2.3	-0.5	-0.0	0.8
Townsend deprivation index at recruitment	1.7	2.3	5.2	-2.3	-2.2	-0.5	1.4	-1.0	-0.8
Medication: Levothyroxine sodium	1.7	2.9	5.1	-2.0	-2.3	-2.2	0.8	0.4	-1.6
Body Mass Index (BMI) (2010)	1.6	2.3	5.2	-2.3	-1.4	-1.4	-1.8	-1.0	-0.5
Average weekly spirits intake	1.6	1.9	4.7	-2.2	-1.7	-1.9	-0.2	0.5	-0.2
Severe depression (siblings)	1.6	1.8	3.4	-1.4	-1.7	-1.8	0.8	0.9	-0.9
Weight	1.6	8.0	17.9	-3.5	-4.2	-3.5	2.0	0.5	1.0
Time employed in main current job	1.6	1.9	3.8	2.0	1.5	1.9	0.8	0.3	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	5.3	1.5	1.0	1.0	1.2	-1.1	2.3
Illnesses of mother	1.6	2.0	5.9	0.4	1.0	1.7	-0.1	-2.4	1.4
Age at last live birth	1.6	2.3	4.3	2.1	2.0	1.9	-0.6	-1.3	0.1
Medication: Lisinopril	1.6	2.0	4.9	1.3	2.2	1.1	-1.7	0.3	-1.2
Medication: Metformin	1.5	2.1	6.2	-0.6	-1.4	-0.4	2.5	1.3	1.5
High blood pressure (mother)	1.5	2.2	7.0	1.0	0.4	-0.6	0.1	2.6	-2.1
Headache pain in last month	1.5	2.5	8.7	-1.5	-1.2	-2.9	1.4	0.6	0.6
Systolic Blood Pressure	1.4	6.9	15.1	3.6	3.9	2.4	-1.5	2.4	-0.1
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	2.4	-1.4	-1.2	-0.9	-1.2	1.6	-1.4
Sitting height	1.4	10.1	21.5	-4.4	-4.6	-3.6	1.5	1.9	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.1	8.6	-1.0	-1.4	-2.0	-2.9	1.7	0.2
Supplements: Vitamin C	1.4	1.6	6.6	0.5	0.4	1.3	-0.9	-2.6	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	4.5	-2.0	-1.3	-1.2	-1.4	0.7	-2.1
Number of operations (self-reported)	1.4	2.1	5.9	-1.2	-1.9	-0.6	2.4	-0.7	0.8
Bipolar Disorder or Schizophrenia	1.3	3.1	9.5	-0.4	-1.0	-1.8	-0.7	3.1	-2.0
Schizophrenia vs Biploar Disorder	1.3	1.7	3.9	-0.5	-0.5	0.3	2.0	-1.6	1.7
Height	1.3	24.2	61.0	-7.0	-7.8	-3.1	4.5	2.2	-0.2
Medication: Co-codamol	1.3	1.5	3.2	-1.5	-1.6	-1.8	0.6	0.5	0.4
Diabetes (mother)	1.3	1.6	3.6	-1.4	-1.9	-0.9	1.4	0.8	-0.9
Hand grip strength (right)	1.3	3.5	9.4	-3.1	-2.4	-1.6	-1.6	0.0	-0.9
Mouth/teeth dental problems: Dentures	1.3	2.1	6.0	-0.7	-1.8	0.2	2.5	0.2	1.6
Lung cancer (father)	1.3	1.6	3.7	-0.6	-0.1	-1.5	-0.7	1.6	-1.9
Exposure to tobacco smoke at home	1.3	1.5	3.4	-1.2	-1.2	-1.3	0.5	1.9	-0.8
Back pain experienced in last month	1.3	1.8	4.4	-1.4	-2.1	-1.0	-0.5	0.3	-1.8
Average weekly champagne plus white wine intake	1.3	1.8	6.2	0.9	-0.9	-0.6	-0.1	2.5	1.6
Medication: Atorvastatin	1.3	1.6	4.3	-0.9	-0.5	-2.1	-1.3	1.6	0.3
Heart disease (siblings)	1.3	1.6	2.7	-1.3	-1.6	-1.4	0.9	0.8	1.2
Breast Cancer	1.2	2.8	6.0	1.5	0.3	2.5	1.6	-2.2	1.1
