Hub : Genes

SNED1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.1698 0.0410 8.3e-09 0.119 0.096 0.135 0.132 0.144 5.3e-15 2.7e-12 5.5e-17 1.2e-16 5.2e-18
2 TCGA Head and Neck Squamous Cell Carcinoma 0.0860 0.0407 9.0e-03 0.011 0.003 0.028 NA 0.009 1.8e-02 1.3e-01 4.0e-04 NA 2.7e-02
3 TCGA Lung Squamous Cell Carcinoma 0.0946 0.0410 9.3e-04 -0.002 0.012 0.026 NA 0.006 7.6e-01 1.3e-02 5.7e-04 NA 5.9e-02
4 TCGA Thyroid Carcinoma 0.0850 0.0430 3.5e-03 0.041 0.029 0.042 NA 0.042 6.7e-05 7.4e-04 6.0e-05 NA 5.9e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.3 0.5 1.3 0.2 -1.1 0.2 0.7
Bipolar Disorder or Schizophrenia 0.9 2.1 6.7 -1.0 -2.6 -0.3 -0.9
Depressed Affect (Nagel 2018) 0.2 0.3 0.5 0.1 0.7 0.7 -0.6
Depression (Nagel 2018) 0.5 0.8 1.6 -0.1 1.3 0.8 -0.9
Intelligence (Savage-Jansen 2018) 0.9 2.8 6.6 0.5 -2.6 -0.3 -2.0
Neuroticism (Nagel 2018) 0.1 0.3 0.6 0.3 0.3 0.8 -0.5
Schizophrenia (2018) 1.4 2.9 6.2 -1.5 -2.5 -0.7 -1.7
Schizophrenia vs Biploar Disorder 1.3 1.7 5.4 -0.1 2.3 1.1 0.4
Worry (Nagel 2018) 0.0 0.1 0.1 -0.2 0.1 0.3 -0.3
Alzheimer’s Disease (in mother) 0.1 0.2 0.5 -0.2 -0.1 -0.4 -0.7
Alzheimer’s Disease (in father) 2.6 2.9 5.2 2.3 -0.5 0.9 2.3
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 0.2 -0.2 0.6 -0.4
Crohns Disease (2017) 0.4 0.8 1.4 -0.9 0.0 -1.2 1.1
Irritable Bowel Disease (IBD) 0.4 1.0 2.3 -1.5 -0.1 -0.9 1.0
Ulcerative Colitis (UC) 0.6 1.1 2.9 -1.7 -0.5 -1.0 0.6
Major Depression (MDD) 0.7 0.9 3.3 -0.3 0.0 0.0 -1.8
Reaction Time 1.0 2.0 3.8 -1.6 0.6 1.0 -1.9
Verbal and Numeric Reasoning (VNR) 1.0 2.4 4.4 0.5 -2.1 -0.8 -2.1
Breast Cancer 0.3 0.8 1.6 -0.3 1.3 0.0 1.2
Ovarian Cancer 0.3 0.4 1.0 1.0 -0.5 -0.4 0.5
Prostate Cancer 0.9 1.3 2.7 0.7 -0.5 -1.6 1.4
Age at First Birth 1.1 1.6 4.4 -1.1 -0.2 0.7 -2.1
Bipolar Disorder (2011) 0.9 0.9 2.0 -1.4 -0.6 0.8 -0.7
Body Mass Index (BMI) (2010) 0.6 0.9 1.6 -1.2 0.9 0.1 1.1
Coronary Artery Disease (CAD) 3.0 3.6 6.5 -2.5 2.4 1.4 0.5
Crohns Disease (2012) 1.1 1.7 3.7 -0.5 1.7 1.9 -0.0
Mean Putamen Volume 0.9 1.0 1.6 1.1 -1.3 0.5 -1.1
Fasting Glucose 0.3 0.3 1.2 -0.1 -0.2 -0.3 1.1
HbA1C 0.9 1.0 2.5 -1.6 0.2 -0.7 0.9
HDL Cholesterol 0.1 0.2 0.4 -0.1 0.1 0.6 -0.5
LDL Cholesterol 0.3 0.4 0.7 0.6 0.8 0.7 0.1
Lupus 1.1 1.7 3.4 0.1 -1.9 -1.5 1.1
Neuroticism (2016) 0.3 0.4 1.0 0.6 0.1 0.4 -1.0
Primary Biliary Cirrhosis 0.2 0.3 0.7 0.1 -0.8 -0.1 0.7
Rheumatoid Arthritis 0.5 0.7 1.6 0.5 0.9 0.4 1.2
Schizophrenia (2014) 0.9 1.9 3.2 -1.8 -1.1 0.7 -1.7
Triglycerides 0.6 1.0 2.2 -0.1 -1.3 -1.5 -0.3
Type 2 Diabetes (T2D) (2012) 1.1 1.3 2.5 -1.1 -1.6 0.3 -1.2
