Hub : Genes

FBLN2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1260	0.0450	0.00470	0.008	NA	0.033	NA	0.017	0.06400	NA	0.00100	NA	0.0140
2	ROSMAP	Brain Pre-frontal Cortex	0.0932	0.0288	0.00046	0.001	0.031	-0.002	0.03	0.000	0.22000	5.9e-05	0.68000	7.9e-05	0.3700
3	TCGA	Breast Invasive Carcinoma	0.0259	0.0107	0.00130	0.016	0.017	0.010	NA	0.012	0.00022	1.8e-04	0.00340	NA	0.0016
4	TCGA	Lung Squamous Cell Carcinoma	0.0529	0.0220	0.00052	0.015	0.021	0.025	NA	0.013	0.00740	1.7e-03	0.00073	NA	0.0120

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	2.0	0.2	1.3	-0.4	1.4
Bipolar Disorder or Schizophrenia	0.2	0.6	1.5	0.2	1.2	-0.8	0.4
Depressed Affect (Nagel 2018)	0.2	0.5	1.6	-0.3	-0.2	0.4	-1.3
Depression (Nagel 2018)	0.2	0.3	0.7	-0.8	-0.1	0.6	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.3	0.2	1.1	0.1	-0.3
Neuroticism (Nagel 2018)	0.2	0.5	1.2	-0.4	-0.6	-0.5	-1.1
Schizophrenia (2018)	0.2	0.3	0.4	0.4	0.6	-0.7	-0.7
Schizophrenia vs Biploar Disorder	0.5	0.6	1.3	-0.3	-1.1	0.9	0.5
Worry (Nagel 2018)	0.2	0.3	0.7	-0.6	-0.8	-0.5	-0.3
Alzheimer’s Disease (in mother)	0.4	0.5	1.7	-1.3	0.2	-0.5	0.1
Alzheimer’s Disease (in father)	1.1	1.2	3.8	2.0	0.2	0.5	-0.8
Alzheimer’s Disease (including proxy)	0.0	0.1	0.2	-0.1	-0.4	-0.1	-0.0
Crohns Disease (2017)	0.6	1.3	3.8	-2.0	-0.5	-1.0	0.5
Irritable Bowel Disease (IBD)	0.6	1.3	4.3	-2.1	-0.4	-0.9	0.3
Ulcerative Colitis (UC)	0.4	0.7	2.0	-1.4	-0.1	-0.8	-0.3
Major Depression (MDD)	0.5	0.6	1.5	-0.9	-0.1	-0.1	1.2
Reaction Time	1.8	3.4	10.2	-1.0	-3.2	-1.5	-0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.5	0.4	-0.1	-1.2	-1.6
Breast Cancer	0.3	0.6	1.3	-1.2	-1.0	-0.2	0.3
Ovarian Cancer	4.0	5.3	11.4	-0.3	-2.4	-3.4	-1.9
Prostate Cancer	0.8	1.2	1.8	1.1	1.1	0.7	1.3
Age at First Birth	0.4	0.6	1.3	-0.8	-1.1	0.6	-0.1
Bipolar Disorder (2011)	1.9	1.9	7.4	0.1	2.7	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.3	2.4	1.1	1.5	-1.1	-0.6
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.6	0.6	0.3	-0.4
Crohns Disease (2012)	0.5	0.8	2.8	-1.7	-0.1	-0.3	0.5
Mean Putamen Volume	1.8	2.1	3.7	0.7	-1.9	-1.7	-1.1
Fasting Glucose	0.4	0.5	0.9	0.2	0.9	-0.4	-1.0
HbA1C	0.2	0.2	0.7	0.1	-0.2	0.1	0.8
HDL Cholesterol	0.6	1.0	1.7	-0.7	-1.0	0.8	1.3
LDL Cholesterol	1.1	1.7	4.3	-0.8	-0.0	-2.1	-1.3
Lupus	0.8	1.3	4.0	-0.9	-2.0	-0.2	0.5
Neuroticism (2016)	0.5	0.8	1.6	0.5	0.5	-1.0	-1.3
Primary Biliary Cirrhosis	0.1	0.1	0.3	0.3	-0.2	-0.5	-0.4
Rheumatoid Arthritis	0.4	0.5	1.9	0.1	-0.3	-1.4	0.1
Schizophrenia (2014)	0.2	0.4	0.6	0.8	0.7	-0.7	0.3
Triglycerides	2.0	3.2	8.8	3.0	1.4	0.4	-1.4
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.5	1.6	1.1	1.3	-0.7