Systolic blood pressure, automated reading	1.2	3.5	7.8	2.8	2.4	1.3	-0.4	2.1	1.2
Hayfever, allergic rhinitis or eczema	1.2	2.6	6.2	-2.0	-1.8	-2.5	1.4	0.2	0.4
Had major operations	1.2	1.4	3.7	-1.2	-1.9	-1.1	0.8	0.0	1.3
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.6	-1.3	-1.4	-0.7	0.6	1.6	-1.1
Fractured/broken bones in last 5 years	1.2	1.5	6.3	-0.2	0.6	1.3	0.3	-2.5	0.9
Taking other prescription medications	1.1	1.7	5.1	-1.1	-1.3	-1.3	0.5	-0.3	2.3
Comparative body size at age 10	1.1	3.1	6.3	-2.5	-1.7	-1.8	0.4	-0.9	-2.4
Pulse wave peak to peak time	1.1	1.3	3.4	-1.6	-1.2	-1.8	0.1	-0.6	0.0
Mean time to correctly identify matches	1.1	2.0	7.6	2.8	1.6	1.2	-0.7	0.3	0.2
Comparative height size at age 10	1.1	6.2	13.6	-3.7	-3.7	-2.1	1.9	1.2	-0.4
Number of full sisters	1.1	1.3	2.0	-1.4	-1.4	-0.8	1.1	-1.2	-0.8
Osteoporosis (self-reported)	1.1	1.4	2.7	-1.5	-0.9	-1.6	-1.4	0.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	7.7	-1.7	-0.9	-1.6	-2.8	0.4	-0.1
Ever depressed for a whole week	1.1	1.3	2.7	-1.6	-1.5	-0.8	1.2	-0.6	-0.5
Ulcerative Colitis	1.0	1.4	4.5	1.4	1.1	2.1	0.4	0.9	-0.4
Allergy or Eczema	1.0	2.5	4.0	-1.3	-1.4	-1.9	2.0	-0.4	1.9
Neuroticism	1.0	2.3	4.4	-1.3	-0.1	-2.1	-2.1	1.7	-0.7
Number of treatments/medications taken	1.0	1.8	7.8	0.5	1.0	-0.6	1.0	-0.3	2.8
Hearing difficulty/problems: Yes	1.0	1.5	3.6	-1.9	-1.7	-1.2	-0.3	-1.0	0.1
Medication: Atenolol	1.0	1.3	2.5	1.6	0.9	1.4	-0.5	0.7	1.4
Neuroticism score	1.0	2.1	4.9	-1.1	-0.8	-2.2	-0.8	2.2	-0.0
Medication: Cholesterol lowering	1.0	1.5	4.0	1.3	2.0	0.2	-1.8	-0.5	-0.1
Pulse wave Arterial Stiffness index	1.0	1.2	3.2	1.5	1.1	1.8	-0.1	0.6	0.1
Standing height	1.0	10.0	22.3	-4.0	-4.7	-2.6	3.2	2.1	-0.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.4	1.0	1.2	0.1	-1.6	1.3	-1.0
Ever had bowel cancer screening	1.0	1.2	2.8	-1.1	-0.3	-1.7	-0.9	1.4	-0.6
Osteoarthritis (self-reported)	1.0	1.3	2.7	-0.6	-1.5	0.6	1.7	1.5	0.0
Smoking status: Current	1.0	1.6	4.1	0.8	2.0	0.9	-0.2	-1.1	1.8
Commuting to job workplace: Public transport	1.0	1.2	2.7	-1.3	-1.1	-1.6	-0.1	0.6	1.1
Supplements: Calcium	1.0	1.1	2.5	-0.4	-0.3	-1.3	-1.6	-0.8	1.3
Alzheimer’s Disease (including proxy)	0.9	1.4	2.0	-1.2	-1.3	-1.4	0.3	1.0	-1.4
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.4	-0.1	-0.1	-0.1	-1.9	0.5	-1.5
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.9	-0.8	-1.3	-0.8	1.1	1.4	0.9
Ever had hysterectomy (womb removed)	0.9	1.0	2.7	0.4	-0.5	-1.1	1.7	1.1	0.6
Pack years adult smoking proportion	0.9	1.4	2.6	1.2	1.6	0.8	-0.8	-1.5	0.9
