Hub : Genes

SNED1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.1698	0.0410	8.3e-09	0.119	0.096	0.135	0.132	0.144	5.3e-15	2.7e-12	5.5e-17	1.2e-16	5.2e-18
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0860	0.0407	9.0e-03	0.011	0.003	0.028	NA	0.009	1.8e-02	1.3e-01	4.0e-04	NA	2.7e-02
3	TCGA	Lung Squamous Cell Carcinoma	0.0946	0.0410	9.3e-04	-0.002	0.012	0.026	NA	0.006	7.6e-01	1.3e-02	5.7e-04	NA	5.9e-02
4	TCGA	Thyroid Carcinoma	0.0850	0.0430	3.5e-03	0.041	0.029	0.042	NA	0.042	6.7e-05	7.4e-04	6.0e-05	NA	5.9e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	1.3	0.2	-1.1	0.2	0.7
Bipolar Disorder or Schizophrenia	0.9	2.1	6.7	-1.0	-2.6	-0.3	-0.9
Depressed Affect (Nagel 2018)	0.2	0.3	0.5	0.1	0.7	0.7	-0.6
Depression (Nagel 2018)	0.5	0.8	1.6	-0.1	1.3	0.8	-0.9
Intelligence (Savage-Jansen 2018)	0.9	2.8	6.6	0.5	-2.6	-0.3	-2.0
Neuroticism (Nagel 2018)	0.1	0.3	0.6	0.3	0.3	0.8	-0.5
Schizophrenia (2018)	1.4	2.9	6.2	-1.5	-2.5	-0.7	-1.7
Schizophrenia vs Biploar Disorder	1.3	1.7	5.4	-0.1	2.3	1.1	0.4
Worry (Nagel 2018)	0.0	0.1	0.1	-0.2	0.1	0.3	-0.3
Alzheimer’s Disease (in mother)	0.1	0.2	0.5	-0.2	-0.1	-0.4	-0.7
Alzheimer’s Disease (in father)	2.6	2.9	5.2	2.3	-0.5	0.9	2.3
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.2	-0.2	0.6	-0.4
Crohns Disease (2017)	0.4	0.8	1.4	-0.9	0.0	-1.2	1.1
Irritable Bowel Disease (IBD)	0.4	1.0	2.3	-1.5	-0.1	-0.9	1.0
Ulcerative Colitis (UC)	0.6	1.1	2.9	-1.7	-0.5	-1.0	0.6
Major Depression (MDD)	0.7	0.9	3.3	-0.3	0.0	0.0	-1.8
Reaction Time	1.0	2.0	3.8	-1.6	0.6	1.0	-1.9
Verbal and Numeric Reasoning (VNR)	1.0	2.4	4.4	0.5	-2.1	-0.8	-2.1
Breast Cancer	0.3	0.8	1.6	-0.3	1.3	0.0	1.2
Ovarian Cancer	0.3	0.4	1.0	1.0	-0.5	-0.4	0.5
Prostate Cancer	0.9	1.3	2.7	0.7	-0.5	-1.6	1.4
Age at First Birth	1.1	1.6	4.4	-1.1	-0.2	0.7	-2.1
Bipolar Disorder (2011)	0.9	0.9	2.0	-1.4	-0.6	0.8	-0.7
Body Mass Index (BMI) (2010)	0.6	0.9	1.6	-1.2	0.9	0.1	1.1
Coronary Artery Disease (CAD)	3.0	3.6	6.5	-2.5	2.4	1.4	0.5
Crohns Disease (2012)	1.1	1.7	3.7	-0.5	1.7	1.9	-0.0
Mean Putamen Volume	0.9	1.0	1.6	1.1	-1.3	0.5	-1.1
Fasting Glucose	0.3	0.3	1.2	-0.1	-0.2	-0.3	1.1
HbA1C	0.9	1.0	2.5	-1.6	0.2	-0.7	0.9
HDL Cholesterol	0.1	0.2	0.4	-0.1	0.1	0.6	-0.5
LDL Cholesterol	0.3	0.4	0.7	0.6	0.8	0.7	0.1
Lupus	1.1	1.7	3.4	0.1	-1.9	-1.5	1.1
Neuroticism (2016)	0.3	0.4	1.0	0.6	0.1	0.4	-1.0
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.1	-0.8	-0.1	0.7
Rheumatoid Arthritis	0.5	0.7	1.6	0.5	0.9	0.4	1.2
Schizophrenia (2014)	0.9	1.9	3.2	-1.8	-1.1	0.7	-1.7
Triglycerides	0.6	1.0	2.2	-0.1	-1.3	-1.5	-0.3
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.5	-1.1	-1.6	0.3	-1.2