Ulcerative Colitis 0.6 0.8 1.8 -0.7 -0.6 -1.4 0.8
Blood Eosinophil Count 0.4 3.2 8.2 0.1 -1.9 -2.9 1.0
Blood Platelet Count 0.5 5.4 10.2 -3.2 1.5 2.1 2.1
Blood Red Count 0.3 2.6 4.8 2.2 -1.7 -1.3 0.9
Blood White Count 0.2 1.7 3.9 -0.5 -1.2 -2.0 1.1
Heel T-Score 0.4 3.1 5.0 -1.8 -0.4 1.9 -2.2
BMI 0.1 0.6 1.5 -1.2 0.8 0.2 0.1
Height 0.3 5.7 7.3 2.7 -2.1 -1.9 -2.7
Waist Hip Ratio (WHR) 0.2 1.1 2.7 -1.2 -0.5 -1.6 0.2
Systolic Blood Pressure 0.2 1.0 3.2 0.7 -0.0 0.3 1.8
Smoking Status 0.3 0.7 1.2 -0.4 1.1 0.9 0.7
Allergy or Eczema 0.4 0.9 2.0 -0.2 0.3 1.4 1.3
Cardiovascular Disease 0.6 2.0 3.4 1.9 -1.6 -1.4 0.2
Hypothyroidism (self reported) 2.9 6.6 14.0 -0.8 1.9 2.9 -3.7
Respiratory disease 1.3 2.9 6.2 0.6 -2.2 -2.5 0.7
Type 2 Diabetes (T2D) (2018) 0.9 1.7 3.1 1.5 -1.8 -1.2 0.3
Lung FEV1/FVC ratio 0.7 3.4 5.6 -1.6 -0.6 2.3 -2.4
Lung FVC 0.5 2.5 3.9 2.0 0.7 1.4 -1.9
Neuroticism 0.2 0.5 1.2 0.5 0.1 1.1 -0.7
Chronotype (morning person) 1.0 2.4 5.6 2.4 -1.4 1.0 -1.0
Hair Pigment 0.2 4.5 10.6 3.3 2.0 0.6 1.8
Tanning 0.3 3.4 7.2 -2.0 -2.7 -1.0 -1.1
Hand grip strength (left) 2.5 6.6 13.0 0.8 -3.6 -3.6 0.0
Number of treatments/medications taken 0.7 1.2 3.2 1.8 -0.4 -1.2 0.3
Average weekly spirits intake 1.9 2.4 5.4 0.4 -2.3 -0.8 -1.8
Sensitivity / hurt feelings 0.4 0.8 1.7 0.6 -1.0 -0.1 1.3
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.1 -0.4 0.4 0.6 -1.0
Hearing difficulty/problems: Yes 0.1 0.1 0.2 -0.5 0.4 0.1 -0.2
Relative age of first facial hair 0.1 0.2 0.4 -0.3 -0.6 -0.3 0.2
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.6 0.1 0.6 1.6 0.5
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 -0.0 0.6 0.1 0.6
Ever had hysterectomy (womb removed) 0.4 0.5 1.1 1.1 -0.9 0.3 -0.1
Systolic blood pressure, automated reading 0.2 0.6 1.8 0.8 0.1 -0.1 1.3
Eye problems/disorders: Diabetes related eye disease 1.1 1.3 2.7 1.2 -0.9 -1.6 0.0
Angina 0.0 0.0 0.1 -0.1 -0.0 0.2 -0.1
Medication for hormone replacement therapy 0.6 0.7 1.6 0.4 -1.3 -0.5 0.8
Vitamin and mineral supplements 0.7 1.0 2.6 -0.8 0.1 -1.6 0.8
Supplements: Zinc 0.4 0.4 0.8 -0.9 -0.4 -0.8 0.2
Medication: Co-codamol 0.4 0.5 1.8 -0.3 -0.0 1.4 0.1
Medication: Metformin 0.8 1.1 2.4 1.1 -1.6 -0.9 -0.2
Diabetes (father) 3.1 3.8 9.2 0.7 3.0 0.8 2.2
Diabetes (mother) 1.7 2.2 4.1 -0.9 -1.2 -2.0 1.5
Severe depression (siblings) 0.5 0.6 2.1 0.3 1.4 0.3 -0.1
Pack years adult smoking proportion 0.6 0.9 2.2 0.5 0.2 -1.0 1.5
Impedance of leg (right) 2.5 12.0 31.4 5.6 -0.9 -3.4 2.0
Leg fat-free mass (left) 0.5 2.8 6.2 -2.5 0.2 0.9 -2.0
Trunk fat percentage 0.6 2.5 4.9 2.2 -1.0 -2.0 0.2
Hand grip strength (right) 1.9 5.3 10.8 1.6 -2.8 -3.3 0.4
