[Hub]/) : Traits : Impedance of leg (left) : ← →

chr2:217,908,472-220,374,137

Best TWAS P=1.66e-14 · Best GWAS P=1.26e-15 conditioned to 0.00363

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	NTR	Blood	CYP27A1	0.21	0.30	enet	44	0.31	3.8e-104	-7.07	-7.7	1.7e-14	0.04	0.24	0.76	TRUE
61	The Cancer Genome Atlas	Thyroid Carcinoma	DIRC3	0.08	0.06	lasso	5	0.07	2.7e-07	7.14	-6.3	3.1e-10	-0.56	0.88	0.11	TRUE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DIRC3	0.12	0.01	blup	275	0.02	3.3e-03	-1.33	-5.6	1.7e-08	-0.51	0.05	0.50	TRUE
32	GTEx	Whole Blood	RQCD1	0.04	0.02	lasso	2	0.00	2.4e-01	-7.26	7.6	2.4e-14	-0.02	0.09	0.66	FALSE
8	GTEx	Brain Cerebellar Hemisphere	RQCD1	0.13	0.04	lasso	11	0.01	2.1e-01	-7.13	-7.6	3.0e-14	0.00	0.07	0.54	FALSE
31	GTEx	Whole Blood	CYP27A1	0.03	0.05	lasso	5	0.02	1.3e-02	-7.04	-7.5	7.3e-14	0.04	0.14	0.77	FALSE
26	GTEx	Testis	CYP27A1	0.20	0.18	lasso	4	0.26	4.0e-12	6.89	-7.4	1.1e-13	0.03	0.25	0.75	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	PLCD4	0.03	0.02	blup	61	0.02	2.1e-03	-7.26	7.4	1.2e-13	-0.02	0.03	0.88	FALSE
20	GTEx	Heart Left Ventricle	RQCD1	0.06	0.05	lasso	3	0.03	9.0e-03	-7.08	-7.4	1.7e-13	0.03	0.11	0.80	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	USP37	0.02	0.02	enet	4	0.02	3.2e-03	-7.33	-7.4	1.7e-13	0.03	0.04	0.92	FALSE
12	GTEx	Breast Mammary Tissue (Male)	BCS1L	0.10	-0.01	enet	7	0.00	3.1e-01	-7.24	7.4	1.8e-13	-0.04	0.06	0.40	FALSE
21	GTEx	Liver	PLCD4	0.24	0.15	lasso	2	0.15	4.5e-05	-7.33	-7.3	2.3e-13	0.03	0.06	0.90	FALSE
35	METSIM	Adipose	CYP27A1	0.06	0.04	lasso	7	0.04	1.1e-06	-7.07	-7.3	2.3e-13	0.03	0.27	0.73	FALSE
64	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	USP37	0.08	0.02	blup	72	0.01	2.2e-01	-7.15	-7.3	2.4e-13	0.02	0.03	0.50	FALSE
45	YFS	Blood	RQCD1	0.03	0.07	lasso	4	0.07	9.5e-21	-7.17	7.3	2.5e-13	-0.01	0.11	0.89	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TTLL4	0.02	0.01	blup	57	0.01	1.4e-02	-7.09	-7.3	2.6e-13	0.03	0.02	0.77	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TTLL4	0.03	0.04	enet	5	0.04	2.9e-03	-7.29	-7.3	2.8e-13	0.04	0.02	0.76	FALSE
22	GTEx	Nerve Tibial	TTLL4	0.15	0.13	enet	19	0.17	4.0e-12	7.04	7.3	3.3e-13	-0.04	0.19	0.81	FALSE
9	GTEx	Brain Cerebellum	USP37	0.13	0.16	lasso	1	0.15	4.2e-05	-7.26	7.3	3.8e-13	-0.01	0.09	0.81	FALSE
3	GTEx	Artery Aorta	PLCD4	0.14	0.18	lasso	4	0.18	2.1e-10	-7.19	7.2	5.7e-13	-0.01	0.10	0.90	FALSE
