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chr10:101,548,177-105,850,787

Best TWAS P=5.2e-19 · Best GWAS P=1.33e-18 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Brain Cerebellum	RP11-179B2.2	0.37	0.21	lasso	4	0.20	1.4e-06	-8.8	-8.9	5.2e-19	0.96	0.00	0.99	TRUE
39	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	-8.1	-8.0	8.7e-16	0.05	0.02	0.98	TRUE
6	GTEx	Artery Aorta	ARL3	0.19	0.07	lasso	6	0.06	4.8e-04	-5.2	6.3	2.9e-10	-0.09	0.23	0.61	TRUE
40	ROSMAP	Brain Pre-frontal Cortex	USMG5	0.04	0.03	lasso	9	0.03	1.6e-04	-3.9	6.2	6.7e-10	-0.01	0.05	0.92	TRUE
5	GTEx	Artery Aorta	TMEM180	0.25	0.23	enet	37	0.25	7.4e-14	-3.5	-6.0	2.0e-09	0.05	1.00	0.00	TRUE
32	GTEx	Thyroid	C10orf95	0.10	0.02	enet	28	0.02	6.6e-03	-3.5	-5.8	6.9e-09	0.05	0.21	0.04	TRUE
23	GTEx	Muscle Skeletal	TMEM180	0.05	0.01	lasso	6	0.01	8.3e-02	-4.1	-5.7	1.5e-08	0.06	0.06	0.53	TRUE
43	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ARL3	0.09	0.02	blup	57	0.05	1.8e-03	-5.2	5.5	4.6e-08	-0.08	0.01	0.60	TRUE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACTR1A	0.04	0.01	blup	51	0.02	7.1e-04	-3.6	-5.4	6.0e-08	0.08	0.03	0.15	TRUE
35	GTEx	Uterus	SEC31B	0.40	0.14	lasso	18	0.05	3.1e-02	4.9	-5.3	1.1e-07	0.02	0.36	0.04	TRUE
36	GTEx	Whole Blood	TMEM180	0.24	0.01	enet	44	0.00	1.4e-01	-3.6	-5.2	2.0e-07	-0.02	0.26	0.08	TRUE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARL3	0.03	0.02	lasso	3	0.02	1.1e-03	-5.2	5.2	2.0e-07	-0.08	0.03	0.73	TRUE
20	GTEx	Heart Left Ventricle	RP11-179B2.2	0.15	0.18	enet	2	0.14	4.8e-08	-8.8	-8.8	1.7e-18	1.00	0.00	1.00	FALSE
19	GTEx	Esophagus Muscularis	RP11-179B2.2	0.15	0.16	lasso	3	0.16	8.1e-10	-8.7	-8.7	3.3e-18	0.98	0.01	0.99	FALSE
8	GTEx	Artery Tibial	RP11-179B2.2	0.11	0.09	lasso	4	0.08	8.8e-07	-8.8	-8.6	5.3e-18	0.96	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Colon Adenocarcinoma	MRPL43	0.07	0.02	blup	52	0.00	1.7e-01	-8.3	8.6	7.0e-18	-0.80	0.01	0.82	FALSE
7	GTEx	Artery Aorta	RP11-179B2.2	0.16	0.11	lasso	2	0.09	7.6e-06	-8.8	-8.4	3.0e-17	0.99	0.00	0.99	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-179B2.2	0.13	0.02	lasso	3	0.03	6.5e-03	-8.8	-8.4	3.6e-17	0.99	0.00	0.99	FALSE
11	GTEx	Brain Frontal Cortex BA9	RP11-179B2.2	0.22	0.15	lasso	2	0.11	7.2e-04	-8.8	-8.3	9.0e-17	0.98	0.01	0.96	FALSE
22	GTEx	Lung	RP11-179B2.2	0.18	0.12	lasso	3	0.12	1.7e-09	-8.8	-8.3	1.1e-16	0.99	0.00	1.00	FALSE
14	GTEx	Breast Mammary Tissue (Male)	RP11-179B2.2	0.16	-0.01	enet	4	-0.01	7.1e-01	8.2	-8.2	2.2e-16	0.77	0.03	0.47	FALSE
13	GTEx	Breast Mammary Tissue	RP11-179B2.2	0.11	0.09	lasso	2	0.07	1.8e-04	-8.8	-7.8	4.9e-15	0.96	0.01	0.99	FALSE
17	GTEx	Cells Transformed fibroblasts	SUFU	0.07	0.04	lasso	3	0.04	3.5e-04	-7.5	-7.7	1.2e-14	0.05	0.29	0.36	FALSE
31	GTEx	Testis	CYP17A1-AS1	0.14	0.08	enet	5	0.10	2.3e-05	-7.5	7.6	2.1e-14	-0.04	0.03	0.96	FALSE
2	GTEx	Adipose Subcutaneous	RP11-179B2.2	0.15	0.08	lasso	6	0.08	3.2e-07	-6.4	-7.6	3.5e-14	0.90	0.01	0.99	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	RP11-179B2.2	0.27	0.15	enet	36	0.15	2.0e-08	-8.8	-7.2	7.1e-13	0.75	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FAM178A	0.14	0.08	lasso	2	0.08	5.9e-04	7.9	7.2	7.9e-13	-0.53	0.07	0.14	FALSE