Townsend deprivation index at recruitment 1.1 1.6 3.1 -0.2 1.8 1.8 -0.1
Current tobacco smoking 2.0 3.3 8.1 -1.4 1.7 0.2 2.8
Average weekly fortified wine intake 0.4 0.5 1.4 0.1 -0.3 0.8 -1.2
Maternal smoking around birth 0.8 1.2 2.6 0.4 -1.2 -1.6 0.7
Fed-up feelings 0.3 0.6 1.7 1.3 0.5 -0.8 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.6 -0.7 1.3 0.7 -0.6
Relative age voice broke 0.2 0.3 0.7 -0.3 -0.4 0.2 -0.8
Taking other prescription medications 1.1 1.8 2.9 1.5 1.7 1.4 0.2
Age when periods started (menarche) 0.9 2.2 4.9 1.6 2.2 0.9 -0.6
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 2.2 0.8 -1.5 -0.8 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 1.9 1.3 -1.4 -0.4 -0.7
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 4.0 -0.2 -2.0 -1.6 0.0
Qualifications: CSEs or equivalent 1.9 2.5 5.2 0.6 -1.3 -2.3 1.7
Serious illness, injury or assault to yourself 0.9 1.1 1.9 0.6 -1.3 -1.4 0.8
High blood pressure 0.5 1.5 2.1 1.4 -1.4 -1.4 0.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.2 -0.5 -0.1 1.1 1.0
Multivitamins +/- minerals 1.1 1.4 4.3 -0.8 0.6 2.1 -0.6
Stomach or abdominal pain in last month 1.4 1.8 2.9 -1.7 -1.3 -1.3 -0.9
Supplements: Glucosamine 0.2 0.3 0.9 0.9 0.1 0.4 -0.4
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.7 -1.3 -1.0 0.1 0.4
Medication: Atenolol 0.5 0.6 1.9 -0.3 0.8 -0.0 1.4
Medication: Levothyroxine sodium 2.0 3.4 11.2 -0.9 -0.5 1.1 -3.4
Sitting height 0.8 5.8 12.0 3.5 -2.3 -0.7 -2.2
Chronic bronchitis/emphysema (father) 1.1 1.3 3.1 -0.2 -0.9 -1.0 1.8
High blood pressure (mother) 0.4 0.6 1.0 -1.0 -0.5 0.6 -0.9
Body mass index (BMI) 0.2 0.7 2.4 -1.5 -0.2 0.1 -0.6
Impedance of leg (left) 3.3 16.0 39.7 6.3 -1.4 -3.9 2.7
Leg predicted mass (left) 0.6 2.9 6.7 -2.6 0.1 0.9 -2.0
Trunk fat mass 0.3 1.3 2.0 1.4 -0.9 -1.4 -0.7
Waist circumference 0.1 0.4 1.0 -0.8 -0.2 -0.0 -1.0
Number of incorrect matches in round 1.0 1.7 4.8 -1.4 0.4 0.0 2.2
Past tobacco smoking 0.4 0.7 1.8 0.9 -0.1 -0.2 1.3
Alcohol usually taken with meals 0.5 0.8 1.7 1.3 0.3 1.1 -0.5
Nervous feelings 0.2 0.4 1.4 1.2 0.5 -0.2 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.9 -0.1 0.9 -0.0 -0.9
Hearing difficulty/problems with background noise 0.8 1.3 3.0 -1.1 -1.7 -0.3 -0.9
Hair/balding pattern: Pattern 2 1.7 2.1 5.4 0.3 0.2 -2.3 1.7
Had menopause 1.9 2.3 4.6 -2.1 -0.5 0.7 -2.0
Had other major operations 2.6 3.2 5.4 -0.3 -2.0 -2.3 1.8
Forced vital capacity (FVC) 0.9 3.5 12.2 3.5 -0.3 -0.4 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 0.9 0.0 -0.8 0.6 -0.9
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.2 -1.1 0.6 0.3 -0.9
