Best TWAS P=1.63e-09 · Best GWAS P=2.01e-11 conditioned to 1.36e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | PIAS1 | 0.26 | 0.12 | enet | 22 | 0.10 | 3.4e-06 | 5.5 | -5.4 | 5.7e-08 | -0.18 | 0.82 | 0.14 | FALSE |
| 2 | GTEx | Artery Tibial | PIAS1 | 0.14 | 0.02 | enet | 26 | 0.08 | 1.6e-06 | 2.0 | -5.4 | 8.5e-08 | -0.18 | 0.28 | 0.68 | FALSE |
| 3 | GTEx | Muscle Skeletal | SMAD3 | 0.13 | 0.10 | enet | 8 | 0.10 | 4.2e-10 | 5.7 | 5.4 | 5.9e-08 | -0.03 | 0.21 | 0.79 | TRUE |
| 4 | GTEx | Nerve Tibial | PIAS1 | 0.20 | 0.10 | lasso | 8 | 0.14 | 3.0e-10 | 5.5 | -6.0 | 1.6e-09 | -0.22 | 0.40 | 0.60 | TRUE |