Hub : Genes

XPC

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1100	0.0390	1.1e-03	0.042	NA	0.040	NA	0.044	4.2e-04	NA	5.8e-04	NA	3.2e-04
2	GTEx	Muscle Skeletal	0.0663	0.0257	2.8e-03	0.069	NA	0.057	NA	0.054	2.4e-07	NA	3.0e-06	NA	5.3e-06
3	GTEx	Thyroid	0.1700	0.0490	2.7e-04	0.093	NA	0.037	NA	0.059	1.4e-07	NA	7.1e-04	NA	2.6e-05
4	NTR	Blood	0.0268	0.0093	1.8e-04	0.019	0.012	0.012	0.013	0.012	7.3e-07	6.6e-05	8.7e-05	3.0e-05	6.2e-05
5	ROSMAP	Brain Pre-frontal Cortex	0.1020	0.0335	7.9e-05	0.042	0.020	0.047	0.048	0.052	3.7e-06	1.2e-03	9.9e-07	7.8e-07	2.8e-07
6	YFS	Blood	0.0364	0.0120	1.2e-04	0.010	0.014	0.016	0.019	0.020	2.6e-04	2.0e-05	2.9e-06	6.1e-07	3.1e-07
7	TCGA	Colon Adenocarcinoma	0.1480	0.0610	4.5e-05	0.066	0.079	0.052	NA	0.049	1.2e-04	2.6e-05	5.5e-04	NA	8.3e-04
8	TCGA	Esophageal Carcinoma	0.2000	0.0860	2.7e-03	0.072	0.023	0.061	NA	0.063	2.7e-03	6.2e-02	5.5e-03	NA	4.6e-03
9	TCGA	Lung Squamous Cell Carcinoma	0.0735	0.0360	8.9e-04	-0.001	0.022	0.019	NA	0.011	5.0e-01	1.4e-03	2.9e-03	NA	1.9e-02
10	TCGA	Stomach Adenocarcinoma	0.0650	0.0360	4.0e-03	0.005	0.017	0.009	NA	0.014	1.3e-01	2.0e-02	6.5e-02	NA	3.1e-02
11	TCGA	Testicular Germ Cell Tumors	0.2180	0.0810	1.4e-04	0.083	0.145	0.160	NA	0.166	7.2e-04	8.0e-06	2.7e-06	NA	1.7e-06
12	TCGA	Thyroid Carcinoma	0.0480	0.0250	7.2e-03	0.000	0.010	0.008	NA	-0.001	3.5e-01	3.1e-02	4.6e-02	NA	3.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.3	2.1	6.1	-1.2	-1.7	-0.5	-0.5	-0.5	1.2	-1.8	-0.6	-1.9	-2.0	-1.1	-2.5
Bipolar Disorder or Schizophrenia	0.3	0.7	2.0	-0.2	-1.0	-0.7	0.2	0.3	0.6	-0.9	-0.0	-1.4	-1.3	-0.8	-1.2
Depressed Affect (Nagel 2018)	1.6	3.5	10.3	0.8	2.2	1.0	-0.8	-0.2	0.3	1.2	2.4	2.7	1.9	2.4	3.2
Depression (Nagel 2018)	0.4	0.6	2.9	-0.1	1.7	0.1	-0.6	0.5	0.6	0.1	1.0	0.7	0.3	0.6	1.2
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	-0.2	-0.4	0.8	0.1	0.6	-0.4	-0.1	-0.1	-0.6	-0.5	-0.7	-0.5
Neuroticism (Nagel 2018)	1.2	2.7	6.7	1.1	1.2	0.5	-0.4	-0.9	-0.0	1.2	2.0	2.6	1.9	2.5	2.6
Schizophrenia (2018)	0.1	0.2	0.6	0.7	0.2	-0.5	0.7	0.8	-0.2	0.2	0.5	-0.2	-0.1	-0.1	0.4
Schizophrenia vs Biploar Disorder	1.2	1.6	4.9	1.7	1.6	0.0	0.9	0.9	-0.5	1.4	0.5	1.4	1.5	0.8	2.2
Worry (Nagel 2018)	0.9	2.0	6.1	0.7	0.3	-0.1	-0.5	-1.8	-0.3	0.9	1.7	2.2	1.7	2.5	1.4
Alzheimer’s Disease (in mother)	0.2	0.2	1.0	0.3	-0.4	-0.1	0.4	0.5	-0.4	-0.0	-0.4	-0.7	-0.1	1.0	-0.6
Alzheimer’s Disease (in father)	1.0	1.0	4.2	1.1	0.5	2.0	-0.6	0.4	-1.1	0.4	1.6	1.0	0.9	0.8	0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	4.5	0.5	0.5	2.1	-0.2	0.7	-0.4	0.2	0.7	0.6	0.4	1.4	0.3
Crohns Disease (2017)	0.3	0.7	2.2	-1.0	-1.0	-1.5	0.4	-1.4	0.4	-0.7	0.2	-0.6	-0.3	0.5	-0.3
Irritable Bowel Disease (IBD)	0.8	2.0	5.2	-1.4	-2.3	-2.1	-0.7	-1.9	0.6	-1.2	0.3	-1.4	-1.2	-0.8	-1.5
Ulcerative Colitis (UC)	1.0	1.9	4.4	-1.0	-2.1	-1.6	-1.6	-1.3	0.5	-1.2	0.3	-1.2	-1.4	-1.4	-1.8
Major Depression (MDD)	0.6	0.8	1.8	0.7	-0.1	-1.3	0.7	-0.3	-0.6	1.0	1.0	0.6	1.1	0.7	1.3
Reaction Time	1.3	2.5	7.8	0.7	0.1	-0.8	0.9	-0.4	0.9	2.7	1.0	2.8	1.2	1.3	2.7
Verbal and Numeric Reasoning (VNR)	1.3	3.2	7.5	-2.0	-2.4	0.2	-1.4	-0.4	1.3	-1.6	-0.6	-1.6	-2.5	-2.7	-2.2
Breast Cancer	0.4	0.9	3.8	0.9	-0.0	-0.3	0.5	2.0	-0.9	0.1	-1.6	-1.5	0.1	-0.6	-0.4
Ovarian Cancer	0.9	1.1	7.0	-0.3	0.5	2.6	-1.1	-0.2	1.2	-0.3	0.4	1.7	-0.1	-0.1	0.7
Prostate Cancer	0.2	0.3	0.7	0.6	0.8	0.1	0.7	0.9	-0.4	-0.0	-0.6	0.1	0.1	0.7	0.1
Age at First Birth	0.5	0.8	2.8	0.6	0.3	0.7	-1.1	0.0	1.0	0.9	1.2	1.7	0.1	0.3	1.0
Bipolar Disorder (2011)	0.5	0.5	2.6	-0.2	-0.5	-1.0	0.3	-0.3	-0.1	-1.6	1.2	-0.2	0.2	0.5	-0.2
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	0.9	0.6	-0.4	0.7	0.3	-0.8	1.1	0.3	0.8	1.1	1.1	1.2
Coronary Artery Disease (CAD)	0.5	0.5	3.1	0.2	-0.1	-0.1	0.7	1.8	0.7	-0.2	-0.7	-0.6	-0.9	-0.9	-0.2
Crohns Disease (2012)	0.3	0.4	1.6	-0.4	-0.9	-1.0	1.3	0.4	0.3	-0.6	-0.6	-0.7	-0.6	0.3	-0.3
Mean Putamen Volume	0.7	0.8	3.1	0.5	0.5	-0.6	-1.8	-0.2	1.3	0.5	1.0	1.3	-0.0	-0.3	1.2
Fasting Glucose	0.4	0.5	1.1	-0.5	-1.1	-0.2	-0.1	-1.0	0.4	-0.5	-0.5	-1.0	-0.5	0.2	-1.0
HbA1C	0.8	0.9	2.1	0.2	-1.4	-1.1	1.2	0.1	0.2	-0.1	-1.5	-0.7	-1.0	-1.0	-1.1
HDL Cholesterol	0.3	0.4	1.6	0.2	-0.8	-1.3	1.0	0.2	-0.3	-0.2	0.1	-1.1	-0.2	0.0	-0.8
LDL Cholesterol	0.5	0.8	2.8	-0.3	-0.3	-0.6	0.4	-1.2	-0.1	0.9	0.7	1.1	1.2	1.7	1.2
