Hub : Genes

XPC

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1100 0.0390 1.1e-03 0.042 NA 0.040 NA 0.044 4.2e-04 NA 5.8e-04 NA 3.2e-04
2 GTEx Muscle Skeletal 0.0663 0.0257 2.8e-03 0.069 NA 0.057 NA 0.054 2.4e-07 NA 3.0e-06 NA 5.3e-06
3 GTEx Thyroid 0.1700 0.0490 2.7e-04 0.093 NA 0.037 NA 0.059 1.4e-07 NA 7.1e-04 NA 2.6e-05
4 NTR Blood 0.0268 0.0093 1.8e-04 0.019 0.012 0.012 0.013 0.012 7.3e-07 6.6e-05 8.7e-05 3.0e-05 6.2e-05
5 ROSMAP Brain Pre-frontal Cortex 0.1020 0.0335 7.9e-05 0.042 0.020 0.047 0.048 0.052 3.7e-06 1.2e-03 9.9e-07 7.8e-07 2.8e-07
6 YFS Blood 0.0364 0.0120 1.2e-04 0.010 0.014 0.016 0.019 0.020 2.6e-04 2.0e-05 2.9e-06 6.1e-07 3.1e-07
7 TCGA Colon Adenocarcinoma 0.1480 0.0610 4.5e-05 0.066 0.079 0.052 NA 0.049 1.2e-04 2.6e-05 5.5e-04 NA 8.3e-04
8 TCGA Esophageal Carcinoma 0.2000 0.0860 2.7e-03 0.072 0.023 0.061 NA 0.063 2.7e-03 6.2e-02 5.5e-03 NA 4.6e-03
9 TCGA Lung Squamous Cell Carcinoma 0.0735 0.0360 8.9e-04 -0.001 0.022 0.019 NA 0.011 5.0e-01 1.4e-03 2.9e-03 NA 1.9e-02
10 TCGA Stomach Adenocarcinoma 0.0650 0.0360 4.0e-03 0.005 0.017 0.009 NA 0.014 1.3e-01 2.0e-02 6.5e-02 NA 3.1e-02
11 TCGA Testicular Germ Cell Tumors 0.2180 0.0810 1.4e-04 0.083 0.145 0.160 NA 0.166 7.2e-04 8.0e-06 2.7e-06 NA 1.7e-06
12 TCGA Thyroid Carcinoma 0.0480 0.0250 7.2e-03 0.000 0.010 0.008 NA -0.001 3.5e-01 3.1e-02 4.6e-02 NA 3.7e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 1.3 2.1 6.1 -1.2 -1.7 -0.5 -0.5 -0.5 1.2 -1.8 -0.6 -1.9 -2.0 -1.1 -2.5
Bipolar Disorder or Schizophrenia 0.3 0.7 2.0 -0.2 -1.0 -0.7 0.2 0.3 0.6 -0.9 -0.0 -1.4 -1.3 -0.8 -1.2
Depressed Affect (Nagel 2018) 1.6 3.5 10.3 0.8 2.2 1.0 -0.8 -0.2 0.3 1.2 2.4 2.7 1.9 2.4 3.2
Depression (Nagel 2018) 0.4 0.6 2.9 -0.1 1.7 0.1 -0.6 0.5 0.6 0.1 1.0 0.7 0.3 0.6 1.2
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.7 -0.2 -0.4 0.8 0.1 0.6 -0.4 -0.1 -0.1 -0.6 -0.5 -0.7 -0.5
Neuroticism (Nagel 2018) 1.2 2.7 6.7 1.1 1.2 0.5 -0.4 -0.9 -0.0 1.2 2.0 2.6 1.9 2.5 2.6
Schizophrenia (2018) 0.1 0.2 0.6 0.7 0.2 -0.5 0.7 0.8 -0.2 0.2 0.5 -0.2 -0.1 -0.1 0.4
Schizophrenia vs Biploar Disorder 1.2 1.6 4.9 1.7 1.6 0.0 0.9 0.9 -0.5 1.4 0.5 1.4 1.5 0.8 2.2
Worry (Nagel 2018) 0.9 2.0 6.1 0.7 0.3 -0.1 -0.5 -1.8 -0.3 0.9 1.7 2.2 1.7 2.5 1.4
Alzheimer’s Disease (in mother) 0.2 0.2 1.0 0.3 -0.4 -0.1 0.4 0.5 -0.4 -0.0 -0.4 -0.7 -0.1 1.0 -0.6
Alzheimer’s Disease (in father) 1.0 1.0 4.2 1.1 0.5 2.0 -0.6 0.4 -1.1 0.4 1.6 1.0 0.9 0.8 0.6
Alzheimer’s Disease (including proxy) 0.5 0.7 4.5 0.5 0.5 2.1 -0.2 0.7 -0.4 0.2 0.7 0.6 0.4 1.4 0.3
Crohns Disease (2017) 0.3 0.7 2.2 -1.0 -1.0 -1.5 0.4 -1.4 0.4 -0.7 0.2 -0.6 -0.3 0.5 -0.3
Irritable Bowel Disease (IBD) 0.8 2.0 5.2 -1.4 -2.3 -2.1 -0.7 -1.9 0.6 -1.2 0.3 -1.4 -1.2 -0.8 -1.5
Ulcerative Colitis (UC) 1.0 1.9 4.4 -1.0 -2.1 -1.6 -1.6 -1.3 0.5 -1.2 0.3 -1.2 -1.4 -1.4 -1.8
Major Depression (MDD) 0.6 0.8 1.8 0.7 -0.1 -1.3 0.7 -0.3 -0.6 1.0 1.0 0.6 1.1 0.7 1.3
Reaction Time 1.3 2.5 7.8 0.7 0.1 -0.8 0.9 -0.4 0.9 2.7 1.0 2.8 1.2 1.3 2.7
Verbal and Numeric Reasoning (VNR) 1.3 3.2 7.5 -2.0 -2.4 0.2 -1.4 -0.4 1.3 -1.6 -0.6 -1.6 -2.5 -2.7 -2.2
Breast Cancer 0.4 0.9 3.8 0.9 -0.0 -0.3 0.5 2.0 -0.9 0.1 -1.6 -1.5 0.1 -0.6 -0.4
Ovarian Cancer 0.9 1.1 7.0 -0.3 0.5 2.6 -1.1 -0.2 1.2 -0.3 0.4 1.7 -0.1 -0.1 0.7
Prostate Cancer 0.2 0.3 0.7 0.6 0.8 0.1 0.7 0.9 -0.4 -0.0 -0.6 0.1 0.1 0.7 0.1
Age at First Birth 0.5 0.8 2.8 0.6 0.3 0.7 -1.1 0.0 1.0 0.9 1.2 1.7 0.1 0.3 1.0
Bipolar Disorder (2011) 0.5 0.5 2.6 -0.2 -0.5 -1.0 0.3 -0.3 -0.1 -1.6 1.2 -0.2 0.2 0.5 -0.2
Body Mass Index (BMI) (2010) 0.5 0.7 1.4 0.9 0.6 -0.4 0.7 0.3 -0.8 1.1 0.3 0.8 1.1 1.1 1.2
Coronary Artery Disease (CAD) 0.5 0.5 3.1 0.2 -0.1 -0.1 0.7 1.8 0.7 -0.2 -0.7 -0.6 -0.9 -0.9 -0.2
Crohns Disease (2012) 0.3 0.4 1.6 -0.4 -0.9 -1.0 1.3 0.4 0.3 -0.6 -0.6 -0.7 -0.6 0.3 -0.3
Mean Putamen Volume 0.7 0.8 3.1 0.5 0.5 -0.6 -1.8 -0.2 1.3 0.5 1.0 1.3 -0.0 -0.3 1.2
Fasting Glucose 0.4 0.5 1.1 -0.5 -1.1 -0.2 -0.1 -1.0 0.4 -0.5 -0.5 -1.0 -0.5 0.2 -1.0
HbA1C 0.8 0.9 2.1 0.2 -1.4 -1.1 1.2 0.1 0.2 -0.1 -1.5 -0.7 -1.0 -1.0 -1.1
HDL Cholesterol 0.3 0.4 1.6 0.2 -0.8 -1.3 1.0 0.2 -0.3 -0.2 0.1 -1.1 -0.2 0.0 -0.8
LDL Cholesterol 0.5 0.8 2.8 -0.3 -0.3 -0.6 0.4 -1.2 -0.1 0.9 0.7 1.1 1.2 1.7 1.2
Lupus 0.7 1.1 3.8 -1.0 -1.1 0.1 -0.3 -0.3 1.3 -0.9 -1.9 -0.3 -1.3 0.0 -1.5