Qualifications: None of the above 1.0 2.1 5.0 -0.6 2.2 0.1 1.7
Financial difficulties in last 2 years 0.4 0.5 1.2 -1.1 -0.2 -0.8 0.5
Mouth/teeth dental problems 0.2 0.2 0.5 0.7 -0.2 0.7 0.0
Heart attack 0.8 1.0 2.8 1.7 0.5 0.8 -0.5
Allergy 0.2 0.5 1.3 0.4 0.7 0.3 -1.2
Pain all over the body in last month 1.5 1.6 4.1 -0.6 2.0 0.8 1.1
Diabetes (self-reported) 1.2 1.8 3.7 0.7 -1.9 -1.5 0.8
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.1 -1.4 0.6 1.4 -0.8
Medication: Ramipril 0.4 0.6 1.0 0.8 0.5 1.0 -0.6
Medication: Simvastatin 1.1 1.7 3.2 1.2 -1.5 0.0 -1.8
Fluid intelligence score 1.1 2.3 3.8 -1.2 -1.9 -1.4 -1.5
Illnesses of siblings 0.5 0.7 1.6 -0.8 0.7 1.2 0.4
Neuroticism score 0.2 0.3 1.2 1.1 0.3 0.2 -0.0
Weight 0.1 0.7 2.3 -0.5 -0.4 -0.1 -1.5
Impedance of arm (right) 1.7 8.1 22.8 4.8 -0.2 -2.3 2.1
Arm fat percentage (right) 0.1 0.5 1.2 0.6 -0.5 -1.1 -0.1
Trunk fat-free mass 0.6 3.5 6.6 -2.4 0.1 1.4 -2.6
Hip circumference 0.2 0.7 1.3 1.1 -0.3 0.5 -1.1
Time employed in main current job 0.2 0.3 0.9 0.0 0.9 0.3 0.4
Alcohol intake versus 10 years previously 0.3 0.4 0.8 -0.2 0.6 0.9 -0.7
Father’s age at death 1.4 1.9 2.3 -1.3 1.2 1.5 -1.3
Worrier / anxious feelings 0.2 0.3 0.8 0.2 -0.9 -0.6 0.2
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 4.2 -2.1 0.7 0.1 -1.3
Falls in the last year 1.4 1.9 5.4 0.1 -1.1 -2.3 0.9
Hair/balding pattern: Pattern 3 0.7 1.0 2.3 -0.9 0.6 1.5 -0.7
Number of live births 1.5 2.1 4.2 -1.5 -0.9 -2.0 1.1
Forced expiratory volume in 1-second (FEV1) 0.9 2.9 8.7 3.0 -0.8 0.4 -1.5
Pulse rate 0.1 0.2 0.4 -0.6 0.5 -0.1 0.2
Happiness 0.3 0.3 0.9 -0.5 0.9 0.2 -0.3
Noisy workplace 0.4 0.5 1.2 -0.2 -0.6 -0.8 -1.1
Qualifications: A levels/AS levels or equivalent 0.6 1.4 3.5 0.1 -0.7 1.2 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.6 0.5 -0.3 1.3 -0.3
Mouth/teeth dental problems: Dentures 0.4 0.7 1.7 -0.6 0.6 0.4 -1.3
Asthma 0.6 1.1 2.3 0.2 -1.4 -1.5 -0.0
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.4 -0.4 -0.1 0.0
Medication: Cholesterol lowering 1.4 2.3 4.5 1.6 -2.1 -0.7 -1.1
Depression (self-reported) 1.8 2.2 3.2 -1.4 1.3 1.8 -1.3
Medication: Lansoprazole 1.7 1.9 5.6 0.4 2.4 1.0 1.0
Prospective memory result 2.1 2.6 6.4 -0.5 1.7 2.5 -0.9
Lung cancer (father) 0.5 0.6 1.8 -0.2 -0.2 -1.3 0.7
Illnesses of mother 0.2 0.2 0.3 -0.5 -0.2 -0.5 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 3.7 1.8 -0.2 1.0 -1.9
Pulse wave Arterial Stiffness index 2.1 2.5 4.2 -1.4 0.4 2.0 -1.9
Impedance of arm (left) 1.8 8.3 23.0 4.8 -0.5 -2.4 2.1
Arm fat mass (right) 0.1 0.4 0.7 -0.3 -0.7 -0.6 -0.8