Ulcerative Colitis	0.6	0.8	1.8	-0.7	-0.6	-1.4	0.8
Blood Eosinophil Count	0.4	3.2	8.2	0.1	-1.9	-2.9	1.0
Blood Platelet Count	0.5	5.4	10.2	-3.2	1.5	2.1	2.1
Blood Red Count	0.3	2.6	4.8	2.2	-1.7	-1.3	0.9
Blood White Count	0.2	1.7	3.9	-0.5	-1.2	-2.0	1.1
Heel T-Score	0.4	3.1	5.0	-1.8	-0.4	1.9	-2.2
BMI	0.1	0.6	1.5	-1.2	0.8	0.2	0.1
Height	0.3	5.7	7.3	2.7	-2.1	-1.9	-2.7
Waist Hip Ratio (WHR)	0.2	1.1	2.7	-1.2	-0.5	-1.6	0.2
Systolic Blood Pressure	0.2	1.0	3.2	0.7	-0.0	0.3	1.8
Smoking Status	0.3	0.7	1.2	-0.4	1.1	0.9	0.7
Allergy or Eczema	0.4	0.9	2.0	-0.2	0.3	1.4	1.3
Cardiovascular Disease	0.6	2.0	3.4	1.9	-1.6	-1.4	0.2
Hypothyroidism (self reported)	2.9	6.6	14.0	-0.8	1.9	2.9	-3.7
Respiratory disease	1.3	2.9	6.2	0.6	-2.2	-2.5	0.7
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.1	1.5	-1.8	-1.2	0.3
Lung FEV1/FVC ratio	0.7	3.4	5.6	-1.6	-0.6	2.3	-2.4
Lung FVC	0.5	2.5	3.9	2.0	0.7	1.4	-1.9
Neuroticism	0.2	0.5	1.2	0.5	0.1	1.1	-0.7
Chronotype (morning person)	1.0	2.4	5.6	2.4	-1.4	1.0	-1.0
Hair Pigment	0.2	4.5	10.6	3.3	2.0	0.6	1.8
Tanning	0.3	3.4	7.2	-2.0	-2.7	-1.0	-1.1
Hand grip strength (left)	2.5	6.6	13.0	0.8	-3.6	-3.6	0.0
Number of treatments/medications taken	0.7	1.2	3.2	1.8	-0.4	-1.2	0.3
Average weekly spirits intake	1.9	2.4	5.4	0.4	-2.3	-0.8	-1.8
Sensitivity / hurt feelings	0.4	0.8	1.7	0.6	-1.0	-0.1	1.3
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.1	-0.4	0.4	0.6	-1.0
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.5	0.4	0.1	-0.2
Relative age of first facial hair	0.1	0.2	0.4	-0.3	-0.6	-0.3	0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.6	0.1	0.6	1.6	0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	-0.0	0.6	0.1	0.6
Ever had hysterectomy (womb removed)	0.4	0.5	1.1	1.1	-0.9	0.3	-0.1
Systolic blood pressure, automated reading	0.2	0.6	1.8	0.8	0.1	-0.1	1.3
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	2.7	1.2	-0.9	-1.6	0.0
Angina	0.0	0.0	0.1	-0.1	-0.0	0.2	-0.1
Medication for hormone replacement therapy	0.6	0.7	1.6	0.4	-1.3	-0.5	0.8
Vitamin and mineral supplements	0.7	1.0	2.6	-0.8	0.1	-1.6	0.8
Supplements: Zinc	0.4	0.4	0.8	-0.9	-0.4	-0.8	0.2
Medication: Co-codamol	0.4	0.5	1.8	-0.3	-0.0	1.4	0.1
Medication: Metformin	0.8	1.1	2.4	1.1	-1.6	-0.9	-0.2
Diabetes (father)	3.1	3.8	9.2	0.7	3.0	0.8	2.2
Diabetes (mother)	1.7	2.2	4.1	-0.9	-1.2	-2.0	1.5
Severe depression (siblings)	0.5	0.6	2.1	0.3	1.4	0.3	-0.1
Pack years adult smoking proportion	0.6	0.9	2.2	0.5	0.2	-1.0	1.5
Impedance of leg (right)	2.5	12.0	31.4	5.6	-0.9	-3.4	2.0
Leg fat-free mass (left)	0.5	2.8	6.2	-2.5	0.2	0.9	-2.0
Trunk fat percentage	0.6	2.5	4.9	2.2	-1.0	-2.0	0.2