Lupus	0.7	1.1	3.8	-1.0	-1.1	0.1	-0.3	-0.3	1.3	-0.9	-1.9	-0.3	-1.3	0.0	-1.5
Neuroticism (2016)	1.3	1.9	5.7	1.9	-0.3	-2.2	2.4	0.4	-0.2	1.8	-1.1	0.3	0.8	1.6	0.7
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.8	0.3	-0.6	0.2	-0.6	-0.2	0.6	-0.5	0.7	0.4	0.7	0.6
Rheumatoid Arthritis	0.8	1.1	4.6	0.5	-2.1	-0.5	0.8	0.1	-0.1	0.4	-1.9	-0.8	-0.7	-0.3	-1.6
Schizophrenia (2014)	0.2	0.4	1.3	1.0	0.7	-0.0	0.7	0.9	-0.2	-0.1	1.1	-0.2	0.1	-0.2	0.9
Triglycerides	0.6	0.9	2.6	0.9	-0.3	0.7	0.9	0.3	-1.6	1.2	-0.1	0.9	1.3	1.5	0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.1	-0.7	-0.1	0.4	-0.2	-0.3	1.0	-0.6	-0.0	0.3	-0.7	0.6	-0.1
Ulcerative Colitis	0.8	1.1	4.0	-0.2	-2.0	-1.8	-0.0	-1.2	-0.5	-0.6	0.3	-1.2	-0.5	-0.4	-1.5
Blood Eosinophil Count	0.2	1.4	4.3	-0.7	-0.3	1.8	-2.1	0.3	0.3	-0.4	-0.2	-0.1	-1.6	-2.1	-1.4
Blood Platelet Count	0.2	2.7	8.2	2.0	-0.8	-0.4	2.9	2.5	-2.7	0.5	-0.4	-2.1	0.7	0.1	-0.7
Blood Red Count	0.6	6.0	25.4	-3.2	-4.5	-2.2	-1.0	-5.0	1.6	-0.4	0.5	0.7	-1.3	-1.4	-1.8
Blood White Count	0.1	0.8	3.8	0.1	-0.1	-0.1	0.7	1.9	0.2	0.9	-0.5	-0.9	-0.9	-1.5	-0.5
Heel T-Score	0.8	6.2	19.3	2.7	3.6	2.1	2.3	4.4	-1.9	0.4	-3.5	-1.2	0.9	2.4	-1.2
BMI	0.5	2.8	6.0	2.2	1.7	0.4	2.4	2.1	-1.1	2.1	0.3	1.0	1.7	1.3	1.9
Height	0.9	17.7	76.2	-3.7	-3.5	-3.0	-4.0	-8.7	0.0	-0.4	7.9	1.6	1.3	-3.6	2.3
Waist Hip Ratio (WHR)	0.7	3.0	9.5	-0.7	-1.1	-0.7	0.1	1.1	1.3	-1.4	-3.1	-2.1	-2.2	-2.3	-2.3
Systolic Blood Pressure	0.9	4.3	8.9	3.0	2.1	1.9	1.4	3.0	-2.3	2.1	-1.5	0.4	2.0	2.7	0.4
Smoking Status	3.1	7.5	18.5	-4.3	-0.1	1.2	-3.7	-1.0	4.3	-3.3	0.1	-0.2	-3.7	-3.1	-1.5
Allergy or Eczema	0.5	1.3	4.2	-0.4	-1.6	-0.5	-0.9	-0.2	0.4	-1.3	-1.1	-1.5	-1.4	-0.8	-2.0
Cardiovascular Disease	1.0	3.2	9.2	3.0	1.7	1.5	1.4	2.5	-1.1	2.5	-0.4	1.2	1.6	0.8	1.9
Hypothyroidism (self reported)	0.9	2.0	10.8	-0.3	1.6	3.3	-1.6	0.6	0.6	-1.2	1.5	1.7	0.1	0.6	0.9
Respiratory disease	1.2	2.6	6.2	1.9	1.2	1.3	1.1	1.0	-1.6	2.2	0.8	1.5	2.1	2.5	1.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.9	-0.2	0.3	0.0	0.5	-0.2	0.4	0.6	-0.7	-0.1	-0.2	-0.9	0.1
Lung FEV1/FVC ratio	1.8	8.9	22.3	-4.2	-3.1	-2.7	-2.9	-4.7	2.4	-3.5	-1.6	-1.0	-2.2	-2.8	-2.8
Lung FVC	0.9	4.8	13.0	2.5	1.1	-0.1	3.6	1.9	-3.6	1.2	1.9	-0.4	2.9	2.3	1.5
Neuroticism	2.0	4.7	12.9	1.5	2.6	0.5	-0.6	-0.4	0.4	1.8	2.5	3.6	2.3	2.7	3.5
Chronotype (morning person)	0.8	1.9	4.3	-1.4	-2.1	-1.1	-1.6	-1.5	-0.3	-1.2	-0.6	-1.6	-0.7	-1.1	-1.9
Hair Pigment	0.1	1.7	4.7	0.8	0.4	-1.0	0.5	-1.1	-0.5	2.2	1.0	1.8	1.7	1.5	1.6
Tanning	0.2	2.8	7.0	-0.2	-0.9	-0.8	0.2	1.0	1.5	-1.4	-2.6	-2.1	-2.4	-2.4	-1.9
Hand grip strength (left)	1.4	3.6	8.1	1.1	2.3	1.5	0.2	0.1	-1.3	1.5	2.5	2.4	2.6	1.7	2.9
Number of treatments/medications taken	0.2	0.3	1.2	1.1	-0.1	0.1	-0.4	0.3	-0.2	1.1	-0.5	0.6	0.3	0.2	0.2
Average weekly spirits intake	1.0	1.2	3.8	-1.6	-1.2	-0.9	-1.7	-2.0	0.6	-0.1	0.6	0.0	-0.8	-1.1	-0.6
Sensitivity / hurt feelings	0.8	1.4	5.0	0.1	0.8	0.6	-0.1	-0.9	0.4	1.1	1.8	2.2	1.0	0.7	1.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	-0.4	0.9	0.2	-0.1	0.8	0.5	1.0	0.7	0.5	-0.2	0.8	0.7
Hearing difficulty/problems: Yes	0.8	1.2	3.6	1.5	1.5	0.4	-0.3	1.0	0.6	0.2	1.5	1.4	0.4	0.2	1.9
Relative age of first facial hair	1.0	2.1	5.2	-1.9	-0.8	0.1	-1.9	-2.3	1.7	-2.0	1.2	0.5	-1.2	-1.5	-0.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	3.5	0.5	-0.2	-0.1	0.6	1.0	-0.4	0.6	-1.9	-0.9	-0.1	0.7	-0.6
Ever used hormone-replacement therapy (HRT)	2.8	3.5	8.2	2.1	1.3	-0.7	2.9	0.7	-0.6	2.8	-0.6	1.6	1.9	2.7	2.2
Ever had hysterectomy (womb removed)	0.5	0.5	2.2	-0.1	-0.0	-1.5	0.8	-0.2	0.6	0.6	-1.4	-0.5	-0.1	0.7	0.1
Systolic blood pressure, automated reading	0.8	2.3	6.2	2.4	1.5	0.7	1.5	2.5	-1.5	1.1	-1.3	-0.0	1.2	2.0	-0.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.7	-0.5	-0.2	-1.3	1.0	-0.2	1.1	-0.5	-0.9	-0.6	-0.8	-0.8	-0.3
Angina	0.3	0.4	1.7	-0.5	-0.2	-0.2	-0.4	-1.3	0.3	0.2	0.7	1.0	-0.0	0.1	0.6
Medication for hormone replacement therapy	0.9	1.0	2.3	0.7	-0.0	-1.0	0.3	-1.3	-0.6	1.5	0.9	1.4	1.2	1.0	1.1
Vitamin and mineral supplements	0.2	0.3	0.9	-0.1	0.9	0.9	0.0	0.6	0.7	-0.7	0.4	-0.2	-0.4	-0.3	0.7
Supplements: Zinc	0.3	0.3	0.8	-0.8	0.3	0.6	-0.4	0.3	0.9	-0.3	0.3	-0.0	-0.5	0.5	-0.6
Medication: Co-codamol	0.6	0.7	2.9	0.1	0.8	-1.7	-0.6	0.4	-0.1	-0.8	0.7	-1.3	-0.1	-1.2	-0.5
Medication: Metformin	0.3	0.4	1.3	-0.3	-0.2	-0.3	0.6	0.0	1.2	-0.2	-1.1	0.2	-0.9	-1.0	-0.3