Fed-up feelings	0.9	1.6	4.4	-1.7	-1.3	-2.1	0.4	0.6	0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	2.7	-1.3	-0.9	-0.2	1.7	-1.0	-0.0
Gout (self-reported)	0.9	1.3	3.1	-1.3	-1.3	-1.8	-0.7	-0.7	-0.3
Medication for cholesterol	0.9	1.3	2.2	-1.5	-1.4	-1.1	-1.3	-0.6	-0.8
Unable to work because of sickness or disability	0.9	1.1	2.7	0.7	-0.1	0.6	1.7	-1.1	1.4
Myopia	0.9	1.3	3.9	0.4	0.7	-0.8	-1.4	0.6	-2.0
Pain experienced in last month	0.9	1.5	3.5	1.2	1.7	1.9	-0.4	-1.1	-0.4
Depression (Nagel 2018)	0.8	1.2	2.8	-1.3	-1.2	-1.2	0.0	1.7	0.3
Neuroticism (Nagel 2018)	0.8	1.9	4.2	-1.1	-1.0	-2.1	-1.4	1.7	-0.2
Worry (Nagel 2018)	0.8	1.7	7.6	-0.1	-0.3	-1.2	-0.9	2.7	-0.2
Ulcerative Colitis (UC)	0.8	1.6	3.9	1.4	1.1	2.0	1.3	0.2	-0.8
Type 2 Diabetes (T2D) (2018)	0.8	1.4	4.6	0.4	-0.3	0.4	0.4	2.1	1.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.7	-0.9	-0.8	-1.7	1.3	-0.7	0.1
Current tobacco smoking	0.8	1.3	3.3	0.7	1.8	0.6	0.2	-1.0	1.7
Average weekly fortified wine intake	0.8	0.9	3.1	-0.2	0.2	-0.2	-1.8	0.4	-1.5
Multivitamins +/- minerals	0.8	1.0	3.0	-0.4	-0.2	-0.9	-1.3	0.7	-1.7
Waist circumference	0.8	2.8	6.0	-1.6	-2.1	-2.4	0.7	0.1	1.7
Hip circumference	0.8	3.3	6.5	-1.7	-2.5	-2.0	1.7	1.0	1.6
Hair/balding pattern: Pattern 3	0.8	1.2	5.1	-0.7	-0.5	-0.3	-0.5	0.8	-2.3
Birth weight	0.8	1.8	5.8	-1.3	-1.5	-0.4	2.4	-1.0	-0.2
Health satisfaction	0.8	1.1	2.0	-1.2	-1.1	-1.4	0.5	-0.2	-1.3
Medication: Allopurinol	0.8	1.1	2.1	-1.4	-1.2	-1.3	-0.9	-0.8	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.8	-1.1	-1.2	-1.7	-0.2	-0.5	-0.4
Arm fat mass (left)	0.8	3.2	6.2	-1.8	-2.5	-2.2	1.5	0.4	1.5
Medication: Bendroflumethiazide	0.8	1.3	3.1	0.7	0.3	0.3	-1.6	1.8	1.1
Irritability	0.8	1.4	5.2	-0.4	-0.2	-1.0	-1.3	0.3	2.3
Diastolic blood pressure, automated reading	0.8	2.4	5.8	2.4	1.9	1.8	1.2	0.4	0.5
Commuting to job workplace: Cycle	0.8	0.9	2.0	-1.1	-0.9	-1.4	-0.2	-1.0	-0.6
Pack years of smoking	0.8	1.2	1.8	1.0	1.3	0.9	-0.9	-1.2	1.2
Depressed Affect (Nagel 2018)	0.7	1.4	2.9	-1.1	-1.0	-1.7	-0.8	1.6	0.2
Reaction Time	0.7	1.3	5.3	2.3	1.2	0.5	-0.3	0.8	-0.1
Prostate Cancer	0.7	1.0	5.1	0.2	0.3	-0.2	-2.3	-0.6	-0.5
LDL Cholesterol	0.7	1.1	1.7	-1.1	-0.1	-1.2	-1.3	1.1	-1.0
Medication for hormone replacement therapy	0.7	0.8	1.6	0.9	1.1	1.1	1.3	0.0	0.2
Maternal smoking around birth	0.7	1.0	2.9	0.3	0.7	1.0	-1.2	-1.7	0.2
Qualifications: CSEs or equivalent	0.7	0.9	2.3	0.6	1.2	0.5	-1.1	0.1	1.5