Hand grip strength (right)	1.9	5.3	10.8	1.6	-2.8	-3.3	0.4
Townsend deprivation index at recruitment	1.1	1.6	3.1	-0.2	1.8	1.8	-0.1
Current tobacco smoking	2.0	3.3	8.1	-1.4	1.7	0.2	2.8
Average weekly fortified wine intake	0.4	0.5	1.4	0.1	-0.3	0.8	-1.2
Maternal smoking around birth	0.8	1.2	2.6	0.4	-1.2	-1.6	0.7
Fed-up feelings	0.3	0.6	1.7	1.3	0.5	-0.8	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	-0.7	1.3	0.7	-0.6
Relative age voice broke	0.2	0.3	0.7	-0.3	-0.4	0.2	-0.8
Taking other prescription medications	1.1	1.8	2.9	1.5	1.7	1.4	0.2
Age when periods started (menarche)	0.9	2.2	4.9	1.6	2.2	0.9	-0.6
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.2	0.8	-1.5	-0.8	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	1.9	1.3	-1.4	-0.4	-0.7
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	4.0	-0.2	-2.0	-1.6	0.0
Qualifications: CSEs or equivalent	1.9	2.5	5.2	0.6	-1.3	-2.3	1.7
Serious illness, injury or assault to yourself	0.9	1.1	1.9	0.6	-1.3	-1.4	0.8
High blood pressure	0.5	1.5	2.1	1.4	-1.4	-1.4	0.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.2	-0.5	-0.1	1.1	1.0
Multivitamins +/- minerals	1.1	1.4	4.3	-0.8	0.6	2.1	-0.6
Stomach or abdominal pain in last month	1.4	1.8	2.9	-1.7	-1.3	-1.3	-0.9
Supplements: Glucosamine	0.2	0.3	0.9	0.9	0.1	0.4	-0.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.7	-1.3	-1.0	0.1	0.4
Medication: Atenolol	0.5	0.6	1.9	-0.3	0.8	-0.0	1.4
Medication: Levothyroxine sodium	2.0	3.4	11.2	-0.9	-0.5	1.1	-3.4
Sitting height	0.8	5.8	12.0	3.5	-2.3	-0.7	-2.2
Chronic bronchitis/emphysema (father)	1.1	1.3	3.1	-0.2	-0.9	-1.0	1.8
High blood pressure (mother)	0.4	0.6	1.0	-1.0	-0.5	0.6	-0.9
Body mass index (BMI)	0.2	0.7	2.4	-1.5	-0.2	0.1	-0.6
Impedance of leg (left)	3.3	16.0	39.7	6.3	-1.4	-3.9	2.7
Leg predicted mass (left)	0.6	2.9	6.7	-2.6	0.1	0.9	-2.0
Trunk fat mass	0.3	1.3	2.0	1.4	-0.9	-1.4	-0.7
Waist circumference	0.1	0.4	1.0	-0.8	-0.2	-0.0	-1.0
Number of incorrect matches in round	1.0	1.7	4.8	-1.4	0.4	0.0	2.2
Past tobacco smoking	0.4	0.7	1.8	0.9	-0.1	-0.2	1.3
Alcohol usually taken with meals	0.5	0.8	1.7	1.3	0.3	1.1	-0.5
Nervous feelings	0.2	0.4	1.4	1.2	0.5	-0.2	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	-0.1	0.9	-0.0	-0.9
Hearing difficulty/problems with background noise	0.8	1.3	3.0	-1.1	-1.7	-0.3	-0.9
Hair/balding pattern: Pattern 2	1.7	2.1	5.4	0.3	0.2	-2.3	1.7
Had menopause	1.9	2.3	4.6	-2.1	-0.5	0.7	-2.0
Had other major operations	2.6	3.2	5.4	-0.3	-2.0	-2.3	1.8
Forced vital capacity (FVC)	0.9	3.5	12.2	3.5	-0.3	-0.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.9	0.0	-0.8	0.6	-0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.2	-1.1	0.6	0.3	-0.9