Diabetes (father)	0.4	0.5	2.0	-0.1	-0.7	-1.4	0.9	-0.4	-0.3	-0.0	-0.1	-0.2	0.4	-1.2	0.6
Diabetes (mother)	0.1	0.1	0.4	-0.1	-0.2	-0.1	0.7	0.1	0.0	0.2	-0.6	-0.3	-0.2	0.1	-0.2
Severe depression (siblings)	0.6	0.7	3.1	0.4	0.6	0.9	0.1	0.2	0.6	1.8	-0.1	1.4	0.5	0.7	1.0
Pack years adult smoking proportion	0.1	0.2	0.6	-0.3	-0.2	-0.6	0.5	-0.1	0.6	-0.7	-0.0	0.6	-0.3	-0.2	0.8
Impedance of leg (right)	2.2	10.8	20.9	-4.5	-1.7	0.2	-4.6	-3.6	4.5	-4.2	-0.4	-0.4	-3.9	-3.6	-2.6
Leg fat-free mass (left)	0.7	3.6	12.3	1.1	0.4	-0.5	0.4	-1.1	-1.8	2.4	3.5	1.8	2.5	0.6	3.0
Trunk fat percentage	0.4	1.7	4.7	-1.7	-0.5	-1.3	-1.3	-1.9	2.2	-0.4	0.2	0.6	-1.4	-1.7	-0.6
Hand grip strength (right)	0.6	1.7	4.1	0.2	2.0	0.8	-0.6	-0.3	-0.5	0.7	1.5	2.0	1.7	1.2	1.9
Townsend deprivation index at recruitment	0.6	0.8	2.6	0.2	-0.2	-1.2	0.2	-1.6	-0.2	1.0	1.5	0.4	0.7	-0.0	1.3
Current tobacco smoking	1.6	2.6	8.6	-2.9	-0.4	0.3	-1.8	-0.6	2.1	-2.0	-0.3	-0.9	-2.4	-1.4	-1.3
Average weekly fortified wine intake	0.3	0.4	2.5	0.7	0.4	0.2	-0.2	-0.1	-0.4	0.4	-0.5	0.3	0.7	1.6	0.5
Maternal smoking around birth	0.3	0.5	1.1	-0.8	-1.0	-0.1	-0.3	-0.8	0.9	0.8	-0.2	0.7	-0.7	-0.8	-0.2
Fed-up feelings	1.0	1.9	5.7	0.6	1.1	0.6	-0.4	-0.2	0.2	0.9	2.4	2.2	1.3	1.5	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	-0.2	0.9	-0.1	-0.2	0.1	0.6	0.0	0.9	0.7	-0.1	0.2	0.7
Relative age voice broke	0.5	0.7	3.3	-0.6	-0.9	-0.6	-1.1	-1.8	0.8	-0.8	0.6	-0.2	-0.4	-0.8	0.0
Taking other prescription medications	2.8	4.4	9.0	2.8	2.1	0.9	1.5	1.4	-1.6	3.0	0.5	1.6	2.8	2.4	2.7
Age when periods started (menarche)	0.4	1.0	5.2	-0.8	-1.8	-0.4	-0.2	-2.3	-0.7	-0.0	1.5	-0.2	0.3	0.3	0.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	3.4	0.1	-1.2	-1.9	1.1	-1.4	-0.7	0.6	-0.1	0.1	0.9	0.6	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.1	0.2	1.1	0.6	-0.6	0.3	-0.5	-1.4	-1.1	-1.1	-0.0	0.7	-1.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.4	-1.1	-1.0	-1.4	-0.7	-1.3	1.8	-0.4	-0.8	0.0	-1.7	-0.8	-0.8
Qualifications: CSEs or equivalent	2.2	2.9	6.2	-2.5	-1.4	-1.3	-1.9	-1.9	2.0	-1.4	-1.7	-0.3	-2.0	-1.2	-1.9
Serious illness, injury or assault to yourself	0.7	0.9	4.0	-0.8	-0.8	-1.4	-0.6	-2.0	0.0	0.5	1.3	0.3	0.4	-0.6	0.8
High blood pressure	0.7	1.9	6.1	2.5	-0.4	-0.4	2.1	1.5	-1.4	2.0	-1.1	0.1	1.1	0.6	0.6
Hayfever, allergic rhinitis or eczema	0.6	1.2	4.2	0.0	-1.6	-0.5	-0.5	0.4	0.2	-0.5	-1.8	-1.4	-1.2	-0.6	-2.0
Multivitamins +/- minerals	0.4	0.5	1.6	0.6	-0.9	-0.8	0.1	0.3	-1.0	0.7	-0.9	-0.3	0.2	0.0	-1.3
Stomach or abdominal pain in last month	0.5	0.7	3.6	-0.4	-1.9	-1.3	0.1	-1.2	-0.3	0.1	-0.4	-0.8	-0.2	0.2	-0.6
Supplements: Glucosamine	1.1	1.4	4.2	0.9	-0.6	-0.6	2.0	1.6	-1.0	0.5	-2.0	-1.5	-0.1	0.0	-1.3
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	8.9	0.2	-1.0	-1.3	1.5	0.9	0.2	0.1	-3.0	-1.2	-1.2	-0.5	-1.7
Medication: Atenolol	0.1	0.1	0.4	0.6	-0.2	0.1	0.2	0.2	-0.1	0.1	0.5	0.4	0.0	0.7	0.1
Medication: Levothyroxine sodium	0.6	0.9	2.2	0.7	1.3	0.9	-0.6	0.5	-0.8	-0.5	1.5	0.6	1.2	1.1	1.2
Sitting height	0.7	4.6	22.1	-1.6	0.1	0.8	-3.2	-2.4	0.8	-0.2	4.7	2.1	0.3	-1.6	2.6
Chronic bronchitis/emphysema (father)	0.4	0.5	1.8	-0.2	0.2	0.9	-1.3	-0.4	1.2	-0.5	0.1	0.9	-0.4	-0.5	0.2
High blood pressure (mother)	0.7	1.0	2.6	-0.8	0.0	0.9	-1.2	0.4	1.3	-1.4	-0.5	-0.3	-1.6	-1.2	-0.6
Body mass index (BMI)	0.5	2.2	4.1	1.9	1.7	0.4	1.5	1.9	-1.0	2.0	0.2	1.2	1.5	1.4	1.6
Impedance of leg (left)	2.9	13.9	27.6	-5.1	-1.8	0.3	-5.2	-3.6	5.2	-4.7	-0.8	-0.2	-4.6	-4.0	-3.0
Leg predicted mass (left)	0.6	3.4	12.8	0.9	0.3	-0.5	0.3	-1.1	-1.7	2.3	3.6	1.8	2.4	0.5	3.0
Trunk fat mass	0.3	1.3	3.9	-1.1	-0.1	-1.0	-1.2	-2.0	1.2	0.3	1.6	1.3	-0.2	-1.2	0.7
Waist circumference	0.1	0.4	1.1	0.4	0.8	-0.3	0.3	0.8	0.2	1.0	0.6	0.5	0.3	-0.5	1.0
Number of incorrect matches in round	2.0	3.3	7.9	1.1	1.4	1.1	0.2	-0.6	-1.0	0.9	2.8	2.3	2.6	2.5	2.6
Past tobacco smoking	2.0	3.6	12.0	2.3	-0.5	-1.1	2.5	1.3	-3.5	1.7	-1.3	-0.9	2.1	2.6	-0.4
Alcohol usually taken with meals	0.2	0.3	1.4	-0.4	0.5	0.3	-0.8	-0.9	0.5	-0.2	0.4	1.2	0.2	0.2	0.4
Nervous feelings	0.2	0.4	1.8	0.0	0.1	0.5	-1.3	-0.3	0.8	0.9	0.0	0.9	-0.1	0.3	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.9	1.3	1.6	0.7	-0.2	0.9	0.1	2.0	0.2	1.8	0.8	1.6	1.6
Hearing difficulty/problems with background noise	1.4	2.2	7.7	2.8	1.6	0.4	0.2	1.8	-0.7	1.3	1.0	1.3	1.4	1.5	1.9
