Best TWAS P=5.18e-10 · Best GWAS P=5.27e-16 conditioned to 1.87e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | XPC | 0.11 | 0.04 | lasso | 6 | 0.04 | 3.2e-04 | 5.3 | -5.1 | 3.0e-07 | 0.00 | 0.02 | 0.94 | FALSE |
| 2 | GTEx | Esophagus Muscularis | CHCHD4 | 0.10 | 0.08 | lasso | 3 | 0.07 | 4.1e-05 | 5.3 | 5.6 | 2.4e-08 | 0.02 | 0.06 | 0.92 | FALSE |
| 3 | GTEx | Heart Left Ventricle | CHCHD4 | 0.14 | 0.11 | enet | 16 | 0.11 | 1.5e-06 | 5.3 | 6.2 | 5.2e-10 | 0.03 | 0.03 | 0.96 | TRUE |
| 4 | GTEx | Muscle Skeletal | CHCHD4 | 0.10 | 0.11 | lasso | 2 | 0.10 | 6.6e-10 | 5.3 | 5.3 | 1.2e-07 | -0.01 | 0.10 | 0.90 | FALSE |
| 5 | NTR | Blood | XPC | 0.03 | 0.02 | bslmm | 575 | 0.01 | 3.0e-05 | -4.2 | -5.2 | 1.5e-07 | 0.00 | 0.19 | 0.80 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | CHCHD4 | 0.12 | 0.11 | lasso | 8 | 0.10 | 2.2e-12 | 5.3 | 5.4 | 6.9e-08 | -0.02 | 0.08 | 0.92 | FALSE |
| 7 | YFS | Blood | XPC | 0.04 | 0.01 | lasso | 5 | 0.02 | 3.2e-07 | -5.6 | 5.2 | 1.5e-07 | -0.03 | 0.03 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FBLN2 | 0.05 | 0.01 | enet | 12 | 0.02 | 7.3e-04 | 8.0 | 5.6 | 2.0e-08 | 0.85 | 0.01 | 0.97 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | CHCHD4 | 0.04 | 0.00 | blup | 43 | 0.01 | 1.6e-02 | -2.9 | 5.6 | 1.8e-08 | 0.01 | 0.02 | 0.59 | FALSE |