Neuroticism (2016) 1.3 1.9 5.7 1.9 -0.3 -2.2 2.4 0.4 -0.2 1.8 -1.1 0.3 0.8 1.6 0.7
Primary Biliary Cirrhosis 0.2 0.3 0.7 0.8 0.3 -0.6 0.2 -0.6 -0.2 0.6 -0.5 0.7 0.4 0.7 0.6
Rheumatoid Arthritis 0.8 1.1 4.6 0.5 -2.1 -0.5 0.8 0.1 -0.1 0.4 -1.9 -0.8 -0.7 -0.3 -1.6
Schizophrenia (2014) 0.2 0.4 1.3 1.0 0.7 -0.0 0.7 0.9 -0.2 -0.1 1.1 -0.2 0.1 -0.2 0.9
Triglycerides 0.6 0.9 2.6 0.9 -0.3 0.7 0.9 0.3 -1.6 1.2 -0.1 0.9 1.3 1.5 0.5
Type 2 Diabetes (T2D) (2012) 0.2 0.3 1.1 -0.7 -0.1 0.4 -0.2 -0.3 1.0 -0.6 -0.0 0.3 -0.7 0.6 -0.1
Ulcerative Colitis 0.8 1.1 4.0 -0.2 -2.0 -1.8 -0.0 -1.2 -0.5 -0.6 0.3 -1.2 -0.5 -0.4 -1.5
Blood Eosinophil Count 0.2 1.4 4.3 -0.7 -0.3 1.8 -2.1 0.3 0.3 -0.4 -0.2 -0.1 -1.6 -2.1 -1.4
Blood Platelet Count 0.2 2.7 8.2 2.0 -0.8 -0.4 2.9 2.5 -2.7 0.5 -0.4 -2.1 0.7 0.1 -0.7
Blood Red Count 0.6 6.0 25.4 -3.2 -4.5 -2.2 -1.0 -5.0 1.6 -0.4 0.5 0.7 -1.3 -1.4 -1.8
Blood White Count 0.1 0.8 3.8 0.1 -0.1 -0.1 0.7 1.9 0.2 0.9 -0.5 -0.9 -0.9 -1.5 -0.5
Heel T-Score 0.8 6.2 19.3 2.7 3.6 2.1 2.3 4.4 -1.9 0.4 -3.5 -1.2 0.9 2.4 -1.2
BMI 0.5 2.8 6.0 2.2 1.7 0.4 2.4 2.1 -1.1 2.1 0.3 1.0 1.7 1.3 1.9
Height 0.9 17.7 76.2 -3.7 -3.5 -3.0 -4.0 -8.7 0.0 -0.4 7.9 1.6 1.3 -3.6 2.3
Waist Hip Ratio (WHR) 0.7 3.0 9.5 -0.7 -1.1 -0.7 0.1 1.1 1.3 -1.4 -3.1 -2.1 -2.2 -2.3 -2.3
Systolic Blood Pressure 0.9 4.3 8.9 3.0 2.1 1.9 1.4 3.0 -2.3 2.1 -1.5 0.4 2.0 2.7 0.4
Smoking Status 3.1 7.5 18.5 -4.3 -0.1 1.2 -3.7 -1.0 4.3 -3.3 0.1 -0.2 -3.7 -3.1 -1.5
Allergy or Eczema 0.5 1.3 4.2 -0.4 -1.6 -0.5 -0.9 -0.2 0.4 -1.3 -1.1 -1.5 -1.4 -0.8 -2.0
Cardiovascular Disease 1.0 3.2 9.2 3.0 1.7 1.5 1.4 2.5 -1.1 2.5 -0.4 1.2 1.6 0.8 1.9
Hypothyroidism (self reported) 0.9 2.0 10.8 -0.3 1.6 3.3 -1.6 0.6 0.6 -1.2 1.5 1.7 0.1 0.6 0.9
Respiratory disease 1.2 2.6 6.2 1.9 1.2 1.3 1.1 1.0 -1.6 2.2 0.8 1.5 2.1 2.5 1.5
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.9 -0.2 0.3 0.0 0.5 -0.2 0.4 0.6 -0.7 -0.1 -0.2 -0.9 0.1
Lung FEV1/FVC ratio 1.8 8.9 22.3 -4.2 -3.1 -2.7 -2.9 -4.7 2.4 -3.5 -1.6 -1.0 -2.2 -2.8 -2.8
Lung FVC 0.9 4.8 13.0 2.5 1.1 -0.1 3.6 1.9 -3.6 1.2 1.9 -0.4 2.9 2.3 1.5
Neuroticism 2.0 4.7 12.9 1.5 2.6 0.5 -0.6 -0.4 0.4 1.8 2.5 3.6 2.3 2.7 3.5
Chronotype (morning person) 0.8 1.9 4.3 -1.4 -2.1 -1.1 -1.6 -1.5 -0.3 -1.2 -0.6 -1.6 -0.7 -1.1 -1.9
Hair Pigment 0.1 1.7 4.7 0.8 0.4 -1.0 0.5 -1.1 -0.5 2.2 1.0 1.8 1.7 1.5 1.6
Tanning 0.2 2.8 7.0 -0.2 -0.9 -0.8 0.2 1.0 1.5 -1.4 -2.6 -2.1 -2.4 -2.4 -1.9
Hand grip strength (left) 1.4 3.6 8.1 1.1 2.3 1.5 0.2 0.1 -1.3 1.5 2.5 2.4 2.6 1.7 2.9
Number of treatments/medications taken 0.2 0.3 1.2 1.1 -0.1 0.1 -0.4 0.3 -0.2 1.1 -0.5 0.6 0.3 0.2 0.2
Average weekly spirits intake 1.0 1.2 3.8 -1.6 -1.2 -0.9 -1.7 -2.0 0.6 -0.1 0.6 0.0 -0.8 -1.1 -0.6
Sensitivity / hurt feelings 0.8 1.4 5.0 0.1 0.8 0.6 -0.1 -0.9 0.4 1.1 1.8 2.2 1.0 0.7 1.8
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.9 -0.4 0.9 0.2 -0.1 0.8 0.5 1.0 0.7 0.5 -0.2 0.8 0.7
Hearing difficulty/problems: Yes 0.8 1.2 3.6 1.5 1.5 0.4 -0.3 1.0 0.6 0.2 1.5 1.4 0.4 0.2 1.9
Relative age of first facial hair 1.0 2.1 5.2 -1.9 -0.8 0.1 -1.9 -2.3 1.7 -2.0 1.2 0.5 -1.2 -1.5 -0.3
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 3.5 0.5 -0.2 -0.1 0.6 1.0 -0.4 0.6 -1.9 -0.9 -0.1 0.7 -0.6
Ever used hormone-replacement therapy (HRT) 2.8 3.5 8.2 2.1 1.3 -0.7 2.9 0.7 -0.6 2.8 -0.6 1.6 1.9 2.7 2.2
Ever had hysterectomy (womb removed) 0.5 0.5 2.2 -0.1 -0.0 -1.5 0.8 -0.2 0.6 0.6 -1.4 -0.5 -0.1 0.7 0.1
Systolic blood pressure, automated reading 0.8 2.3 6.2 2.4 1.5 0.7 1.5 2.5 -1.5 1.1 -1.3 -0.0 1.2 2.0 -0.0
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.7 -0.5 -0.2 -1.3 1.0 -0.2 1.1 -0.5 -0.9 -0.6 -0.8 -0.8 -0.3
Angina 0.3 0.4 1.7 -0.5 -0.2 -0.2 -0.4 -1.3 0.3 0.2 0.7 1.0 -0.0 0.1 0.6
Medication for hormone replacement therapy 0.9 1.0 2.3 0.7 -0.0 -1.0 0.3 -1.3 -0.6 1.5 0.9 1.4 1.2 1.0 1.1
Vitamin and mineral supplements 0.2 0.3 0.9 -0.1 0.9 0.9 0.0 0.6 0.7 -0.7 0.4 -0.2 -0.4 -0.3 0.7
Supplements: Zinc 0.3 0.3 0.8 -0.8 0.3 0.6 -0.4 0.3 0.9 -0.3 0.3 -0.0 -0.5 0.5 -0.6
Medication: Co-codamol 0.6 0.7 2.9 0.1 0.8 -1.7 -0.6 0.4 -0.1 -0.8 0.7 -1.3 -0.1 -1.2 -0.5
Medication: Metformin 0.3 0.4 1.3 -0.3 -0.2 -0.3 0.6 0.0 1.2 -0.2 -1.1 0.2 -0.9 -1.0 -0.3