Hair/balding pattern: Pattern 2	0.5	0.6	2.3	1.5	1.0	0.2	0.4	1.4	-1.1	-0.2	0.0	-0.4	0.8	0.4	-0.1
Had menopause	0.3	0.3	1.8	0.2	-0.3	-0.7	1.3	1.0	-0.0	0.2	-0.6	-0.1	-0.2	-0.2	-0.1
Had other major operations	0.2	0.2	0.5	0.6	0.2	-0.6	0.3	0.3	0.5	-0.7	-0.7	-0.4	-0.5	-0.5	0.0
Forced vital capacity (FVC)	0.8	2.9	17.6	-0.0	-0.6	0.5	-0.4	-1.1	-2.0	0.8	4.2	1.2	2.1	0.6	2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.6	0.5	1.2	1.6	-0.5	0.7	-1.1	-1.6	-0.5	-0.7	0.4	1.2	-1.0
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	4.4	-0.8	0.5	0.7	-1.4	-0.5	2.1	-0.6	-0.5	1.3	-0.9	0.1	0.3
Qualifications: None of the above	0.6	1.2	7.1	-0.4	0.9	1.1	-0.5	-0.4	-0.4	0.2	2.7	1.2	0.9	0.1	1.7
Financial difficulties in last 2 years	0.5	0.6	2.0	-0.6	-1.1	-0.7	0.5	0.6	0.7	-0.1	-0.8	-0.8	-1.4	-0.9	-0.6
Mouth/teeth dental problems	0.1	0.2	0.5	-0.7	0.3	0.5	0.1	-0.2	0.4	-0.5	-0.1	-0.4	-0.6	-0.1	-0.7
Heart attack	1.5	1.9	8.4	1.4	0.2	-0.0	2.9	0.6	-1.8	2.1	-0.8	0.1	1.2	1.8	0.1
Allergy	0.4	0.9	3.2	0.9	1.1	0.3	1.8	1.1	-0.9	0.5	0.6	0.2	1.0	0.9	1.2
Pain all over the body in last month	1.8	1.9	4.4	1.7	0.5	0.8	0.6	0.4	-1.2	1.3	1.1	2.0	1.8	2.1	1.6
Diabetes (self-reported)	0.7	1.1	4.7	-0.9	0.2	0.3	-0.3	-0.5	2.2	0.2	-1.5	0.5	-1.3	-1.7	-0.1
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.4	2.1	0.8	-0.6	1.6	1.8	-1.5	1.1	-1.7	-1.3	0.8	0.7	0.2
Medication: Ramipril	0.5	0.7	1.7	1.0	-0.4	-1.3	1.2	0.1	-1.1	1.3	-1.0	-0.5	0.5	-0.1	-0.2
Medication: Simvastatin	1.7	2.5	6.8	2.4	2.2	1.3	1.0	2.6	-0.7	2.4	-0.9	1.0	0.8	0.2	1.2
Fluid intelligence score	0.9	1.9	5.7	-1.4	-2.4	-0.1	-1.4	-0.6	0.9	-0.9	-0.1	-1.0	-1.8	-2.3	-1.4
Illnesses of siblings	0.3	0.5	3.0	-0.9	-0.8	-0.2	-0.6	-1.7	0.5	0.2	-0.2	0.6	-0.3	-0.2	-0.4
Neuroticism score	1.1	2.4	8.1	0.6	1.9	1.0	-1.3	-0.5	1.1	1.1	1.8	2.8	1.0	1.7	1.9
Weight	0.4	1.7	7.8	0.2	0.4	-0.2	-0.5	-0.9	-0.6	1.4	2.8	1.6	1.4	-0.1	2.1
Impedance of arm (right)	1.7	7.9	13.2	-3.6	-3.0	-1.7	-2.1	-3.2	3.2	-2.6	-1.7	-1.6	-3.5	-3.0	-3.3
Arm fat percentage (right)	0.1	0.4	1.3	0.8	0.6	-0.5	1.0	0.6	0.1	1.2	-0.3	0.7	0.4	0.5	0.5
Trunk fat-free mass	1.0	5.9	24.1	1.3	1.0	0.6	-0.2	-0.9	-2.4	2.0	4.9	2.2	3.4	0.9	4.1
Hip circumference	0.4	1.8	6.4	0.5	0.9	-0.4	-0.4	-0.5	-0.5	1.6	2.5	1.9	1.5	0.4	2.2
Time employed in main current job	0.6	0.7	2.3	-0.7	-0.8	-0.4	-1.5	-1.4	0.7	-1.1	0.6	0.5	-0.4	-0.4	-0.1
Alcohol intake versus 10 years previously	0.2	0.4	1.1	0.4	1.0	-0.5	0.6	0.8	-0.8	0.3	0.3	-0.6	0.6	0.5	0.2
Father’s age at death	0.7	0.9	2.9	-0.3	-0.1	-0.9	-0.7	-0.2	0.7	-0.8	-1.7	-1.5	-0.9	-0.7	-1.3
Worrier / anxious feelings	1.8	3.4	9.5	0.6	1.2	1.0	-0.4	-1.5	0.2	1.6	2.6	3.1	2.1	2.7	2.3
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.9	0.6	2.1	1.0	-0.7	0.8	0.6	1.2	1.2	2.2	0.8	1.2	2.1
Falls in the last year	0.0	0.1	0.3	-0.1	-0.3	0.4	0.0	-0.2	-0.1	-0.0	0.3	0.5	-0.0	0.2	0.0
Hair/balding pattern: Pattern 3	2.1	3.2	7.0	-2.6	-1.7	-0.1	-2.2	-1.9	1.9	-1.9	0.1	-0.3	-2.0	-2.5	-1.2
Number of live births	1.1	1.6	3.1	0.6	0.4	1.8	1.5	0.4	-1.2	1.4	1.0	1.1	1.6	1.6	1.5
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	6.6	-1.5	-2.1	-0.8	-1.5	-2.6	-1.1	-0.8	2.5	0.0	0.6	-0.5	0.2
Pulse rate	1.2	2.0	10.4	-1.2	-1.8	-2.0	-0.8	-3.2	-0.1	-0.3	1.5	0.9	1.1	0.5	0.4
Happiness	0.3	0.4	1.3	0.3	0.2	-0.3	-0.5	-0.3	0.3	1.1	-0.4	1.1	0.3	1.1	0.4
Noisy workplace	0.5	0.6	1.8	-0.9	-0.1	-0.6	-1.0	-0.0	1.0	-1.4	-0.9	0.4	-1.0	-0.6	-0.6
Qualifications: A levels/AS levels or equivalent	0.8	1.7	5.3	2.3	0.4	0.1	1.5	1.2	-2.1	1.6	-0.5	-0.5	1.4	1.5	-0.2
Serious illness, injury or assault of a close relative in last 2 years	3.8	4.3	10.6	-2.1	-0.6	-0.2	-1.1	0.9	2.2	-2.6	-2.4	-2.3	-3.3	-2.5	-2.4
Mouth/teeth dental problems: Dentures	0.2	0.3	2.1	0.2	-0.2	0.2	-0.6	0.2	0.7	-0.2	-0.0	1.4	0.0	0.0	0.7
Asthma	0.3	0.6	1.5	0.7	0.5	0.2	0.1	-0.3	-0.4	1.2	0.9	1.0	1.1	0.9	1.2
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	5.4	-1.6	-0.4	0.1	-1.3	0.5	2.2	-1.4	-2.3	-0.5	-2.3	-1.2	-1.8
Medication: Cholesterol lowering	0.5	0.8	3.5	1.2	1.1	0.2	0.9	1.0	-0.1	1.9	-1.3	0.1	0.1	-0.5	0.4
Depression (self-reported)	0.3	0.4	1.2	-0.2	1.0	0.1	-0.5	-0.3	0.5	0.6	0.8	1.1	0.2	0.6	0.9
Medication: Lansoprazole	1.9	2.2	5.4	1.3	1.2	0.6	1.7	0.5	-0.6	1.4	0.7	2.1	1.9	1.9	2.3