Trunk predicted mass 0.6 3.7 7.0 -2.4 0.1 1.5 -2.6
Standing height 0.2 2.3 5.2 2.3 -0.6 -0.4 -1.9
Length of working week for main job 0.7 0.8 1.4 -0.7 1.0 0.6 1.2
Exposure to tobacco smoke at home 3.5 3.9 9.0 -1.1 3.0 2.3 0.3
Breastfed as a baby 0.4 0.5 0.9 0.2 -0.8 -0.9 -0.6
Tense / ‘highly strung’ 0.3 0.6 1.3 -0.6 0.6 0.5 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.9 -0.9 1.4 0.9 -0.1
Hair/balding pattern: Pattern 4 0.9 2.1 7.1 2.7 0.4 0.5 -1.0
Birth weight of first child 0.3 0.5 1.1 1.0 0.1 -0.0 -1.0
Peak expiratory flow (PEF) 0.9 2.0 7.3 2.7 -0.5 0.8 -0.1
Pulse wave reflection index 1.4 1.8 3.8 -0.9 0.3 2.0 -1.5
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.9 -0.1 0.9 0.4 0.2
Loud music exposure frequency 0.2 0.3 0.4 0.7 -0.6 0.2 0.4
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 2.4 -0.7 -1.1 0.9 -1.5
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.7 0.9 0.0 -0.4 -0.0
Blood clot in the leg (DVT) 0.3 0.4 0.7 0.8 0.0 -0.8 0.5
Medication: Paracetamol 0.6 1.0 1.7 0.3 1.1 1.3 -1.0
Headache pain in last month 0.1 0.1 0.3 0.6 0.1 0.1 0.5
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 3.6 -1.1 1.9 1.4 0.5
Glaucoma (self-reported) 0.5 0.6 1.8 0.6 -0.2 -1.3 0.2
Gout (self-reported) 0.3 0.4 1.5 -1.2 -0.4 0.3 0.2
Hypothyroidism/myxoedema (self-reported) 3.9 7.7 13.4 -0.5 2.3 3.5 -3.7
Medication: Amlodipine 0.5 0.7 1.1 0.6 -0.9 -1.0 0.8
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.6 0.0 0.2 -0.8 0.1
Birth weight 0.3 0.6 1.3 -1.2 -0.0 0.2 -0.9
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.5 0.5 -0.4 -0.3 -0.7
High blood pressure (siblings) 0.2 0.4 1.3 -0.2 -0.2 -1.1 -0.1
Forced vital capacity (FVC), Best measure 0.6 2.1 5.7 2.4 -0.1 0.1 -1.7
Body fat percentage 0.5 1.9 3.5 1.8 -1.0 -1.9 -0.1
Leg fat percentage (right) 0.3 1.2 2.6 1.3 -0.9 -1.6 -0.3
Arm fat-free mass (right) 0.4 2.2 4.2 -2.0 -0.3 0.6 -2.0
Exposure to tobacco smoke outside home 0.2 0.3 1.2 0.1 0.2 -0.1 1.1
Comparative body size at age 10 0.4 1.1 2.1 -1.4 0.4 1.4 -0.3
Number of full brothers 0.9 1.1 2.9 0.7 1.7 1.0 -0.3
Worry too long after embarrassment 1.1 1.8 4.1 -0.6 2.0 1.3 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.4 -0.9 1.2 0.9 -0.5
Wheeze or whistling in the chest in last year 0.5 0.9 1.4 -1.1 -0.8 -0.6 1.2
Number of children fathered 1.4 1.6 5.2 -2.3 -0.6 -0.1 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 2.7 1.6 -0.4 1.0 -1.5
Age at first live birth 0.3 0.6 2.2 1.5 -0.2 0.4 -0.1
Pulse wave peak to peak time 2.2 2.6 4.4 1.5 -0.5 -2.1 1.8
Health satisfaction 0.6 0.8 1.3 -1.1 1.1 -0.2 0.6
