TWAS hub - CHCHD4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1710	0.0600	9.4e-04	0.063	NA	0.051	NA	0.045	1.7e-05	NA	9.8e-05	NA	2.5e-04
2	GTEx	Esophagus Muscularis	0.0950	0.0370	5.2e-03	0.084	NA	0.063	NA	0.071	8.9e-06	NA	1.1e-04	NA	4.1e-05
3	GTEx	Heart Left Ventricle	0.1447	0.0472	1.1e-03	0.108	NA	0.112	NA	0.110	2.3e-06	NA	1.5e-06	NA	1.8e-06
4	GTEx	Muscle Skeletal	0.0989	0.0276	5.1e-06	0.106	NA	0.090	NA	0.099	1.3e-10	NA	4.1e-09	NA	6.6e-10
5	GTEx	Testis	0.2670	0.0750	2.0e-04	0.009	NA	0.001	NA	0.003	1.2e-01	NA	2.8e-01	NA	2.3e-01
6	ROSMAP	Brain Pre-frontal Cortex	0.1200	0.0286	2.7e-09	0.107	0.068	0.066	0.085	0.096	1.2e-13	3.9e-09	7.4e-09	4.7e-11	2.2e-12
7	TCGA	Brain Lower Grade Glioma	0.0296	0.0153	4.7e-04	0.021	0.020	0.027	NA	0.024	1.6e-03	2.1e-03	4.4e-04	NA	8.0e-04
8	TCGA	Soft Tissue Sarcoma	0.0580	0.0350	6.1e-03	0.021	0.023	0.007	NA	0.013	1.9e-02	1.6e-02	1.2e-01	NA	5.7e-02
9	TCGA	Thyroid Carcinoma	0.0390	0.0230	2.8e-03	0.005	0.014	0.004	NA	0.008	1.0e-01	1.6e-02	1.2e-01	NA	4.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Impedance of whole body	4.8	24.2	53.1	2.5	5.8	7.3	5.3	2.2	5.3	5.1	3.8	5.0
Impedance of leg (left)	4.7	22.9	38.6	2.3	5.6	6.2	5.3	2.3	5.4	4.8	3.7	5.6
Hair/balding pattern: Pattern 3	3.8	5.6	8.5	1.4	2.6	2.9	2.4	2.6	2.5	2.3	2.2	2.2
Smoking Status	3.7	8.9	16.6	1.3	3.6	3.0	4.0	1.8	4.1	2.4	1.8	3.4
Taking other prescription medications	3.7	5.7	9.6	-2.2	-2.7	-2.0	-2.7	-1.2	-2.7	-3.1	-2.7	-1.5
Impedance of leg (right)	3.6	17.5	32.8	1.9	5.0	5.7	4.6	1.8	4.6	4.2	3.3	4.7
Ever used hormone-replacement therapy (HRT)	3.5	4.5	10.3	-3.2	-1.9	-2.0	-2.2	-0.6	-2.3	-2.5	-2.5	-0.2
Medication for cholesterol	3.5	5.3	8.1	1.1	2.5	2.1	2.7	2.8	2.6	2.6	2.1	1.3
Hair/balding pattern: Pattern 2	3.3	4.2	15.8	-1.0	-1.6	-2.3	-1.7	-4.0	-1.8	-1.5	-1.1	-1.7
High blood pressure (siblings)	3.3	4.7	7.5	-1.4	-2.7	-2.1	-2.5	-2.6	-2.5	-1.9	-1.2	-2.0
Impedance of arm (left)	3.1	14.6	41.0	2.1	4.5	6.4	3.8	1.5	3.8	3.9	2.9	3.4
Had major operations	3.1	3.7	4.7	2.2	2.1	2.0	2.0	2.1	1.9	2.1	1.7	0.8
Eye problems/disorders: Glaucoma	3.1	3.7	7.3	-0.1	2.4	2.7	2.4	0.6	2.3	1.6	0.9	2.3
Medication: Simvastatin	3.0	4.4	7.4	-0.9	-2.5	-2.3	-2.4	-1.7	-2.4	-2.7	-2.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.3	5.3	-0.9	-2.0	-0.9	-2.3	-2.0	-2.3	-2.1	-1.9	-1.4