Supplements: Glucosamine	0.7	0.9	2.2	-0.9	-1.5	-0.5	-0.2	0.2	1.5
Number of incorrect matches in round	0.7	1.1	2.7	1.1	0.1	0.1	1.7	1.6	0.6
Had menopause	0.7	0.9	3.1	1.0	0.5	1.8	0.1	-0.4	1.0
Allergy	0.7	1.7	4.4	1.4	1.5	2.1	-0.9	-0.8	-0.1
Pulse rate	0.7	1.2	2.8	1.7	1.5	0.7	-0.4	-0.0	-1.2
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.8	-0.6	0.0	-1.0	1.0	-1.7	0.4
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.5	-0.6	-1.9	-0.3	1.5	0.8	0.2
Medication: Blood pressure	0.7	1.2	4.5	0.9	2.1	0.8	-0.9	-0.5	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.7	-0.8	-0.9	-0.5	1.1	-0.6	-1.3
Alcohol intake frequency.	0.7	1.5	3.5	-1.9	-1.4	-1.3	1.2	0.6	-0.2
Commuting to job workplace: Walk	0.7	0.8	2.6	-0.8	-1.6	0.2	-0.7	-0.5	0.8
Financial situation satisfaction	0.7	0.9	1.8	-1.2	-1.3	-1.0	-0.5	0.2	-1.0
Medication: Paracetamol	0.7	1.1	5.9	0.0	0.2	-0.4	-0.2	0.7	2.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.7	1.6	1.2	0.7	0.1	0.3	-0.0
Leg fat mass (left)	0.7	2.7	5.5	-1.8	-2.4	-2.0	0.8	0.6	1.5
Crohns Disease (2017)	0.6	1.3	2.8	-0.8	-1.1	-1.0	0.8	1.1	-1.7
Age at First Birth	0.6	0.9	3.2	0.6	0.2	0.6	1.1	-0.1	1.8
Cardiovascular Disease	0.6	2.1	4.8	1.8	2.2	1.2	-1.0	1.0	-1.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.8	-0.1	-1.0	-1.7	0.3	0.5	0.7
Body mass index (BMI)	0.6	2.5	5.7	-1.7	-2.1	-2.4	0.5	-0.5	1.3
Hearing difficulty/problems with background noise	0.6	1.0	2.2	-1.2	-0.5	1.5	0.7	-1.0	-0.5
Mouth/teeth dental problems	0.6	1.0	2.1	1.4	1.4	0.6	-0.1	-1.2	-0.1
Medication: Simvastatin	0.6	0.9	2.2	0.7	1.5	0.5	-0.3	-1.5	-0.2
Worrier / anxious feelings	0.6	1.0	2.9	0.6	0.6	-1.1	-1.1	1.7	-0.6
Noisy workplace	0.6	0.8	1.5	-1.2	-0.8	-1.0	1.1	-0.1	0.3
Medication: Lansoprazole	0.6	0.6	1.9	0.6	0.7	0.1	-0.5	0.9	1.4
Arm fat mass (right)	0.6	2.7	5.5	-1.8	-2.3	-1.9	1.3	0.0	1.5
Medication: Paracetamol	0.6	1.0	2.5	-0.8	-0.9	-0.9	-0.2	1.1	1.6
Medication: Amlodipine	0.6	0.8	1.8	1.0	1.2	0.4	-0.7	1.3	0.1
Number of full brothers	0.6	0.8	2.0	0.1	0.6	0.4	0.5	-1.4	-1.4
Shortness of breath walking on level ground	0.6	0.8	3.3	-0.6	0.1	-0.5	0.2	-0.8	-1.8
Eye problems/disorders: None of the above	0.6	0.7	1.4	-1.2	-1.0	-1.1	0.2	-0.5	-0.5
Medication: Seretide 50 evohaler	0.6	0.7	2.8	-0.3	-0.2	-0.9	0.2	-0.9	1.7
Heart disease (mother)	0.6	0.8	2.4	-0.6	-0.7	-1.5	-0.7	0.6	-0.9
Medication: Aspirin	0.6	0.8	2.2	0.2	1.0	-0.5	-1.5	1.2	-0.2
Knee pain experienced in last month	0.6	0.9	4.3	-0.1	-0.4	-2.1	-0.4	0.0	1.0
Asthma (self-reported)	0.6	1.3	3.3	-1.4	-1.8	-1.2	-0.3	0.8	-0.2
