[Hub]/) : Traits : Impedance of leg (left) : ← →

chr1:15,752,716-18,074,702

Best TWAS P=2.02e-12 · Best GWAS P=1.66e-09 conditioned to 0.0192

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
48	GTEx	Whole Blood	MST1P2	0.05	0.02	enet	14	0.04	1.8e-04	-4.5	7.0	2.0e-12	-0.59	0.23	0.64	TRUE
38	GTEx	Skin Sun Exposed Lower leg	MST1P2	0.24	0.00	enet	29	0.13	8.8e-11	4.5	6.8	1.2e-11	-0.55	0.10	0.90	FALSE
2	GTEx	Adipose Subcutaneous	CROCC	0.18	0.15	enet	24	0.19	2.9e-15	-5.3	-6.3	2.9e-10	0.69	0.11	0.89	FALSE
6	GTEx	Artery Tibial	MFAP2	0.15	0.06	enet	20	0.07	2.3e-06	-5.7	6.2	4.3e-10	-0.79	0.01	0.99	FALSE
40	GTEx	Skin Sun Exposed Lower leg	NBPF1	0.14	0.04	lasso	7	0.05	2.9e-05	-5.3	-6.2	7.4e-10	0.84	0.04	0.96	FALSE
42	GTEx	Testis	CROCC	0.18	0.03	lasso	4	0.04	1.0e-02	5.1	-6.1	1.1e-09	0.86	0.04	0.67	FALSE
14	GTEx	Esophagus Mucosa	CROCC	0.14	0.08	enet	18	0.14	9.5e-10	-5.7	-6.1	1.2e-09	0.74	0.04	0.96	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	ATP13A2	0.05	0.00	enet	1	0.01	1.6e-02	-6.0	6.0	1.7e-09	-1.00	0.00	0.76	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MFAP2	0.17	0.22	enet	10	0.23	6.8e-26	-6.0	5.9	2.9e-09	-0.95	0.00	1.00	FALSE
4	GTEx	Adipose Visceral Omentum	MST1L	0.15	0.08	enet	21	0.11	1.7e-06	4.3	-5.9	3.6e-09	0.87	0.02	0.98	FALSE
56	The Cancer Genome Atlas	Esophageal Carcinoma	CROCC	0.17	0.05	lasso	4	0.09	7.7e-04	-5.3	-5.9	4.3e-09	0.71	0.05	0.72	FALSE
62	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MST1P9	0.04	0.02	lasso	5	0.02	1.0e-03	-5.5	-5.8	5.4e-09	0.86	0.03	0.85	FALSE
3	GTEx	Adipose Subcutaneous	MST1P2	0.12	0.01	enet	20	0.04	2.1e-04	-3.0	5.8	6.2e-09	-0.35	0.07	0.10	FALSE
49	GTEx	Whole Blood	MST1L	0.08	0.02	enet	12	0.04	6.3e-05	-4.0	-5.8	6.8e-09	0.83	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	ATP13A2	0.11	0.04	blup	54	0.08	3.4e-05	4.3	5.8	7.3e-09	-0.80	0.01	0.97	FALSE
57	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ATP13A2	0.05	0.08	enet	5	0.07	2.1e-08	-5.5	5.8	7.3e-09	-0.88	0.02	0.98	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	MST1L	0.31	0.10	lasso	6	0.14	2.2e-05	-5.5	-5.8	8.0e-09	0.84	0.04	0.94	FALSE
44	GTEx	Testis	MST1P2	0.44	0.03	enet	33	0.25	2.8e-11	5.1	5.7	9.4e-09	-0.55	0.04	0.84	FALSE
20	GTEx	Heart Atrial Appendage	MST1P2	0.20	0.09	lasso	4	0.09	6.7e-05	-5.5	5.7	1.0e-08	-0.88	0.03	0.94	FALSE
23	GTEx	Liver	MST1P2	0.20	0.14	lasso	4	0.10	7.6e-04	5.1	5.7	1.0e-08	-0.92	0.01	0.94	FALSE