Ulcerative Colitis	0.1	0.1	0.2	-0.4	0.4	0.2	0.2
Blood Eosinophil Count	0.6	5.0	10.0	0.2	3.0	-3.2	-1.1
Blood Platelet Count	0.1	1.6	2.9	1.3	-1.7	0.8	1.1
Blood Red Count	0.3	2.6	5.6	-2.4	-2.2	-0.3	0.4
Blood White Count	0.1	0.7	2.4	0.2	-0.4	-1.6	-0.5
Heel T-Score	0.2	1.9	4.9	-2.2	1.3	-0.5	-0.8
BMI	0.3	1.5	3.8	0.4	0.3	-1.3	-2.0
Height	0.9	17.5	24.9	-4.7	4.2	5.0	2.3
Waist Hip Ratio (WHR)	0.0	0.0	0.1	-0.2	-0.1	0.1	0.3
Systolic Blood Pressure	0.4	2.2	5.5	0.6	-0.4	-1.7	-2.4
Smoking Status	0.3	0.8	2.2	0.3	0.4	1.5	0.8
Allergy or Eczema	0.5	1.4	2.1	1.4	1.0	-0.7	-1.4
Cardiovascular Disease	0.4	1.2	2.7	-0.0	0.6	-1.6	-1.3
Hypothyroidism (self reported)	0.6	1.3	3.4	1.1	1.8	0.2	-0.8
Respiratory disease	0.4	0.9	2.2	-1.5	-1.2	-0.4	-0.2
Type 2 Diabetes (T2D) (2018)	3.0	5.6	11.6	0.9	1.2	-2.9	-3.4
Lung FEV1/FVC ratio	0.2	1.1	4.0	2.0	-0.2	-0.4	-0.2
Lung FVC	1.0	4.9	12.3	3.5	1.3	1.7	-1.7
Neuroticism	0.2	0.5	1.2	1.1	-0.3	0.3	-0.8
Chronotype (morning person)	0.5	1.1	1.9	-1.1	-0.0	1.4	1.0
Hair Pigment	0.1	2.0	4.6	-1.5	-0.2	0.9	2.1
Tanning	0.0	0.6	1.1	-0.4	1.1	-0.3	-1.0
Hand grip strength (left)	1.0	2.6	4.2	2.0	2.0	0.9	-1.3
Number of treatments/medications taken	0.5	1.0	2.2	-0.8	-1.5	-0.9	-0.4
Average weekly spirits intake	0.4	0.5	0.8	-0.8	-0.7	-0.9	0.5
Sensitivity / hurt feelings	0.5	0.8	1.2	-0.9	-1.0	-1.1	0.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.0	-1.0	-0.7	-0.0	-0.8
Hearing difficulty/problems: Yes	1.2	1.8	4.5	-0.0	-1.4	-0.8	-2.1
Relative age of first facial hair	0.2	0.3	0.5	-0.1	0.7	0.7	0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.9	-1.0	-0.2	0.5	0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.8	-1.1	-0.5	0.4	1.7
Ever had hysterectomy (womb removed)	0.4	0.4	1.5	-0.1	-1.2	-0.5	0.3
Systolic blood pressure, automated reading	1.2	3.5	6.7	-1.5	-1.0	-2.0	-2.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.9	-0.3	-0.3	-0.9	0.2
Angina	1.1	1.4	3.3	-0.5	-1.8	-1.3	-0.6
Medication for hormone replacement therapy	1.7	2.0	3.5	1.5	-1.9	0.5	1.4
Vitamin and mineral supplements	0.3	0.4	1.0	-1.0	0.6	-0.6	0.3
Supplements: Zinc	1.2	1.3	2.5	1.6	1.6	0.6	0.1
Medication: Co-codamol	0.7	0.8	1.4	-1.2	1.2	0.5	0.3
Medication: Metformin	0.4	0.6	1.0	0.7	0.4	-1.0	-0.9
Diabetes (father)	1.4	1.8	4.1	0.9	-0.7	-2.0	-1.3
Diabetes (mother)	1.2	1.5	3.1	0.1	-1.1	-1.8	-1.3
Severe depression (siblings)	0.8	0.9	2.7	0.2	-0.9	-1.6	0.0
Pack years adult smoking proportion	1.1	1.7	2.4	-1.4	1.3	-1.5	-0.8
Impedance of leg (right)	2.4	11.6	25.0	-3.2	-1.7	2.9	5.0
Leg fat-free mass (left)	0.5	2.5	8.0	0.1	2.8	1.0	-1.1
Trunk fat percentage	1.7	6.8	13.6	-3.7	-1.3	1.1	3.3