Prospective memory result	2.4	2.9	6.8	0.3	2.0	2.6	0.9	0.2	-0.7	1.6	1.6	1.9	2.1	2.2	2.2
Lung cancer (father)	1.2	1.4	3.4	1.1	1.9	0.7	0.8	1.3	-0.2	1.5	-0.1	1.1	1.1	1.6	1.2
Illnesses of mother	0.5	0.6	1.5	0.1	-1.2	-1.2	0.4	-0.1	-0.8	1.0	-0.3	-0.7	0.4	-1.0	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	3.6	-1.4	-1.7	-0.6	-1.3	-1.5	-0.6	-1.2	1.9	-0.6	-0.0	-1.0	-0.4
Pulse wave Arterial Stiffness index	0.7	0.8	2.8	-0.6	-0.2	-0.9	-0.3	-0.0	-0.4	-1.1	1.1	-1.7	-0.5	-1.2	-1.0
Impedance of arm (left)	2.2	10.1	17.0	-4.1	-3.5	-2.2	-2.6	-3.9	3.4	-2.9	-1.9	-1.6	-3.8	-3.2	-3.8
Arm fat mass (right)	0.2	0.9	2.2	0.9	0.8	-0.1	0.6	0.2	-0.3	1.5	1.0	1.4	1.1	0.5	1.5
Trunk predicted mass	1.0	5.8	24.1	1.2	0.9	0.6	-0.2	-0.9	-2.4	1.9	4.9	2.2	3.3	0.9	4.0
Standing height	1.1	10.6	37.2	-3.6	-2.6	-1.3	-4.6	-6.1	0.9	-1.4	5.7	1.2	-0.2	-3.2	1.2
Length of working week for main job	2.5	2.8	11.8	0.9	-0.1	-1.0	0.7	-2.0	-1.2	1.2	3.4	1.8	1.8	-0.1	2.4
Exposure to tobacco smoke at home	2.1	2.4	9.1	-0.9	0.9	2.7	-1.7	-0.7	1.0	-0.4	3.0	1.4	0.1	-0.2	1.9
Breastfed as a baby	1.7	2.2	7.8	-0.4	-1.1	-2.8	1.1	-0.3	0.2	-0.0	-2.6	-2.1	-1.0	-0.3	-1.8
Tense / ‘highly strung’	0.5	0.8	2.4	1.1	0.4	-0.7	-0.0	-0.8	0.1	1.3	0.3	1.2	0.7	1.6	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	2.2	-0.1	0.5	-0.8	-0.5	-0.2	1.5	-0.4	-0.3	-0.3	-0.9	-0.6	-0.2
Hair/balding pattern: Pattern 4	0.5	1.1	2.7	0.6	0.4	1.1	-0.5	0.0	-0.7	1.2	1.6	1.3	1.1	1.6	1.1
Birth weight of first child	1.4	2.5	7.9	0.3	2.6	2.8	-1.4	0.9	1.0	0.1	1.9	2.3	0.4	0.9	1.0
Peak expiratory flow (PEF)	0.6	1.3	3.7	-0.7	-1.4	-1.9	-0.7	-1.7	-1.0	-1.0	-0.1	-1.5	0.0	-1.0	-1.0
Pulse wave reflection index	1.1	1.3	5.7	0.8	2.4	2.0	-0.6	1.5	-0.3	-0.1	1.5	0.7	0.2	0.1	0.7
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.1	0.3	0.4	0.8	-0.3	0.4	1.5	0.3	0.1	1.1	-0.7	-0.2	0.9
Loud music exposure frequency	1.8	2.0	4.5	1.5	1.5	-0.5	1.0	-0.8	-1.2	1.3	1.2	1.2	2.1	1.7	2.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.9	0.7	0.8	0.2	0.5	0.8	-0.6	0.5	-1.4	-0.4	0.1	0.7	-0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.8	0.4	0.7	1.5	-1.0	1.7	-0.0	0.8	-1.0	-0.1	-0.1	-0.0	-0.1
Blood clot in the leg (DVT)	1.2	1.5	4.4	-0.5	1.5	1.5	-2.1	-0.6	1.6	0.1	1.1	1.6	0.1	0.2	1.5
Medication: Paracetamol	0.5	0.8	2.3	-0.5	-0.9	-1.5	-1.1	-0.5	1.0	-0.7	0.1	-0.6	-1.0	-0.6	-1.0
Headache pain in last month	0.3	0.5	3.1	-0.0	-0.2	0.7	-0.8	-0.6	0.0	0.5	1.8	0.9	0.2	0.5	0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.7	-0.6	0.1	0.1	-0.6	0.5	-0.5	-1.6	1.1	-0.8	0.1	0.9	-0.6
Glaucoma (self-reported)	0.9	1.1	3.9	-1.6	-1.0	-0.5	-1.7	-2.0	0.9	-0.7	0.3	0.2	-0.7	-0.4	-0.1
Gout (self-reported)	0.7	0.9	2.7	0.7	1.0	0.6	0.8	0.2	0.1	1.7	-0.4	1.4	0.8	1.4	1.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	4.0	0.4	1.0	2.0	-1.5	0.1	-0.2	-0.9	1.8	1.2	0.6	0.2	1.1
Medication: Amlodipine	0.1	0.1	0.4	0.1	-0.4	-0.3	-0.2	0.0	-0.1	0.1	-0.4	-0.7	0.0	-0.2	0.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.7	0.2	1.2	-0.0	0.3	0.3	-0.1	1.3	0.7	0.9	0.7	0.6	1.3
Birth weight	0.8	1.7	4.4	1.8	1.2	1.0	1.4	1.5	-2.1	0.1	0.8	0.4	1.4	2.0	0.3
Chronic bronchitis/emphysema (mother)	0.8	1.0	4.3	-1.3	-1.6	-1.3	-0.2	-2.1	-0.1	-0.6	0.7	0.0	-0.2	0.2	-0.4
High blood pressure (siblings)	1.8	2.5	8.6	2.6	0.6	-0.4	2.6	2.9	-1.9	0.1	-0.6	-1.7	0.6	0.5	-0.1
Forced vital capacity (FVC), Best measure	0.4	1.3	10.3	-0.4	-0.8	-0.0	-0.2	-0.8	-1.4	-0.1	3.2	0.1	1.0	-0.2	1.0
Body fat percentage	0.2	0.7	2.5	-0.9	0.1	-0.7	-0.9	-1.0	1.6	-0.0	0.3	1.0	-0.7	-0.8	-0.0
Leg fat percentage (right)	0.3	1.1	4.0	0.4	1.7	1.1	-0.6	0.4	0.8	0.8	1.0	2.0	0.5	0.3	1.4
Arm fat-free mass (right)	0.7	3.7	16.8	0.7	1.0	0.4	-0.7	-0.9	-1.3	1.5	4.1	2.1	2.4	0.4	3.3
Exposure to tobacco smoke outside home	0.8	1.1	2.9	-1.7	1.0	1.4	-1.7	-0.3	1.2	-0.7	1.3	0.0	-0.8	-0.6	0.5
Comparative body size at age 10	0.7	1.9	7.1	1.0	2.7	0.3	1.8	2.0	-1.3	0.2	-0.1	-0.6	1.1	2.0	0.3
Number of full brothers	0.7	0.9	3.7	-0.6	0.2	-0.5	-1.1	-0.3	-0.4	-1.9	0.9	-1.6	-0.6	-0.6	-1.1
Worry too long after embarrassment	0.4	0.7	4.2	-0.3	-0.2	0.7	-0.8	-0.5	2.0	0.3	-0.1	1.4	-1.0	-0.4	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.2	0.1	-0.4	-0.6	0.9	0.2	-0.7	1.1	-0.7	-0.7	0.1	0.3	-0.2
Wheeze or whistling in the chest in last year	0.2	0.4	1.4	0.3	1.0	0.5	-0.7	0.3	-0.1	0.2	0.4	1.2	0.5	0.4	0.5
