[Hub]/) : Traits : Impedance of leg (left) : ← →

chr1:8,655,495-12,013,869

Best TWAS P=5.98e-14 · Best GWAS P=4.41e-25 conditioned to 5.2e-13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Thyroid	RP4-635E18.7	0.07	0.02	lasso	2	0.01	5.5e-02	-5.8	-7.5	6.0e-14	0.22	0.18	0.03	TRUE
12	NTR	Blood	SPSB1	0.02	0.00	enet	12	0.01	3.5e-03	-5.6	-6.1	9.1e-10	0.05	0.05	0.51	TRUE
7	GTEx	Esophagus Mucosa	KIF1B	0.10	0.00	enet	17	0.01	1.2e-01	-4.6	-6.0	2.5e-09	0.08	0.22	0.04	TRUE
2	GTEx	Adipose Subcutaneous	EXOSC10	0.17	0.00	lasso	3	0.00	1.8e-01	-5.8	-5.2	1.8e-07	0.08	0.05	0.04	TRUE
14	ROSMAP	Brain Pre-frontal Cortex	MTOR	0.07	0.05	bslmm	423	0.04	2.0e-06	-5.1	-6.1	1.1e-09	0.13	1.00	0.00	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	EXOSC10	0.06	0.06	lasso	2	0.06	4.9e-08	-5.8	-5.8	7.0e-09	0.07	1.00	0.00	FALSE
8	GTEx	Lung	EXOSC10	0.11	0.07	lasso	4	0.05	1.2e-04	-5.8	-5.8	7.1e-09	0.06	0.88	0.01	FALSE
6	GTEx	Brain Cerebellum	RP4-635E18.7	0.17	0.17	lasso	5	0.09	1.3e-03	-5.8	-5.8	8.2e-09	0.07	0.38	0.03	FALSE
1	CommonMind	Brain Pre-frontal Cortex	EXOSC10	0.06	0.08	lasso	2	0.07	6.8e-09	-5.8	-5.7	1.2e-08	0.08	1.00	0.00	FALSE
9	GTEx	Muscle Skeletal	KIF1B	0.04	0.08	lasso	1	0.07	3.1e-07	-5.6	-5.6	1.9e-08	-0.01	0.98	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	RP4-635E18.7	0.19	0.08	lasso	6	0.05	9.0e-04	-5.7	-5.4	7.6e-08	0.09	0.44	0.02	FALSE
5	GTEx	Brain Cerebellum	EXOSC10	0.33	0.16	lasso	6	0.18	3.8e-06	-5.8	-5.4	8.3e-08	0.10	0.78	0.01	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MTOR	0.02	0.02	blup	54	0.02	5.4e-03	-5.4	-5.3	1.2e-07	0.10	0.06	0.69	FALSE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTOR	0.03	0.01	blup	54	0.02	5.9e-03	-5.4	-5.3	1.3e-07	0.08	0.03	0.74	FALSE
10	GTEx	Thyroid	KIF1B	0.13	0.14	lasso	5	0.16	5.3e-12	-5.6	-5.3	1.4e-07	0.00	1.00	0.00	FALSE
4	GTEx	Brain Cerebellar Hemisphere	EXOSC10	0.23	0.10	lasso	3	0.12	6.4e-04	-4.8	-5.2	1.8e-07	0.10	0.19	0.04	FALSE