Qualifications: None of the above	1.0	2.1	5.0	-0.6	2.2	0.1	1.7
Financial difficulties in last 2 years	0.4	0.5	1.2	-1.1	-0.2	-0.8	0.5
Mouth/teeth dental problems	0.2	0.2	0.5	0.7	-0.2	0.7	0.0
Heart attack	0.8	1.0	2.8	1.7	0.5	0.8	-0.5
Allergy	0.2	0.5	1.3	0.4	0.7	0.3	-1.2
Pain all over the body in last month	1.5	1.6	4.1	-0.6	2.0	0.8	1.1
Diabetes (self-reported)	1.2	1.8	3.7	0.7	-1.9	-1.5	0.8
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.1	-1.4	0.6	1.4	-0.8
Medication: Ramipril	0.4	0.6	1.0	0.8	0.5	1.0	-0.6
Medication: Simvastatin	1.1	1.7	3.2	1.2	-1.5	0.0	-1.8
Fluid intelligence score	1.1	2.3	3.8	-1.2	-1.9	-1.4	-1.5
Illnesses of siblings	0.5	0.7	1.6	-0.8	0.7	1.2	0.4
Neuroticism score	0.2	0.3	1.2	1.1	0.3	0.2	-0.0
Weight	0.1	0.7	2.3	-0.5	-0.4	-0.1	-1.5
Impedance of arm (right)	1.7	8.1	22.8	4.8	-0.2	-2.3	2.1
Arm fat percentage (right)	0.1	0.5	1.2	0.6	-0.5	-1.1	-0.1
Trunk fat-free mass	0.6	3.5	6.6	-2.4	0.1	1.4	-2.6
Hip circumference	0.2	0.7	1.3	1.1	-0.3	0.5	-1.1
Time employed in main current job	0.2	0.3	0.9	0.0	0.9	0.3	0.4
Alcohol intake versus 10 years previously	0.3	0.4	0.8	-0.2	0.6	0.9	-0.7
Father’s age at death	1.4	1.9	2.3	-1.3	1.2	1.5	-1.3
Worrier / anxious feelings	0.2	0.3	0.8	0.2	-0.9	-0.6	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	4.2	-2.1	0.7	0.1	-1.3
Falls in the last year	1.4	1.9	5.4	0.1	-1.1	-2.3	0.9
Hair/balding pattern: Pattern 3	0.7	1.0	2.3	-0.9	0.6	1.5	-0.7
Number of live births	1.5	2.1	4.2	-1.5	-0.9	-2.0	1.1
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	8.7	3.0	-0.8	0.4	-1.5
Pulse rate	0.1	0.2	0.4	-0.6	0.5	-0.1	0.2
Happiness	0.3	0.3	0.9	-0.5	0.9	0.2	-0.3
Noisy workplace	0.4	0.5	1.2	-0.2	-0.6	-0.8	-1.1
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.5	0.1	-0.7	1.2	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.6	0.5	-0.3	1.3	-0.3
Mouth/teeth dental problems: Dentures	0.4	0.7	1.7	-0.6	0.6	0.4	-1.3
Asthma	0.6	1.1	2.3	0.2	-1.4	-1.5	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.4	-0.4	-0.1	0.0
Medication: Cholesterol lowering	1.4	2.3	4.5	1.6	-2.1	-0.7	-1.1
Depression (self-reported)	1.8	2.2	3.2	-1.4	1.3	1.8	-1.3
Medication: Lansoprazole	1.7	1.9	5.6	0.4	2.4	1.0	1.0
Prospective memory result	2.1	2.6	6.4	-0.5	1.7	2.5	-0.9
Lung cancer (father)	0.5	0.6	1.8	-0.2	-0.2	-1.3	0.7
Illnesses of mother	0.2	0.2	0.3	-0.5	-0.2	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.7	1.8	-0.2	1.0	-1.9
Pulse wave Arterial Stiffness index	2.1	2.5	4.2	-1.4	0.4	2.0	-1.9
Impedance of arm (left)	1.8	8.3	23.0	4.8	-0.5	-2.4	2.1
Arm fat mass (right)	0.1	0.4	0.7	-0.3	-0.7	-0.6	-0.8