Hand grip strength (right)	0.9	2.5	4.3	1.9	2.1	1.1	-1.0
Townsend deprivation index at recruitment	0.5	0.8	1.7	-1.0	0.5	0.4	1.3
Current tobacco smoking	0.3	0.5	1.4	-0.3	-0.4	-0.7	-1.2
Average weekly fortified wine intake	0.9	1.0	2.1	-1.1	-0.8	-1.4	-0.6
Maternal smoking around birth	1.5	2.2	4.8	1.4	2.2	1.0	1.0
Fed-up feelings	0.3	0.5	0.7	-0.8	-0.8	0.7	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.4	-0.8	0.5	-0.0
Relative age voice broke	0.2	0.3	0.5	-0.7	-0.7	0.4	-0.2
Taking other prescription medications	0.9	1.4	2.7	-1.7	-1.5	-0.7	0.5
Age when periods started (menarche)	2.2	5.3	10.1	-1.9	-3.2	-2.1	-1.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.5	-0.1	-1.2	-0.1	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.7	-2.2	0.1	-0.4	0.4
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	6.1	-0.1	0.3	1.2	2.5
Qualifications: CSEs or equivalent	2.5	3.3	7.2	0.9	0.4	2.3	2.7
Serious illness, injury or assault to yourself	1.6	1.9	4.8	0.5	-0.1	2.2	1.7
High blood pressure	0.6	1.8	3.7	-0.7	-0.0	-1.7	-1.9
Hayfever, allergic rhinitis or eczema	0.4	1.0	1.8	1.4	0.6	-0.8	-1.0
Multivitamins +/- minerals	0.8	1.0	2.7	1.7	0.5	-0.6	-0.8
Stomach or abdominal pain in last month	0.3	0.3	1.2	0.0	0.2	-1.1	-0.3
Supplements: Glucosamine	1.2	1.5	3.5	0.0	0.8	1.9	1.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	0.4	0.9	0.8	0.4
Medication: Atenolol	0.2	0.2	0.4	-0.4	-0.6	-0.5	-0.1
Medication: Levothyroxine sodium	0.5	0.9	2.6	0.9	1.6	-0.1	-0.4
Sitting height	0.5	3.7	10.6	0.5	3.3	1.9	-0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.4	0.3	0.6	0.5
High blood pressure (mother)	2.7	3.7	7.9	1.5	2.8	-1.2	-1.8
Body mass index (BMI)	0.1	0.2	0.5	-0.1	0.6	-0.7	-0.1
Impedance of leg (left)	2.8	13.8	31.6	-3.2	-1.6	3.4	5.6
Leg predicted mass (left)	0.5	2.6	8.4	0.1	2.9	0.9	-1.2
Trunk fat mass	0.9	4.0	8.3	-2.9	0.2	1.4	2.4
Waist circumference	0.2	0.7	1.3	-1.0	1.1	0.4	0.6
Number of incorrect matches in round	0.5	0.9	2.3	-0.0	-0.6	1.0	1.5
Past tobacco smoking	2.3	4.3	9.9	-1.1	-1.8	-3.1	-1.7
Alcohol usually taken with meals	0.5	0.8	3.0	0.2	1.7	0.3	-0.2
Nervous feelings	0.7	1.2	3.4	-0.1	-1.8	-1.0	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.5	-0.3	0.7	0.2
Hearing difficulty/problems with background noise	0.5	0.8	1.6	-0.3	-0.7	1.1	-1.2
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	0.2	0.8	0.5	-0.5
Had menopause	0.1	0.2	0.7	-0.0	-0.1	-0.2	0.8
Had other major operations	0.7	0.8	3.0	0.2	1.7	0.5	0.1
Forced vital capacity (FVC)	0.6	2.2	5.4	1.2	1.2	2.3	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.7	-1.9	0.4	-1.3	-0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.6	-0.7	0.1	0.8	0.5