38	NTR	Blood	RQCD1	0.02	0.04	lasso	5	0.03	1.9e-11	-7.26	7.2	5.9e-13	-0.01	0.09	0.91	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	TTLL4	0.07	0.10	blup	57	0.09	4.9e-07	-7.08	-7.2	6.1e-13	0.00	0.04	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PLCD4	0.06	0.09	blup	382	0.09	1.3e-10	-7.26	7.2	6.4e-13	0.00	0.09	0.91	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	USP37	0.05	0.03	blup	72	0.04	3.4e-05	-7.20	-7.2	6.4e-13	0.02	0.05	0.94	FALSE
18	GTEx	Esophagus Mucosa	TTLL4	0.08	0.08	enet	15	0.08	4.3e-06	6.78	-7.2	6.8e-13	0.03	0.31	0.69	FALSE
7	GTEx	Brain Cerebellar Hemisphere	PLCD4	0.12	0.15	lasso	2	0.07	8.9e-03	-7.17	7.2	7.8e-13	-0.01	0.08	0.63	FALSE
44	YFS	Blood	CYP27A1	0.32	0.52	lasso	16	0.53	2.9e-210	-7.00	-7.2	8.2e-13	0.04	0.25	0.75	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	RQCD1	0.04	0.06	enet	31	0.07	3.1e-09	-7.24	-7.2	8.3e-13	0.03	0.07	0.93	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	TTLL4	0.16	0.09	enet	13	0.08	1.6e-03	-7.07	-7.1	1.2e-12	0.03	0.14	0.75	FALSE
30	GTEx	Thyroid	CYP27A1	0.07	0.05	enet	23	0.04	4.8e-04	-7.03	-7.1	1.3e-12	0.06	0.16	0.82	FALSE
29	GTEx	Thyroid	USP37	0.09	0.08	lasso	8	0.06	1.8e-05	-7.26	-7.0	1.8e-12	-0.01	0.10	0.90	FALSE
46	YFS	Blood	TTLL4	0.02	0.02	lasso	10	0.01	6.9e-05	-7.02	-7.0	2.2e-12	0.04	0.20	0.80	FALSE
23	GTEx	Nerve Tibial	USP37	0.06	0.06	lasso	4	0.05	1.1e-04	-6.78	-7.0	2.3e-12	-0.01	0.17	0.63	FALSE
6	GTEx	Artery Tibial	PLCD4	0.07	0.02	lasso	2	0.03	9.9e-04	-7.11	7.0	2.4e-12	0.01	0.11	0.86	FALSE
40	NTR	Blood	USP37	0.01	0.01	blup	407	0.01	1.7e-03	-7.12	-7.0	2.8e-12	0.05	0.07	0.77	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VIL1	0.02	0.01	blup	50	0.01	8.6e-03	-7.06	7.0	3.7e-12	-0.04	0.02	0.65	FALSE
10	GTEx	Breast Mammary Tissue	BCS1L	0.05	0.03	enet	7	0.03	6.8e-03	6.78	6.9	3.9e-12	-0.07	0.09	0.74	FALSE
19	GTEx	Esophagus Mucosa	USP37	0.10	0.07	enet	42	0.06	5.6e-05	-7.17	-6.9	4.9e-12	-0.02	0.10	0.89	FALSE
28	GTEx	Thyroid	PLCD4	0.08	0.10	lasso	2	0.10	3.5e-08	-7.26	-6.9	6.5e-12	0.03	0.05	0.95	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	VIL1	0.06	0.06	blup	50	0.05	6.3e-04	-6.91	6.9	6.6e-12	-0.04	0.02	0.69	FALSE
17	GTEx	Colon Transverse	CYP27A1	0.16	0.12	lasso	6	0.14	2.3e-07	-6.31	-6.8	8.5e-12	0.01	0.37	0.61	FALSE
14	GTEx	Breast Mammary Tissue (Female)	BCS1L	0.06	0.03	lasso	1	-0.01	7.1e-01	6.78	6.8	1.2e-11	-0.03	0.04	0.16	FALSE
16	GTEx	Cells Transformed fibroblasts	USP37	0.11	0.06	enet	16	0.07	4.5e-06	-6.98	-6.7	2.9e-11	0.00	0.13	0.86	FALSE
