Best TWAS P=5.76e-12 · Best GWAS P=1.22e-14 conditioned to 0.000266
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-446E9.1 | 0.07 | 0.00 | lasso | 6 | 0.00 | 6.6e-01 | 3.3 | -5.3 | 1.2e-07 | -0.71 | 0.04 | 0.54 | FALSE |
| 2 | GTEx | Brain Cerebellum | RPS20 | 0.26 | 0.07 | enet | 17 | 0.10 | 5.4e-04 | 6.7 | 5.2 | 2.1e-07 | 0.64 | 0.10 | 0.74 | FALSE |
| 3 | GTEx | Esophagus Muscularis | RPS20 | 0.12 | 0.04 | lasso | 6 | 0.05 | 7.2e-04 | 6.8 | 6.9 | 5.8e-12 | 0.81 | 0.16 | 0.73 | TRUE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | RPS20 | 0.18 | 0.03 | enet | 12 | 0.07 | 1.5e-04 | 6.5 | 6.3 | 3.7e-10 | 0.80 | 0.16 | 0.44 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | RP11-446E9.1 | 0.23 | 0.32 | lasso | 7 | 0.34 | 2.0e-45 | 4.9 | -5.3 | 1.4e-07 | -0.56 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPS20 | 0.33 | 0.07 | enet | 8 | 0.07 | 1.7e-08 | 5.4 | 5.3 | 1.2e-07 | 0.52 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPS20 | 0.04 | 0.03 | lasso | 3 | 0.04 | 1.3e-04 | 5.4 | 5.8 | 6.9e-09 | 0.60 | 0.00 | 0.96 | FALSE |