Hub : Genes

FBLN2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1260 0.0450 0.00470 0.008 NA 0.033 NA 0.017 0.06400 NA 0.00100 NA 0.0140
2 ROSMAP Brain Pre-frontal Cortex 0.0932 0.0288 0.00046 0.001 0.031 -0.002 0.03 0.000 0.22000 5.9e-05 0.68000 7.9e-05 0.3700
3 TCGA Breast Invasive Carcinoma 0.0259 0.0107 0.00130 0.016 0.017 0.010 NA 0.012 0.00022 1.8e-04 0.00340 NA 0.0016
4 TCGA Lung Squamous Cell Carcinoma 0.0529 0.0220 0.00052 0.015 0.021 0.025 NA 0.013 0.00740 1.7e-03 0.00073 NA 0.0120

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.6 1.0 2.0 0.2 1.3 -0.4 1.4
Bipolar Disorder or Schizophrenia 0.2 0.6 1.5 0.2 1.2 -0.8 0.4
Depressed Affect (Nagel 2018) 0.2 0.5 1.6 -0.3 -0.2 0.4 -1.3
Depression (Nagel 2018) 0.2 0.3 0.7 -0.8 -0.1 0.6 -0.3
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.3 0.2 1.1 0.1 -0.3
Neuroticism (Nagel 2018) 0.2 0.5 1.2 -0.4 -0.6 -0.5 -1.1
Schizophrenia (2018) 0.2 0.3 0.4 0.4 0.6 -0.7 -0.7
Schizophrenia vs Biploar Disorder 0.5 0.6 1.3 -0.3 -1.1 0.9 0.5
Worry (Nagel 2018) 0.2 0.3 0.7 -0.6 -0.8 -0.5 -0.3
Alzheimer’s Disease (in mother) 0.4 0.5 1.7 -1.3 0.2 -0.5 0.1
Alzheimer’s Disease (in father) 1.1 1.2 3.8 2.0 0.2 0.5 -0.8
Alzheimer’s Disease (including proxy) 0.0 0.1 0.2 -0.1 -0.4 -0.1 -0.0
Crohns Disease (2017) 0.6 1.3 3.8 -2.0 -0.5 -1.0 0.5
Irritable Bowel Disease (IBD) 0.6 1.3 4.3 -2.1 -0.4 -0.9 0.3
Ulcerative Colitis (UC) 0.4 0.7 2.0 -1.4 -0.1 -0.8 -0.3
Major Depression (MDD) 0.5 0.6 1.5 -0.9 -0.1 -0.1 1.2
Reaction Time 1.8 3.4 10.2 -1.0 -3.2 -1.5 -0.4
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.5 0.4 -0.1 -1.2 -1.6
Breast Cancer 0.3 0.6 1.3 -1.2 -1.0 -0.2 0.3
Ovarian Cancer 4.0 5.3 11.4 -0.3 -2.4 -3.4 -1.9
Prostate Cancer 0.8 1.2 1.8 1.1 1.1 0.7 1.3
Age at First Birth 0.4 0.6 1.3 -0.8 -1.1 0.6 -0.1
Bipolar Disorder (2011) 1.9 1.9 7.4 0.1 2.7 0.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.3 2.4 1.1 1.5 -1.1 -0.6
Coronary Artery Disease (CAD) 0.2 0.2 0.4 -0.6 0.6 0.3 -0.4
Crohns Disease (2012) 0.5 0.8 2.8 -1.7 -0.1 -0.3 0.5
Mean Putamen Volume 1.8 2.1 3.7 0.7 -1.9 -1.7 -1.1
Fasting Glucose 0.4 0.5 0.9 0.2 0.9 -0.4 -1.0
HbA1C 0.2 0.2 0.7 0.1 -0.2 0.1 0.8
HDL Cholesterol 0.6 1.0 1.7 -0.7 -1.0 0.8 1.3
LDL Cholesterol 1.1 1.7 4.3 -0.8 -0.0 -2.1 -1.3
Lupus 0.8 1.3 4.0 -0.9 -2.0 -0.2 0.5
Neuroticism (2016) 0.5 0.8 1.6 0.5 0.5 -1.0 -1.3
Primary Biliary Cirrhosis 0.1 0.1 0.3 0.3 -0.2 -0.5 -0.4
Rheumatoid Arthritis 0.4 0.5 1.9 0.1 -0.3 -1.4 0.1
Schizophrenia (2014) 0.2 0.4 0.6 0.8 0.7 -0.7 0.3
Triglycerides 2.0 3.2 8.8 3.0 1.4 0.4 -1.4
Type 2 Diabetes (T2D) (2012) 1.2 1.4 2.5 1.6 1.1 1.3 -0.7
