Best TWAS P=4.52e-09 · Best GWAS P=2.6e-10 conditioned to 0.0126
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | NADK | 0.18 | 0.11 | lasso | 7 | 0.09 | 3.1e-03 | 5.6 | 5.7 | 1.0e-08 | -0.84 | 0.02 | 0.70 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | RP5-890O3.9 | 0.24 | 0.02 | lasso | 9 | 0.02 | 1.3e-01 | 6.2 | -5.9 | 4.5e-09 | 0.86 | 0.01 | 0.75 | TRUE |
| 3 | GTEx | Lung | NADK | 0.07 | 0.03 | lasso | 3 | 0.02 | 8.5e-03 | -4.0 | 5.1 | 2.9e-07 | -0.91 | 0.02 | 0.93 | FALSE |
| 4 | GTEx | Muscle Skeletal | NADK | 0.06 | 0.00 | enet | 9 | 0.00 | 1.3e-01 | 5.6 | 5.8 | 5.0e-09 | -0.77 | 0.04 | 0.86 | FALSE |
| 5 | GTEx | Muscle Skeletal | TMEM52 | 0.11 | 0.08 | lasso | 6 | 0.10 | 7.2e-10 | 5.7 | -5.4 | 6.5e-08 | 0.78 | 0.12 | 0.87 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | TMEM52 | 0.17 | 0.14 | lasso | 7 | 0.15 | 2.0e-12 | -5.1 | -5.1 | 2.8e-07 | 0.86 | 0.05 | 0.95 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | MMP23B | 0.05 | 0.04 | lasso | 2 | 0.03 | 1.9e-04 | 5.3 | 5.2 | 1.5e-07 | -0.75 | 0.05 | 0.93 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC35E2 | 0.03 | 0.03 | blup | 35 | 0.01 | 7.0e-02 | 6.0 | 5.3 | 1.1e-07 | -0.93 | 0.01 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC35E2 | 0.03 | 0.00 | blup | 34 | 0.01 | 5.3e-02 | 5.3 | -5.4 | 5.4e-08 | 0.81 | 0.01 | 0.64 | FALSE |