Number of children fathered	0.3	0.3	1.0	-0.9	0.6	-0.0	-0.4	-0.7	-0.2	-0.2	1.0	0.2	0.3	-0.7	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.4	-0.4	0.4	1.2	-1.0	0.3	0.6	0.2	0.1	0.4	-0.2	-0.1	-0.1
Age at first live birth	0.2	0.3	2.1	0.1	0.1	0.6	-0.2	0.3	-0.3	-0.7	1.4	-0.2	0.3	0.1	0.5
Pulse wave peak to peak time	0.5	0.6	2.7	0.2	-0.2	0.8	-0.2	-0.5	0.5	0.9	-0.7	1.6	0.5	1.0	1.0
Health satisfaction	0.4	0.5	1.6	-0.1	-0.1	0.5	-1.2	-0.1	1.1	0.5	-0.9	1.0	-0.6	0.3	-0.5
Shortness of breath walking on level ground	0.6	0.8	2.5	0.1	0.3	-1.0	0.1	-1.6	-0.5	0.2	1.5	0.8	1.0	0.9	0.6
Qualifications: College or University degree	1.0	3.3	10.5	3.2	0.8	0.6	2.4	2.1	-2.3	2.3	-0.3	-0.5	1.8	1.6	0.4
Eye problems/disorders: None of the above	1.0	1.1	2.5	1.0	1.1	1.0	1.1	1.0	-1.6	1.6	-0.2	-0.0	1.1	1.3	0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.3	0.3	0.4	-0.5	0.7	0.0	-0.2	0.4	0.1	0.5	0.5	1.1	0.7
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.5	0.3	-0.1	0.4	-0.4	-0.7	0.1	0.7	0.1	0.6	0.6	0.0
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	0.1	0.6	1.0	0.3	0.6	0.2	-0.3	0.3	0.6	0.1	1.0	0.2
Neck or shoulder pain in last month	0.8	1.2	3.6	-0.9	0.0	1.9	-1.5	0.4	1.1	-1.5	-0.0	0.1	-1.4	-1.3	-0.5
Medication: Blood pressure	0.3	0.4	1.6	1.0	-0.4	-0.7	0.6	-0.2	-0.1	1.3	-0.9	-0.1	0.1	-0.9	0.3
Angina (self-reported)	0.3	0.4	1.7	-0.5	-0.1	-0.2	-0.5	-1.3	0.5	0.2	0.7	1.1	-0.1	-0.0	0.8
Migraine (self-reported)	0.5	0.6	1.8	-1.2	0.5	0.4	-1.4	-0.0	1.1	-1.2	0.3	-0.3	-0.7	-0.3	0.1
Medication: Ibuprofen	1.1	1.3	2.9	-1.5	0.2	1.2	-1.5	0.7	1.7	-1.1	-1.1	0.0	-1.6	-0.7	-0.8
Medication: Allopurinol	2.0	2.7	6.4	1.4	2.4	1.0	0.2	0.6	-0.1	2.5	0.3	2.3	1.7	1.6	2.4
Medication: Omeprazole	0.8	0.9	2.2	0.9	-0.4	-1.3	1.3	-0.1	-1.5	0.8	1.4	-0.6	1.1	-0.3	0.5
Medication: Seretide 50 evohaler	1.6	1.9	3.7	1.0	0.4	-0.5	-0.5	-1.8	-0.8	1.4	1.9	1.7	1.9	1.3	1.9
Mean time to correctly identify matches	1.4	2.6	8.8	0.7	0.5	-0.6	0.8	-0.9	0.8	2.3	1.4	3.0	1.6	1.6	2.7
Heart disease (mother)	1.3	1.6	6.4	0.5	2.5	0.9	-0.1	0.4	0.5	1.1	0.3	1.8	0.7	1.7	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	-1.2	-0.7	0.5	-1.1	-1.1	0.6	0.0	-0.2	0.1	-0.7	-0.1	-0.5
Whole body fat mass	0.2	0.8	2.1	-0.6	0.2	-0.6	-0.8	-1.3	1.0	0.5	1.3	1.4	0.0	-0.7	0.9
Leg fat mass (right)	0.3	1.2	4.0	0.3	1.2	0.2	-0.6	-0.5	0.4	1.1	1.7	2.0	0.9	0.1	1.8
Arm predicted mass (right)	0.8	4.1	18.9	0.7	1.1	0.5	-0.7	-0.9	-1.2	1.3	4.3	2.3	2.4	0.5	3.5
Pulse rate, automated reading	0.7	2.2	8.5	-0.7	-0.8	-0.9	0.1	-2.9	-0.2	0.1	1.9	1.7	1.6	2.4	1.1
Alcohol intake frequency.	0.3	0.6	1.3	0.4	0.8	0.3	0.4	0.2	-0.6	0.8	0.3	1.1	1.1	1.1	1.1
Comparative height size at age 10	0.7	4.1	19.1	-2.4	-1.9	-0.8	-2.5	-2.7	0.1	-0.7	4.4	0.5	-0.0	-2.4	1.0
Number of full sisters	1.7	2.1	6.0	0.4	-0.2	-2.0	1.7	1.1	-0.7	-0.9	-2.3	-2.5	-0.9	0.0	-1.9
Suffer from ‘nerves’	1.3	2.0	7.5	1.4	1.7	0.9	-0.4	-0.5	0.3	1.5	0.9	2.7	1.3	1.9	1.5
Overall health rating	0.6	1.2	4.6	1.4	0.5	-0.4	0.6	0.6	-0.7	2.1	0.8	1.1	1.1	1.1	1.4
Chest pain or discomfort	0.3	0.5	1.2	1.0	0.8	0.1	0.3	0.7	-0.0	1.0	0.0	1.1	0.6	0.0	1.1
Had major operations	2.0	2.3	6.6	-2.4	-2.6	-1.0	-1.0	-2.3	1.4	-0.8	0.4	-0.7	-1.5	-1.3	-1.2
Age at last live birth	0.5	0.8	2.4	1.6	0.0	0.7	1.2	0.9	-1.1	-0.2	0.9	-0.8	0.7	0.6	0.7
Family relationship satisfaction	1.2	1.4	3.4	-1.0	0.8	0.7	-1.5	0.1	1.7	-1.0	-1.8	0.1	-1.7	-0.8	-1.3
Leg pain on walking	0.8	1.0	2.9	0.3	0.9	-0.1	-1.0	-0.9	0.0	1.2	1.7	1.6	0.9	-0.4	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.9	5.8	-1.0	-1.8	-1.9	-0.7	-0.5	-0.1	-1.5	-0.8	-1.8	-1.1	-0.8	-2.4
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.7	1.4	1.1	1.0	-0.2	0.6	-1.3	1.1	1.2	1.5	1.7	1.0	1.4
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	6.0	1.4	1.8	1.1	0.5	-0.3	-1.5	1.0	1.4	1.6	2.4	2.5	1.8
Medication: Aspirin	1.0	1.4	4.2	1.6	0.9	0.2	1.8	0.9	-0.9	2.1	-0.4	0.5	1.2	-0.5	1.4
Supplements: Vitamin C	0.6	0.7	2.2	0.8	0.8	0.5	0.3	-0.1	-0.7	0.1	0.4	0.7	1.5	1.4	1.2
Knee pain experienced in last month	0.8	1.3	2.7	1.6	0.3	0.6	0.3	1.3	-1.6	1.6	1.0	0.5	1.4	1.0	1.3
Hypertension (Self-reported)	0.4	1.2	3.4	1.9	-0.7	-0.4	1.8	1.0	-1.1	1.6	-1.2	0.0	0.9	0.4	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	9.2	2.1	0.5	-0.1	3.0	0.9	-1.2	1.3	-0.8	0.0	1.4	1.0	0.7