Qualifications: None of the above	0.3	0.6	1.9	-1.4	-0.4	0.4	-0.0
Financial difficulties in last 2 years	0.3	0.4	0.9	0.8	1.0	0.1	0.3
Mouth/teeth dental problems	2.4	3.6	5.5	1.6	-1.4	2.1	2.3
Heart attack	0.7	0.9	3.2	0.1	-1.8	-0.1	0.6
Allergy	0.2	0.4	1.1	-1.1	-0.5	0.2	0.2
Pain all over the body in last month	0.6	0.7	1.5	-0.1	-1.2	1.1	0.0
Diabetes (self-reported)	1.3	2.0	3.1	-0.1	1.8	-1.5	-1.6
Hayfever/allergic rhinitis (self-reported)	0.9	1.3	3.9	0.2	0.4	-2.0	-1.0
Medication: Ramipril	0.1	0.1	0.3	-0.5	0.0	-0.4	-0.2
Medication: Simvastatin	0.3	0.4	0.8	0.9	0.5	-0.4	-0.8
Fluid intelligence score	0.1	0.2	0.4	-0.2	-0.4	-0.6	-0.2
Illnesses of siblings	0.3	0.4	0.7	-0.7	-0.7	0.8	0.1
Neuroticism score	0.1	0.3	0.3	0.6	-0.6	0.6	0.2
Weight	0.4	1.9	4.2	-1.3	2.0	1.1	0.6
Impedance of arm (right)	2.5	11.6	26.0	-5.1	-3.2	0.1	3.2
Arm fat percentage (right)	0.6	2.6	6.1	-2.5	-1.1	-0.6	1.6
Trunk fat-free mass	1.1	6.1	18.5	1.1	4.3	1.3	-1.6
Hip circumference	0.4	1.7	3.0	-1.7	1.5	0.8	0.9
Time employed in main current job	1.6	1.9	3.6	-1.6	-1.1	-1.9	0.1
Alcohol intake versus 10 years previously	0.7	1.0	1.4	-1.2	-0.4	1.1	1.1
Father’s age at death	0.2	0.3	0.6	-0.6	-0.1	-0.3	-0.8
Worrier / anxious feelings	0.6	1.0	2.1	-0.9	-1.4	-1.0	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.0	0.3	0.5	-0.1
Falls in the last year	0.7	1.0	2.0	-0.6	-0.8	-1.0	-1.4
Hair/balding pattern: Pattern 3	1.0	1.5	2.9	-0.2	-1.5	-1.7	-0.7
Number of live births	0.2	0.3	0.6	-0.3	-0.8	0.2	0.5
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	5.1	2.1	1.4	2.2	-0.3
Pulse rate	0.5	0.8	1.9	-0.8	-1.4	-0.4	0.7
Happiness	0.8	0.9	1.9	-0.4	-1.4	-1.1	-0.6
Noisy workplace	0.8	1.0	2.0	1.1	1.4	0.2	0.6
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.0	-0.2	0.0	-1.4	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.1	2.7	1.6	1.1	-1.4	-1.6
Mouth/teeth dental problems: Dentures	1.0	1.7	3.3	-1.2	0.6	-1.8	-1.4
Asthma	0.3	0.5	0.8	-0.8	-0.6	0.9	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.2	0.7	-0.1	1.1	-0.0
Medication: Cholesterol lowering	0.7	1.1	2.1	0.0	0.5	1.5	1.4
Depression (self-reported)	0.4	0.5	0.9	-0.3	-0.3	-1.0	-0.9
Medication: Lansoprazole	1.4	1.6	3.3	-0.8	-0.4	-1.8	-1.5
Prospective memory result	2.6	3.2	6.7	0.7	1.6	2.6	1.8
Lung cancer (father)	1.0	1.2	2.6	1.1	-0.6	1.6	0.7
Illnesses of mother	0.8	1.0	2.9	-0.4	-1.7	0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	3.8	1.9	1.2	1.9	-0.3
Pulse wave Arterial Stiffness index	2.0	2.4	5.3	-0.4	0.9	2.3	1.8
Impedance of arm (left)	2.7	12.3	25.7	-5.1	-3.7	0.2	3.1