Trunk predicted mass	0.6	3.7	7.0	-2.4	0.1	1.5	-2.6
Standing height	0.2	2.3	5.2	2.3	-0.6	-0.4	-1.9
Length of working week for main job	0.7	0.8	1.4	-0.7	1.0	0.6	1.2
Exposure to tobacco smoke at home	3.5	3.9	9.0	-1.1	3.0	2.3	0.3
Breastfed as a baby	0.4	0.5	0.9	0.2	-0.8	-0.9	-0.6
Tense / ‘highly strung’	0.3	0.6	1.3	-0.6	0.6	0.5	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.9	-0.9	1.4	0.9	-0.1
Hair/balding pattern: Pattern 4	0.9	2.1	7.1	2.7	0.4	0.5	-1.0
Birth weight of first child	0.3	0.5	1.1	1.0	0.1	-0.0	-1.0
Peak expiratory flow (PEF)	0.9	2.0	7.3	2.7	-0.5	0.8	-0.1
Pulse wave reflection index	1.4	1.8	3.8	-0.9	0.3	2.0	-1.5
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.9	-0.1	0.9	0.4	0.2
Loud music exposure frequency	0.2	0.3	0.4	0.7	-0.6	0.2	0.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.4	-0.7	-1.1	0.9	-1.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	0.9	0.0	-0.4	-0.0
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.8	0.0	-0.8	0.5
Medication: Paracetamol	0.6	1.0	1.7	0.3	1.1	1.3	-1.0
Headache pain in last month	0.1	0.1	0.3	0.6	0.1	0.1	0.5
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.6	-1.1	1.9	1.4	0.5
Glaucoma (self-reported)	0.5	0.6	1.8	0.6	-0.2	-1.3	0.2
Gout (self-reported)	0.3	0.4	1.5	-1.2	-0.4	0.3	0.2
Hypothyroidism/myxoedema (self-reported)	3.9	7.7	13.4	-0.5	2.3	3.5	-3.7
Medication: Amlodipine	0.5	0.7	1.1	0.6	-0.9	-1.0	0.8
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.6	0.0	0.2	-0.8	0.1
Birth weight	0.3	0.6	1.3	-1.2	-0.0	0.2	-0.9
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	0.5	-0.4	-0.3	-0.7
High blood pressure (siblings)	0.2	0.4	1.3	-0.2	-0.2	-1.1	-0.1
Forced vital capacity (FVC), Best measure	0.6	2.1	5.7	2.4	-0.1	0.1	-1.7
Body fat percentage	0.5	1.9	3.5	1.8	-1.0	-1.9	-0.1
Leg fat percentage (right)	0.3	1.2	2.6	1.3	-0.9	-1.6	-0.3
Arm fat-free mass (right)	0.4	2.2	4.2	-2.0	-0.3	0.6	-2.0
Exposure to tobacco smoke outside home	0.2	0.3	1.2	0.1	0.2	-0.1	1.1
Comparative body size at age 10	0.4	1.1	2.1	-1.4	0.4	1.4	-0.3
Number of full brothers	0.9	1.1	2.9	0.7	1.7	1.0	-0.3
Worry too long after embarrassment	1.1	1.8	4.1	-0.6	2.0	1.3	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.4	-0.9	1.2	0.9	-0.5
Wheeze or whistling in the chest in last year	0.5	0.9	1.4	-1.1	-0.8	-0.6	1.2
Number of children fathered	1.4	1.6	5.2	-2.3	-0.6	-0.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.7	1.6	-0.4	1.0	-1.5
Age at first live birth	0.3	0.6	2.2	1.5	-0.2	0.4	-0.1
Pulse wave peak to peak time	2.2	2.6	4.4	1.5	-0.5	-2.1	1.8
Health satisfaction	0.6	0.8	1.3	-1.1	1.1	-0.2	0.6