27	GTEx	Thyroid	BCS1L	0.07	0.00	lasso	3	0.00	6.6e-01	-7.26	6.6	3.1e-11	-0.04	0.07	0.57	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	PLCD4	0.05	0.04	blup	363	0.06	4.6e-08	-7.17	6.6	3.9e-11	0.01	0.10	0.90	FALSE
2	GTEx	Adipose Subcutaneous	USP37	0.05	0.03	lasso	6	0.03	2.0e-03	-5.16	-6.6	5.3e-11	0.03	0.12	0.88	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TTLL4	0.04	0.04	blup	58	0.03	1.3e-04	-7.30	-6.5	5.6e-11	0.07	0.02	0.98	FALSE
56	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CYP27A1	0.07	0.10	lasso	2	0.09	7.3e-05	-6.31	6.5	6.3e-11	-0.02	0.02	0.94	FALSE
4	GTEx	Artery Aorta	USP37	0.08	0.05	lasso	4	0.04	1.7e-03	-6.67	-6.5	8.7e-11	-0.02	0.09	0.48	FALSE
13	GTEx	Breast Mammary Tissue (Male)	USP37	0.08	-0.01	enet	5	0.00	4.3e-01	6.88	-6.4	1.3e-10	-0.01	0.04	0.14	FALSE
33	GTEx	Whole Blood	RP11-459I19.1	0.06	0.00	enet	36	0.02	1.3e-02	-7.04	-6.4	1.7e-10	0.02	0.12	0.75	FALSE
39	NTR	Blood	TTLL4	0.01	0.01	bslmm	385	0.01	7.0e-03	-7.03	-6.4	1.8e-10	0.05	0.14	0.51	FALSE
11	GTEx	Breast Mammary Tissue	USP37	0.20	0.02	lasso	5	0.01	1.1e-01	-7.17	-6.3	3.9e-10	0.02	0.06	0.16	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF142	0.09	0.03	blup	46	0.03	7.6e-04	-7.26	-6.1	1.2e-09	0.06	0.02	0.92	FALSE
47	YFS	Blood	ZNF142	0.10	0.12	lasso	8	0.16	1.1e-51	-7.23	-5.8	6.9e-09	0.07	0.06	0.94	FALSE
57	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC11A1	0.06	0.01	blup	51	0.04	2.2e-05	-5.16	-5.5	4.4e-08	0.03	0.03	0.94	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	CYP27A1	0.04	0.04	enet	10	0.03	3.8e-04	-7.04	-5.3	1.1e-07	0.09	0.02	0.97	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC11A1	0.03	0.01	blup	51	0.02	1.1e-03	-2.46	-5.3	1.2e-07	0.03	0.04	0.52	FALSE
24	GTEx	Pancreas	USP37	0.10	0.01	lasso	6	0.01	1.8e-01	-7.15	-5.3	1.3e-07	-0.03	0.08	0.51	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	ZNF142	0.03	0.01	enet	8	0.01	7.3e-03	-7.21	-5.3	1.3e-07	0.07	0.07	0.86	FALSE
36	METSIM	Adipose	USP37	0.04	0.02	blup	405	0.02	1.5e-04	-7.14	-5.2	1.7e-07	-0.06	0.12	0.88	FALSE
34	METSIM	Adipose	CTDSP1	0.07	0.05	lasso	5	0.06	9.9e-09	-4.91	5.2	2.1e-07	-0.06	0.23	0.77	FALSE
5	GTEx	Artery Coronary	PLCD4	0.13	0.02	lasso	5	0.02	8.5e-02	-7.15	5.2	2.2e-07	0.05	0.09	0.50	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	USP37	0.11	0.01	enet	13	0.07	1.9e-04	0.23	-5.2	2.3e-07	0.08	0.12	0.69	FALSE