Medication: Bendroflumethiazide	2.9	4.4	7.6	-0.9	-2.4	-1.6	-2.7	-2.3	-2.8	-2.1	-1.6	-1.9
Vascular/heart problems diagnosed by doctor	2.9	7.8	12.2	2.0	3.1	2.2	3.4	3.1	3.5	2.9	2.4	2.0
Lung FEV1/FVC ratio	2.8	14.0	22.8	2.7	4.8	3.1	4.1	-2.0	4.2	4.5	4.0	3.4
Illnesses of father: None of the above (group 1)	2.8	3.4	5.8	0.8	1.7	1.4	2.0	2.4	2.0	2.3	2.2	1.2
Cholesterol lowering medication	2.8	4.2	6.7	-0.7	-2.5	-1.9	-2.4	-2.2	-2.3	-2.6	-1.9	-1.1
Average weekly spirits intake	2.6	3.2	7.7	2.0	1.7	2.8	1.7	1.4	1.7	1.7	1.6	0.8
Heart attack	2.6	3.3	4.5	-1.0	-1.7	-1.6	-2.1	-1.7	-2.1	-1.9	-1.9	-2.0
Impedance of arm (right)	2.6	12.0	35.3	2.0	4.0	5.9	3.5	1.1	3.4	3.5	2.5	3.0
Lung cancer (father)	2.6	3.1	6.4	-2.3	-1.6	-1.6	-1.7	-0.7	-1.6	-2.3	-2.5	-0.2
Medication: Blood pressure	2.6	5.0	9.8	-1.4	-2.8	-1.6	-2.5	-3.1	-2.6	-1.9	-1.3	-2.1
Past tobacco smoking	2.4	4.4	9.6	-1.0	-2.6	-1.9	-2.8	-0.9	-2.8	-1.2	-0.4	-3.1
Ever had bowel cancer screening	2.4	2.8	6.8	-2.6	-1.6	-0.6	-1.5	-0.2	-1.6	-2.3	-2.2	-0.6
Medication: Aspirin	2.4	3.2	5.9	-0.8	-1.8	-2.1	-2.0	-1.1	-2.0	-2.4	-2.2	-0.8
Smoking status: Current	2.4	3.8	6.6	0.7	2.2	1.9	2.6	1.6	2.5	2.1	1.7	1.5
Medication: Aspirin	2.3	3.0	5.1	-1.0	-1.8	-2.3	-2.0	-1.0	-2.0	-2.2	-1.8	-0.7
Hayfever/allergic rhinitis (self-reported)	2.2	2.8	4.6	-0.4	-2.1	-2.1	-2.1	-1.1	-2.0	-1.7	-1.3	-1.5
Medication: Allopurinol	2.2	3.0	6.7	-1.7	-1.5	-1.8	-1.8	0.2	-1.6	-2.6	-2.4	0.6
Ever smoked	2.2	3.8	10.9	0.4	2.5	1.9	2.5	0.4	2.4	0.9	0.1	3.3
Heart attack/myocardial infarction (self-reported)	2.2	2.8	4.1	-1.0	-1.6	-1.5	-1.9	-1.5	-2.0	-1.7	-1.7	-2.0
Cardiovascular Disease	2.1	6.8	11.6	-1.8	-3.2	-2.1	-3.4	-2.2	-3.3	-3.0	-2.5	-0.8
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	5.6	1.6	1.5	1.1	1.3	2.4	1.2	1.1	0.3	1.7
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.0	0.5	1.2	2.0	1.8	0.2	1.8	1.9	1.7	1.5
High cholesterol (Self-reported)	2.0	3.5	7.2	-0.2	-2.5	-2.7	-2.4	-1.3	-2.4	-1.7	-0.7	-1.2
Basal cell carcinoma (self-reported)	2.0	2.4	4.0	-1.9	-1.7	-0.8	-1.7	-0.3	-1.6	-1.8	-2.0	-1.3
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	7.2	-0.9	1.3	1.3	1.2	2.7	1.4	0.7	0.2	2.3
Verbal and Numeric Reasoning (VNR)	1.8	4.4	7.4	2.7	1.7	2.3	2.2	0.1	2.1	2.6	2.7	0.8
