Best TWAS P=1.21e-18 · Best GWAS P=3.22e-34 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HELLS | 0.04 | 0.04 | enet | 12 | 0.04 | 5.1e-06 | -6.45 | -8.8 | 1.2e-18 | 0.23 | 0.97 | 0.00 | TRUE |
| 2 | GTEx | Adrenal Gland | NOC3L | 0.21 | 0.10 | lasso | 5 | 0.18 | 4.4e-07 | 0.85 | -6.0 | 1.9e-09 | 0.80 | 0.05 | 0.95 | TRUE |
| 3 | GTEx | Brain Cerebellum | HELLS | 0.26 | 0.20 | lasso | 9 | 0.19 | 2.8e-06 | -5.79 | -5.7 | 1.3e-08 | -0.06 | 0.95 | 0.01 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | HELLS | 0.16 | 0.09 | enet | 20 | 0.15 | 1.0e-04 | -5.36 | -5.8 | 6.2e-09 | 0.09 | 0.54 | 0.06 | FALSE |
| 5 | GTEx | Muscle Skeletal | NOC3L | 0.09 | 0.05 | enet | 7 | 0.05 | 7.5e-06 | -2.57 | -5.6 | 2.1e-08 | 0.25 | 0.87 | 0.00 | TRUE |
| 6 | GTEx | Nerve Tibial | HELLS | 0.12 | 0.12 | enet | 17 | 0.10 | 1.6e-07 | -6.42 | -6.0 | 2.4e-09 | -0.09 | 1.00 | 0.00 | TRUE |
| 7 | GTEx | Nerve Tibial | PLCE1 | 0.35 | 0.11 | enet | 25 | 0.23 | 2.1e-16 | 1.93 | -8.8 | 1.2e-18 | 0.29 | 1.00 | 0.00 | TRUE |
| 8 | GTEx | Ovary | HELLS | 0.15 | 0.04 | lasso | 5 | 0.09 | 3.1e-03 | -6.44 | -6.4 | 1.5e-10 | 0.07 | 0.17 | 0.09 | FALSE |
| 9 | GTEx | Pituitary | CYP2C8 | 0.20 | 0.05 | lasso | 7 | 0.04 | 4.1e-02 | -5.32 | -5.4 | 6.5e-08 | 0.48 | 0.16 | 0.07 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | PLCE1 | 0.11 | 0.09 | lasso | 2 | 0.07 | 7.1e-05 | 4.41 | -7.4 | 1.2e-13 | 0.23 | 0.18 | 0.08 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | HELLS | 0.05 | 0.02 | lasso | 3 | 0.00 | 1.2e-01 | -5.66 | -5.3 | 1.3e-07 | -0.08 | 0.43 | 0.02 | FALSE |
| 12 | GTEx | Testis | ZNF518A | 0.27 | 0.15 | enet | 21 | 0.18 | 1.6e-08 | -5.32 | -6.4 | 1.7e-10 | 0.07 | 0.04 | 0.96 | TRUE |
| 13 | GTEx | Testis | PIPSL | 0.14 | 0.00 | enet | 21 | 0.00 | 3.0e-01 | -2.73 | 7.8 | 8.4e-15 | -0.20 | 0.06 | 0.15 | FALSE |
| 14 | GTEx | Thyroid | HELLS | 0.07 | 0.00 | enet | 8 | 0.00 | 2.7e-01 | -6.46 | -6.2 | 4.4e-10 | 0.08 | 0.09 | 0.12 | TRUE |
| 15 | METSIM | Adipose | HELLS | 0.03 | 0.04 | lasso | 3 | 0.03 | 9.3e-05 | -6.42 | -6.4 | 1.2e-10 | 0.04 | 0.99 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HELLS | 0.04 | 0.01 | blup | 47 | 0.03 | 1.3e-06 | -6.45 | -7.0 | 2.8e-12 | 0.20 | 0.04 | 0.96 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLCE1 | 0.11 | 0.09 | blup | 166 | 0.10 | 1.1e-19 | -3.24 | -7.6 | 2.2e-14 | 0.20 | 1.00 | 0.00 | TRUE |
| 18 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TBC1D12 | 0.04 | 0.01 | blup | 63 | 0.03 | 8.3e-03 | -5.67 | 6.6 | 3.3e-11 | 0.03 | 0.08 | 0.04 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HELLS | 0.03 | 0.03 | blup | 47 | 0.03 | 1.7e-04 | -5.36 | -6.6 | 3.4e-11 | 0.08 | 0.40 | 0.50 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NOC3L | 0.05 | 0.01 | enet | 5 | 0.03 | 6.3e-04 | 9.20 | -6.8 | 8.5e-12 | 0.70 | 0.29 | 0.04 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HELLS | 0.03 | 0.03 | lasso | 3 | 0.02 | 5.7e-03 | -5.66 | -5.2 | 1.7e-07 | 0.00 | 0.24 | 0.55 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HELLS | 0.03 | 0.02 | blup | 47 | 0.03 | 2.1e-04 | -5.66 | -6.1 | 1.1e-09 | 0.12 | 0.06 | 0.88 | FALSE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLCE1 | 0.11 | 0.01 | blup | 167 | 0.05 | 3.9e-06 | 2.49 | -6.3 | 3.4e-10 | 0.22 | 0.35 | 0.03 | FALSE |
| 24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBC1D12 | 0.04 | 0.04 | blup | 63 | 0.03 | 3.9e-04 | -6.44 | -7.7 | 1.5e-14 | 0.12 | 0.24 | 0.50 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | HELLS | 0.05 | 0.02 | blup | 47 | 0.03 | 9.6e-04 | -5.36 | -7.5 | 7.6e-14 | 0.24 | 0.08 | 0.79 | FALSE |