Diabetes (father) 0.4 0.5 2.0 -0.1 -0.7 -1.4 0.9 -0.4 -0.3 -0.0 -0.1 -0.2 0.4 -1.2 0.6
Diabetes (mother) 0.1 0.1 0.4 -0.1 -0.2 -0.1 0.7 0.1 0.0 0.2 -0.6 -0.3 -0.2 0.1 -0.2
Severe depression (siblings) 0.6 0.7 3.1 0.4 0.6 0.9 0.1 0.2 0.6 1.8 -0.1 1.4 0.5 0.7 1.0
Pack years adult smoking proportion 0.1 0.2 0.6 -0.3 -0.2 -0.6 0.5 -0.1 0.6 -0.7 -0.0 0.6 -0.3 -0.2 0.8
Impedance of leg (right) 2.2 10.8 20.9 -4.5 -1.7 0.2 -4.6 -3.6 4.5 -4.2 -0.4 -0.4 -3.9 -3.6 -2.6
Leg fat-free mass (left) 0.7 3.6 12.3 1.1 0.4 -0.5 0.4 -1.1 -1.8 2.4 3.5 1.8 2.5 0.6 3.0
Trunk fat percentage 0.4 1.7 4.7 -1.7 -0.5 -1.3 -1.3 -1.9 2.2 -0.4 0.2 0.6 -1.4 -1.7 -0.6
Hand grip strength (right) 0.6 1.7 4.1 0.2 2.0 0.8 -0.6 -0.3 -0.5 0.7 1.5 2.0 1.7 1.2 1.9
Townsend deprivation index at recruitment 0.6 0.8 2.6 0.2 -0.2 -1.2 0.2 -1.6 -0.2 1.0 1.5 0.4 0.7 -0.0 1.3
Current tobacco smoking 1.6 2.6 8.6 -2.9 -0.4 0.3 -1.8 -0.6 2.1 -2.0 -0.3 -0.9 -2.4 -1.4 -1.3
Average weekly fortified wine intake 0.3 0.4 2.5 0.7 0.4 0.2 -0.2 -0.1 -0.4 0.4 -0.5 0.3 0.7 1.6 0.5
Maternal smoking around birth 0.3 0.5 1.1 -0.8 -1.0 -0.1 -0.3 -0.8 0.9 0.8 -0.2 0.7 -0.7 -0.8 -0.2
Fed-up feelings 1.0 1.9 5.7 0.6 1.1 0.6 -0.4 -0.2 0.2 0.9 2.4 2.2 1.3 1.5 2.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.8 -0.2 0.9 -0.1 -0.2 0.1 0.6 0.0 0.9 0.7 -0.1 0.2 0.7
Relative age voice broke 0.5 0.7 3.3 -0.6 -0.9 -0.6 -1.1 -1.8 0.8 -0.8 0.6 -0.2 -0.4 -0.8 0.0
Taking other prescription medications 2.8 4.4 9.0 2.8 2.1 0.9 1.5 1.4 -1.6 3.0 0.5 1.6 2.8 2.4 2.7
Age when periods started (menarche) 0.4 1.0 5.2 -0.8 -1.8 -0.4 -0.2 -2.3 -0.7 -0.0 1.5 -0.2 0.3 0.3 0.2
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 3.4 0.1 -1.2 -1.9 1.1 -1.4 -0.7 0.6 -0.1 0.1 0.9 0.6 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 2.1 0.2 1.1 0.6 -0.6 0.3 -0.5 -1.4 -1.1 -1.1 -0.0 0.7 -1.1
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 3.4 -1.1 -1.0 -1.4 -0.7 -1.3 1.8 -0.4 -0.8 0.0 -1.7 -0.8 -0.8
Qualifications: CSEs or equivalent 2.2 2.9 6.2 -2.5 -1.4 -1.3 -1.9 -1.9 2.0 -1.4 -1.7 -0.3 -2.0 -1.2 -1.9
Serious illness, injury or assault to yourself 0.7 0.9 4.0 -0.8 -0.8 -1.4 -0.6 -2.0 0.0 0.5 1.3 0.3 0.4 -0.6 0.8
High blood pressure 0.7 1.9 6.1 2.5 -0.4 -0.4 2.1 1.5 -1.4 2.0 -1.1 0.1 1.1 0.6 0.6
Hayfever, allergic rhinitis or eczema 0.6 1.2 4.2 0.0 -1.6 -0.5 -0.5 0.4 0.2 -0.5 -1.8 -1.4 -1.2 -0.6 -2.0
Multivitamins +/- minerals 0.4 0.5 1.6 0.6 -0.9 -0.8 0.1 0.3 -1.0 0.7 -0.9 -0.3 0.2 0.0 -1.3
Stomach or abdominal pain in last month 0.5 0.7 3.6 -0.4 -1.9 -1.3 0.1 -1.2 -0.3 0.1 -0.4 -0.8 -0.2 0.2 -0.6
Supplements: Glucosamine 1.1 1.4 4.2 0.9 -0.6 -0.6 2.0 1.6 -1.0 0.5 -2.0 -1.5 -0.1 0.0 -1.3
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 8.9 0.2 -1.0 -1.3 1.5 0.9 0.2 0.1 -3.0 -1.2 -1.2 -0.5 -1.7
Medication: Atenolol 0.1 0.1 0.4 0.6 -0.2 0.1 0.2 0.2 -0.1 0.1 0.5 0.4 0.0 0.7 0.1
Medication: Levothyroxine sodium 0.6 0.9 2.2 0.7 1.3 0.9 -0.6 0.5 -0.8 -0.5 1.5 0.6 1.2 1.1 1.2
Sitting height 0.7 4.6 22.1 -1.6 0.1 0.8 -3.2 -2.4 0.8 -0.2 4.7 2.1 0.3 -1.6 2.6
Chronic bronchitis/emphysema (father) 0.4 0.5 1.8 -0.2 0.2 0.9 -1.3 -0.4 1.2 -0.5 0.1 0.9 -0.4 -0.5 0.2
High blood pressure (mother) 0.7 1.0 2.6 -0.8 0.0 0.9 -1.2 0.4 1.3 -1.4 -0.5 -0.3 -1.6 -1.2 -0.6
Body mass index (BMI) 0.5 2.2 4.1 1.9 1.7 0.4 1.5 1.9 -1.0 2.0 0.2 1.2 1.5 1.4 1.6
Impedance of leg (left) 2.9 13.9 27.6 -5.1 -1.8 0.3 -5.2 -3.6 5.2 -4.7 -0.8 -0.2 -4.6 -4.0 -3.0
Leg predicted mass (left) 0.6 3.4 12.8 0.9 0.3 -0.5 0.3 -1.1 -1.7 2.3 3.6 1.8 2.4 0.5 3.0
Trunk fat mass 0.3 1.3 3.9 -1.1 -0.1 -1.0 -1.2 -2.0 1.2 0.3 1.6 1.3 -0.2 -1.2 0.7
Waist circumference 0.1 0.4 1.1 0.4 0.8 -0.3 0.3 0.8 0.2 1.0 0.6 0.5 0.3 -0.5 1.0
Number of incorrect matches in round 2.0 3.3 7.9 1.1 1.4 1.1 0.2 -0.6 -1.0 0.9 2.8 2.3 2.6 2.5 2.6
Past tobacco smoking 2.0 3.6 12.0 2.3 -0.5 -1.1 2.5 1.3 -3.5 1.7 -1.3 -0.9 2.1 2.6 -0.4
Alcohol usually taken with meals 0.2 0.3 1.4 -0.4 0.5 0.3 -0.8 -0.9 0.5 -0.2 0.4 1.2 0.2 0.2 0.4
Nervous feelings 0.2 0.4 1.8 0.0 0.1 0.5 -1.3 -0.3 0.8 0.9 0.0 0.9 -0.1 0.3 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 3.9 1.3 1.6 0.7 -0.2 0.9 0.1 2.0 0.2 1.8 0.8 1.6 1.6
Hearing difficulty/problems with background noise 1.4 2.2 7.7 2.8 1.6 0.4 0.2 1.8 -0.7 1.3 1.0 1.3 1.4 1.5 1.9