Ulcerative Colitis 0.1 0.1 0.2 -0.4 0.4 0.2 0.2
Blood Eosinophil Count 0.6 5.0 10.0 0.2 3.0 -3.2 -1.1
Blood Platelet Count 0.1 1.6 2.9 1.3 -1.7 0.8 1.1
Blood Red Count 0.3 2.6 5.6 -2.4 -2.2 -0.3 0.4
Blood White Count 0.1 0.7 2.4 0.2 -0.4 -1.6 -0.5
Heel T-Score 0.2 1.9 4.9 -2.2 1.3 -0.5 -0.8
BMI 0.3 1.5 3.8 0.4 0.3 -1.3 -2.0
Height 0.9 17.5 24.9 -4.7 4.2 5.0 2.3
Waist Hip Ratio (WHR) 0.0 0.0 0.1 -0.2 -0.1 0.1 0.3
Systolic Blood Pressure 0.4 2.2 5.5 0.6 -0.4 -1.7 -2.4
Smoking Status 0.3 0.8 2.2 0.3 0.4 1.5 0.8
Allergy or Eczema 0.5 1.4 2.1 1.4 1.0 -0.7 -1.4
Cardiovascular Disease 0.4 1.2 2.7 -0.0 0.6 -1.6 -1.3
Hypothyroidism (self reported) 0.6 1.3 3.4 1.1 1.8 0.2 -0.8
Respiratory disease 0.4 0.9 2.2 -1.5 -1.2 -0.4 -0.2
Type 2 Diabetes (T2D) (2018) 3.0 5.6 11.6 0.9 1.2 -2.9 -3.4
Lung FEV1/FVC ratio 0.2 1.1 4.0 2.0 -0.2 -0.4 -0.2
Lung FVC 1.0 4.9 12.3 3.5 1.3 1.7 -1.7
Neuroticism 0.2 0.5 1.2 1.1 -0.3 0.3 -0.8
Chronotype (morning person) 0.5 1.1 1.9 -1.1 -0.0 1.4 1.0
Hair Pigment 0.1 2.0 4.6 -1.5 -0.2 0.9 2.1
Tanning 0.0 0.6 1.1 -0.4 1.1 -0.3 -1.0
Hand grip strength (left) 1.0 2.6 4.2 2.0 2.0 0.9 -1.3
Number of treatments/medications taken 0.5 1.0 2.2 -0.8 -1.5 -0.9 -0.4
Average weekly spirits intake 0.4 0.5 0.8 -0.8 -0.7 -0.9 0.5
Sensitivity / hurt feelings 0.5 0.8 1.2 -0.9 -1.0 -1.1 0.4
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.0 -1.0 -0.7 -0.0 -0.8
Hearing difficulty/problems: Yes 1.2 1.8 4.5 -0.0 -1.4 -0.8 -2.1
Relative age of first facial hair 0.2 0.3 0.5 -0.1 0.7 0.7 0.6
Other serious medical condition/disability diagnosed by doctor 0.3 0.3 0.9 -1.0 -0.2 0.5 0.2
Ever used hormone-replacement therapy (HRT) 0.8 1.1 2.8 -1.1 -0.5 0.4 1.7
Ever had hysterectomy (womb removed) 0.4 0.4 1.5 -0.1 -1.2 -0.5 0.3
Systolic blood pressure, automated reading 1.2 3.5 6.7 -1.5 -1.0 -2.0 -2.6
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 0.9 -0.3 -0.3 -0.9 0.2
Angina 1.1 1.4 3.3 -0.5 -1.8 -1.3 -0.6
Medication for hormone replacement therapy 1.7 2.0 3.5 1.5 -1.9 0.5 1.4
Vitamin and mineral supplements 0.3 0.4 1.0 -1.0 0.6 -0.6 0.3
Supplements: Zinc 1.2 1.3 2.5 1.6 1.6 0.6 0.1
Medication: Co-codamol 0.7 0.8 1.4 -1.2 1.2 0.5 0.3
Medication: Metformin 0.4 0.6 1.0 0.7 0.4 -1.0 -0.9
Diabetes (father) 1.4 1.8 4.1 0.9 -0.7 -2.0 -1.3
Diabetes (mother) 1.2 1.5 3.1 0.1 -1.1 -1.8 -1.3
Severe depression (siblings) 0.8 0.9 2.7 0.2 -0.9 -1.6 0.0
Pack years adult smoking proportion 1.1 1.7 2.4 -1.4 1.3 -1.5 -0.8
Impedance of leg (right) 2.4 11.6 25.0 -3.2 -1.7 2.9 5.0
Leg fat-free mass (left) 0.5 2.5 8.0 0.1 2.8 1.0 -1.1
Trunk fat percentage 1.7 6.8 13.6 -3.7 -1.3 1.1 3.3