Medication: Aspirin	0.6	0.8	2.2	0.5	1.5	-0.3	-1.3	0.7	0.2
Medication: Gliclazide	0.6	0.7	2.2	0.7	0.3	0.8	-0.2	-0.9	1.5
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.3	-0.9	-0.8	-1.2	-1.0	0.7	0.3
Vascular/heart problems diagnosed by doctor	0.6	1.5	3.4	-1.7	-1.8	-1.5	0.1	-0.4	-0.4
Basal cell carcinoma (self-reported)	0.6	0.8	1.4	-1.2	-0.9	-0.8	0.9	-0.3	-1.0
Schizophrenia (2018)	0.5	0.9	1.4	-0.9	-1.0	-0.9	0.6	1.1	-1.2
Verbal and Numeric Reasoning (VNR)	0.5	1.1	5.4	-0.6	-0.8	0.5	0.2	-2.3	0.0
Lupus	0.5	0.8	2.1	0.1	1.4	-0.9	-1.0	0.8	0.3
Rheumatoid Arthritis	0.5	0.7	1.8	-1.2	-0.5	-0.7	-0.1	-1.4	-0.5
Lung FEV1/FVC ratio	0.5	2.7	8.5	1.9	1.3	0.8	-1.2	0.4	2.9
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.4	-0.9	-1.1	-0.5	-0.2	1.2	0.2
Supplements: Zinc	0.5	0.5	1.6	0.8	0.7	0.3	0.2	-1.3	0.3
Serious illness, injury or assault to yourself	0.5	0.6	1.6	0.5	0.9	-0.2	-0.4	-0.8	-1.3
High blood pressure	0.5	1.5	3.2	1.8	1.6	1.7	-0.0	0.6	0.1
Stomach or abdominal pain in last month	0.5	0.6	1.4	-0.6	-0.7	-0.2	1.2	1.1	0.5
Nervous feelings	0.5	1.0	2.4	-0.7	-0.8	-1.6	0.6	1.5	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.4	0.9	1.2	0.6	-1.1	1.0	0.4
Hair/balding pattern: Pattern 2	0.5	0.7	2.1	0.1	-0.1	-0.5	1.5	1.3	0.2
Fluid intelligence score	0.5	1.0	3.6	-0.6	-1.0	0.4	-0.5	-1.9	0.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	4.2	-2.0	-1.0	-1.9	-1.0	0.5	0.5
Asthma	0.5	0.9	2.5	-1.2	-1.6	-1.0	-0.3	0.6	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.4	-1.9	-0.9	-1.6	-0.9	0.1	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.8	-1.3	-0.9	-1.2	-0.5	-0.3	0.6
Pulse wave reflection index	0.5	0.6	2.2	0.1	-0.4	0.8	1.0	0.0	1.5
Blood clot in the leg (DVT)	0.5	0.6	1.4	-1.2	-1.0	-0.6	0.9	0.3	0.1
Emphysema/chronic bronchitis	0.5	0.6	1.4	-0.6	-0.3	-1.0	-0.6	1.2	-0.4
Neck or shoulder pain in last month	0.5	0.8	2.4	-1.0	-1.6	-0.1	0.9	-0.4	0.5
Migraine (self-reported)	0.5	0.7	2.5	0.6	1.6	0.2	0.2	-1.0	-0.2
Medication: Omeprazole	0.5	0.5	1.0	1.0	0.7	0.4	-0.7	0.5	-0.9
Whole body fat mass	0.5	2.0	3.9	-1.2	-2.0	-1.5	1.1	0.8	1.5
Leg fat mass (right)	0.5	2.1	3.8	-1.3	-2.0	-1.7	0.7	0.5	1.8
Leg pain on walking	0.5	0.6	2.1	0.8	0.6	-0.0	0.8	-0.2	1.4
Illnesses of father: Heart disease	0.5	0.7	1.6	-0.4	-1.3	1.0	0.9	-0.8	0.1
Smoking status: Previous	0.5	0.7	1.8	-0.7	-0.9	1.4	-0.4	0.3	-0.8
Mood swings	0.5	0.9	3.0	-0.4	-0.4	-1.1	-0.2	1.7	1.0