Current tobacco smoking	1.8	3.0	5.0	0.6	1.9	1.6	2.2	1.4	2.2	2.0	1.8	1.4
Qualifications: CSEs or equivalent	1.8	2.4	5.0	1.4	2.2	1.6	1.7	0.3	1.6	1.6	0.6	1.9
Illnesses of father: High blood pressure	1.8	2.2	3.8	-0.6	-1.6	-1.1	-1.8	-0.5	-1.8	-1.7	-2.0	-1.4
Systolic Blood Pressure	1.7	8.3	12.7	-2.3	-3.3	-1.9	-3.5	-2.1	-3.3	-3.6	-3.2	-2.1
Medication: Ramipril	1.7	2.1	7.4	-0.3	-1.2	-1.7	-1.5	-2.7	-1.6	-1.0	-0.9	-0.8
Eye problems/disorders: None of the above	1.7	2.0	3.2	0.0	-1.5	-1.8	-1.7	0.5	-1.6	-1.6	-1.5	-1.4
Knee pain experienced in last month	1.7	2.6	5.2	0.7	-2.0	-1.4	-1.7	-1.4	-2.0	-1.4	-1.0	-2.3
Ever depressed for a whole week	1.7	2.1	3.8	-0.4	1.8	1.9	1.7	0.9	1.8	1.1	0.8	1.6
Relative age of first facial hair	1.6	3.3	5.4	1.4	2.3	1.4	2.0	0.9	2.1	2.0	1.6	2.1
High blood pressure	1.6	4.4	7.5	-1.6	-2.4	-1.4	-2.5	-2.7	-2.6	-2.0	-1.5	-1.4
Fluid intelligence score	1.6	3.4	6.7	2.6	1.3	1.9	1.7	0.7	1.7	2.3	2.6	0.8
Medication: Cholesterol lowering	1.6	2.5	4.2	-1.1	-1.4	-2.0	-1.8	-0.9	-1.8	-1.8	-2.0	-0.0
Qualifications: College or University degree	1.6	5.2	7.5	-0.9	-2.7	-1.7	-2.7	-1.2	-2.7	-2.6	-2.2	-2.7
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	5.1	-2.2	-0.7	-1.5	-1.3	0.0	-1.1	-1.8	-1.8	-0.6
Risk taking	1.6	2.3	4.6	-2.1	-2.1	-1.2	-1.6	-0.9	-1.4	-1.4	-0.9	-1.3
Irritable Bowel Disease (IBD)	1.5	3.6	7.8	1.6	1.8	2.2	1.9	0.8	1.8	2.3	2.8	0.8
Chronotype (morning person)	1.5	3.4	8.6	2.9	1.6	1.4	1.7	0.4	1.4	2.5	2.5	-0.3
Hearing difficulty/problems with background noise	1.5	2.4	3.5	-1.7	-1.9	-1.8	-1.7	-1.0	-1.7	-1.9	-1.4	-0.1
Pain all over the body in last month	1.5	1.6	2.7	-1.5	-1.4	-0.8	-1.6	0.0	-1.5	-1.6	-1.3	-0.5
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	4.4	-1.2	-1.2	-1.0	-1.3	-2.1	-1.2	-1.5	-1.8	-0.1
Comparative body size at age 10	1.5	4.1	6.6	-2.6	-1.8	-1.4	-1.9	-2.5	-1.8	-2.0	-2.5	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	5.4	2.2	2.3	0.5	2.1	-0.0	1.9	2.3	1.9	1.1
Friendships satisfaction	1.5	1.8	3.6	1.5	1.9	1.2	1.4	1.2	1.4	1.1	0.5	1.6
Osteoporosis (self-reported)	1.5	1.9	3.8	-0.1	1.7	1.0	1.8	1.1	1.8	1.1	0.6	2.0
Average weekly beer plus cider intake	1.5	2.2	4.2	0.6	1.8	1.1	1.6	2.0	1.7	0.9	0.2	2.0