Hand grip strength (right) 0.9 2.5 4.3 1.9 2.1 1.1 -1.0
Townsend deprivation index at recruitment 0.5 0.8 1.7 -1.0 0.5 0.4 1.3
Current tobacco smoking 0.3 0.5 1.4 -0.3 -0.4 -0.7 -1.2
Average weekly fortified wine intake 0.9 1.0 2.1 -1.1 -0.8 -1.4 -0.6
Maternal smoking around birth 1.5 2.2 4.8 1.4 2.2 1.0 1.0
Fed-up feelings 0.3 0.5 0.7 -0.8 -0.8 0.7 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.6 -0.4 -0.8 0.5 -0.0
Relative age voice broke 0.2 0.3 0.5 -0.7 -0.7 0.4 -0.2
Taking other prescription medications 0.9 1.4 2.7 -1.7 -1.5 -0.7 0.5
Age when periods started (menarche) 2.2 5.3 10.1 -1.9 -3.2 -2.1 -1.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.5 -0.1 -1.2 -0.1 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 4.7 -2.2 0.1 -0.4 0.4
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 6.1 -0.1 0.3 1.2 2.5
Qualifications: CSEs or equivalent 2.5 3.3 7.2 0.9 0.4 2.3 2.7
Serious illness, injury or assault to yourself 1.6 1.9 4.8 0.5 -0.1 2.2 1.7
High blood pressure 0.6 1.8 3.7 -0.7 -0.0 -1.7 -1.9
Hayfever, allergic rhinitis or eczema 0.4 1.0 1.8 1.4 0.6 -0.8 -1.0
Multivitamins +/- minerals 0.8 1.0 2.7 1.7 0.5 -0.6 -0.8
Stomach or abdominal pain in last month 0.3 0.3 1.2 0.0 0.2 -1.1 -0.3
Supplements: Glucosamine 1.2 1.5 3.5 0.0 0.8 1.9 1.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.7 0.4 0.9 0.8 0.4
Medication: Atenolol 0.2 0.2 0.4 -0.4 -0.6 -0.5 -0.1
Medication: Levothyroxine sodium 0.5 0.9 2.6 0.9 1.6 -0.1 -0.4
Sitting height 0.5 3.7 10.6 0.5 3.3 1.9 -0.7
Chronic bronchitis/emphysema (father) 0.2 0.2 0.4 -0.4 0.3 0.6 0.5
High blood pressure (mother) 2.7 3.7 7.9 1.5 2.8 -1.2 -1.8
Body mass index (BMI) 0.1 0.2 0.5 -0.1 0.6 -0.7 -0.1
Impedance of leg (left) 2.8 13.8 31.6 -3.2 -1.6 3.4 5.6
Leg predicted mass (left) 0.5 2.6 8.4 0.1 2.9 0.9 -1.2
Trunk fat mass 0.9 4.0 8.3 -2.9 0.2 1.4 2.4
Waist circumference 0.2 0.7 1.3 -1.0 1.1 0.4 0.6
Number of incorrect matches in round 0.5 0.9 2.3 -0.0 -0.6 1.0 1.5
Past tobacco smoking 2.3 4.3 9.9 -1.1 -1.8 -3.1 -1.7
Alcohol usually taken with meals 0.5 0.8 3.0 0.2 1.7 0.3 -0.2
Nervous feelings 0.7 1.2 3.4 -0.1 -1.8 -1.0 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.5 -0.5 -0.3 0.7 0.2
Hearing difficulty/problems with background noise 0.5 0.8 1.6 -0.3 -0.7 1.1 -1.2
Hair/balding pattern: Pattern 2 0.2 0.3 0.7 0.2 0.8 0.5 -0.5
Had menopause 0.1 0.2 0.7 -0.0 -0.1 -0.2 0.8
Had other major operations 0.7 0.8 3.0 0.2 1.7 0.5 0.1
Forced vital capacity (FVC) 0.6 2.2 5.4 1.2 1.2 2.3 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 3.7 -1.9 0.4 -1.3 -0.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.6 -0.7 0.1 0.8 0.5