Long-standing illness, disability or infirmity	0.5	0.7	2.0	-0.3	-0.9	-0.1	1.1	-0.2	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	0.8	0.6	0.7	0.9	-0.9	0.2	-0.9
Friendships satisfaction	0.5	0.7	3.0	0.4	0.1	0.5	-0.4	-1.7	0.7
Wears glasses or contact lenses	0.5	0.6	2.6	0.2	-0.2	-0.8	-1.6	0.4	-0.5
Ever taken oral contraceptive pill	0.5	0.6	1.1	0.8	1.0	0.4	-0.9	0.8	-0.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	0.8	0.3	-0.9	-0.9	-0.9	0.8	0.8
Age started oral contraceptive pill	0.5	0.6	1.7	-1.0	-0.4	-0.5	-1.3	-0.5	0.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.4	-1.1	-0.9	-0.5	1.2	0.4	0.3
Irritable Bowel Disease (IBD)	0.4	0.9	2.3	0.4	-0.0	0.8	1.5	0.8	-1.4
Fasting Glucose	0.4	0.4	1.8	-0.1	0.1	0.2	0.3	-0.8	1.3
Blood Red Count	0.4	3.8	11.3	2.1	1.7	3.4	2.0	-0.3	0.2
Blood White Count	0.4	3.0	5.3	1.7	2.3	1.1	-2.3	0.7	1.7
Smoking Status	0.4	0.9	2.6	0.4	1.1	1.6	-0.6	-1.0	0.6
Lung FVC	0.4	2.0	8.2	-0.7	1.2	-0.5	-2.9	-0.0	1.2
Diabetes (father)	0.4	0.5	1.4	0.1	0.2	1.0	-1.2	-0.1	-0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.1	-1.1	-0.9	-0.3	-0.9	-0.2	-0.1
Trunk fat mass	0.4	1.8	2.9	-0.9	-1.7	-1.3	1.2	0.9	1.7
Past tobacco smoking	0.4	0.7	2.9	0.2	-0.0	-1.7	0.6	1.0	-0.1
Forced vital capacity (FVC)	0.4	1.3	4.2	-2.0	-0.9	-1.5	-0.8	0.4	0.2
Diabetes (self-reported)	0.4	0.6	1.5	0.0	-0.3	0.0	1.2	0.6	1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.9	-0.7	-0.5	0.2	0.6	-1.4	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.8	-0.5	-0.7	-0.3	0.7	1.4	-1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.8	3.2	-0.3	-0.2	-0.3	1.1	-1.8	0.4
Hair/balding pattern: Pattern 4	0.4	1.0	2.5	-1.1	-1.5	-0.2	0.2	-1.6	0.4
Peak expiratory flow (PEF)	0.4	0.9	2.4	-1.1	-0.4	-1.6	-1.2	0.2	0.5
Exposure to tobacco smoke outside home	0.4	0.5	1.7	0.4	0.2	0.8	0.7	1.3	0.1
Worry too long after embarrassment	0.4	0.7	2.0	-1.2	-0.7	-1.4	0.6	-0.0	0.5
Wheeze or whistling in the chest in last year	0.4	0.7	2.6	-0.1	-0.2	-0.2	-1.6	-1.0	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.5	-0.6	-0.5	-0.4	-0.6	1.2	-0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.0	0.2	0.8	1.4	0.3	-0.5	-0.4
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	0.3	0.9	0.6	-0.6	0.0	-1.1
Hypertension (Self-reported)	0.4	1.2	2.7	1.6	1.4	1.6	-0.1	0.2	-0.1
Qualifications: nursing, teaching	0.4	0.6	1.9	0.1	0.2	0.7	-0.1	-1.0	-1.4
Mineral and other dietary supplements	0.4	0.6	1.4	-0.1	0.9	0.3	1.2	-0.1	-1.1
Breast cancer (self-reported)	0.4	0.4	1.2	-1.1	-0.2	-0.3	-0.3	-0.7	-0.8