Arm fat mass (right)	0.3	1.3	3.1	-1.8	0.4	0.3	1.3
Trunk predicted mass	1.1	6.2	19.0	1.1	4.4	1.4	-1.6
Standing height	0.9	9.2	18.7	-2.2	3.2	4.3	1.6
Length of working week for main job	0.3	0.3	0.9	-0.2	-1.0	-0.5	0.1
Exposure to tobacco smoke at home	0.7	0.7	1.1	-0.8	1.1	0.7	0.8
Breastfed as a baby	0.2	0.2	0.5	-0.4	-0.2	-0.1	0.7
Tense / ‘highly strung’	0.0	0.1	0.1	-0.2	0.2	-0.4	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.8	0.9	0.9	0.6	-0.2
Hair/balding pattern: Pattern 4	0.3	0.7	1.3	0.2	-1.1	0.4	1.1
Birth weight of first child	0.2	0.4	1.2	0.0	-1.1	0.1	0.7
Peak expiratory flow (PEF)	1.2	2.8	5.2	2.0	2.3	1.4	-0.2
Pulse wave reflection index	2.0	2.4	6.3	2.5	1.2	1.4	-0.2
Ever highly irritable/argumentative for 2 days	2.7	3.3	5.3	1.4	1.1	2.1	2.3
Loud music exposure frequency	1.4	1.5	3.1	0.2	0.9	1.8	1.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.5	0.8	0.3	-0.9	-1.2
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	3.5	-1.1	1.1	-1.9	-1.8
Blood clot in the leg (DVT)	1.2	1.6	3.3	1.8	-1.6	-0.6	-0.2
Medication: Paracetamol	0.0	0.0	0.2	0.0	0.0	-0.4	-0.1
Headache pain in last month	1.1	1.9	3.8	1.9	0.5	-0.8	-1.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	-0.1	0.2	0.8	0.9
Glaucoma (self-reported)	2.0	2.4	7.3	-2.7	-1.4	-0.4	0.1
Gout (self-reported)	0.8	1.1	2.3	-1.1	-1.5	0.3	0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.9	0.8	1.4	0.2	-0.1
Medication: Amlodipine	2.3	3.2	5.4	-1.8	-2.3	-1.8	-0.7
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.1	0.5	0.2	-0.1
Birth weight	0.3	0.6	1.8	-0.7	1.3	0.2	-0.2
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.6	0.6	0.6	0.2	0.8
High blood pressure (siblings)	0.3	0.5	1.0	0.4	1.0	-0.5	-0.6
Forced vital capacity (FVC), Best measure	0.7	2.4	6.1	1.0	1.5	2.5	-0.3
Body fat percentage	1.5	5.8	11.1	-3.3	-1.1	1.0	3.2
Leg fat percentage (right)	0.8	3.0	7.2	-2.7	-0.4	0.3	2.2
Arm fat-free mass (right)	1.0	5.2	15.0	1.1	3.9	2.1	-0.6
Exposure to tobacco smoke outside home	1.9	2.5	5.0	0.4	1.6	2.2	1.6
Comparative body size at age 10	0.3	0.8	1.9	1.4	0.5	-0.3	-1.0
Number of full brothers	1.7	2.1	6.1	0.3	1.0	2.5	1.1
Worry too long after embarrassment	0.1	0.2	0.3	0.2	-0.5	-0.6	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	3.4	-1.9	-1.5	-0.4	0.4
Wheeze or whistling in the chest in last year	0.3	0.5	1.8	0.1	1.4	0.5	-0.2
Number of children fathered	1.1	1.2	3.5	0.0	1.9	0.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	11.4	-0.9	-3.4	-0.7	-0.0
Age at first live birth	0.7	1.2	3.5	1.9	0.5	-0.7	-0.6
Pulse wave peak to peak time	1.7	2.0	4.4	0.1	-0.7	-2.1	-1.8
Health satisfaction	0.6	0.8	2.0	-0.6	-1.0	-1.4	0.2