Fractured/broken bones in last 5 years	1.5	1.9	3.7	0.6	1.9	1.4	1.8	0.6	1.8	1.1	0.4	1.7
Ulcerative Colitis (UC)	1.4	2.6	5.0	2.2	1.4	1.9	1.4	0.1	1.4	2.0	2.2	0.5
Neuroticism (2016)	1.4	2.0	5.5	-0.6	-1.3	-1.2	-1.4	-2.4	-1.5	-1.6	-1.5	-0.6
Heel T-Score	1.4	10.8	16.6	-3.2	-3.6	-2.9	-3.8	-0.9	-3.5	-4.1	-4.0	-2.4
Respiratory disease	1.4	3.2	5.1	-0.5	-1.9	-1.6	-2.0	-1.3	-2.0	-2.3	-2.1	-1.7
Systolic blood pressure, automated reading	1.4	4.0	7.2	-2.1	-2.4	-0.2	-2.3	-1.1	-2.2	-2.7	-2.2	-1.5
Pulse rate	1.4	2.3	3.9	1.0	2.0	1.6	1.7	0.2	1.6	2.0	2.0	0.4
Medication: Lansoprazole	1.4	1.6	4.8	-1.3	-1.3	-0.6	-1.3	-2.2	-1.2	-1.3	-0.9	-0.3
Glaucoma (self-reported)	1.4	1.7	3.4	0.8	1.6	1.8	1.5	0.7	1.4	1.2	1.0	1.2
Ever taken oral contraceptive pill	1.4	1.5	3.2	-1.3	-1.2	-1.3	-1.4	-0.3	-1.4	-1.8	-1.4	-0.0
Schizophrenia vs Biploar Disorder	1.3	1.7	2.9	-1.1	-1.5	-1.2	-1.5	-0.7	-1.5	-1.6	-1.7	-0.4
Blood Red Count	1.3	12.2	16.4	3.6	3.8	3.8	3.2	3.1	3.1	4.0	4.0	2.4
Lung FVC	1.3	6.4	17.5	-1.1	-2.7	-4.2	-2.4	-0.4	-2.5	-1.9	-1.0	-3.8
Exposure to tobacco smoke at home	1.3	1.4	6.1	-0.2	1.2	0.7	1.3	2.5	1.4	0.4	0.0	0.9
Mood swings	1.3	2.3	7.2	0.7	1.9	1.0	1.8	-0.6	2.0	0.2	-0.7	2.7
Prospective memory result	1.2	1.5	5.0	-1.4	-0.6	-1.0	-0.7	0.1	-0.8	-1.7	-2.2	-1.0
Illnesses of father: Heart disease	1.2	1.7	4.8	-0.2	-0.6	-1.4	-0.9	-1.9	-0.9	-1.8	-2.2	-0.1
Number of operations (self-reported)	1.2	1.7	2.3	1.4	1.4	1.4	1.3	0.3	1.3	1.4	1.4	1.5
Myopia	1.2	1.8	3.4	-0.4	-1.5	-1.7	-1.4	-0.1	-1.4	-1.8	-1.5	-1.1
Fasting Glucose	1.1	1.4	5.6	1.1	0.7	-0.9	0.6	2.4	0.7	0.7	1.6	-0.0
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	5.5	-0.4	-1.1	-1.2	-1.1	0.3	-1.1	-2.1	-2.3	0.2
Qualifications: A levels/AS levels or equivalent	1.1	2.5	4.5	-0.9	-1.9	-1.5	-2.1	-0.8	-2.1	-1.4	-1.2	-1.8
Standing height	1.1	10.8	20.1	4.0	4.5	0.9	3.9	0.6	3.5	4.0	3.6	1.9
Birth weight	1.1	2.3	3.8	-0.8	-1.9	-1.8	-1.8	-1.3	-1.8	-0.9	-0.5	-1.9
Age at last live birth	1.1	1.6	2.7	-0.3	-1.3	-1.4	-1.3	-1.1	-1.4	-1.2	-1.1	-1.6
Illnesses of siblings: Diabetes	1.1	1.4	2.8	0.8	-1.5	-1.2	-1.2	-1.2	-1.2	-0.8	0.3	-1.7
Smoking status: Previous	1.1	1.6	5.1	0.7	1.5	0.8	1.6	-0.1	1.7	0.3	-0.3	2.3
Ulcerative Colitis	1.0	1.5	4.9	2.2	0.6	1.2	0.6	-0.9	0.4	1.5	1.7	-0.6