Miserableness	0.4	0.8	2.6	-0.8	-0.8	-1.6	0.5	0.7	0.3
Guilty feelings	0.4	0.6	1.7	-0.7	0.3	-0.2	-1.1	0.6	-1.3
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.5	-0.4	0.7	0.1	0.6	-1.2	-0.2
Medication: Blood pressure	0.4	0.7	1.3	1.0	0.2	0.9	0.6	1.1	0.9
High cholesterol (Self-reported)	0.4	0.8	2.4	0.5	1.6	0.2	-1.3	-0.5	0.3
Illnesses of father: High blood pressure	0.4	0.5	2.4	0.4	0.4	-0.4	0.1	-0.2	1.5
Alcohol drinker status: Previous	0.4	0.5	2.4	-0.1	0.1	-0.1	-0.6	0.4	-1.6
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.4	0.2	0.4	1.1	0.8	-1.5	0.7
HbA1C	0.3	0.3	0.6	0.2	0.3	0.5	-0.8	-0.8	0.5
Neuroticism (2016)	0.3	0.4	1.0	-0.8	-0.3	-0.7	-0.3	1.0	0.2
Primary Biliary Cirrhosis	0.3	0.4	0.9	-0.6	-0.6	-0.1	0.7	-1.0	-0.4
Schizophrenia (2014)	0.3	0.8	3.0	-0.0	-0.1	-1.0	0.5	1.7	-0.5
BMI	0.3	2.0	4.8	-1.7	-1.6	-2.2	1.3	0.0	0.4
Respiratory disease	0.3	0.8	1.4	-0.9	-1.2	-0.8	-0.8	1.0	0.3
Chronotype (morning person)	0.3	0.6	1.3	-0.2	-0.1	-0.8	-1.1	0.7	-1.0
Relative age of first facial hair	0.3	0.5	0.9	0.9	1.0	-0.7	-0.9	0.1	-0.3
Trunk fat percentage	0.3	1.3	4.7	1.1	0.3	0.2	0.9	0.8	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.1	0.6	-0.9	-0.5	0.9	0.7
Age when periods started (menarche)	0.3	0.7	2.6	0.3	0.0	0.1	0.0	1.6	1.1
Alcohol usually taken with meals	0.3	0.4	1.4	-0.0	-0.4	0.3	0.3	1.2	-0.9
Number of live births	0.3	0.4	0.9	-0.9	-0.5	0.3	-0.0	-1.0	0.3
Happiness	0.3	0.4	0.6	0.4	0.8	0.6	0.5	-0.7	0.6
Prospective memory result	0.3	0.4	1.1	-0.1	0.0	-1.0	0.5	0.9	-0.2
Tense / ‘highly strung’	0.3	0.5	1.8	0.6	0.3	0.4	-0.0	1.3	0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	1.5	-0.4	0.5	-0.9	-1.2	-0.4	-0.7
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	0.4	0.6	0.5	-0.5	-0.9	0.6
High blood pressure (siblings)	0.3	0.5	1.5	-0.2	-0.8	-0.3	-0.8	1.2	0.1
Forced vital capacity (FVC), Best measure	0.3	1.0	3.1	-1.8	-0.8	-1.0	-0.6	0.1	0.9
Leg fat percentage (right)	0.3	1.2	5.1	1.2	0.5	0.5	-0.3	0.6	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.5	-0.4	0.1	-0.4	-0.8	-0.2	1.2
Number of children fathered	0.3	0.3	0.8	0.4	0.7	-0.9	-0.5	-0.4	-0.2
Medication for pain relief, constipation, heartburn	0.3	0.4	1.0	0.1	-0.3	0.7	-0.3	-1.0	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.8	0.9	0.6	-0.5	0.2	-0.2	0.8
Diabetes diagnosed by doctor	0.3	0.4	1.4	-0.1	-0.4	0.1	0.8	0.7	1.2
Number of self-reported non-cancer illnesses	0.3	0.5	2.4	0.2	-0.2	-0.4	0.5	1.5	-0.3
Hearing aid user	0.3	0.3	1.0	0.4	-0.6	0.0	1.0	-0.4	0.2