Shortness of breath walking on level ground	0.8	1.0	2.2	0.7	-0.7	-0.8	-1.5
Qualifications: College or University degree	0.6	1.9	3.7	-0.0	-0.1	-1.9	-1.9
Eye problems/disorders: None of the above	0.8	1.0	2.0	1.4	0.3	0.6	1.2
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.1	0.3	0.2	-0.0
Emphysema/chronic bronchitis	0.7	0.8	1.7	-1.1	1.3	0.5	-0.3
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.4
Neck or shoulder pain in last month	1.2	1.7	5.1	0.2	-0.2	-2.3	-1.2
Medication: Blood pressure	0.5	0.9	1.8	-0.5	-0.1	-1.3	-1.4
Angina (self-reported)	0.9	1.2	2.4	-0.1	-1.6	-1.2	-1.0
Migraine (self-reported)	1.9	2.4	4.5	-0.3	1.7	-2.1	-1.4
Medication: Ibuprofen	0.0	0.0	0.1	-0.0	-0.2	-0.1	-0.3
Medication: Allopurinol	0.2	0.3	0.6	-0.8	-0.4	0.6	0.4
Medication: Omeprazole	0.1	0.1	0.3	-0.2	-0.1	-0.2	0.5
Medication: Seretide 50 evohaler	0.3	0.4	0.6	-0.8	0.8	0.0	0.6
Mean time to correctly identify matches	2.2	4.1	11.6	-1.7	-3.4	-1.4	0.0
Heart disease (mother)	0.5	0.6	0.9	1.0	1.0	-0.3	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.0	-1.7	0.6	-0.4	1.2
Whole body fat mass	0.8	3.5	6.1	-2.5	0.4	1.5	2.4
Leg fat mass (right)	0.5	2.1	3.9	-2.0	0.7	1.1	1.7
Arm predicted mass (right)	1.0	5.3	14.7	1.3	3.8	2.1	-0.6
Pulse rate, automated reading	0.6	1.8	2.8	-1.5	-1.7	-1.5	0.1
Alcohol intake frequency.	0.5	1.2	3.3	-1.1	-0.5	1.8	0.2
Comparative height size at age 10	1.0	5.7	13.0	-1.7	1.5	3.6	2.1
Number of full sisters	1.6	1.9	3.0	1.7	1.5	1.6	-0.0
Suffer from ‘nerves’	1.0	1.6	2.9	-0.5	-1.7	-1.4	-1.1
Overall health rating	1.6	3.5	10.4	-1.6	-3.2	-0.3	0.9
Chest pain or discomfort	0.2	0.3	0.9	0.3	-0.1	-0.2	-1.0
Had major operations	2.8	3.3	8.6	-2.9	-0.8	0.5	2.0
Age at last live birth	0.7	1.0	2.7	1.6	0.1	-0.5	-1.0
Family relationship satisfaction	0.2	0.3	0.6	0.5	0.8	-0.3	0.5
Leg pain on walking	0.5	0.6	1.4	-1.2	1.0	-0.2	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.0	0.9	1.7	-0.2	-0.4
Commuting to job workplace: Car/motor vehicle	0.9	1.1	2.1	1.5	0.4	-1.0	-1.0
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	3.3	-1.8	-1.5	0.1	0.5
Medication: Aspirin	0.7	0.9	2.8	-0.1	-0.6	-1.7	-0.6
Supplements: Vitamin C	0.2	0.2	0.5	0.3	-0.5	0.7	0.3
Knee pain experienced in last month	0.9	1.4	2.3	-0.9	-1.3	0.8	1.5
Hypertension (Self-reported)	0.8	2.1	4.4	-0.6	-0.2	-1.9	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.5	0.6	-1.6	-0.4	0.6
Illnesses of father: Heart disease	0.5	0.7	1.3	-1.1	0.6	-0.4	0.9
Illnesses of siblings: Diabetes	2.0	2.5	6.1	0.1	-1.6	-2.5	-1.2
Smoking status: Previous	1.9	2.8	7.8	0.6	1.0	2.8	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	7.3	0.8	1.6	2.7	1.1