Hair/balding pattern: Pattern 2 0.5 0.6 2.3 1.5 1.0 0.2 0.4 1.4 -1.1 -0.2 0.0 -0.4 0.8 0.4 -0.1
Had menopause 0.3 0.3 1.8 0.2 -0.3 -0.7 1.3 1.0 -0.0 0.2 -0.6 -0.1 -0.2 -0.2 -0.1
Had other major operations 0.2 0.2 0.5 0.6 0.2 -0.6 0.3 0.3 0.5 -0.7 -0.7 -0.4 -0.5 -0.5 0.0
Forced vital capacity (FVC) 0.8 2.9 17.6 -0.0 -0.6 0.5 -0.4 -1.1 -2.0 0.8 4.2 1.2 2.1 0.6 2.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 2.6 0.5 1.2 1.6 -0.5 0.7 -1.1 -1.6 -0.5 -0.7 0.4 1.2 -1.0
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 4.4 -0.8 0.5 0.7 -1.4 -0.5 2.1 -0.6 -0.5 1.3 -0.9 0.1 0.3
Qualifications: None of the above 0.6 1.2 7.1 -0.4 0.9 1.1 -0.5 -0.4 -0.4 0.2 2.7 1.2 0.9 0.1 1.7
Financial difficulties in last 2 years 0.5 0.6 2.0 -0.6 -1.1 -0.7 0.5 0.6 0.7 -0.1 -0.8 -0.8 -1.4 -0.9 -0.6
Mouth/teeth dental problems 0.1 0.2 0.5 -0.7 0.3 0.5 0.1 -0.2 0.4 -0.5 -0.1 -0.4 -0.6 -0.1 -0.7
Heart attack 1.5 1.9 8.4 1.4 0.2 -0.0 2.9 0.6 -1.8 2.1 -0.8 0.1 1.2 1.8 0.1
Allergy 0.4 0.9 3.2 0.9 1.1 0.3 1.8 1.1 -0.9 0.5 0.6 0.2 1.0 0.9 1.2
Pain all over the body in last month 1.8 1.9 4.4 1.7 0.5 0.8 0.6 0.4 -1.2 1.3 1.1 2.0 1.8 2.1 1.6
Diabetes (self-reported) 0.7 1.1 4.7 -0.9 0.2 0.3 -0.3 -0.5 2.2 0.2 -1.5 0.5 -1.3 -1.7 -0.1
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 4.4 2.1 0.8 -0.6 1.6 1.8 -1.5 1.1 -1.7 -1.3 0.8 0.7 0.2
Medication: Ramipril 0.5 0.7 1.7 1.0 -0.4 -1.3 1.2 0.1 -1.1 1.3 -1.0 -0.5 0.5 -0.1 -0.2
Medication: Simvastatin 1.7 2.5 6.8 2.4 2.2 1.3 1.0 2.6 -0.7 2.4 -0.9 1.0 0.8 0.2 1.2
Fluid intelligence score 0.9 1.9 5.7 -1.4 -2.4 -0.1 -1.4 -0.6 0.9 -0.9 -0.1 -1.0 -1.8 -2.3 -1.4
Illnesses of siblings 0.3 0.5 3.0 -0.9 -0.8 -0.2 -0.6 -1.7 0.5 0.2 -0.2 0.6 -0.3 -0.2 -0.4
Neuroticism score 1.1 2.4 8.1 0.6 1.9 1.0 -1.3 -0.5 1.1 1.1 1.8 2.8 1.0 1.7 1.9
Weight 0.4 1.7 7.8 0.2 0.4 -0.2 -0.5 -0.9 -0.6 1.4 2.8 1.6 1.4 -0.1 2.1
Impedance of arm (right) 1.7 7.9 13.2 -3.6 -3.0 -1.7 -2.1 -3.2 3.2 -2.6 -1.7 -1.6 -3.5 -3.0 -3.3
Arm fat percentage (right) 0.1 0.4 1.3 0.8 0.6 -0.5 1.0 0.6 0.1 1.2 -0.3 0.7 0.4 0.5 0.5
Trunk fat-free mass 1.0 5.9 24.1 1.3 1.0 0.6 -0.2 -0.9 -2.4 2.0 4.9 2.2 3.4 0.9 4.1
Hip circumference 0.4 1.8 6.4 0.5 0.9 -0.4 -0.4 -0.5 -0.5 1.6 2.5 1.9 1.5 0.4 2.2
Time employed in main current job 0.6 0.7 2.3 -0.7 -0.8 -0.4 -1.5 -1.4 0.7 -1.1 0.6 0.5 -0.4 -0.4 -0.1
Alcohol intake versus 10 years previously 0.2 0.4 1.1 0.4 1.0 -0.5 0.6 0.8 -0.8 0.3 0.3 -0.6 0.6 0.5 0.2
Father’s age at death 0.7 0.9 2.9 -0.3 -0.1 -0.9 -0.7 -0.2 0.7 -0.8 -1.7 -1.5 -0.9 -0.7 -1.3
Worrier / anxious feelings 1.8 3.4 9.5 0.6 1.2 1.0 -0.4 -1.5 0.2 1.6 2.6 3.1 2.1 2.7 2.3
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 4.9 0.6 2.1 1.0 -0.7 0.8 0.6 1.2 1.2 2.2 0.8 1.2 2.1
Falls in the last year 0.0 0.1 0.3 -0.1 -0.3 0.4 0.0 -0.2 -0.1 -0.0 0.3 0.5 -0.0 0.2 0.0
Hair/balding pattern: Pattern 3 2.1 3.2 7.0 -2.6 -1.7 -0.1 -2.2 -1.9 1.9 -1.9 0.1 -0.3 -2.0 -2.5 -1.2
Number of live births 1.1 1.6 3.1 0.6 0.4 1.8 1.5 0.4 -1.2 1.4 1.0 1.1 1.6 1.6 1.5
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 6.6 -1.5 -2.1 -0.8 -1.5 -2.6 -1.1 -0.8 2.5 0.0 0.6 -0.5 0.2
Pulse rate 1.2 2.0 10.4 -1.2 -1.8 -2.0 -0.8 -3.2 -0.1 -0.3 1.5 0.9 1.1 0.5 0.4
Happiness 0.3 0.4 1.3 0.3 0.2 -0.3 -0.5 -0.3 0.3 1.1 -0.4 1.1 0.3 1.1 0.4
Noisy workplace 0.5 0.6 1.8 -0.9 -0.1 -0.6 -1.0 -0.0 1.0 -1.4 -0.9 0.4 -1.0 -0.6 -0.6
Qualifications: A levels/AS levels or equivalent 0.8 1.7 5.3 2.3 0.4 0.1 1.5 1.2 -2.1 1.6 -0.5 -0.5 1.4 1.5 -0.2
Serious illness, injury or assault of a close relative in last 2 years 3.8 4.3 10.6 -2.1 -0.6 -0.2 -1.1 0.9 2.2 -2.6 -2.4 -2.3 -3.3 -2.5 -2.4
Mouth/teeth dental problems: Dentures 0.2 0.3 2.1 0.2 -0.2 0.2 -0.6 0.2 0.7 -0.2 -0.0 1.4 0.0 0.0 0.7
Asthma 0.3 0.6 1.5 0.7 0.5 0.2 0.1 -0.3 -0.4 1.2 0.9 1.0 1.1 0.9 1.2
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 5.4 -1.6 -0.4 0.1 -1.3 0.5 2.2 -1.4 -2.3 -0.5 -2.3 -1.2 -1.8
Medication: Cholesterol lowering 0.5 0.8 3.5 1.2 1.1 0.2 0.9 1.0 -0.1 1.9 -1.3 0.1 0.1 -0.5 0.4
Depression (self-reported) 0.3 0.4 1.2 -0.2 1.0 0.1 -0.5 -0.3 0.5 0.6 0.8 1.1 0.2 0.6 0.9
Medication: Lansoprazole 1.9 2.2 5.4 1.3 1.2 0.6 1.7 0.5 -0.6 1.4 0.7 2.1 1.9 1.9 2.3
Prospective memory result 2.4 2.9 6.8 0.3 2.0 2.6 0.9 0.2 -0.7 1.6 1.6 1.9 2.1 2.2 2.2