Supplements: Glucosamine	1.0	1.3	3.8	0.6	-1.5	-0.8	-1.3	0.6	-1.4	-0.8	-0.6	-2.0
Time employed in main current job	1.0	1.2	1.8	-0.1	1.3	1.1	1.2	-0.8	1.3	1.1	1.0	1.3
Alcohol intake versus 10 years previously	1.0	1.4	2.8	-0.4	-1.1	-1.6	-1.2	-0.5	-1.3	-1.2	-1.7	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	8.6	-1.0	-0.6	-0.0	-0.4	-2.9	-0.4	-1.2	-1.7	0.8
Heart disease (mother)	1.0	1.2	3.6	-1.6	-0.4	-1.2	-0.4	-0.5	-0.3	-1.3	-1.9	1.0
Chest pain or discomfort	1.0	1.5	7.7	-0.7	-0.9	-0.9	-0.9	-2.8	-0.8	-1.0	-0.9	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.1	3.9	1.4	0.7	0.6	0.8	-0.1	0.7	1.5	2.0	-0.4
Hypertension (Self-reported)	1.0	2.7	5.4	-1.3	-1.8	-0.8	-2.0	-2.3	-2.1	-1.5	-1.1	-1.2
Guilty feelings	1.0	1.5	2.1	-0.6	-1.4	-1.2	-1.4	-1.0	-1.2	-1.4	-1.3	-1.4
Bipolar Disorder (2018)	0.9	1.5	6.2	0.8	1.2	2.5	1.2	-0.1	1.2	1.0	0.7	0.2
Hand grip strength (left)	0.9	2.3	11.2	-0.9	-1.0	-3.3	-1.1	-0.9	-1.2	-1.5	-1.3	-0.6
Body mass index (BMI)	0.9	3.8	7.1	-1.8	-2.1	-1.3	-2.1	-1.1	-2.1	-2.5	-2.7	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.5	0.3	0.9	1.3	1.0	1.3	1.0	1.0	0.5	1.6
Pulse wave Arterial Stiffness index	0.9	1.1	2.0	1.4	0.7	-0.0	1.0	1.3	1.0	1.1	1.1	-0.9
Exposure to tobacco smoke outside home	0.9	1.2	2.6	0.9	1.3	0.1	1.6	1.6	1.6	0.8	0.3	0.6
Migraine (self-reported)	0.9	1.1	3.1	-0.1	1.1	0.3	1.4	1.8	1.4	0.8	0.6	0.9
Medication: Omeprazole	0.9	1.1	4.1	0.4	-0.8	0.5	-0.7	-2.0	-0.9	-0.4	-0.0	-1.7
Number of full sisters	0.9	1.1	4.3	-0.7	-0.9	-2.1	-1.0	-0.8	-1.0	-0.4	-0.5	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.5	0.6	1.0	1.6	1.1	1.2	1.0	0.9	0.8	-0.5
Mineral and other dietary supplements	0.9	1.2	3.5	-0.4	1.3	0.9	1.3	-0.1	1.4	0.8	0.4	1.9
Prostate Cancer	0.8	1.1	3.8	-1.9	-0.9	-0.8	-1.0	-0.3	-0.9	-1.1	-1.3	-0.1
BMI	0.8	4.8	8.8	-1.6	-2.6	-1.7	-2.6	-0.1	-2.5	-2.7	-3.0	-1.3
Height	0.8	15.1	29.4	5.2	5.4	0.6	4.5	0.6	4.0	4.5	4.6	1.3
Trunk fat percentage	0.8	3.2	12.1	0.0	2.1	3.5	1.6	0.5	1.5	0.9	-0.4	2.4
Father’s age at death	0.8	1.0	3.8	-1.5	0.5	1.0	0.2	2.0	0.4	0.5	0.8	0.9
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	6.8	2.0	1.5	-0.8	1.4	-0.0	1.3	2.4	2.6	-0.4
Blood clot in the leg (DVT)	0.8	1.1	3.0	-1.4	0.9	0.4	0.5	-0.3	0.5	-0.8	-1.5	1.7
Comparative height size at age 10	0.8	4.5	9.0	2.6	2.2	0.4	2.5	-1.3	2.2	2.7	3.0	0.1