47	GTEx	Thyroid	MST1P2	0.18	0.11	lasso	9	0.13	2.7e-10	4.5	5.7	1.1e-08	-0.81	0.03	0.97	FALSE
16	GTEx	Esophagus Mucosa	NBPF1	0.17	0.09	enet	27	0.12	1.5e-08	-5.1	-5.7	1.2e-08	0.71	0.20	0.79	FALSE
9	GTEx	Brain Cortex	MST1L	0.38	0.12	enet	26	0.09	1.7e-03	4.3	-5.7	1.3e-08	0.70	0.06	0.64	FALSE
22	GTEx	Heart Left Ventricle	CROCC	0.19	0.07	enet	29	0.13	1.8e-07	-5.2	-5.7	1.3e-08	0.65	0.10	0.90	FALSE
34	GTEx	Ovary	CROCC	0.22	0.05	lasso	4	0.02	1.2e-01	-4.9	-5.7	1.3e-08	0.58	0.08	0.33	FALSE
24	GTEx	Lung	MFAP2	0.09	0.08	enet	19	0.06	1.3e-05	-5.6	5.7	1.6e-08	-0.85	0.01	0.98	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	SDHB	0.03	0.02	blup	99	0.02	1.3e-03	-4.7	5.6	2.1e-08	-0.80	0.06	0.75	FALSE
31	GTEx	Nerve Tibial	ATP13A2	0.05	0.03	lasso	5	0.03	4.8e-03	-5.4	5.6	2.5e-08	-0.67	0.06	0.91	FALSE
5	GTEx	Artery Tibial	CROCC	0.25	0.11	enet	36	0.14	3.6e-11	-5.3	-5.6	2.7e-08	0.57	0.11	0.88	FALSE
33	GTEx	Nerve Tibial	RP1-37C10.3	0.07	0.02	lasso	5	0.01	4.3e-02	-4.4	5.5	3.0e-08	-0.55	0.14	0.63	FALSE
35	GTEx	Pancreas	MST1P2	0.17	0.05	enet	23	0.13	5.4e-06	4.5	5.5	3.3e-08	-0.80	0.10	0.85	FALSE
8	GTEx	Brain Cerebellum	MST1P2	0.38	0.04	enet	28	0.21	6.0e-07	-4.0	5.5	3.5e-08	-0.63	0.06	0.75	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ATP13A2	0.06	0.04	blup	54	0.05	7.7e-07	-5.3	5.5	3.7e-08	-0.73	0.06	0.94	FALSE
7	GTEx	Artery Tibial	MST1L	0.21	0.08	lasso	6	0.12	5.0e-10	-5.3	-5.5	3.9e-08	0.76	0.10	0.90	FALSE
65	The Cancer Genome Atlas	Soft Tissue Sarcoma	SDHB	0.06	0.03	blup	99	0.02	2.1e-02	-5.5	5.5	5.0e-08	-0.84	0.03	0.60	FALSE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	MFAP2	0.12	0.06	blup	38	0.07	4.3e-05	-5.1	5.4	5.5e-08	-0.85	0.01	0.98	FALSE
29	GTEx	Nerve Tibial	MFAP2	0.09	0.06	lasso	3	0.07	9.7e-06	4.3	5.4	6.5e-08	-0.82	0.03	0.97	FALSE
19	GTEx	Heart Atrial Appendage	CROCC	0.13	0.10	enet	11	0.13	1.5e-06	-4.0	-5.4	7.9e-08	0.73	0.57	0.33	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	NBPF1	0.08	0.02	lasso	3	0.00	2.8e-01	-4.7	-5.4	8.1e-08	0.59	0.09	0.56	FALSE
15	GTEx	Esophagus Mucosa	MST1L	0.13	0.07	enet	23	0.07	2.7e-05	4.5	-5.4	8.2e-08	0.71	0.06	0.92	FALSE
13	GTEx	Cells Transformed fibroblasts	MST1L	0.09	0.02	enet	12	0.03	3.1e-03	-4.0	-5.3	8.7e-08	0.70	0.13	0.70	FALSE
25	GTEx	Lung	MST1P2	0.20	0.10	enet	26	0.10	5.0e-08	4.5	5.3	9.4e-08	-0.76	0.13	0.86	FALSE
32	GTEx	Nerve Tibial	MST1L	0.23	0.16	lasso	7	0.22	6.6e-16	-4.0	-5.3	9.7e-08	0.86	0.04	0.96	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MFAP2	0.10	0.05	enet	21	0.07	5.7e-08	-4.1	5.3	9.8e-08	-0.67	0.17	0.82	FALSE