Shortness of breath walking on level ground 0.7 0.8 2.8 0.2 -0.4 0.3 -1.7
Qualifications: College or University degree 0.3 0.8 1.5 -0.6 -1.2 -0.1 -1.2
Eye problems/disorders: None of the above 3.5 4.0 10.1 -1.7 1.6 3.2 -0.6
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.1 0.3 -0.2 -0.3 0.2
Emphysema/chronic bronchitis 0.5 0.6 1.3 0.3 0.5 -1.1 0.8
Medication for pain relief, constipation, heartburn 0.3 0.5 1.8 -0.2 0.4 0.1 1.3
Neck or shoulder pain in last month 1.7 2.4 3.9 -1.6 -2.0 -1.7 0.5
Medication: Blood pressure 0.7 1.3 2.8 1.7 -1.2 -0.8 -0.5
Angina (self-reported) 0.0 0.0 0.1 0.1 0.2 0.3 0.0
Migraine (self-reported) 0.4 0.5 1.6 -0.2 0.3 1.3 -0.5
Medication: Ibuprofen 0.3 0.4 0.9 0.2 -0.5 0.5 -0.9
Medication: Allopurinol 0.4 0.6 1.5 -0.6 0.6 1.2 -0.2
Medication: Omeprazole 1.0 1.1 3.8 -2.0 -0.8 -0.0 -0.0
Medication: Seretide 50 evohaler 1.3 1.5 4.7 -0.5 -2.2 -1.0 0.3
Mean time to correctly identify matches 1.4 2.7 4.8 -1.4 1.2 1.6 -2.2
Heart disease (mother) 0.6 0.7 2.1 -0.1 -0.1 -1.4 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.4 4.3 -0.5 -0.6 -0.7 2.1
Whole body fat mass 0.3 1.2 2.2 0.9 -1.0 -1.5 -0.7
Leg fat mass (right) 0.3 1.1 2.2 0.4 -1.1 -1.5 -0.9
Arm predicted mass (right) 0.4 2.1 4.4 -1.9 -0.5 0.7 -2.1
Pulse rate, automated reading 0.1 0.3 1.0 -0.5 -0.1 -0.2 1.0
Alcohol intake frequency. 0.2 0.5 1.2 -0.1 -1.1 -0.8 -0.6
Comparative height size at age 10 0.5 2.8 7.3 0.1 -2.0 -0.3 -2.7
Number of full sisters 0.3 0.4 1.4 -0.1 0.4 0.4 -1.2
Suffer from ‘nerves’ 0.6 1.0 2.3 0.9 0.9 1.5 -0.0
Overall health rating 0.3 0.7 2.1 -0.8 -0.4 -1.4 -0.3
Chest pain or discomfort 0.5 0.7 1.3 0.7 1.1 -0.8 0.6
Had major operations 0.9 1.1 3.7 -1.9 0.5 -0.4 0.4
Age at last live birth 0.1 0.2 0.5 -0.0 0.5 -0.2 0.7
Family relationship satisfaction 0.4 0.5 1.0 -0.7 0.1 -0.6 1.0
Leg pain on walking 1.1 1.3 3.3 -1.8 -0.8 -1.1 -0.4
Qualifications: NVQ or HND or HNC or equivalent 3.2 3.9 7.8 2.8 -2.5 -0.8 -0.9
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.8 0.8 0.3 -0.9 0.0
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.8 -0.5 0.7 0.9 0.8
Medication: Aspirin 0.6 0.7 1.2 1.1 -0.5 -0.7 -1.0
Supplements: Vitamin C 2.1 2.5 4.3 2.0 -1.3 -2.1 -0.5
Knee pain experienced in last month 1.5 2.3 5.1 -2.3 -0.9 -1.2 -1.4
Hypertension (Self-reported) 0.6 1.6 2.6 1.6 -1.4 -1.4 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.1 3.6 -1.9 -0.1 1.0 -0.0
Illnesses of father: Heart disease 0.6 0.8 2.2 0.5 -0.5 1.5 -0.6
Illnesses of siblings: Diabetes 0.4 0.5 1.7 0.1 -0.3 -1.3 0.3
Smoking status: Previous 0.6 0.9 3.4 -0.2 -0.4 0.3 -1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 2.4 1.5 -0.6 -1.5 0.1