Shortness of breath walking on level ground	0.7	0.8	2.8	0.2	-0.4	0.3	-1.7
Qualifications: College or University degree	0.3	0.8	1.5	-0.6	-1.2	-0.1	-1.2
Eye problems/disorders: None of the above	3.5	4.0	10.1	-1.7	1.6	3.2	-0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	0.3	-0.2	-0.3	0.2
Emphysema/chronic bronchitis	0.5	0.6	1.3	0.3	0.5	-1.1	0.8
Medication for pain relief, constipation, heartburn	0.3	0.5	1.8	-0.2	0.4	0.1	1.3
Neck or shoulder pain in last month	1.7	2.4	3.9	-1.6	-2.0	-1.7	0.5
Medication: Blood pressure	0.7	1.3	2.8	1.7	-1.2	-0.8	-0.5
Angina (self-reported)	0.0	0.0	0.1	0.1	0.2	0.3	0.0
Migraine (self-reported)	0.4	0.5	1.6	-0.2	0.3	1.3	-0.5
Medication: Ibuprofen	0.3	0.4	0.9	0.2	-0.5	0.5	-0.9
Medication: Allopurinol	0.4	0.6	1.5	-0.6	0.6	1.2	-0.2
Medication: Omeprazole	1.0	1.1	3.8	-2.0	-0.8	-0.0	-0.0
Medication: Seretide 50 evohaler	1.3	1.5	4.7	-0.5	-2.2	-1.0	0.3
Mean time to correctly identify matches	1.4	2.7	4.8	-1.4	1.2	1.6	-2.2
Heart disease (mother)	0.6	0.7	2.1	-0.1	-0.1	-1.4	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	4.3	-0.5	-0.6	-0.7	2.1
Whole body fat mass	0.3	1.2	2.2	0.9	-1.0	-1.5	-0.7
Leg fat mass (right)	0.3	1.1	2.2	0.4	-1.1	-1.5	-0.9
Arm predicted mass (right)	0.4	2.1	4.4	-1.9	-0.5	0.7	-2.1
Pulse rate, automated reading	0.1	0.3	1.0	-0.5	-0.1	-0.2	1.0
Alcohol intake frequency.	0.2	0.5	1.2	-0.1	-1.1	-0.8	-0.6
Comparative height size at age 10	0.5	2.8	7.3	0.1	-2.0	-0.3	-2.7
Number of full sisters	0.3	0.4	1.4	-0.1	0.4	0.4	-1.2
Suffer from ‘nerves’	0.6	1.0	2.3	0.9	0.9	1.5	-0.0
Overall health rating	0.3	0.7	2.1	-0.8	-0.4	-1.4	-0.3
Chest pain or discomfort	0.5	0.7	1.3	0.7	1.1	-0.8	0.6
Had major operations	0.9	1.1	3.7	-1.9	0.5	-0.4	0.4
Age at last live birth	0.1	0.2	0.5	-0.0	0.5	-0.2	0.7
Family relationship satisfaction	0.4	0.5	1.0	-0.7	0.1	-0.6	1.0
Leg pain on walking	1.1	1.3	3.3	-1.8	-0.8	-1.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	3.2	3.9	7.8	2.8	-2.5	-0.8	-0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	0.8	0.3	-0.9	0.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.8	-0.5	0.7	0.9	0.8
Medication: Aspirin	0.6	0.7	1.2	1.1	-0.5	-0.7	-1.0
Supplements: Vitamin C	2.1	2.5	4.3	2.0	-1.3	-2.1	-0.5
Knee pain experienced in last month	1.5	2.3	5.1	-2.3	-0.9	-1.2	-1.4
Hypertension (Self-reported)	0.6	1.6	2.6	1.6	-1.4	-1.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	3.6	-1.9	-0.1	1.0	-0.0
Illnesses of father: Heart disease	0.6	0.8	2.2	0.5	-0.5	1.5	-0.6
Illnesses of siblings: Diabetes	0.4	0.5	1.7	0.1	-0.3	-1.3	0.3
Smoking status: Previous	0.6	0.9	3.4	-0.2	-0.4	0.3	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.4	1.5	-0.6	-1.5	0.1