27	GTEx	Muscle Skeletal	NBPF1	0.05	0.05	lasso	3	0.05	2.2e-05	-5.2	-5.3	1.1e-07	0.62	0.17	0.78	FALSE
30	GTEx	Nerve Tibial	EPHA2	0.19	0.13	enet	29	0.14	6.7e-10	-5.1	5.3	1.2e-07	-0.01	0.01	0.99	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	MST1P9	0.13	0.09	lasso	6	0.11	3.3e-11	4.5	-5.3	1.2e-07	0.85	0.02	0.98	FALSE
26	GTEx	Muscle Skeletal	CROCC	0.09	0.01	lasso	6	0.02	1.1e-02	-5.0	-5.3	1.3e-07	0.49	0.14	0.52	FALSE
46	GTEx	Thyroid	EPHA2	0.10	0.05	lasso	9	0.06	1.7e-05	-5.1	5.3	1.3e-07	-0.06	0.01	0.98	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	SDHB	0.04	0.04	lasso	2	0.03	5.4e-05	-5.2	5.3	1.3e-07	-0.78	0.10	0.88	FALSE
45	GTEx	Testis	NBPF1	0.12	-0.01	enet	11	0.00	6.1e-01	-5.1	-5.3	1.4e-07	0.69	0.05	0.33	FALSE
10	GTEx	Brain Hippocampus	MST1P2	0.41	0.07	lasso	6	0.19	3.4e-05	2.8	5.2	1.5e-07	-0.61	0.03	0.66	FALSE
12	GTEx	Cells Transformed fibroblasts	CROCC	0.27	0.11	lasso	11	0.16	7.3e-12	-4.0	-5.2	1.5e-07	0.58	0.42	0.57	FALSE
18	GTEx	Esophagus Muscularis	MFAP2	0.14	0.15	lasso	3	0.12	8.8e-08	-5.1	5.2	1.5e-07	-0.84	0.07	0.93	FALSE
53	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MST1P9	0.11	0.11	blup	38	0.08	1.3e-04	-6.0	-5.3	1.5e-07	0.93	0.00	1.00	FALSE
28	GTEx	Nerve Tibial	SDHB	0.10	0.07	lasso	3	0.07	1.7e-05	-5.2	5.2	1.6e-07	-0.77	0.07	0.92	FALSE
17	GTEx	Esophagus Mucosa	RP1-37C10.3	0.10	0.10	enet	4	0.07	3.8e-05	-5.5	5.2	1.7e-07	-0.90	0.01	0.99	FALSE
41	GTEx	Stomach	NBPF1	0.09	0.01	lasso	2	0.00	4.0e-01	-5.1	-5.2	1.7e-07	0.57	0.06	0.24	FALSE
39	GTEx	Skin Sun Exposed Lower leg	MST1L	0.34	0.20	enet	37	0.25	5.6e-21	-4.0	-5.2	1.9e-07	0.78	0.38	0.62	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CROCC	0.09	0.04	lasso	4	0.06	1.3e-05	-4.0	-5.2	1.9e-07	0.76	0.05	0.94	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	CROCC	0.16	0.12	lasso	7	0.15	9.9e-09	-4.9	-5.2	2.1e-07	0.70	0.22	0.78	FALSE
64	The Cancer Genome Atlas	Rectum Adenocarcinoma	ATP13A2	0.13	0.06	lasso	3	0.08	6.4e-03	-4.4	5.2	2.3e-07	-0.80	0.02	0.48	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATP13A2	0.08	0.06	lasso	5	0.08	6.9e-10	4.5	5.1	2.7e-07	-0.81	0.28	0.72	FALSE
43	GTEx	Testis	SDHB	0.14	0.13	lasso	3	0.09	6.4e-05	-5.3	5.1	2.7e-07	-0.76	0.11	0.86	FALSE
21	GTEx	Heart Atrial Appendage	RP11-108M9.5	0.26	0.10	lasso	12	0.12	5.5e-06	-4.1	-5.1	2.9e-07	0.56	0.21	0.62	FALSE