Lung cancer (father) 1.2 1.4 3.4 1.1 1.9 0.7 0.8 1.3 -0.2 1.5 -0.1 1.1 1.1 1.6 1.2
Illnesses of mother 0.5 0.6 1.5 0.1 -1.2 -1.2 0.4 -0.1 -0.8 1.0 -0.3 -0.7 0.4 -1.0 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 3.6 -1.4 -1.7 -0.6 -1.3 -1.5 -0.6 -1.2 1.9 -0.6 -0.0 -1.0 -0.4
Pulse wave Arterial Stiffness index 0.7 0.8 2.8 -0.6 -0.2 -0.9 -0.3 -0.0 -0.4 -1.1 1.1 -1.7 -0.5 -1.2 -1.0
Impedance of arm (left) 2.2 10.1 17.0 -4.1 -3.5 -2.2 -2.6 -3.9 3.4 -2.9 -1.9 -1.6 -3.8 -3.2 -3.8
Arm fat mass (right) 0.2 0.9 2.2 0.9 0.8 -0.1 0.6 0.2 -0.3 1.5 1.0 1.4 1.1 0.5 1.5
Trunk predicted mass 1.0 5.8 24.1 1.2 0.9 0.6 -0.2 -0.9 -2.4 1.9 4.9 2.2 3.3 0.9 4.0
Standing height 1.1 10.6 37.2 -3.6 -2.6 -1.3 -4.6 -6.1 0.9 -1.4 5.7 1.2 -0.2 -3.2 1.2
Length of working week for main job 2.5 2.8 11.8 0.9 -0.1 -1.0 0.7 -2.0 -1.2 1.2 3.4 1.8 1.8 -0.1 2.4
Exposure to tobacco smoke at home 2.1 2.4 9.1 -0.9 0.9 2.7 -1.7 -0.7 1.0 -0.4 3.0 1.4 0.1 -0.2 1.9
Breastfed as a baby 1.7 2.2 7.8 -0.4 -1.1 -2.8 1.1 -0.3 0.2 -0.0 -2.6 -2.1 -1.0 -0.3 -1.8
Tense / ‘highly strung’ 0.5 0.8 2.4 1.1 0.4 -0.7 -0.0 -0.8 0.1 1.3 0.3 1.2 0.7 1.6 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 2.2 -0.1 0.5 -0.8 -0.5 -0.2 1.5 -0.4 -0.3 -0.3 -0.9 -0.6 -0.2
Hair/balding pattern: Pattern 4 0.5 1.1 2.7 0.6 0.4 1.1 -0.5 0.0 -0.7 1.2 1.6 1.3 1.1 1.6 1.1
Birth weight of first child 1.4 2.5 7.9 0.3 2.6 2.8 -1.4 0.9 1.0 0.1 1.9 2.3 0.4 0.9 1.0
Peak expiratory flow (PEF) 0.6 1.3 3.7 -0.7 -1.4 -1.9 -0.7 -1.7 -1.0 -1.0 -0.1 -1.5 0.0 -1.0 -1.0
Pulse wave reflection index 1.1 1.3 5.7 0.8 2.4 2.0 -0.6 1.5 -0.3 -0.1 1.5 0.7 0.2 0.1 0.7
Ever highly irritable/argumentative for 2 days 0.4 0.5 2.1 0.3 0.4 0.8 -0.3 0.4 1.5 0.3 0.1 1.1 -0.7 -0.2 0.9
Loud music exposure frequency 1.8 2.0 4.5 1.5 1.5 -0.5 1.0 -0.8 -1.2 1.3 1.2 1.2 2.1 1.7 2.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.9 0.7 0.8 0.2 0.5 0.8 -0.6 0.5 -1.4 -0.4 0.1 0.7 -0.4
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 2.8 0.4 0.7 1.5 -1.0 1.7 -0.0 0.8 -1.0 -0.1 -0.1 -0.0 -0.1
Blood clot in the leg (DVT) 1.2 1.5 4.4 -0.5 1.5 1.5 -2.1 -0.6 1.6 0.1 1.1 1.6 0.1 0.2 1.5
Medication: Paracetamol 0.5 0.8 2.3 -0.5 -0.9 -1.5 -1.1 -0.5 1.0 -0.7 0.1 -0.6 -1.0 -0.6 -1.0
Headache pain in last month 0.3 0.5 3.1 -0.0 -0.2 0.7 -0.8 -0.6 0.0 0.5 1.8 0.9 0.2 0.5 0.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.7 -0.6 0.1 0.1 -0.6 0.5 -0.5 -1.6 1.1 -0.8 0.1 0.9 -0.6
Glaucoma (self-reported) 0.9 1.1 3.9 -1.6 -1.0 -0.5 -1.7 -2.0 0.9 -0.7 0.3 0.2 -0.7 -0.4 -0.1
Gout (self-reported) 0.7 0.9 2.7 0.7 1.0 0.6 0.8 0.2 0.1 1.7 -0.4 1.4 0.8 1.4 1.1
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 4.0 0.4 1.0 2.0 -1.5 0.1 -0.2 -0.9 1.8 1.2 0.6 0.2 1.1
Medication: Amlodipine 0.1 0.1 0.4 0.1 -0.4 -0.3 -0.2 0.0 -0.1 0.1 -0.4 -0.7 0.0 -0.2 0.1
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.7 0.2 1.2 -0.0 0.3 0.3 -0.1 1.3 0.7 0.9 0.7 0.6 1.3
Birth weight 0.8 1.7 4.4 1.8 1.2 1.0 1.4 1.5 -2.1 0.1 0.8 0.4 1.4 2.0 0.3
Chronic bronchitis/emphysema (mother) 0.8 1.0 4.3 -1.3 -1.6 -1.3 -0.2 -2.1 -0.1 -0.6 0.7 0.0 -0.2 0.2 -0.4
High blood pressure (siblings) 1.8 2.5 8.6 2.6 0.6 -0.4 2.6 2.9 -1.9 0.1 -0.6 -1.7 0.6 0.5 -0.1
Forced vital capacity (FVC), Best measure 0.4 1.3 10.3 -0.4 -0.8 -0.0 -0.2 -0.8 -1.4 -0.1 3.2 0.1 1.0 -0.2 1.0
Body fat percentage 0.2 0.7 2.5 -0.9 0.1 -0.7 -0.9 -1.0 1.6 -0.0 0.3 1.0 -0.7 -0.8 -0.0
Leg fat percentage (right) 0.3 1.1 4.0 0.4 1.7 1.1 -0.6 0.4 0.8 0.8 1.0 2.0 0.5 0.3 1.4
Arm fat-free mass (right) 0.7 3.7 16.8 0.7 1.0 0.4 -0.7 -0.9 -1.3 1.5 4.1 2.1 2.4 0.4 3.3
Exposure to tobacco smoke outside home 0.8 1.1 2.9 -1.7 1.0 1.4 -1.7 -0.3 1.2 -0.7 1.3 0.0 -0.8 -0.6 0.5
Comparative body size at age 10 0.7 1.9 7.1 1.0 2.7 0.3 1.8 2.0 -1.3 0.2 -0.1 -0.6 1.1 2.0 0.3
Number of full brothers 0.7 0.9 3.7 -0.6 0.2 -0.5 -1.1 -0.3 -0.4 -1.9 0.9 -1.6 -0.6 -0.6 -1.1
Worry too long after embarrassment 0.4 0.7 4.2 -0.3 -0.2 0.7 -0.8 -0.5 2.0 0.3 -0.1 1.4 -1.0 -0.4 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 1.2 0.1 -0.4 -0.6 0.9 0.2 -0.7 1.1 -0.7 -0.7 0.1 0.3 -0.2
Wheeze or whistling in the chest in last year 0.2 0.4 1.4 0.3 1.0 0.5 -0.7 0.3 -0.1 0.2 0.4 1.2 0.5 0.4 0.5