Whole body fat-free mass	0.8	4.8	15.0	0.7	3.9	1.3	-1.4
Leg fat-free mass (right)	0.5	2.9	8.8	0.3	3.0	1.0	-1.3
Arm fat percentage (left)	0.7	2.7	6.6	-2.6	-1.3	-0.5	1.5
Average weekly red wine intake	0.2	0.2	0.5	0.7	-0.0	0.5	-0.3
Handedness (chirality/laterality): Left-handed	0.7	0.9	3.5	1.9	0.0	0.1	0.2
Mood swings	0.3	0.5	0.8	-0.8	-0.9	0.8	0.3
Loneliness, isolation	0.7	0.9	2.9	0.8	0.3	0.2	-1.7
Long-standing illness, disability or infirmity	0.3	0.5	1.1	0.3	-0.9	-1.0	-0.2
Ever had bowel cancer screening	0.4	0.4	1.2	-0.6	-0.2	-1.1	0.1
Diabetes diagnosed by doctor	1.7	2.8	4.9	0.6	1.2	-2.1	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.3	1.1	0.4	-0.1	0.1
Friendships satisfaction	0.5	0.7	1.8	0.6	1.3	0.8	-0.0
Qualifications: nursing, teaching	0.0	0.1	0.2	-0.0	-0.2	0.4	0.1
Commuting to job workplace: Walk	0.8	0.9	2.0	-1.1	-1.4	-0.4	0.4
Eye problems/disorders: Cataract	0.1	0.2	0.3	-0.3	-0.5	0.5	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.7	-1.3	0.3	0.9	0.3
Medication for cholesterol	0.9	1.4	3.3	0.1	1.8	1.5	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.1	1.4	1.3	1.1	0.9
Back pain experienced in last month	1.0	1.4	2.1	1.2	1.4	-0.6	-1.4
Mineral and other dietary supplements	0.3	0.3	1.0	-0.4	1.0	-0.4	0.2
Breast cancer (self-reported)	1.2	1.4	2.5	0.5	1.2	1.6	1.2
Asthma (self-reported)	0.3	0.5	0.9	-0.9	-0.3	1.0	0.5
Osteoporosis (self-reported)	0.7	0.9	2.3	-0.2	-0.2	1.1	1.5
Osteoarthritis (self-reported)	3.5	4.6	8.4	-2.8	0.0	1.5	2.9
Medication: Aspirin	0.5	0.6	1.7	-0.1	-0.9	-1.3	-0.3
Medication: Gliclazide	0.3	0.3	0.9	1.0	-0.5	0.1	-0.4
Illnesses of father: None of the above (group 1)	1.6	2.0	3.9	2.0	1.2	1.7	-0.1
Smoking status: Current	0.2	0.3	0.6	-0.6	-0.1	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.1	1.6	-0.2	-1.4	-2.0
Whole body water mass	0.9	4.9	15.2	0.8	3.9	1.4	-1.3
Leg predicted mass (right)	0.5	2.8	8.7	0.3	2.9	0.9	-1.3
Arm fat mass (left)	0.3	1.1	3.2	-1.8	0.1	0.2	1.1
Number of self-reported non-cancer illnesses	0.3	0.6	1.3	-1.1	-0.8	0.2	0.6
Average weekly champagne plus white wine intake	0.8	1.1	2.4	-1.4	0.1	-1.6	-0.0
Miserableness	0.1	0.2	0.4	-0.3	0.6	-0.2	-0.4
Guilty feelings	1.9	2.9	5.5	2.4	0.8	-0.7	-2.2
Wears glasses or contact lenses	0.3	0.3	0.8	-0.2	-0.9	0.2	0.7
Ever taken oral contraceptive pill	0.7	0.8	2.3	1.5	0.9	0.1	0.1
Hearing aid user	0.9	1.0	2.6	1.0	-1.6	0.5	-0.1
Mother’s age at death	0.4	0.5	1.0	-0.1	-0.5	-1.0	-0.9
Financial situation satisfaction	0.6	0.8	2.0	0.6	-0.7	-1.4	-0.4
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	0.0	-0.1	0.3	0.3
