Best TWAS P=1.16e-11 · Best GWAS P=3.4e-12 conditioned to 0.947
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PASK | 0.17 | 0.09 | enet | 13 | 0.09 | 8.3e-08 | 5.1 | -5.7 | 1.4e-08 | -0.66 | 0.93 | 0.07 | FALSE |
| 2 | GTEx | Esophagus Mucosa | PASK | 0.19 | 0.13 | lasso | 6 | 0.14 | 1.1e-09 | 5.1 | -5.4 | 6.3e-08 | -0.59 | 0.99 | 0.01 | FALSE |
| 3 | GTEx | Heart Left Ventricle | PASK | 0.10 | 0.03 | lasso | 6 | 0.03 | 9.4e-03 | -5.3 | -6.8 | 1.3e-11 | -0.62 | 0.03 | 0.79 | FALSE |
| 4 | GTEx | Lung | PASK | 0.09 | 0.02 | lasso | 2 | 0.03 | 3.7e-03 | -4.3 | -6.0 | 2.0e-09 | -0.47 | 0.43 | 0.05 | FALSE |
| 5 | GTEx | Muscle Skeletal | PASK | 0.06 | 0.00 | enet | 13 | 0.01 | 8.6e-02 | 5.1 | -6.4 | 2.0e-10 | -0.58 | 0.03 | 0.64 | TRUE |
| 6 | GTEx | Nerve Tibial | PASK | 0.26 | 0.18 | enet | 12 | 0.22 | 1.0e-15 | 5.1 | -6.2 | 7.2e-10 | -0.59 | 0.98 | 0.02 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | PASK | 0.28 | 0.16 | enet | 17 | 0.19 | 1.9e-10 | 4.9 | -6.1 | 8.2e-10 | -0.69 | 0.93 | 0.07 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | AC005104.3 | 0.27 | 0.06 | enet | 24 | 0.20 | 5.6e-11 | -2.1 | -5.6 | 1.8e-08 | -0.24 | 0.60 | 0.04 | TRUE |
| 9 | GTEx | Skin Sun Exposed Lower leg | PASK | 0.27 | 0.18 | enet | 10 | 0.18 | 4.5e-15 | 4.9 | -5.3 | 1.5e-07 | -0.58 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Small Intestine Terminal Ileum | MTERFD2 | 0.37 | 0.24 | lasso | 3 | 0.18 | 7.3e-05 | 6.2 | -6.4 | 1.3e-10 | -0.57 | 0.12 | 0.38 | FALSE |
| 11 | GTEx | Testis | MTERFD2 | 0.43 | 0.17 | enet | 32 | 0.25 | 1.4e-11 | 6.2 | 6.2 | 7.4e-10 | 0.58 | 0.20 | 0.80 | FALSE |
| 12 | GTEx | Thyroid | PASK | 0.22 | 0.04 | enet | 41 | 0.09 | 1.2e-07 | 5.4 | -5.3 | 1.4e-07 | -0.49 | 0.60 | 0.32 | FALSE |
| 13 | GTEx | Thyroid | MTERFD2 | 0.12 | 0.09 | lasso | 2 | 0.08 | 1.8e-06 | 6.1 | -5.2 | 2.2e-07 | -0.47 | 0.28 | 0.71 | FALSE |
| 14 | GTEx | Whole Blood | PASK | 0.25 | 0.15 | enet | 10 | 0.21 | 4.4e-19 | 6.1 | -6.8 | 1.2e-11 | -0.57 | 0.27 | 0.73 | TRUE |
| 15 | METSIM | Adipose | PASK | 0.09 | 0.03 | bslmm | 441 | 0.08 | 9.4e-12 | 7.0 | -5.8 | 5.7e-09 | -0.71 | 0.00 | 1.00 | FALSE |
| 16 | NTR | Blood | PASK | 0.08 | 0.09 | bslmm | 437 | 0.09 | 1.0e-26 | 6.2 | -6.4 | 1.2e-10 | -0.60 | 0.22 | 0.78 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | SNED1 | 0.17 | 0.12 | lasso | 4 | 0.14 | 5.2e-18 | 4.6 | 6.3 | 2.9e-10 | 0.54 | 0.96 | 0.04 | FALSE |
| 18 | YFS | Blood | PASK | 0.31 | 0.46 | lasso | 11 | 0.48 | 1.8e-181 | 6.1 | -6.6 | 3.7e-11 | -0.62 | 0.40 | 0.60 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PASK | 0.04 | 0.00 | blup | 92 | 0.01 | 3.2e-02 | 6.2 | -6.0 | 1.9e-09 | -0.50 | 0.04 | 0.16 | FALSE |