Qualifications: None of the above 0.3 0.6 1.9 -1.4 -0.4 0.4 -0.0
Financial difficulties in last 2 years 0.3 0.4 0.9 0.8 1.0 0.1 0.3
Mouth/teeth dental problems 2.4 3.6 5.5 1.6 -1.4 2.1 2.3
Heart attack 0.7 0.9 3.2 0.1 -1.8 -0.1 0.6
Allergy 0.2 0.4 1.1 -1.1 -0.5 0.2 0.2
Pain all over the body in last month 0.6 0.7 1.5 -0.1 -1.2 1.1 0.0
Diabetes (self-reported) 1.3 2.0 3.1 -0.1 1.8 -1.5 -1.6
Hayfever/allergic rhinitis (self-reported) 0.9 1.3 3.9 0.2 0.4 -2.0 -1.0
Medication: Ramipril 0.1 0.1 0.3 -0.5 0.0 -0.4 -0.2
Medication: Simvastatin 0.3 0.4 0.8 0.9 0.5 -0.4 -0.8
Fluid intelligence score 0.1 0.2 0.4 -0.2 -0.4 -0.6 -0.2
Illnesses of siblings 0.3 0.4 0.7 -0.7 -0.7 0.8 0.1
Neuroticism score 0.1 0.3 0.3 0.6 -0.6 0.6 0.2
Weight 0.4 1.9 4.2 -1.3 2.0 1.1 0.6
Impedance of arm (right) 2.5 11.6 26.0 -5.1 -3.2 0.1 3.2
Arm fat percentage (right) 0.6 2.6 6.1 -2.5 -1.1 -0.6 1.6
Trunk fat-free mass 1.1 6.1 18.5 1.1 4.3 1.3 -1.6
Hip circumference 0.4 1.7 3.0 -1.7 1.5 0.8 0.9
Time employed in main current job 1.6 1.9 3.6 -1.6 -1.1 -1.9 0.1
Alcohol intake versus 10 years previously 0.7 1.0 1.4 -1.2 -0.4 1.1 1.1
Father’s age at death 0.2 0.3 0.6 -0.6 -0.1 -0.3 -0.8
Worrier / anxious feelings 0.6 1.0 2.1 -0.9 -1.4 -1.0 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.3 0.0 0.3 0.5 -0.1
Falls in the last year 0.7 1.0 2.0 -0.6 -0.8 -1.0 -1.4
Hair/balding pattern: Pattern 3 1.0 1.5 2.9 -0.2 -1.5 -1.7 -0.7
Number of live births 0.2 0.3 0.6 -0.3 -0.8 0.2 0.5
Forced expiratory volume in 1-second (FEV1) 0.9 2.9 5.1 2.1 1.4 2.2 -0.3
Pulse rate 0.5 0.8 1.9 -0.8 -1.4 -0.4 0.7
Happiness 0.8 0.9 1.9 -0.4 -1.4 -1.1 -0.6
Noisy workplace 0.8 1.0 2.0 1.1 1.4 0.2 0.6
Qualifications: A levels/AS levels or equivalent 0.4 1.0 2.0 -0.2 0.0 -1.4 -1.4
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.1 2.7 1.6 1.1 -1.4 -1.6
Mouth/teeth dental problems: Dentures 1.0 1.7 3.3 -1.2 0.6 -1.8 -1.4
Asthma 0.3 0.5 0.8 -0.8 -0.6 0.9 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.2 0.7 -0.1 1.1 -0.0
Medication: Cholesterol lowering 0.7 1.1 2.1 0.0 0.5 1.5 1.4
Depression (self-reported) 0.4 0.5 0.9 -0.3 -0.3 -1.0 -0.9
Medication: Lansoprazole 1.4 1.6 3.3 -0.8 -0.4 -1.8 -1.5
Prospective memory result 2.6 3.2 6.7 0.7 1.6 2.6 1.8
Lung cancer (father) 1.0 1.2 2.6 1.1 -0.6 1.6 0.7
Illnesses of mother 0.8 1.0 2.9 -0.4 -1.7 0.8 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 3.8 1.9 1.2 1.9 -0.3
Pulse wave Arterial Stiffness index 2.0 2.4 5.3 -0.4 0.9 2.3 1.8
Impedance of arm (left) 2.7 12.3 25.7 -5.1 -3.7 0.2 3.1
Arm fat mass (right) 0.3 1.3 3.1 -1.8 0.4 0.3 1.3