Overall health rating	0.8	1.8	6.5	-0.2	-1.3	-0.4	-1.2	-2.6	-1.3	-1.3	-1.4	-1.0
Family relationship satisfaction	0.8	1.0	2.6	0.5	1.1	1.2	1.1	0.1	1.2	0.8	0.3	1.6
Back pain experienced in last month	0.8	1.2	5.3	2.3	0.9	-0.1	1.1	0.7	1.0	0.9	0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	7.4	0.9	-0.9	-1.5	-0.5	0.3	-0.4	0.9	1.8	-2.7
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.7	-1.4	1.1	0.5	0.7	0.1	0.7	-0.4	-1.1	1.9
Severe depression (siblings)	0.7	0.8	2.4	-1.1	-0.4	0.3	-0.6	-0.4	-0.6	-1.3	-1.5	0.7
Age when periods started (menarche)	0.7	1.6	2.7	1.1	1.2	1.4	1.1	1.5	1.1	1.4	1.6	-0.2
Serious illness, injury or assault to yourself	0.7	0.8	1.5	1.0	1.2	0.7	1.1	-0.0	1.0	1.0	0.9	0.6
Multivitamins +/- minerals	0.7	0.8	1.7	1.2	-0.9	-0.8	-1.1	-0.1	-1.2	-0.5	-0.1	-1.3
Diabetes (self-reported)	0.7	1.1	5.8	-1.6	0.7	0.5	0.2	-0.5	0.2	-0.0	-0.5	2.4
Noisy workplace	0.7	0.9	2.2	-0.3	0.6	0.1	0.9	1.2	0.9	1.0	1.2	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	6.0	1.6	1.4	-0.7	1.5	-0.2	1.4	2.3	2.4	-0.4
Gout (self-reported)	0.7	0.9	1.9	-1.3	-0.7	-0.6	-0.9	0.7	-0.9	-1.4	-1.3	0.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.9	0.6	1.2	0.4	1.0	-0.5	1.0	1.4	1.1	-0.1
Number of full brothers	0.7	0.9	2.3	1.3	0.6	0.2	0.7	1.1	0.8	1.1	1.5	-0.5
Worry too long after embarrassment	0.7	1.2	2.7	1.2	1.2	1.3	1.2	0.8	1.2	0.4	0.0	1.6
Suffer from ‘nerves’	0.7	1.1	4.3	0.1	-0.3	-0.7	-0.6	-1.5	-0.6	-1.4	-2.1	0.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.6	0.3	-1.1	-0.9	-0.9	-0.6	-0.9	-1.1	-0.9	-1.3
Qualifications: nursing, teaching	0.7	1.1	3.9	-0.1	-0.4	-0.2	-0.9	-0.8	-1.1	-1.5	-2.0	-0.8
Average weekly champagne plus white wine intake	0.7	1.0	3.7	0.2	1.5	1.2	0.8	-0.1	0.9	0.3	-0.2	1.9
Medication: Lisinopril	0.7	0.9	1.7	0.3	-1.3	-0.8	-1.1	-0.5	-1.2	-1.1	-0.8	-0.7
Medication: Atorvastatin	0.7	0.9	2.4	-1.6	-0.9	-0.5	-1.1	-1.5	-1.0	-0.5	-0.4	0.3
Diastolic blood pressure, automated reading	0.7	2.2	4.0	-0.7	-1.4	-0.7	-1.5	-1.7	-1.7	-1.8	-1.3	-2.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	4.4	0.9	0.1	1.0	-0.1	-2.1	-0.3	0.2	0.6	-0.9
Crohns Disease (2017)	0.6	1.3	2.7	0.2	1.2	1.4	1.2	0.9	1.2	1.3	1.6	0.7
Ovarian Cancer	0.6	0.8	3.3	0.1	0.8	1.8	0.9	0.4	1.0	0.1	-0.1	1.2