Whole body fat-free mass 0.6 3.2 5.9 -2.4 0.1 1.2 -2.4
Leg fat-free mass (right) 0.5 2.5 5.6 -2.4 0.0 1.0 -1.8
Arm fat percentage (left) 0.1 0.6 1.6 0.3 -0.8 -1.3 -0.1
Average weekly red wine intake 3.2 4.7 10.9 1.4 -2.2 -3.3 1.1
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.9 -0.4 -0.5 -1.0 0.5
Mood swings 0.0 0.0 0.1 -0.3 0.2 -0.1 -0.0
Loneliness, isolation 0.8 1.1 1.9 1.4 1.0 1.1 -0.5
Long-standing illness, disability or infirmity 0.7 1.0 2.2 0.1 -1.1 -1.5 0.7
Ever had bowel cancer screening 0.3 0.4 1.4 0.2 1.2 -0.2 0.2
Diabetes diagnosed by doctor 1.9 3.1 8.0 0.9 -2.8 -1.8 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 -0.1 -0.5 -0.6 0.2
Friendships satisfaction 0.9 1.2 1.7 -1.3 1.3 1.1 -0.2
Qualifications: nursing, teaching 1.4 2.1 6.3 0.9 -1.2 0.3 -2.5
Commuting to job workplace: Walk 0.3 0.3 0.5 -0.6 -0.4 0.7 -0.3
Eye problems/disorders: Cataract 3.1 3.6 5.6 2.1 -1.2 -2.4 1.7
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 2.4 -0.1 -0.5 -1.4 1.6
Medication for cholesterol 2.4 3.6 5.6 -1.7 0.9 2.4 -2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.7 -0.8 0.3 0.5 -0.5
Back pain experienced in last month 0.3 0.4 1.3 -0.2 0.3 0.4 -1.2
Mineral and other dietary supplements 1.9 2.6 4.5 -1.2 -1.9 -2.1 0.9
Breast cancer (self-reported) 0.6 0.7 1.8 -1.4 -0.6 -0.5 0.5
Asthma (self-reported) 1.0 1.9 3.8 0.3 -1.9 -1.9 0.1
Osteoporosis (self-reported) 0.7 0.8 1.1 1.1 1.1 0.4 1.0
Osteoarthritis (self-reported) 2.7 3.5 9.7 -3.1 2.0 0.2 0.3
Medication: Aspirin 0.6 0.8 1.6 0.9 -0.5 -0.7 -1.3
Medication: Gliclazide 2.6 3.0 6.9 0.4 -2.6 -2.2 0.1
Illnesses of father: None of the above (group 1) 1.4 1.8 4.4 0.7 -1.0 -2.1 -1.1
Smoking status: Current 1.8 2.8 8.2 -1.1 1.4 0.1 2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 3.8 0.6 0.1 1.8 -1.9
Whole body water mass 0.6 3.4 6.6 -2.6 0.1 1.2 -2.3
Leg predicted mass (right) 0.4 2.4 5.5 -2.4 0.0 1.0 -1.7
Arm fat mass (left) 0.1 0.4 0.6 -0.2 -0.6 -0.8 -0.7
Number of self-reported non-cancer illnesses 0.1 0.2 0.3 -0.5 -0.4 -0.3 0.6
Average weekly champagne plus white wine intake 1.7 2.4 6.5 -1.6 0.5 2.5 0.6
Miserableness 0.1 0.2 0.5 -0.3 -0.2 -0.0 -0.7
Guilty feelings 0.7 1.1 2.7 1.6 0.4 -0.7 0.9
Wears glasses or contact lenses 2.8 3.2 5.3 2.3 -1.7 -0.3 -2.1
Ever taken oral contraceptive pill 1.9 2.1 4.0 2.0 0.1 -1.2 1.7
Hearing aid user 0.4 0.4 1.2 0.4 0.1 -0.6 1.1
Mother’s age at death 0.5 0.6 1.8 -1.4 0.3 0.7 0.3
Financial situation satisfaction 1.1 1.3 4.2 -2.0 0.7 0.7 -0.4
Tinnitus: Yes, now most or all of the time 2.0 2.3 8.8 3.0 0.3 -0.4 0.6