Alcohol drinker status: Never	0.3	0.4	1.2	0.6	0.6	1.1	-0.3	-0.5	-0.0
Ever smoked	0.3	0.6	1.9	-0.6	-0.1	1.0	0.4	-1.4	0.2
Cholesterol lowering medication	0.3	0.5	1.5	-1.2	-0.3	-1.0	0.4	-0.1	0.5
Alzheimer’s Disease (in father)	0.2	0.2	1.1	0.1	-0.0	-0.3	-0.5	0.0	1.1
Crohns Disease (2012)	0.2	0.4	1.3	0.3	0.2	0.3	-0.2	0.8	-1.1
Blood Eosinophil Count	0.2	1.5	3.6	1.9	1.4	1.8	0.6	-0.0	-0.1
Waist Hip Ratio (WHR)	0.2	0.7	2.2	0.7	1.1	-0.4	-1.5	-0.3	-0.0
Vitamin and mineral supplements	0.2	0.3	1.5	-0.3	-0.4	-0.3	1.2	-0.0	-0.0
Relative age voice broke	0.2	0.3	1.4	0.6	0.1	-1.2	-0.4	0.3	0.1
Had other major operations	0.2	0.2	0.8	-0.3	-0.3	0.6	0.9	0.1	-0.2
Pain all over the body in last month	0.2	0.2	0.7	0.1	0.4	0.1	0.2	-0.8	0.7
Illnesses of siblings	0.2	0.3	0.8	0.5	0.9	-0.2	0.1	-0.9	0.4
Arm fat percentage (right)	0.2	0.7	3.0	0.5	0.0	0.1	0.8	-0.3	1.7
Body fat percentage	0.2	0.9	4.1	0.7	0.0	-0.0	0.4	0.8	2.0
Qualifications: College or University degree	0.2	0.7	2.0	0.1	0.2	1.0	-0.0	-1.4	-1.0
Overall health rating	0.2	0.5	1.6	-0.2	-0.5	-1.3	0.1	0.7	0.7
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.0	-0.2	0.4	0.3	0.7	-0.5
Arm fat percentage (left)	0.2	0.9	4.2	0.2	-0.5	-0.5	0.8	0.1	2.0
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.4	-0.1	-0.5	0.8	0.2	-0.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.7	0.0	-0.9	0.2	0.5	-0.2	0.7
Leg fat percentage (left)	0.2	0.8	3.7	0.6	-0.0	-0.2	-0.2	0.8	1.9
Tanning	0.1	1.4	5.2	-2.3	-1.1	-1.3	-0.3	0.3	-0.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.2	0.1	0.0	-0.1	0.6	-0.4
Father’s age at death	0.1	0.1	0.4	-0.1	-0.2	-0.2	0.6	-0.1	-0.3
Falls in the last year	0.1	0.1	0.2	-0.5	0.2	0.1	0.5	-0.2	0.3
Breastfed as a baby	0.1	0.2	0.7	-0.0	0.3	-0.1	-0.1	-0.8	-0.4
Glaucoma (self-reported)	0.1	0.2	0.5	0.3	-0.2	0.5	-0.4	0.7	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	0.1	-0.2	0.2	0.4	0.7	0.6
Pulse rate, automated reading	0.1	0.3	1.1	0.0	-0.3	-0.6	0.2	0.7	-1.0
Chest pain or discomfort	0.1	0.1	0.3	-0.5	-0.4	-0.4	0.5	0.2	0.0
Eye problems/disorders: Cataract	0.1	0.2	0.5	-0.0	0.2	-0.5	-0.1	0.5	-0.7
Mother’s age at death	0.1	0.1	0.3	0.1	-0.2	0.2	-0.1	0.5	-0.5
Average weekly beer plus cider intake	0.1	0.1	0.3	-0.5	0.2	-0.2	-0.5	-0.0	-0.3
Risk taking	0.1	0.2	0.9	0.1	0.1	-0.3	-0.3	0.9	0.2
Hair Pigment	0.0	0.9	2.7	-0.6	-1.6	-0.5	0.1	0.2	1.5
Qualifications: None of the above	0.0	0.1	0.2	0.2	-0.2	0.4	-0.1	0.2	-0.3

Hub : Genes

MAPK10

Models

Trait associations