Whole body fat-free mass	0.6	3.2	5.9	-2.4	0.1	1.2	-2.4
Leg fat-free mass (right)	0.5	2.5	5.6	-2.4	0.0	1.0	-1.8
Arm fat percentage (left)	0.1	0.6	1.6	0.3	-0.8	-1.3	-0.1
Average weekly red wine intake	3.2	4.7	10.9	1.4	-2.2	-3.3	1.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	-0.4	-0.5	-1.0	0.5
Mood swings	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.0
Loneliness, isolation	0.8	1.1	1.9	1.4	1.0	1.1	-0.5
Long-standing illness, disability or infirmity	0.7	1.0	2.2	0.1	-1.1	-1.5	0.7
Ever had bowel cancer screening	0.3	0.4	1.4	0.2	1.2	-0.2	0.2
Diabetes diagnosed by doctor	1.9	3.1	8.0	0.9	-2.8	-1.8	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.1	-0.5	-0.6	0.2
Friendships satisfaction	0.9	1.2	1.7	-1.3	1.3	1.1	-0.2
Qualifications: nursing, teaching	1.4	2.1	6.3	0.9	-1.2	0.3	-2.5
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.6	-0.4	0.7	-0.3
Eye problems/disorders: Cataract	3.1	3.6	5.6	2.1	-1.2	-2.4	1.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	2.4	-0.1	-0.5	-1.4	1.6
Medication for cholesterol	2.4	3.6	5.6	-1.7	0.9	2.4	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	-0.8	0.3	0.5	-0.5
Back pain experienced in last month	0.3	0.4	1.3	-0.2	0.3	0.4	-1.2
Mineral and other dietary supplements	1.9	2.6	4.5	-1.2	-1.9	-2.1	0.9
Breast cancer (self-reported)	0.6	0.7	1.8	-1.4	-0.6	-0.5	0.5
Asthma (self-reported)	1.0	1.9	3.8	0.3	-1.9	-1.9	0.1
Osteoporosis (self-reported)	0.7	0.8	1.1	1.1	1.1	0.4	1.0
Osteoarthritis (self-reported)	2.7	3.5	9.7	-3.1	2.0	0.2	0.3
Medication: Aspirin	0.6	0.8	1.6	0.9	-0.5	-0.7	-1.3
Medication: Gliclazide	2.6	3.0	6.9	0.4	-2.6	-2.2	0.1
Illnesses of father: None of the above (group 1)	1.4	1.8	4.4	0.7	-1.0	-2.1	-1.1
Smoking status: Current	1.8	2.8	8.2	-1.1	1.4	0.1	2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	3.8	0.6	0.1	1.8	-1.9
Whole body water mass	0.6	3.4	6.6	-2.6	0.1	1.2	-2.3
Leg predicted mass (right)	0.4	2.4	5.5	-2.4	0.0	1.0	-1.7
Arm fat mass (left)	0.1	0.4	0.6	-0.2	-0.6	-0.8	-0.7
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	-0.5	-0.4	-0.3	0.6
Average weekly champagne plus white wine intake	1.7	2.4	6.5	-1.6	0.5	2.5	0.6
Miserableness	0.1	0.2	0.5	-0.3	-0.2	-0.0	-0.7
Guilty feelings	0.7	1.1	2.7	1.6	0.4	-0.7	0.9
Wears glasses or contact lenses	2.8	3.2	5.3	2.3	-1.7	-0.3	-2.1
Ever taken oral contraceptive pill	1.9	2.1	4.0	2.0	0.1	-1.2	1.7
Hearing aid user	0.4	0.4	1.2	0.4	0.1	-0.6	1.1
Mother’s age at death	0.5	0.6	1.8	-1.4	0.3	0.7	0.3
Financial situation satisfaction	1.1	1.3	4.2	-2.0	0.7	0.7	-0.4
Tinnitus: Yes, now most or all of the time	2.0	2.3	8.8	3.0	0.3	-0.4	0.6