Trunk predicted mass 1.1 6.2 19.0 1.1 4.4 1.4 -1.6
Standing height 0.9 9.2 18.7 -2.2 3.2 4.3 1.6
Length of working week for main job 0.3 0.3 0.9 -0.2 -1.0 -0.5 0.1
Exposure to tobacco smoke at home 0.7 0.7 1.1 -0.8 1.1 0.7 0.8
Breastfed as a baby 0.2 0.2 0.5 -0.4 -0.2 -0.1 0.7
Tense / ‘highly strung’ 0.0 0.1 0.1 -0.2 0.2 -0.4 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 0.8 0.9 0.9 0.6 -0.2
Hair/balding pattern: Pattern 4 0.3 0.7 1.3 0.2 -1.1 0.4 1.1
Birth weight of first child 0.2 0.4 1.2 0.0 -1.1 0.1 0.7
Peak expiratory flow (PEF) 1.2 2.8 5.2 2.0 2.3 1.4 -0.2
Pulse wave reflection index 2.0 2.4 6.3 2.5 1.2 1.4 -0.2
Ever highly irritable/argumentative for 2 days 2.7 3.3 5.3 1.4 1.1 2.1 2.3
Loud music exposure frequency 1.4 1.5 3.1 0.2 0.9 1.8 1.4
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.5 0.8 0.3 -0.9 -1.2
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 3.5 -1.1 1.1 -1.9 -1.8
Blood clot in the leg (DVT) 1.2 1.6 3.3 1.8 -1.6 -0.6 -0.2
Medication: Paracetamol 0.0 0.0 0.2 0.0 0.0 -0.4 -0.1
Headache pain in last month 1.1 1.9 3.8 1.9 0.5 -0.8 -1.7
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.7 -0.1 0.2 0.8 0.9
Glaucoma (self-reported) 2.0 2.4 7.3 -2.7 -1.4 -0.4 0.1
Gout (self-reported) 0.8 1.1 2.3 -1.1 -1.5 0.3 0.8
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.9 0.8 1.4 0.2 -0.1
Medication: Amlodipine 2.3 3.2 5.4 -1.8 -2.3 -1.8 -0.7
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 0.1 0.5 0.2 -0.1
Birth weight 0.3 0.6 1.8 -0.7 1.3 0.2 -0.2
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.6 0.6 0.6 0.2 0.8
High blood pressure (siblings) 0.3 0.5 1.0 0.4 1.0 -0.5 -0.6
Forced vital capacity (FVC), Best measure 0.7 2.4 6.1 1.0 1.5 2.5 -0.3
Body fat percentage 1.5 5.8 11.1 -3.3 -1.1 1.0 3.2
Leg fat percentage (right) 0.8 3.0 7.2 -2.7 -0.4 0.3 2.2
Arm fat-free mass (right) 1.0 5.2 15.0 1.1 3.9 2.1 -0.6
Exposure to tobacco smoke outside home 1.9 2.5 5.0 0.4 1.6 2.2 1.6
Comparative body size at age 10 0.3 0.8 1.9 1.4 0.5 -0.3 -1.0
Number of full brothers 1.7 2.1 6.1 0.3 1.0 2.5 1.1
Worry too long after embarrassment 0.1 0.2 0.3 0.2 -0.5 -0.6 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 3.4 -1.9 -1.5 -0.4 0.4
Wheeze or whistling in the chest in last year 0.3 0.5 1.8 0.1 1.4 0.5 -0.2
Number of children fathered 1.1 1.2 3.5 0.0 1.9 0.8 0.7
Reason for reducing amount of alcohol drunk: Health precaution 2.7 3.2 11.4 -0.9 -3.4 -0.7 -0.0
Age at first live birth 0.7 1.2 3.5 1.9 0.5 -0.7 -0.6
Pulse wave peak to peak time 1.7 2.0 4.4 0.1 -0.7 -2.1 -1.8
Health satisfaction 0.6 0.8 2.0 -0.6 -1.0 -1.4 0.2