24	GTEx	Nerve Tibial	RP11-179B2.2	0.15	0.08	lasso	2	0.12	6.4e-09	-8.7	-7.1	1.5e-12	0.88	0.01	0.99	FALSE
34	GTEx	Thyroid	RP11-179B2.2	0.18	0.12	lasso	7	0.11	8.3e-09	-6.4	-7.1	1.7e-12	0.91	0.04	0.96	FALSE
16	GTEx	Cells Transformed fibroblasts	GBF1	0.07	0.00	enet	2	0.00	1.4e-01	-7.0	-6.6	3.7e-11	0.08	0.04	0.48	FALSE
41	YFS	Blood	NT5C2	0.13	0.10	bslmm	382	0.11	7.3e-35	-7.8	-6.5	6.0e-11	0.05	0.02	0.98	FALSE
9	GTEx	Brain Cerebellum	TRIM8	0.34	-0.01	enet	25	0.07	4.7e-03	2.5	6.4	1.5e-10	-0.08	0.07	0.37	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEMA4G	0.04	0.01	blup	52	0.02	1.2e-03	-6.2	-6.3	3.4e-10	0.83	0.01	0.80	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEMA4G	0.03	0.01	blup	52	0.01	4.2e-02	-8.7	-6.2	5.8e-10	0.82	0.00	0.90	FALSE
27	GTEx	Skin Sun Exposed Lower leg	RP11-179B2.2	0.12	0.09	lasso	2	0.08	1.7e-07	-6.2	-6.1	1.3e-09	0.86	0.05	0.94	FALSE
37	METSIM	Adipose	MRPL43	0.05	0.04	bslmm	422	0.04	1.9e-06	3.9	-5.9	4.4e-09	0.46	0.94	0.02	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	-4.4	5.9	4.5e-09	-0.02	0.38	0.60	FALSE
15	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	-7.5	-5.8	6.2e-09	0.02	0.05	0.40	FALSE
45	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MRPL43	0.03	0.02	blup	52	0.03	3.0e-04	3.8	5.8	6.2e-09	-0.68	0.10	0.51	FALSE
29	GTEx	Testis	NT5C2	0.20	0.03	lasso	8	0.08	2.8e-04	-7.5	-5.8	6.6e-09	0.07	0.09	0.81	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	ARL3	0.24	0.14	bslmm	368	0.16	3.9e-20	-5.2	5.8	7.5e-09	-0.06	1.00	0.00	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	SEMA4G	0.07	0.08	blup	52	0.08	5.1e-08	3.8	-5.7	1.1e-08	0.75	0.04	0.96	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARL3	0.04	0.02	blup	57	0.03	9.2e-04	-5.2	5.6	2.6e-08	-0.08	0.06	0.56	FALSE
33	GTEx	Thyroid	WBP1L	0.26	0.10	enet	9	0.13	2.1e-10	-2.0	5.5	4.2e-08	-0.06	0.18	0.82	FALSE
12	GTEx	Breast Mammary Tissue	SFXN2	0.11	0.00	enet	12	0.03	1.3e-02	-3.5	5.4	5.3e-08	-0.06	0.19	0.05	FALSE
21	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	3.2	5.4	5.7e-08	-0.01	0.07	0.10	FALSE
28	GTEx	Stomach	BTRC	0.12	0.04	enet	10	0.04	4.9e-03	1.9	5.4	8.5e-08	-0.07	0.17	0.04	FALSE
18	GTEx	Colon Sigmoid	ARL3	0.13	0.10	lasso	6	0.05	5.5e-03	-5.2	5.3	1.2e-07	-0.09	0.15	0.37	FALSE
51	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MRPL43	0.06	0.04	blup	51	0.04	7.4e-04	3.9	5.2	1.7e-07	-0.52	0.55	0.08	FALSE
30	GTEx	Testis	HIF1AN	0.12	0.08	lasso	3	0.06	1.6e-03	5.0	-5.2	2.0e-07	0.07	0.34	0.04	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM180	0.06	0.03	lasso	5	0.03	3.7e-04	-4.7	-5.2	2.3e-07	0.07	0.00	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	USMG5	0.03	0.01	bslmm	352	0.00	7.5e-02	-3.9	5.2	2.4e-07	-0.03	0.16	0.42	FALSE
3	GTEx	Adipose Visceral Omentum	SEC31B	0.18	0.28	lasso	10	0.27	1.5e-14	5.0	-5.2	2.6e-07	0.06	1.00	0.00	FALSE
26	GTEx	Skin Sun Exposed Lower leg	HIF1AN	0.07	0.05	lasso	8	0.03	2.2e-03	5.0	-5.1	2.7e-07	0.06	0.93	0.00	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	SEC31B	0.12	0.19	blup	51	0.20	1.1e-18	5.0	-5.1	2.7e-07	0.06	0.04	0.96	FALSE