Best TWAS P=6.49e-13 · Best GWAS P=4.17e-13 conditioned to 0.00134
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | GTEx | Skin Sun Exposed Lower leg | R3HCC1L | 0.10 | 0.05 | enet | 14 | 0.05 | 3.4e-05 | -6.3 | 7.2 | 6.5e-13 | 0.68 | 0.08 | 0.91 | TRUE |
| 2 | GTEx | Nerve Tibial | R3HCC1L | 0.06 | 0.07 | enet | 8 | 0.05 | 1.1e-04 | 5.8 | 6.3 | 2.7e-10 | 0.87 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Testis | LOXL4 | 0.48 | 0.47 | enet | 8 | 0.46 | 1.0e-22 | -6.2 | 6.2 | 6.3e-10 | 0.48 | 0.66 | 0.34 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LOXL4 | 0.08 | 0.00 | blup | 51 | 0.02 | 9.4e-03 | 4.7 | 6.1 | 8.5e-10 | 0.62 | 0.01 | 0.45 | FALSE |
| 1 | GTEx | Esophagus Muscularis | LOXL4 | 0.16 | 0.16 | lasso | 3 | 0.15 | 2.4e-09 | -6.0 | 6.1 | 9.2e-10 | 0.49 | 0.73 | 0.27 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOXL4 | 0.09 | 0.05 | enet | 12 | 0.05 | 3.0e-06 | -5.4 | 6.0 | 1.6e-09 | 0.42 | 0.52 | 0.33 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | R3HCC1L | 0.03 | 0.04 | lasso | 3 | 0.02 | 1.1e-03 | -5.9 | 5.8 | 8.2e-09 | 0.46 | 0.58 | 0.28 | FALSE |