Illnesses of father: Heart disease	1.2	1.7	4.1	1.1	1.8	0.3	-0.0	-0.2	-0.9	1.6	0.8	1.8	1.9	1.0	2.0
Illnesses of siblings: Diabetes	0.8	1.0	2.7	1.3	-0.6	-0.8	1.6	1.2	-1.6	0.6	-0.8	-0.9	0.9	0.7	0.1
Smoking status: Previous	1.4	2.1	5.6	-1.1	1.1	1.3	-2.1	-0.3	2.4	-1.3	1.6	1.2	-1.1	-2.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	7.6	-2.2	-1.5	-0.0	-2.1	-2.8	1.0	-0.6	1.8	0.6	-0.6	-1.4	-0.1
Whole body fat-free mass	0.9	4.9	19.6	1.1	0.8	0.1	0.0	-0.9	-2.1	2.1	4.4	2.1	3.0	0.7	3.7
Leg fat-free mass (right)	0.6	3.2	11.5	0.9	0.4	-0.4	0.2	-0.8	-1.6	2.3	3.4	1.8	2.3	0.6	2.9
Arm fat percentage (left)	0.1	0.3	1.1	0.6	0.5	-0.5	0.8	0.4	0.0	1.0	-0.3	0.6	0.3	0.3	0.2
Average weekly red wine intake	0.3	0.4	1.1	-0.6	-0.1	1.1	-0.5	0.4	0.6	-0.2	-0.4	-0.1	-0.8	-0.9	-0.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.7	0.9	0.1	0.1	1.1	0.9	-0.0	0.3	-1.2	-1.3	-0.4	-0.5	-0.6
Mood swings	1.7	3.0	8.7	-1.0	1.4	0.9	-3.0	-1.5	2.6	-0.1	1.9	2.7	0.1	0.3	1.9
Loneliness, isolation	0.5	0.8	2.1	0.6	1.4	0.6	-0.5	1.0	-0.8	0.2	0.6	0.3	1.0	1.2	1.1
Long-standing illness, disability or infirmity	0.6	0.9	3.4	0.2	-0.6	0.2	-0.1	-0.3	0.0	1.5	1.2	1.8	0.7	0.7	1.4
Ever had bowel cancer screening	1.9	2.2	6.3	1.7	1.0	0.9	2.5	1.4	-0.3	2.3	0.3	1.2	1.0	1.9	1.4
Diabetes diagnosed by doctor	0.2	0.4	1.2	-0.5	-0.0	-0.7	0.7	-0.5	0.8	0.4	-1.1	-0.0	-0.5	-1.0	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.4	0.1	-0.4	0.1	-0.1	1.2	0.4	-0.4	-0.9	-1.0	-1.0	-1.1	-0.4
Friendships satisfaction	0.8	1.0	3.9	-1.6	-0.4	-0.4	-1.2	-2.0	1.4	-0.6	-0.0	0.4	-0.9	-0.5	-0.4
Qualifications: nursing, teaching	0.6	0.9	3.4	0.9	0.2	-0.0	0.3	-0.6	-0.8	1.9	0.4	0.9	1.4	1.2	1.0
Commuting to job workplace: Walk	1.1	1.2	4.2	-0.2	-0.4	1.3	0.3	1.7	0.1	-1.5	-0.6	-2.0	-1.0	-0.5	-1.1
Eye problems/disorders: Cataract	0.3	0.4	1.2	-0.6	0.0	-0.1	-1.0	-0.2	1.1	-1.0	0.0	0.4	-0.7	-0.4	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	5.9	0.1	0.4	0.7	-0.3	-1.2	0.2	0.0	2.4	2.0	1.1	0.7	2.0
Medication for cholesterol	2.3	3.5	6.8	-2.5	-0.8	-0.1	-2.1	-1.2	2.0	-2.5	-0.3	-1.6	-2.6	-2.2	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	5.0	-1.0	0.1	1.0	0.2	-1.3	-0.5	-0.1	2.2	-0.1	0.3	-0.3	1.1
Back pain experienced in last month	0.5	0.7	2.5	-0.6	-0.0	-0.3	-1.6	-0.4	0.8	-0.4	1.4	0.0	-0.6	-1.5	0.0
Mineral and other dietary supplements	0.5	0.7	1.8	-1.4	0.5	0.5	-0.8	-1.0	1.0	-0.8	0.9	1.2	-0.5	0.2	0.7
Breast cancer (self-reported)	0.6	0.7	2.2	-0.4	0.1	-1.3	-0.2	-0.1	1.3	0.0	-1.5	-0.0	-1.1	-0.4	-1.1
Asthma (self-reported)	0.4	0.9	2.2	1.0	0.5	0.3	0.3	-0.0	-0.6	1.5	0.7	1.0	1.3	1.1	1.2
Osteoporosis (self-reported)	1.1	1.4	5.1	-1.6	0.5	1.3	-2.3	-0.7	1.9	-0.7	0.4	1.3	-1.0	0.1	-0.0
Osteoarthritis (self-reported)	0.4	0.5	1.3	1.1	0.4	-0.2	0.6	0.0	-0.4	0.3	0.7	0.7	0.9	0.6	1.1
Medication: Aspirin	1.2	1.6	5.5	1.7	1.0	0.5	1.7	1.0	-0.7	2.3	-0.1	0.7	1.2	-0.5	1.8
Medication: Gliclazide	0.2	0.2	1.0	-0.2	0.6	-0.2	0.2	0.3	1.0	-0.4	-0.3	0.0	-0.4	-0.6	0.3
Illnesses of father: None of the above (group 1)	1.2	1.5	3.8	-2.0	-1.5	-0.3	-1.1	-0.9	1.5	-1.4	0.0	-0.5	-1.7	-0.7	-1.2
Smoking status: Current	1.9	3.0	10.3	-3.2	-0.6	0.1	-1.8	-0.9	2.3	-2.0	-0.4	-0.9	-2.5	-1.4	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	7.0	0.2	-1.4	-0.3	1.4	0.6	-2.6	0.1	0.5	-1.4	1.2	1.3	-0.8
Whole body water mass	0.8	4.8	19.2	1.2	0.8	0.1	0.1	-0.9	-2.1	2.0	4.4	2.0	3.0	0.7	3.6
Leg predicted mass (right)	0.6	3.1	11.8	0.8	0.4	-0.3	0.1	-0.8	-1.7	2.2	3.4	1.7	2.3	0.5	2.9
Arm fat mass (left)	0.1	0.6	1.7	0.5	0.6	-0.2	0.2	-0.2	-0.0	1.2	1.0	1.3	0.8	0.2	1.2
Number of self-reported non-cancer illnesses	0.3	0.5	2.6	0.9	0.4	0.1	0.4	0.4	-0.1	1.6	-0.2	0.6	0.6	0.9	1.0
Average weekly champagne plus white wine intake	0.7	1.0	4.6	-0.8	-0.6	-0.7	-1.4	-2.1	1.4	0.1	-0.1	1.2	0.2	-0.1	0.5
Miserableness	1.2	2.1	5.3	-0.3	1.3	1.1	-2.3	-0.9	1.4	0.8	2.1	2.1	0.4	0.9	2.0
Guilty feelings	0.7	1.1	2.8	1.3	1.7	1.3	1.0	1.4	-1.1	0.2	-0.1	-0.1	0.9	1.3	0.4
Wears glasses or contact lenses	0.5	0.6	1.9	0.1	0.9	0.7	0.1	-0.4	-0.1	0.2	1.4	1.0	1.0	0.1	1.1
Ever taken oral contraceptive pill	0.7	0.7	2.0	1.4	1.0	0.6	0.3	0.8	-0.5	1.3	-0.5	0.7	0.8	1.0	0.7
Hearing aid user	0.6	0.7	2.8	0.7	1.2	1.5	0.5	1.7	0.4	0.1	0.5	0.5	0.1	0.6	0.7
Mother’s age at death	0.2	0.2	1.0	0.1	-0.5	-1.0	-0.5	-0.6	0.5	-0.3	-0.5	-0.0	-0.1	-0.1	-0.2