Commuting to job workplace: Public transport	1.4	1.7	3.3	-0.4	1.7	1.8	-0.5
Eye problems/disorders: Glaucoma	1.8	2.1	4.7	1.6	-1.0	-2.2	0.3
Medication: Blood pressure	0.4	0.8	1.7	-0.0	0.2	-1.2	1.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	-0.9	0.6	0.3	-0.9
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.1	1.4	0.2	0.4	-1.4
High cholesterol (Self-reported)	0.9	1.6	2.4	1.6	-1.3	-1.4	-0.4
Medication: Bendroflumethiazide	1.3	2.0	5.3	0.9	-0.3	-2.3	1.2
Medication: Paracetamol	1.0	1.6	2.8	-0.3	1.3	1.7	-1.4
Medication: Lisinopril	0.3	0.3	0.8	-0.6	0.9	0.2	-0.5
Medication: Atorvastatin	0.5	0.6	1.8	1.3	-0.8	-0.2	0.1
Illnesses of father: High blood pressure	0.9	1.1	2.7	-1.6	-0.1	-1.0	0.8
Alcohol drinker status: Never	0.3	0.4	0.7	-0.4	-0.5	-0.9	0.7
Ever smoked	0.8	1.4	2.5	-1.6	1.1	0.6	-1.3
Basal metabolic rate	0.4	2.2	4.3	-1.9	-0.1	0.8	-2.1
Leg fat percentage (left)	0.4	1.6	2.7	1.6	-1.0	-1.6	0.0
Arm fat-free mass (left)	0.4	2.0	4.1	-1.9	0.0	0.7	-2.0
Number of operations (self-reported)	1.9	2.8	5.3	-1.4	-2.3	-2.0	-0.1
Average weekly beer plus cider intake	0.4	0.6	1.3	-1.1	0.1	-0.3	1.0
Irritability	0.7	1.2	3.3	0.4	-1.8	-1.1	0.1
Risk taking	0.7	1.0	2.0	-1.4	-1.0	-0.6	0.7
Ever had prostate specific antigen (PSA) test	5.3	6.1	14.4	-0.3	3.1	3.8	-0.8
Fractured/broken bones in last 5 years	0.5	0.7	1.3	-0.6	-0.6	-1.1	0.8
Age started oral contraceptive pill	0.6	0.7	1.8	0.2	0.7	1.4	-0.7
Diastolic blood pressure, automated reading	0.3	1.0	2.9	0.4	-0.7	-0.7	1.7
Ever depressed for a whole week	0.4	0.5	1.3	-1.1	0.7	0.5	-0.0
Unable to work because of sickness or disability	0.7	0.9	2.3	0.1	1.5	0.9	0.7
Commuting to job workplace: Cycle	2.5	3.1	8.1	-1.2	-2.9	-1.6	0.0
Myopia	3.3	4.8	11.8	3.4	-0.6	1.3	-2.3
Vascular/heart problems diagnosed by doctor	0.5	1.2	2.0	-1.3	0.9	1.4	-0.7
Cholesterol lowering medication	0.3	0.5	0.7	0.6	-0.8	-0.8	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.4	1.8	6.8	-2.6	-0.3	0.3	0.3
Pain experienced in last month	0.6	1.0	1.6	1.3	0.9	-0.2	1.2
Supplements: Calcium	0.4	0.4	0.8	0.8	-0.3	0.2	0.9
Basal cell carcinoma (self-reported)	0.5	0.6	1.4	-1.2	0.5	0.9	-0.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.0	1.7	0.4	0.8	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	0.6	0.4	-0.8	0.6
Heart disease (siblings)	0.9	1.1	3.6	1.9	0.1	-0.1	0.9
Alcohol drinker status: Previous	0.7	0.8	2.1	0.7	0.1	1.4	-0.8
Pack years of smoking	0.5	0.8	1.9	0.5	-0.0	-1.0	1.4
Impedance of whole body	2.7	13.6	35.6	6.0	-1.0	-3.5	2.4
Leg fat mass (left)	0.3	1.0	2.0	0.6	-1.1	-1.4	-0.7
Arm predicted mass (left)	0.4	1.9	3.8	-1.8	-0.1	0.6	-1.9