Coronary Artery Disease (CAD)	0.6	0.7	1.3	-0.8	-1.1	-0.1	-1.0	-0.4	-1.0	-1.0	-1.1	0.1
Triglycerides	0.6	0.9	3.1	0.6	-1.1	-1.8	-0.9	0.1	-1.0	-0.1	0.2	-1.4
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.1	-1.4	-0.9	-0.4	-0.8	-0.8	-0.9	-1.1	-0.7	-0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.6	-1.3	0.5	1.2	0.4	-0.8	0.4	0.5	0.5	1.2
Illnesses of mother	0.6	0.8	4.6	2.1	-0.4	-0.0	-0.3	0.2	-0.3	0.2	1.1	-0.8
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.0	-0.4	-0.9	-0.7	-0.9	-1.0	-1.0	-1.1	-1.4	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.2	0.6	-0.7	0.1	-0.7	1.8	-0.8	-0.7	-0.7	-1.0
Medication: Blood pressure	0.6	1.0	3.9	-0.7	-0.6	-0.4	-1.0	-2.0	-1.1	-0.9	-0.8	0.1
Mean time to correctly identify matches	0.6	1.1	3.9	-2.0	-0.1	1.1	-0.4	0.4	-0.4	-1.1	-1.1	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.7	-0.1	1.1	0.7	0.9	-1.3	1.0	0.6	0.4	0.9
Loneliness, isolation	0.6	0.8	2.0	-0.0	-1.2	-1.4	-1.1	0.2	-0.9	-1.2	-0.7	-0.4
Breast cancer (self-reported)	0.6	0.7	1.1	-0.9	0.8	0.6	1.0	-1.0	0.8	0.9	0.6	1.1
Hearing aid user	0.6	0.7	2.2	-1.5	-0.6	-0.4	-0.1	0.6	0.0	-1.0	-1.4	-0.4
Alcohol drinker status: Previous	0.6	0.7	1.8	-0.5	-0.4	-1.3	-0.5	-1.3	-0.7	-0.9	-0.9	-0.1
Alzheimer’s Disease (in father)	0.5	0.5	1.9	0.9	-0.6	-0.7	-0.3	0.8	-0.4	-0.1	0.4	-1.4
Reaction Time	0.5	0.9	2.3	-1.3	-0.4	0.8	-0.5	-0.7	-0.6	-1.0	-1.0	1.5
Breast Cancer	0.5	1.2	2.8	1.0	-1.4	-0.8	-1.0	-1.3	-1.0	-0.8	-0.5	-1.7
Schizophrenia (2014)	0.5	1.1	2.5	-1.5	-0.9	0.2	-1.0	-0.8	-1.0	-1.2	-1.6	-0.3
Neuroticism	0.5	1.2	4.2	-0.5	-0.2	-0.9	-0.3	-1.0	-0.3	-1.8	-2.1	0.8
Hearing difficulty/problems: Yes	0.5	0.7	2.8	-1.7	-0.5	-0.5	-0.3	-0.8	-0.2	-0.8	-1.0	1.0
Diabetes (father)	0.5	0.6	2.0	1.2	-0.4	0.1	-0.5	1.4	-0.5	0.5	0.9	0.1
Average weekly fortified wine intake	0.5	0.6	3.1	-1.7	-0.4	-0.4	-0.8	-0.2	-0.7	-0.6	-0.5	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	3.1	-1.4	-0.4	0.2	-1.0	1.8	-0.9	-0.8	-1.2	-0.3
Stomach or abdominal pain in last month	0.5	0.6	1.7	0.8	0.6	0.7	0.6	0.5	0.6	1.1	1.3	0.0
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-0.4	0.9	0.7	0.9	-1.1	0.9	0.1	-0.3	1.1
Trunk fat-free mass	0.5	2.7	14.9	0.4	-1.0	-3.9	-1.0	-1.2	-1.3	-1.1	-0.7	-1.7
Falls in the last year	0.5	0.6	1.8	0.1	0.4	0.6	0.7	1.2	0.7	0.8	1.3	0.3