Shortness of breath walking on level ground 0.8 1.0 2.2 0.7 -0.7 -0.8 -1.5
Qualifications: College or University degree 0.6 1.9 3.7 -0.0 -0.1 -1.9 -1.9
Eye problems/disorders: None of the above 0.8 1.0 2.0 1.4 0.3 0.6 1.2
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.1 0.1 0.3 0.2 -0.0
Emphysema/chronic bronchitis 0.7 0.8 1.7 -1.1 1.3 0.5 -0.3
Medication for pain relief, constipation, heartburn 0.0 0.0 0.1 -0.1 -0.1 0.1 -0.4
Neck or shoulder pain in last month 1.2 1.7 5.1 0.2 -0.2 -2.3 -1.2
Medication: Blood pressure 0.5 0.9 1.8 -0.5 -0.1 -1.3 -1.4
Angina (self-reported) 0.9 1.2 2.4 -0.1 -1.6 -1.2 -1.0
Migraine (self-reported) 1.9 2.4 4.5 -0.3 1.7 -2.1 -1.4
Medication: Ibuprofen 0.0 0.0 0.1 -0.0 -0.2 -0.1 -0.3
Medication: Allopurinol 0.2 0.3 0.6 -0.8 -0.4 0.6 0.4
Medication: Omeprazole 0.1 0.1 0.3 -0.2 -0.1 -0.2 0.5
Medication: Seretide 50 evohaler 0.3 0.4 0.6 -0.8 0.8 0.0 0.6
Mean time to correctly identify matches 2.2 4.1 11.6 -1.7 -3.4 -1.4 0.0
Heart disease (mother) 0.5 0.6 0.9 1.0 1.0 -0.3 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 3.0 -1.7 0.6 -0.4 1.2
Whole body fat mass 0.8 3.5 6.1 -2.5 0.4 1.5 2.4
Leg fat mass (right) 0.5 2.1 3.9 -2.0 0.7 1.1 1.7
Arm predicted mass (right) 1.0 5.3 14.7 1.3 3.8 2.1 -0.6
Pulse rate, automated reading 0.6 1.8 2.8 -1.5 -1.7 -1.5 0.1
Alcohol intake frequency. 0.5 1.2 3.3 -1.1 -0.5 1.8 0.2
Comparative height size at age 10 1.0 5.7 13.0 -1.7 1.5 3.6 2.1
Number of full sisters 1.6 1.9 3.0 1.7 1.5 1.6 -0.0
Suffer from ‘nerves’ 1.0 1.6 2.9 -0.5 -1.7 -1.4 -1.1
Overall health rating 1.6 3.5 10.4 -1.6 -3.2 -0.3 0.9
Chest pain or discomfort 0.2 0.3 0.9 0.3 -0.1 -0.2 -1.0
Had major operations 2.8 3.3 8.6 -2.9 -0.8 0.5 2.0
Age at last live birth 0.7 1.0 2.7 1.6 0.1 -0.5 -1.0
Family relationship satisfaction 0.2 0.3 0.6 0.5 0.8 -0.3 0.5
Leg pain on walking 0.5 0.6 1.4 -1.2 1.0 -0.2 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 3.0 0.9 1.7 -0.2 -0.4
Commuting to job workplace: Car/motor vehicle 0.9 1.1 2.1 1.5 0.4 -1.0 -1.0
Illness, injury, bereavement, stress in last 2 years 1.2 1.4 3.3 -1.8 -1.5 0.1 0.5
Medication: Aspirin 0.7 0.9 2.8 -0.1 -0.6 -1.7 -0.6
Supplements: Vitamin C 0.2 0.2 0.5 0.3 -0.5 0.7 0.3
Knee pain experienced in last month 0.9 1.4 2.3 -0.9 -1.3 0.8 1.5
Hypertension (Self-reported) 0.8 2.1 4.4 -0.6 -0.2 -1.9 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 2.5 0.6 -1.6 -0.4 0.6
Illnesses of father: Heart disease 0.5 0.7 1.3 -1.1 0.6 -0.4 0.9
Illnesses of siblings: Diabetes 2.0 2.5 6.1 0.1 -1.6 -2.5 -1.2
Smoking status: Previous 1.9 2.8 7.8 0.6 1.0 2.8 1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 7.3 0.8 1.6 2.7 1.1