Commuting to job workplace: Public transport 1.4 1.7 3.3 -0.4 1.7 1.8 -0.5
Eye problems/disorders: Glaucoma 1.8 2.1 4.7 1.6 -1.0 -2.2 0.3
Medication: Blood pressure 0.4 0.8 1.7 -0.0 0.2 -1.2 1.3
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.9 -0.9 0.6 0.3 -0.9
Supplements: Fish oil (including cod liver oil) 0.8 1.1 2.1 1.4 0.2 0.4 -1.4
High cholesterol (Self-reported) 0.9 1.6 2.4 1.6 -1.3 -1.4 -0.4
Medication: Bendroflumethiazide 1.3 2.0 5.3 0.9 -0.3 -2.3 1.2
Medication: Paracetamol 1.0 1.6 2.8 -0.3 1.3 1.7 -1.4
Medication: Lisinopril 0.3 0.3 0.8 -0.6 0.9 0.2 -0.5
Medication: Atorvastatin 0.5 0.6 1.8 1.3 -0.8 -0.2 0.1
Illnesses of father: High blood pressure 0.9 1.1 2.7 -1.6 -0.1 -1.0 0.8
Alcohol drinker status: Never 0.3 0.4 0.7 -0.4 -0.5 -0.9 0.7
Ever smoked 0.8 1.4 2.5 -1.6 1.1 0.6 -1.3
Basal metabolic rate 0.4 2.2 4.3 -1.9 -0.1 0.8 -2.1
Leg fat percentage (left) 0.4 1.6 2.7 1.6 -1.0 -1.6 0.0
Arm fat-free mass (left) 0.4 2.0 4.1 -1.9 0.0 0.7 -2.0
Number of operations (self-reported) 1.9 2.8 5.3 -1.4 -2.3 -2.0 -0.1
Average weekly beer plus cider intake 0.4 0.6 1.3 -1.1 0.1 -0.3 1.0
Irritability 0.7 1.2 3.3 0.4 -1.8 -1.1 0.1
Risk taking 0.7 1.0 2.0 -1.4 -1.0 -0.6 0.7
Ever had prostate specific antigen (PSA) test 5.3 6.1 14.4 -0.3 3.1 3.8 -0.8
Fractured/broken bones in last 5 years 0.5 0.7 1.3 -0.6 -0.6 -1.1 0.8
Age started oral contraceptive pill 0.6 0.7 1.8 0.2 0.7 1.4 -0.7
Diastolic blood pressure, automated reading 0.3 1.0 2.9 0.4 -0.7 -0.7 1.7
Ever depressed for a whole week 0.4 0.5 1.3 -1.1 0.7 0.5 -0.0
Unable to work because of sickness or disability 0.7 0.9 2.3 0.1 1.5 0.9 0.7
Commuting to job workplace: Cycle 2.5 3.1 8.1 -1.2 -2.9 -1.6 0.0
Myopia 3.3 4.8 11.8 3.4 -0.6 1.3 -2.3
Vascular/heart problems diagnosed by doctor 0.5 1.2 2.0 -1.3 0.9 1.4 -0.7
Cholesterol lowering medication 0.3 0.5 0.7 0.6 -0.8 -0.8 -0.4
Medication: Omeprazole (e.g. Zanprol) 1.4 1.8 6.8 -2.6 -0.3 0.3 0.3
Pain experienced in last month 0.6 1.0 1.6 1.3 0.9 -0.2 1.2
Supplements: Calcium 0.4 0.4 0.8 0.8 -0.3 0.2 0.9
Basal cell carcinoma (self-reported) 0.5 0.6 1.4 -1.2 0.5 0.9 -0.4
Heart attack/myocardial infarction (self-reported) 0.8 1.0 3.0 1.7 0.4 0.8 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.7 0.6 0.4 -0.8 0.6
Heart disease (siblings) 0.9 1.1 3.6 1.9 0.1 -0.1 0.9
Alcohol drinker status: Previous 0.7 0.8 2.1 0.7 0.1 1.4 -0.8
Pack years of smoking 0.5 0.8 1.9 0.5 -0.0 -1.0 1.4
Impedance of whole body 2.7 13.6 35.6 6.0 -1.0 -3.5 2.4
Leg fat mass (left) 0.3 1.0 2.0 0.6 -1.1 -1.4 -0.7
Arm predicted mass (left) 0.4 1.9 3.8 -1.8 -0.1 0.6 -1.9