Number of children fathered 0.3 0.3 1.0 -0.9 0.6 -0.0 -0.4 -0.7 -0.2 -0.2 1.0 0.2 0.3 -0.7 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 1.4 -0.4 0.4 1.2 -1.0 0.3 0.6 0.2 0.1 0.4 -0.2 -0.1 -0.1
Age at first live birth 0.2 0.3 2.1 0.1 0.1 0.6 -0.2 0.3 -0.3 -0.7 1.4 -0.2 0.3 0.1 0.5
Pulse wave peak to peak time 0.5 0.6 2.7 0.2 -0.2 0.8 -0.2 -0.5 0.5 0.9 -0.7 1.6 0.5 1.0 1.0
Health satisfaction 0.4 0.5 1.6 -0.1 -0.1 0.5 -1.2 -0.1 1.1 0.5 -0.9 1.0 -0.6 0.3 -0.5
Shortness of breath walking on level ground 0.6 0.8 2.5 0.1 0.3 -1.0 0.1 -1.6 -0.5 0.2 1.5 0.8 1.0 0.9 0.6
Qualifications: College or University degree 1.0 3.3 10.5 3.2 0.8 0.6 2.4 2.1 -2.3 2.3 -0.3 -0.5 1.8 1.6 0.4
Eye problems/disorders: None of the above 1.0 1.1 2.5 1.0 1.1 1.0 1.1 1.0 -1.6 1.6 -0.2 -0.0 1.1 1.3 0.4
Mouth/teeth dental problems: Loose teeth 0.2 0.3 1.3 0.3 0.4 -0.5 0.7 0.0 -0.2 0.4 0.1 0.5 0.5 1.1 0.7
Emphysema/chronic bronchitis 0.2 0.2 0.5 0.5 0.3 -0.1 0.4 -0.4 -0.7 0.1 0.7 0.1 0.6 0.6 0.0
Medication for pain relief, constipation, heartburn 0.2 0.3 1.0 0.1 0.6 1.0 0.3 0.6 0.2 -0.3 0.3 0.6 0.1 1.0 0.2
Neck or shoulder pain in last month 0.8 1.2 3.6 -0.9 0.0 1.9 -1.5 0.4 1.1 -1.5 -0.0 0.1 -1.4 -1.3 -0.5
Medication: Blood pressure 0.3 0.4 1.6 1.0 -0.4 -0.7 0.6 -0.2 -0.1 1.3 -0.9 -0.1 0.1 -0.9 0.3
Angina (self-reported) 0.3 0.4 1.7 -0.5 -0.1 -0.2 -0.5 -1.3 0.5 0.2 0.7 1.1 -0.1 -0.0 0.8
Migraine (self-reported) 0.5 0.6 1.8 -1.2 0.5 0.4 -1.4 -0.0 1.1 -1.2 0.3 -0.3 -0.7 -0.3 0.1
Medication: Ibuprofen 1.1 1.3 2.9 -1.5 0.2 1.2 -1.5 0.7 1.7 -1.1 -1.1 0.0 -1.6 -0.7 -0.8
Medication: Allopurinol 2.0 2.7 6.4 1.4 2.4 1.0 0.2 0.6 -0.1 2.5 0.3 2.3 1.7 1.6 2.4
Medication: Omeprazole 0.8 0.9 2.2 0.9 -0.4 -1.3 1.3 -0.1 -1.5 0.8 1.4 -0.6 1.1 -0.3 0.5
Medication: Seretide 50 evohaler 1.6 1.9 3.7 1.0 0.4 -0.5 -0.5 -1.8 -0.8 1.4 1.9 1.7 1.9 1.3 1.9
Mean time to correctly identify matches 1.4 2.6 8.8 0.7 0.5 -0.6 0.8 -0.9 0.8 2.3 1.4 3.0 1.6 1.6 2.7
Heart disease (mother) 1.3 1.6 6.4 0.5 2.5 0.9 -0.1 0.4 0.5 1.1 0.3 1.8 0.7 1.7 1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.4 -1.2 -0.7 0.5 -1.1 -1.1 0.6 0.0 -0.2 0.1 -0.7 -0.1 -0.5
Whole body fat mass 0.2 0.8 2.1 -0.6 0.2 -0.6 -0.8 -1.3 1.0 0.5 1.3 1.4 0.0 -0.7 0.9
Leg fat mass (right) 0.3 1.2 4.0 0.3 1.2 0.2 -0.6 -0.5 0.4 1.1 1.7 2.0 0.9 0.1 1.8
Arm predicted mass (right) 0.8 4.1 18.9 0.7 1.1 0.5 -0.7 -0.9 -1.2 1.3 4.3 2.3 2.4 0.5 3.5
Pulse rate, automated reading 0.7 2.2 8.5 -0.7 -0.8 -0.9 0.1 -2.9 -0.2 0.1 1.9 1.7 1.6 2.4 1.1
Alcohol intake frequency. 0.3 0.6 1.3 0.4 0.8 0.3 0.4 0.2 -0.6 0.8 0.3 1.1 1.1 1.1 1.1
Comparative height size at age 10 0.7 4.1 19.1 -2.4 -1.9 -0.8 -2.5 -2.7 0.1 -0.7 4.4 0.5 -0.0 -2.4 1.0
Number of full sisters 1.7 2.1 6.0 0.4 -0.2 -2.0 1.7 1.1 -0.7 -0.9 -2.3 -2.5 -0.9 0.0 -1.9
Suffer from ‘nerves’ 1.3 2.0 7.5 1.4 1.7 0.9 -0.4 -0.5 0.3 1.5 0.9 2.7 1.3 1.9 1.5
Overall health rating 0.6 1.2 4.6 1.4 0.5 -0.4 0.6 0.6 -0.7 2.1 0.8 1.1 1.1 1.1 1.4
Chest pain or discomfort 0.3 0.5 1.2 1.0 0.8 0.1 0.3 0.7 -0.0 1.0 0.0 1.1 0.6 0.0 1.1
Had major operations 2.0 2.3 6.6 -2.4 -2.6 -1.0 -1.0 -2.3 1.4 -0.8 0.4 -0.7 -1.5 -1.3 -1.2
Age at last live birth 0.5 0.8 2.4 1.6 0.0 0.7 1.2 0.9 -1.1 -0.2 0.9 -0.8 0.7 0.6 0.7
Family relationship satisfaction 1.2 1.4 3.4 -1.0 0.8 0.7 -1.5 0.1 1.7 -1.0 -1.8 0.1 -1.7 -0.8 -1.3
Leg pain on walking 0.8 1.0 2.9 0.3 0.9 -0.1 -1.0 -0.9 0.0 1.2 1.7 1.6 0.9 -0.4 1.3
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.9 5.8 -1.0 -1.8 -1.9 -0.7 -0.5 -0.1 -1.5 -0.8 -1.8 -1.1 -0.8 -2.4
Commuting to job workplace: Car/motor vehicle 1.2 1.4 2.7 1.4 1.1 1.0 -0.2 0.6 -1.3 1.1 1.2 1.5 1.7 1.0 1.4
Illness, injury, bereavement, stress in last 2 years 2.0 2.5 6.0 1.4 1.8 1.1 0.5 -0.3 -1.5 1.0 1.4 1.6 2.4 2.5 1.8
Medication: Aspirin 1.0 1.4 4.2 1.6 0.9 0.2 1.8 0.9 -0.9 2.1 -0.4 0.5 1.2 -0.5 1.4
Supplements: Vitamin C 0.6 0.7 2.2 0.8 0.8 0.5 0.3 -0.1 -0.7 0.1 0.4 0.7 1.5 1.4 1.2
Knee pain experienced in last month 0.8 1.3 2.7 1.6 0.3 0.6 0.3 1.3 -1.6 1.6 1.0 0.5 1.4 1.0 1.3
Hypertension (Self-reported) 0.4 1.2 3.4 1.9 -0.7 -0.4 1.8 1.0 -1.1 1.6 -1.2 0.0 0.9 0.4 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.8 9.2 2.1 0.5 -0.1 3.0 0.9 -1.2 1.3 -0.8 0.0 1.4 1.0 0.7
Illnesses of father: Heart disease 1.2 1.7 4.1 1.1 1.8 0.3 -0.0 -0.2 -0.9 1.6 0.8 1.8 1.9 1.0 2.0