Commuting to job workplace: Public transport	0.3	0.4	0.6	-0.8	-0.4	0.7	0.5
Eye problems/disorders: Glaucoma	2.9	3.5	8.0	-2.8	-1.7	-1.4	-1.0
Medication: Blood pressure	0.7	1.3	2.5	-0.6	-1.6	-1.3	-0.8
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.0	0.1	1.6	1.7	0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.8	-0.6	-0.2	-0.6	-1.4
High cholesterol (Self-reported)	0.6	1.1	2.4	-0.1	0.7	1.2	1.6
Medication: Bendroflumethiazide	1.3	2.0	4.1	-0.3	-1.1	-2.0	-1.6
Medication: Paracetamol	0.1	0.2	0.4	0.3	0.2	-0.6	-0.6
Medication: Lisinopril	2.4	3.1	6.0	-0.1	-1.0	-2.4	-2.3
Medication: Atorvastatin	1.4	1.8	4.1	-1.1	-1.2	0.5	2.0
Illnesses of father: High blood pressure	1.1	1.3	3.5	-1.9	-1.1	-0.4	0.5
Alcohol drinker status: Never	0.2	0.2	0.4	-0.3	-0.3	0.6	-0.4
Ever smoked	1.5	2.6	4.9	0.9	1.9	2.2	1.0
Basal metabolic rate	0.7	3.7	12.1	0.2	3.5	1.4	-0.8
Leg fat percentage (left)	1.0	3.5	6.9	-2.5	-0.1	0.7	2.6
Arm fat-free mass (left)	1.0	4.9	15.8	0.7	4.0	1.8	-0.4
Number of operations (self-reported)	0.9	1.3	4.0	-2.0	-0.5	0.1	1.0
Average weekly beer plus cider intake	1.6	2.3	4.2	0.8	1.5	2.1	1.4
Irritability	0.2	0.4	0.8	0.3	-0.0	0.8	0.9
Risk taking	0.5	0.7	1.6	0.7	1.3	-0.5	-0.7
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.8	-1.0	-0.2	-1.3	-1.0
Fractured/broken bones in last 5 years	2.3	3.0	7.2	-0.6	-1.1	2.7	1.7
Age started oral contraceptive pill	2.0	2.5	3.9	-1.4	-1.5	-1.4	-2.0
Diastolic blood pressure, automated reading	1.6	4.8	9.6	-1.5	0.5	-2.7	-3.1
Ever depressed for a whole week	1.3	1.6	4.3	-2.1	-1.1	0.5	0.7
Unable to work because of sickness or disability	1.9	2.5	7.7	-1.2	-2.8	-0.8	-0.4
Commuting to job workplace: Cycle	1.1	1.3	1.8	-1.2	-1.0	-1.3	-1.0
Myopia	0.0	0.1	0.1	-0.3	0.3	-0.3	-0.0
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.0	0.8	0.1	2.0	1.8
Cholesterol lowering medication	0.8	1.2	1.9	-1.3	-1.0	-1.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	0.2	-0.3	-0.2	0.6
Pain experienced in last month	0.4	0.7	1.3	0.8	-0.8	-0.7	-1.2
Supplements: Calcium	1.1	1.2	2.3	1.5	-0.1	1.2	1.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	0.5	0.1	0.6	0.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.1	-0.1	-1.7	-0.3	0.7
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.3	1.8	-1.2	-0.7	-0.2
Heart disease (siblings)	0.3	0.4	1.2	-0.0	0.2	-0.5	-1.1
Alcohol drinker status: Previous	0.8	0.9	3.0	-0.3	0.2	1.7	0.6
Pack years of smoking	1.2	1.8	3.0	-1.7	1.0	-1.6	-0.8
Impedance of whole body	2.7	13.5	21.3	-4.6	-3.0	1.7	4.5
Leg fat mass (left)	0.6	2.2	3.4	-1.9	0.8	1.3	1.8
Arm predicted mass (left)	1.0	5.1	15.6	0.7	4.0	2.0	-0.3