Whole body fat-free mass 0.8 4.8 15.0 0.7 3.9 1.3 -1.4
Leg fat-free mass (right) 0.5 2.9 8.8 0.3 3.0 1.0 -1.3
Arm fat percentage (left) 0.7 2.7 6.6 -2.6 -1.3 -0.5 1.5
Average weekly red wine intake 0.2 0.2 0.5 0.7 -0.0 0.5 -0.3
Handedness (chirality/laterality): Left-handed 0.7 0.9 3.5 1.9 0.0 0.1 0.2
Mood swings 0.3 0.5 0.8 -0.8 -0.9 0.8 0.3
Loneliness, isolation 0.7 0.9 2.9 0.8 0.3 0.2 -1.7
Long-standing illness, disability or infirmity 0.3 0.5 1.1 0.3 -0.9 -1.0 -0.2
Ever had bowel cancer screening 0.4 0.4 1.2 -0.6 -0.2 -1.1 0.1
Diabetes diagnosed by doctor 1.7 2.8 4.9 0.6 1.2 -2.1 -2.2
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 1.3 1.1 0.4 -0.1 0.1
Friendships satisfaction 0.5 0.7 1.8 0.6 1.3 0.8 -0.0
Qualifications: nursing, teaching 0.0 0.1 0.2 -0.0 -0.2 0.4 0.1
Commuting to job workplace: Walk 0.8 0.9 2.0 -1.1 -1.4 -0.4 0.4
Eye problems/disorders: Cataract 0.1 0.2 0.3 -0.3 -0.5 0.5 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.7 -1.3 0.3 0.9 0.3
Medication for cholesterol 0.9 1.4 3.3 0.1 1.8 1.5 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 2.1 1.4 1.3 1.1 0.9
Back pain experienced in last month 1.0 1.4 2.1 1.2 1.4 -0.6 -1.4
Mineral and other dietary supplements 0.3 0.3 1.0 -0.4 1.0 -0.4 0.2
Breast cancer (self-reported) 1.2 1.4 2.5 0.5 1.2 1.6 1.2
Asthma (self-reported) 0.3 0.5 0.9 -0.9 -0.3 1.0 0.5
Osteoporosis (self-reported) 0.7 0.9 2.3 -0.2 -0.2 1.1 1.5
Osteoarthritis (self-reported) 3.5 4.6 8.4 -2.8 0.0 1.5 2.9
Medication: Aspirin 0.5 0.6 1.7 -0.1 -0.9 -1.3 -0.3
Medication: Gliclazide 0.3 0.3 0.9 1.0 -0.5 0.1 -0.4
Illnesses of father: None of the above (group 1) 1.6 2.0 3.9 2.0 1.2 1.7 -0.1
Smoking status: Current 0.2 0.3 0.6 -0.6 -0.1 -0.4 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 4.1 1.6 -0.2 -1.4 -2.0
Whole body water mass 0.9 4.9 15.2 0.8 3.9 1.4 -1.3
Leg predicted mass (right) 0.5 2.8 8.7 0.3 2.9 0.9 -1.3
Arm fat mass (left) 0.3 1.1 3.2 -1.8 0.1 0.2 1.1
Number of self-reported non-cancer illnesses 0.3 0.6 1.3 -1.1 -0.8 0.2 0.6
Average weekly champagne plus white wine intake 0.8 1.1 2.4 -1.4 0.1 -1.6 -0.0
Miserableness 0.1 0.2 0.4 -0.3 0.6 -0.2 -0.4
Guilty feelings 1.9 2.9 5.5 2.4 0.8 -0.7 -2.2
Wears glasses or contact lenses 0.3 0.3 0.8 -0.2 -0.9 0.2 0.7
Ever taken oral contraceptive pill 0.7 0.8 2.3 1.5 0.9 0.1 0.1
Hearing aid user 0.9 1.0 2.6 1.0 -1.6 0.5 -0.1
Mother’s age at death 0.4 0.5 1.0 -0.1 -0.5 -1.0 -0.9
Financial situation satisfaction 0.6 0.8 2.0 0.6 -0.7 -1.4 -0.4
Tinnitus: Yes, now most or all of the time 0.0 0.0 0.1 0.0 -0.1 0.3 0.3
