Best TWAS P=1.08e-08 · Best GWAS P=1.86e-09 conditioned to 0.0233
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RPP25L | 0.10 | 0.09 | enet | 10 | 0.05 | 8.5e-04 | 5.5 | 5.6 | 2.5e-08 | -0.32 | 0.04 | 0.95 | FALSE |
| 2 | GTEx | Artery Tibial | RP11-195F19.9 | 0.35 | 0.20 | enet | 23 | 0.26 | 5.3e-20 | 3.9 | -5.4 | 7.5e-08 | 0.25 | 0.66 | 0.26 | FALSE |
| 3 | GTEx | Brain Caudate basal ganglia | RPP25L | 0.17 | 0.02 | lasso | 7 | 0.00 | 3.5e-01 | 5.5 | 5.5 | 4.8e-08 | -0.41 | 0.07 | 0.47 | FALSE |
| 4 | GTEx | Esophagus Mucosa | RP11-195F19.9 | 0.18 | 0.09 | lasso | 4 | 0.14 | 1.1e-09 | 3.4 | -5.1 | 3.1e-07 | 0.15 | 0.11 | 0.88 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | RP11-195F19.9 | 0.25 | 0.09 | enet | 14 | 0.15 | 2.3e-07 | 3.4 | -5.3 | 1.1e-07 | 0.25 | 0.19 | 0.77 | FALSE |
| 6 | GTEx | Stomach | RP11-195F19.9 | 0.13 | 0.06 | enet | 15 | 0.11 | 5.0e-06 | 3.9 | -5.7 | 1.1e-08 | 0.26 | 0.26 | 0.45 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | SIGMAR1 | 0.25 | 0.16 | enet | 27 | 0.19 | 1.2e-23 | 3.9 | -5.5 | 4.8e-08 | 0.17 | 0.72 | 0.19 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UBE2R2 | 0.04 | 0.01 | blup | 57 | 0.02 | 1.3e-03 | 4.6 | -5.5 | 4.9e-08 | 0.48 | 0.01 | 0.80 | TRUE |