Illnesses of siblings: Diabetes 0.8 1.0 2.7 1.3 -0.6 -0.8 1.6 1.2 -1.6 0.6 -0.8 -0.9 0.9 0.7 0.1
Smoking status: Previous 1.4 2.1 5.6 -1.1 1.1 1.3 -2.1 -0.3 2.4 -1.3 1.6 1.2 -1.1 -2.0 0.9
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.2 7.6 -2.2 -1.5 -0.0 -2.1 -2.8 1.0 -0.6 1.8 0.6 -0.6 -1.4 -0.1
Whole body fat-free mass 0.9 4.9 19.6 1.1 0.8 0.1 0.0 -0.9 -2.1 2.1 4.4 2.1 3.0 0.7 3.7
Leg fat-free mass (right) 0.6 3.2 11.5 0.9 0.4 -0.4 0.2 -0.8 -1.6 2.3 3.4 1.8 2.3 0.6 2.9
Arm fat percentage (left) 0.1 0.3 1.1 0.6 0.5 -0.5 0.8 0.4 0.0 1.0 -0.3 0.6 0.3 0.3 0.2
Average weekly red wine intake 0.3 0.4 1.1 -0.6 -0.1 1.1 -0.5 0.4 0.6 -0.2 -0.4 -0.1 -0.8 -0.9 -0.8
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.7 0.9 0.1 0.1 1.1 0.9 -0.0 0.3 -1.2 -1.3 -0.4 -0.5 -0.6
Mood swings 1.7 3.0 8.7 -1.0 1.4 0.9 -3.0 -1.5 2.6 -0.1 1.9 2.7 0.1 0.3 1.9
Loneliness, isolation 0.5 0.8 2.1 0.6 1.4 0.6 -0.5 1.0 -0.8 0.2 0.6 0.3 1.0 1.2 1.1
Long-standing illness, disability or infirmity 0.6 0.9 3.4 0.2 -0.6 0.2 -0.1 -0.3 0.0 1.5 1.2 1.8 0.7 0.7 1.4
Ever had bowel cancer screening 1.9 2.2 6.3 1.7 1.0 0.9 2.5 1.4 -0.3 2.3 0.3 1.2 1.0 1.9 1.4
Diabetes diagnosed by doctor 0.2 0.4 1.2 -0.5 -0.0 -0.7 0.7 -0.5 0.8 0.4 -1.1 -0.0 -0.5 -1.0 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.4 0.1 -0.4 0.1 -0.1 1.2 0.4 -0.4 -0.9 -1.0 -1.0 -1.1 -0.4
Friendships satisfaction 0.8 1.0 3.9 -1.6 -0.4 -0.4 -1.2 -2.0 1.4 -0.6 -0.0 0.4 -0.9 -0.5 -0.4
Qualifications: nursing, teaching 0.6 0.9 3.4 0.9 0.2 -0.0 0.3 -0.6 -0.8 1.9 0.4 0.9 1.4 1.2 1.0
Commuting to job workplace: Walk 1.1 1.2 4.2 -0.2 -0.4 1.3 0.3 1.7 0.1 -1.5 -0.6 -2.0 -1.0 -0.5 -1.1
Eye problems/disorders: Cataract 0.3 0.4 1.2 -0.6 0.0 -0.1 -1.0 -0.2 1.1 -1.0 0.0 0.4 -0.7 -0.4 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 5.9 0.1 0.4 0.7 -0.3 -1.2 0.2 0.0 2.4 2.0 1.1 0.7 2.0
Medication for cholesterol 2.3 3.5 6.8 -2.5 -0.8 -0.1 -2.1 -1.2 2.0 -2.5 -0.3 -1.6 -2.6 -2.2 -1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 5.0 -1.0 0.1 1.0 0.2 -1.3 -0.5 -0.1 2.2 -0.1 0.3 -0.3 1.1
Back pain experienced in last month 0.5 0.7 2.5 -0.6 -0.0 -0.3 -1.6 -0.4 0.8 -0.4 1.4 0.0 -0.6 -1.5 0.0
Mineral and other dietary supplements 0.5 0.7 1.8 -1.4 0.5 0.5 -0.8 -1.0 1.0 -0.8 0.9 1.2 -0.5 0.2 0.7
Breast cancer (self-reported) 0.6 0.7 2.2 -0.4 0.1 -1.3 -0.2 -0.1 1.3 0.0 -1.5 -0.0 -1.1 -0.4 -1.1
Asthma (self-reported) 0.4 0.9 2.2 1.0 0.5 0.3 0.3 -0.0 -0.6 1.5 0.7 1.0 1.3 1.1 1.2
Osteoporosis (self-reported) 1.1 1.4 5.1 -1.6 0.5 1.3 -2.3 -0.7 1.9 -0.7 0.4 1.3 -1.0 0.1 -0.0
Osteoarthritis (self-reported) 0.4 0.5 1.3 1.1 0.4 -0.2 0.6 0.0 -0.4 0.3 0.7 0.7 0.9 0.6 1.1
Medication: Aspirin 1.2 1.6 5.5 1.7 1.0 0.5 1.7 1.0 -0.7 2.3 -0.1 0.7 1.2 -0.5 1.8
Medication: Gliclazide 0.2 0.2 1.0 -0.2 0.6 -0.2 0.2 0.3 1.0 -0.4 -0.3 0.0 -0.4 -0.6 0.3
Illnesses of father: None of the above (group 1) 1.2 1.5 3.8 -2.0 -1.5 -0.3 -1.1 -0.9 1.5 -1.4 0.0 -0.5 -1.7 -0.7 -1.2
Smoking status: Current 1.9 3.0 10.3 -3.2 -0.6 0.1 -1.8 -0.9 2.3 -2.0 -0.4 -0.9 -2.5 -1.4 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 7.0 0.2 -1.4 -0.3 1.4 0.6 -2.6 0.1 0.5 -1.4 1.2 1.3 -0.8
Whole body water mass 0.8 4.8 19.2 1.2 0.8 0.1 0.1 -0.9 -2.1 2.0 4.4 2.0 3.0 0.7 3.6
Leg predicted mass (right) 0.6 3.1 11.8 0.8 0.4 -0.3 0.1 -0.8 -1.7 2.2 3.4 1.7 2.3 0.5 2.9
Arm fat mass (left) 0.1 0.6 1.7 0.5 0.6 -0.2 0.2 -0.2 -0.0 1.2 1.0 1.3 0.8 0.2 1.2
Number of self-reported non-cancer illnesses 0.3 0.5 2.6 0.9 0.4 0.1 0.4 0.4 -0.1 1.6 -0.2 0.6 0.6 0.9 1.0
Average weekly champagne plus white wine intake 0.7 1.0 4.6 -0.8 -0.6 -0.7 -1.4 -2.1 1.4 0.1 -0.1 1.2 0.2 -0.1 0.5
Miserableness 1.2 2.1 5.3 -0.3 1.3 1.1 -2.3 -0.9 1.4 0.8 2.1 2.1 0.4 0.9 2.0
Guilty feelings 0.7 1.1 2.8 1.3 1.7 1.3 1.0 1.4 -1.1 0.2 -0.1 -0.1 0.9 1.3 0.4
Wears glasses or contact lenses 0.5 0.6 1.9 0.1 0.9 0.7 0.1 -0.4 -0.1 0.2 1.4 1.0 1.0 0.1 1.1
Ever taken oral contraceptive pill 0.7 0.7 2.0 1.4 1.0 0.6 0.3 0.8 -0.5 1.3 -0.5 0.7 0.8 1.0 0.7
Hearing aid user 0.6 0.7 2.8 0.7 1.2 1.5 0.5 1.7 0.4 0.1 0.5 0.5 0.1 0.6 0.7
Mother’s age at death 0.2 0.2 1.0 0.1 -0.5 -1.0 -0.5 -0.6 0.5 -0.3 -0.5 -0.0 -0.1 -0.1 -0.2
Financial situation satisfaction 0.6 0.8 3.6 -0.6 0.1 -0.8 0.2 0.4 1.0 -0.7 -1.9 -0.2 -1.2 -0.9 -0.7