Financial situation satisfaction	0.6	0.8	3.6	-0.6	0.1	-0.8	0.2	0.4	1.0	-0.7	-1.9	-0.2	-1.2	-0.9	-0.7
Tinnitus: Yes, now most or all of the time	1.3	1.5	6.3	-0.4	0.0	1.6	-2.5	-0.3	0.7	-0.3	1.7	2.0	0.1	0.1	1.1
Commuting to job workplace: Public transport	0.4	0.5	2.4	0.5	0.2	-0.7	0.8	0.5	-0.3	1.6	-0.6	0.1	0.6	0.7	0.7
Eye problems/disorders: Glaucoma	2.0	2.3	6.1	-2.3	-0.9	0.0	-2.5	-1.7	2.4	-1.7	0.1	0.4	-1.5	-1.1	-0.3
Medication: Blood pressure	2.1	3.9	9.1	2.9	0.3	0.4	3.0	2.3	-2.2	2.1	0.1	1.2	2.3	2.5	1.5
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.9	0.6	-0.4	-0.8	0.6	0.2	-0.9	0.7	0.7	-0.6	0.3	0.0	-0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.1	1.1	0.6	0.1	-0.4	0.7	0.0	0.0	-0.2	-0.1	0.6	-0.3	0.1
High cholesterol (Self-reported)	1.1	1.9	4.9	2.1	0.6	0.2	1.9	2.2	-1.5	1.7	-2.0	-0.3	0.6	0.4	-0.3
Medication: Bendroflumethiazide	2.0	3.1	9.4	3.1	0.1	-0.3	2.6	1.0	-2.1	2.4	-0.3	0.6	2.3	1.7	0.9
Medication: Paracetamol	0.2	0.3	1.6	-0.4	0.0	-0.2	-1.2	0.2	1.1	-0.2	0.3	0.1	-0.9	-0.4	-0.2
Medication: Lisinopril	0.6	0.7	1.8	0.7	0.0	1.3	0.9	1.3	-0.6	1.3	0.0	0.9	0.6	0.3	0.9
Medication: Atorvastatin	0.4	0.5	2.5	0.2	-0.2	0.4	1.6	0.7	-0.0	0.7	-1.2	0.6	-0.0	0.4	-0.2
Illnesses of father: High blood pressure	0.9	1.1	2.3	1.5	0.8	0.5	1.1	1.1	-1.1	1.3	0.9	0.3	1.2	1.0	1.1
Alcohol drinker status: Never	0.6	0.7	2.1	-0.2	-0.0	-0.1	-0.1	-1.0	-1.2	0.1	1.4	0.6	1.3	1.1	0.6
Ever smoked	1.8	3.1	13.4	-2.3	0.2	0.1	-2.0	-1.2	3.7	-1.3	0.1	0.4	-2.5	-2.5	0.1
Basal metabolic rate	0.7	4.1	17.6	0.8	0.8	0.1	-0.3	-1.1	-1.6	1.9	4.2	2.1	2.6	0.5	3.4
Leg fat percentage (left)	0.3	1.2	4.7	0.2	1.7	1.1	-0.9	0.5	1.1	0.7	0.8	2.2	0.2	0.2	1.2
Arm fat-free mass (left)	0.7	3.7	17.1	0.6	1.0	0.6	-0.6	-0.8	-1.0	1.2	4.1	2.3	2.2	0.5	3.4
Number of operations (self-reported)	0.7	1.1	2.8	-0.7	-1.1	-1.0	-0.9	-1.3	1.4	-1.7	-0.2	-0.3	-1.0	-1.3	-0.5
Average weekly beer plus cider intake	0.9	1.3	4.0	-1.6	0.2	-0.2	-1.7	-1.2	2.0	-1.1	1.1	1.0	-0.9	-0.7	0.2
Irritability	0.6	0.9	2.8	0.6	1.1	1.2	-0.7	0.2	1.2	0.1	1.1	1.7	0.2	0.5	1.3
Risk taking	1.3	1.9	8.8	1.7	2.1	1.3	0.9	3.0	-1.3	0.1	-0.4	-0.4	1.0	0.8	0.6
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.1	0.1	-0.5	-1.0	1.0	-0.4	0.0	0.1	-0.3	-0.3	-0.2	-0.9	-0.3
Fractured/broken bones in last 5 years	1.3	1.7	5.4	-1.5	-0.4	0.9	-2.0	-2.0	1.1	0.4	1.4	2.3	0.1	-0.2	0.9
Age started oral contraceptive pill	1.0	1.3	3.5	-0.0	-1.8	-1.7	1.9	-1.1	-0.5	0.4	-1.4	-1.3	0.2	0.4	-0.8
Diastolic blood pressure, automated reading	0.8	2.6	8.6	2.1	-0.2	-0.4	1.2	0.0	-1.9	2.4	0.9	0.7	2.3	2.9	1.1
Ever depressed for a whole week	1.0	1.2	3.2	-1.5	-0.1	-1.0	-0.8	-1.8	1.6	-0.4	1.4	1.1	-0.0	0.3	1.3
Unable to work because of sickness or disability	1.4	1.8	6.1	0.2	0.2	1.1	-1.4	-0.8	0.4	1.9	1.7	2.5	0.9	0.1	2.0
Commuting to job workplace: Cycle	0.3	0.4	1.7	0.2	-0.7	0.4	0.1	0.2	0.5	-0.0	-1.3	-0.2	-1.0	-0.3	-0.7
Myopia	0.8	1.2	3.2	1.3	1.6	0.9	0.9	1.3	-1.2	1.8	0.6	-0.0	1.0	0.3	0.9
Vascular/heart problems diagnosed by doctor	1.2	3.3	9.4	-3.1	-0.2	0.1	-3.0	-1.9	1.9	-2.5	1.0	-0.3	-1.7	-1.3	-1.0
Cholesterol lowering medication	2.1	3.0	6.2	2.2	1.5	1.0	1.8	2.0	-1.5	2.5	-0.1	1.8	1.9	1.8	1.5
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	4.2	0.6	-0.6	-1.3	0.5	-1.3	-1.2	0.8	2.0	0.2	1.4	-0.3	1.1
Pain experienced in last month	0.5	0.9	1.7	-1.0	-0.7	-0.6	0.8	-0.5	0.4	-1.3	-1.2	-1.2	-0.8	-1.1	-1.3
Supplements: Calcium	1.1	1.2	3.8	-0.2	-1.7	-1.5	1.1	-0.1	-0.7	0.1	-0.1	-1.9	-0.6	-1.2	-1.2
Basal cell carcinoma (self-reported)	1.1	1.3	2.7	1.5	1.2	0.8	1.2	1.6	-1.2	0.9	-0.9	-0.2	0.9	1.6	0.1
Heart attack/myocardial infarction (self-reported)	1.3	1.7	7.7	1.2	0.2	0.2	2.8	0.7	-1.7	1.9	-0.8	-0.0	1.1	1.7	0.0
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	4.5	-0.8	1.1	1.4	-2.1	-0.8	1.7	-0.2	1.0	1.5	-0.1	-0.0	1.4
Heart disease (siblings)	0.7	0.9	3.6	0.7	1.1	0.5	0.3	-0.1	-0.7	0.5	1.9	0.9	1.0	0.9	1.3
Alcohol drinker status: Previous	1.0	1.1	4.5	1.0	0.5	-0.3	0.5	-0.5	-0.5	2.1	0.5	1.5	1.4	0.8	1.4
Pack years of smoking	0.1	0.2	1.0	0.1	-0.1	-0.6	0.7	0.0	0.2	-0.3	0.3	0.6	0.1	-0.1	1.0
Impedance of whole body	3.0	15.4	28.8	-5.4	-3.3	-1.3	-4.3	-4.3	5.0	-4.3	-1.7	-1.4	-5.0	-4.2	-4.1
Leg fat mass (left)	0.3	1.2	4.2	0.2	1.2	0.2	-0.6	-0.4	0.5	1.1	1.7	2.1	0.8	0.1	1.8
Arm predicted mass (left)	0.7	3.6	17.1	0.5	1.0	0.5	-0.6	-0.8	-0.9	1.3	4.1	2.2	2.1	0.2	3.4