Commuting to job workplace: Public transport 0.3 0.4 0.6 -0.8 -0.4 0.7 0.5
Eye problems/disorders: Glaucoma 2.9 3.5 8.0 -2.8 -1.7 -1.4 -1.0
Medication: Blood pressure 0.7 1.3 2.5 -0.6 -1.6 -1.3 -0.8
Pain type(s) experienced in last month: Hip pain 1.3 1.6 3.0 0.1 1.6 1.7 0.8
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.8 -0.6 -0.2 -0.6 -1.4
High cholesterol (Self-reported) 0.6 1.1 2.4 -0.1 0.7 1.2 1.6
Medication: Bendroflumethiazide 1.3 2.0 4.1 -0.3 -1.1 -2.0 -1.6
Medication: Paracetamol 0.1 0.2 0.4 0.3 0.2 -0.6 -0.6
Medication: Lisinopril 2.4 3.1 6.0 -0.1 -1.0 -2.4 -2.3
Medication: Atorvastatin 1.4 1.8 4.1 -1.1 -1.2 0.5 2.0
Illnesses of father: High blood pressure 1.1 1.3 3.5 -1.9 -1.1 -0.4 0.5
Alcohol drinker status: Never 0.2 0.2 0.4 -0.3 -0.3 0.6 -0.4
Ever smoked 1.5 2.6 4.9 0.9 1.9 2.2 1.0
Basal metabolic rate 0.7 3.7 12.1 0.2 3.5 1.4 -0.8
Leg fat percentage (left) 1.0 3.5 6.9 -2.5 -0.1 0.7 2.6
Arm fat-free mass (left) 1.0 4.9 15.8 0.7 4.0 1.8 -0.4
Number of operations (self-reported) 0.9 1.3 4.0 -2.0 -0.5 0.1 1.0
Average weekly beer plus cider intake 1.6 2.3 4.2 0.8 1.5 2.1 1.4
Irritability 0.2 0.4 0.8 0.3 -0.0 0.8 0.9
Risk taking 0.5 0.7 1.6 0.7 1.3 -0.5 -0.7
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.8 -1.0 -0.2 -1.3 -1.0
Fractured/broken bones in last 5 years 2.3 3.0 7.2 -0.6 -1.1 2.7 1.7
Age started oral contraceptive pill 2.0 2.5 3.9 -1.4 -1.5 -1.4 -2.0
Diastolic blood pressure, automated reading 1.6 4.8 9.6 -1.5 0.5 -2.7 -3.1
Ever depressed for a whole week 1.3 1.6 4.3 -2.1 -1.1 0.5 0.7
Unable to work because of sickness or disability 1.9 2.5 7.7 -1.2 -2.8 -0.8 -0.4
Commuting to job workplace: Cycle 1.1 1.3 1.8 -1.2 -1.0 -1.3 -1.0
Myopia 0.0 0.1 0.1 -0.3 0.3 -0.3 -0.0
Vascular/heart problems diagnosed by doctor 0.7 2.0 4.0 0.8 0.1 2.0 1.8
Cholesterol lowering medication 0.8 1.2 1.9 -1.3 -1.0 -1.4 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.3 0.2 -0.3 -0.2 0.6
Pain experienced in last month 0.4 0.7 1.3 0.8 -0.8 -0.7 -1.2
Supplements: Calcium 1.1 1.2 2.3 1.5 -0.1 1.2 1.1
Basal cell carcinoma (self-reported) 0.2 0.2 0.3 0.5 0.1 0.6 0.4
Heart attack/myocardial infarction (self-reported) 0.7 0.9 3.1 -0.1 -1.7 -0.3 0.7
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 3.3 1.8 -1.2 -0.7 -0.2
Heart disease (siblings) 0.3 0.4 1.2 -0.0 0.2 -0.5 -1.1
Alcohol drinker status: Previous 0.8 0.9 3.0 -0.3 0.2 1.7 0.6
Pack years of smoking 1.2 1.8 3.0 -1.7 1.0 -1.6 -0.8
Impedance of whole body 2.7 13.5 21.3 -4.6 -3.0 1.7 4.5
Leg fat mass (left) 0.6 2.2 3.4 -1.9 0.8 1.3 1.8
Arm predicted mass (left) 1.0 5.1 15.6 0.7 4.0 2.0 -0.3