Tinnitus: Yes, now most or all of the time 1.3 1.5 6.3 -0.4 0.0 1.6 -2.5 -0.3 0.7 -0.3 1.7 2.0 0.1 0.1 1.1
Commuting to job workplace: Public transport 0.4 0.5 2.4 0.5 0.2 -0.7 0.8 0.5 -0.3 1.6 -0.6 0.1 0.6 0.7 0.7
Eye problems/disorders: Glaucoma 2.0 2.3 6.1 -2.3 -0.9 0.0 -2.5 -1.7 2.4 -1.7 0.1 0.4 -1.5 -1.1 -0.3
Medication: Blood pressure 2.1 3.9 9.1 2.9 0.3 0.4 3.0 2.3 -2.2 2.1 0.1 1.2 2.3 2.5 1.5
Pain type(s) experienced in last month: Hip pain 0.3 0.3 0.9 0.6 -0.4 -0.8 0.6 0.2 -0.9 0.7 0.7 -0.6 0.3 0.0 -0.3
Supplements: Fish oil (including cod liver oil) 0.2 0.2 1.1 1.1 0.6 0.1 -0.4 0.7 0.0 0.0 -0.2 -0.1 0.6 -0.3 0.1
High cholesterol (Self-reported) 1.1 1.9 4.9 2.1 0.6 0.2 1.9 2.2 -1.5 1.7 -2.0 -0.3 0.6 0.4 -0.3
Medication: Bendroflumethiazide 2.0 3.1 9.4 3.1 0.1 -0.3 2.6 1.0 -2.1 2.4 -0.3 0.6 2.3 1.7 0.9
Medication: Paracetamol 0.2 0.3 1.6 -0.4 0.0 -0.2 -1.2 0.2 1.1 -0.2 0.3 0.1 -0.9 -0.4 -0.2
Medication: Lisinopril 0.6 0.7 1.8 0.7 0.0 1.3 0.9 1.3 -0.6 1.3 0.0 0.9 0.6 0.3 0.9
Medication: Atorvastatin 0.4 0.5 2.5 0.2 -0.2 0.4 1.6 0.7 -0.0 0.7 -1.2 0.6 -0.0 0.4 -0.2
Illnesses of father: High blood pressure 0.9 1.1 2.3 1.5 0.8 0.5 1.1 1.1 -1.1 1.3 0.9 0.3 1.2 1.0 1.1
Alcohol drinker status: Never 0.6 0.7 2.1 -0.2 -0.0 -0.1 -0.1 -1.0 -1.2 0.1 1.4 0.6 1.3 1.1 0.6
Ever smoked 1.8 3.1 13.4 -2.3 0.2 0.1 -2.0 -1.2 3.7 -1.3 0.1 0.4 -2.5 -2.5 0.1
Basal metabolic rate 0.7 4.1 17.6 0.8 0.8 0.1 -0.3 -1.1 -1.6 1.9 4.2 2.1 2.6 0.5 3.4
Leg fat percentage (left) 0.3 1.2 4.7 0.2 1.7 1.1 -0.9 0.5 1.1 0.7 0.8 2.2 0.2 0.2 1.2
Arm fat-free mass (left) 0.7 3.7 17.1 0.6 1.0 0.6 -0.6 -0.8 -1.0 1.2 4.1 2.3 2.2 0.5 3.4
Number of operations (self-reported) 0.7 1.1 2.8 -0.7 -1.1 -1.0 -0.9 -1.3 1.4 -1.7 -0.2 -0.3 -1.0 -1.3 -0.5
Average weekly beer plus cider intake 0.9 1.3 4.0 -1.6 0.2 -0.2 -1.7 -1.2 2.0 -1.1 1.1 1.0 -0.9 -0.7 0.2
Irritability 0.6 0.9 2.8 0.6 1.1 1.2 -0.7 0.2 1.2 0.1 1.1 1.7 0.2 0.5 1.3
Risk taking 1.3 1.9 8.8 1.7 2.1 1.3 0.9 3.0 -1.3 0.1 -0.4 -0.4 1.0 0.8 0.6
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.1 0.1 -0.5 -1.0 1.0 -0.4 0.0 0.1 -0.3 -0.3 -0.2 -0.9 -0.3
Fractured/broken bones in last 5 years 1.3 1.7 5.4 -1.5 -0.4 0.9 -2.0 -2.0 1.1 0.4 1.4 2.3 0.1 -0.2 0.9
Age started oral contraceptive pill 1.0 1.3 3.5 -0.0 -1.8 -1.7 1.9 -1.1 -0.5 0.4 -1.4 -1.3 0.2 0.4 -0.8
Diastolic blood pressure, automated reading 0.8 2.6 8.6 2.1 -0.2 -0.4 1.2 0.0 -1.9 2.4 0.9 0.7 2.3 2.9 1.1
Ever depressed for a whole week 1.0 1.2 3.2 -1.5 -0.1 -1.0 -0.8 -1.8 1.6 -0.4 1.4 1.1 -0.0 0.3 1.3
Unable to work because of sickness or disability 1.4 1.8 6.1 0.2 0.2 1.1 -1.4 -0.8 0.4 1.9 1.7 2.5 0.9 0.1 2.0
Commuting to job workplace: Cycle 0.3 0.4 1.7 0.2 -0.7 0.4 0.1 0.2 0.5 -0.0 -1.3 -0.2 -1.0 -0.3 -0.7
Myopia 0.8 1.2 3.2 1.3 1.6 0.9 0.9 1.3 -1.2 1.8 0.6 -0.0 1.0 0.3 0.9
Vascular/heart problems diagnosed by doctor 1.2 3.3 9.4 -3.1 -0.2 0.1 -3.0 -1.9 1.9 -2.5 1.0 -0.3 -1.7 -1.3 -1.0
Cholesterol lowering medication 2.1 3.0 6.2 2.2 1.5 1.0 1.8 2.0 -1.5 2.5 -0.1 1.8 1.9 1.8 1.5
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 4.2 0.6 -0.6 -1.3 0.5 -1.3 -1.2 0.8 2.0 0.2 1.4 -0.3 1.1
Pain experienced in last month 0.5 0.9 1.7 -1.0 -0.7 -0.6 0.8 -0.5 0.4 -1.3 -1.2 -1.2 -0.8 -1.1 -1.3
Supplements: Calcium 1.1 1.2 3.8 -0.2 -1.7 -1.5 1.1 -0.1 -0.7 0.1 -0.1 -1.9 -0.6 -1.2 -1.2
Basal cell carcinoma (self-reported) 1.1 1.3 2.7 1.5 1.2 0.8 1.2 1.6 -1.2 0.9 -0.9 -0.2 0.9 1.6 0.1
Heart attack/myocardial infarction (self-reported) 1.3 1.7 7.7 1.2 0.2 0.2 2.8 0.7 -1.7 1.9 -0.8 -0.0 1.1 1.7 0.0
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 4.5 -0.8 1.1 1.4 -2.1 -0.8 1.7 -0.2 1.0 1.5 -0.1 -0.0 1.4
Heart disease (siblings) 0.7 0.9 3.6 0.7 1.1 0.5 0.3 -0.1 -0.7 0.5 1.9 0.9 1.0 0.9 1.3
Alcohol drinker status: Previous 1.0 1.1 4.5 1.0 0.5 -0.3 0.5 -0.5 -0.5 2.1 0.5 1.5 1.4 0.8 1.4
Pack years of smoking 0.1 0.2 1.0 0.1 -0.1 -0.6 0.7 0.0 0.2 -0.3 0.3 0.6 0.1 -0.1 1.0
Impedance of whole body 3.0 15.4 28.8 -5.4 -3.3 -1.3 -4.3 -4.3 5.0 -4.3 -1.7 -1.4 -5.0 -4.2 -4.1
Leg fat mass (left) 0.3 1.2 4.2 0.2 1.2 0.2 -0.6 -0.4 0.5 1.1 1.7 2.1 0.8 0.1 1.8
Arm predicted mass (left) 0.7 3.6 17.1 0.5 1.0 0.5 -0.6 -0.8 -0.9 1.3 4.1 2.2 2.1 0.2 3.4