Best TWAS P=2.22e-19 · Best GWAS P=7.29e-26 conditioned to 4.86e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CEP120 | 0.12 | 0.08 | lasso | 3 | 0.05 | 5.5e-05 | -5.1 | -5.5 | 3.0e-08 | -0.29 | 0.87 | 0.01 | FALSE |
| 2 | GTEx | Artery Aorta | CSNK1G3 | 0.11 | 0.07 | lasso | 2 | 0.01 | 6.5e-02 | 5.0 | 5.2 | 1.7e-07 | 0.52 | 0.15 | 0.09 | FALSE |
| 3 | GTEx | Artery Aorta | KRT8P33 | 0.10 | 0.04 | lasso | 6 | 0.05 | 9.1e-04 | 5.9 | -7.7 | 1.7e-14 | -0.62 | 0.03 | 0.88 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | KRT8P33 | 0.16 | -0.01 | lasso | 8 | 0.01 | 2.1e-01 | -5.7 | -5.4 | 6.8e-08 | -0.36 | 0.08 | 0.34 | FALSE |
| 5 | GTEx | Esophagus Mucosa | CSNK1G3 | 0.14 | 0.05 | lasso | 3 | 0.07 | 2.0e-05 | -6.3 | -6.0 | 1.8e-09 | -0.44 | 0.78 | 0.11 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CSNK1G3 | 0.04 | 0.02 | enet | 8 | 0.02 | 1.2e-04 | -6.4 | -6.5 | 7.2e-11 | -0.56 | 0.03 | 0.21 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | CEP120 | 0.06 | 0.02 | blup | 70 | 0.04 | 3.6e-03 | -3.4 | -6.3 | 3.8e-10 | -0.64 | 0.13 | 0.15 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CEP120 | 0.03 | 0.02 | enet | 5 | 0.04 | 7.3e-05 | 5.9 | -6.7 | 1.8e-11 | -0.66 | 0.03 | 0.83 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | CSNK1G3 | 0.06 | 0.05 | lasso | 2 | 0.04 | 2.0e-05 | -6.3 | -6.2 | 5.8e-10 | -0.44 | 0.12 | 0.83 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CEP120 | 0.10 | 0.14 | blup | 70 | 0.14 | 2.6e-14 | 9.5 | -9.0 | 2.2e-19 | -0.83 | 0.17 | 0.83 | TRUE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CSNK1G3 | 0.06 | 0.04 | enet | 10 | 0.05 | 2.3e-06 | -6.9 | -8.0 | 1.4e-15 | -0.57 | 0.00 | 0.99 | FALSE |