Depression (self-reported)	0.5	0.6	4.1	-0.0	0.2	0.5	0.4	2.0	0.3	-0.4	-0.8	0.5
Pulse wave reflection index	0.5	0.6	1.7	-0.1	-0.7	-1.3	-0.6	0.4	-0.5	-0.9	-1.3	-0.3
Loud music exposure frequency	0.5	0.6	2.7	-0.8	-0.5	-1.6	-0.7	-0.1	-0.6	-0.7	-0.2	-0.4
Headache pain in last month	0.5	0.9	3.3	1.8	0.6	-0.7	1.0	0.4	1.0	0.8	1.1	-0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.3	0.8	0.4	0.4	1.1	1.1	1.1	1.0	1.2	-0.9
Pulse wave peak to peak time	0.5	0.6	1.3	-1.0	-0.2	0.1	-0.6	-1.2	-0.6	-0.6	-0.7	1.1
Neck or shoulder pain in last month	0.5	0.7	2.1	-0.0	0.5	0.4	0.8	0.9	0.9	1.0	1.4	0.9
Medication: Ibuprofen	0.5	0.6	1.2	0.1	0.6	1.0	0.8	1.1	0.9	0.6	0.0	1.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	0.1	-0.5	-0.9	-0.5	-0.9	-0.6	-0.6	-1.0	-1.1
Asthma (self-reported)	0.5	1.0	2.1	0.1	-0.8	-1.1	-1.0	-0.7	-1.0	-1.4	-1.4	-0.5
Miserableness	0.5	0.9	1.9	0.7	1.0	1.0	1.1	-0.0	1.1	-0.2	-1.0	1.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	3.1	-0.4	0.5	-0.2	0.6	-0.6	0.6	0.6	0.3	1.8
Commuting to job workplace: Public transport	0.5	0.6	1.1	-0.6	-0.8	-1.0	-0.9	-0.6	-0.8	-0.9	-0.9	0.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.3	1.1	-0.6	-0.8	-0.4	0.2	-0.5	0.2	0.5	-1.5
Age started oral contraceptive pill	0.5	0.6	3.6	-0.7	0.1	0.2	-0.1	1.9	-0.3	0.1	0.7	-0.8
Commuting to job workplace: Cycle	0.5	0.6	2.4	-0.5	0.3	1.5	0.4	1.2	0.4	0.6	0.4	0.5
Supplements: Calcium	0.5	0.5	2.2	1.1	-0.3	0.1	-0.3	-0.3	-0.5	0.3	0.7	-1.5
Depressed Affect (Nagel 2018)	0.4	0.8	3.0	-0.7	-0.3	-0.9	-0.3	-0.3	-0.2	-1.3	-1.7	0.7
Major Depression (MDD)	0.4	0.4	0.7	-0.2	-0.7	-0.7	-0.8	-0.2	-0.9	-0.8	-0.6	-0.7
Mean Putamen Volume	0.4	0.5	2.2	-0.5	0.1	-0.3	-0.3	0.1	-0.2	-0.6	-1.1	1.5
Rheumatoid Arthritis	0.4	0.6	2.2	1.2	-0.2	0.5	-0.0	-0.4	0.1	1.1	1.5	-0.4
Hand grip strength (right)	0.4	1.1	5.1	-1.0	-0.3	-2.2	-0.5	-0.8	-0.5	-1.0	-1.2	0.3
Maternal smoking around birth	0.4	0.6	2.3	0.5	0.8	0.3	0.7	0.2	0.8	0.6	0.6	1.5
Relative age voice broke	0.4	0.6	1.5	1.2	1.1	0.7	0.5	-0.7	0.7	0.4	0.1	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.3	-1.5	-0.8	-0.6	-1.3	0.8	-1.2	-0.8	-0.7	-1.0
Financial difficulties in last 2 years	0.4	0.6	2.2	1.5	-0.0	-0.1	0.5	0.8	0.4	1.1	0.9	-0.1
Illnesses of siblings	0.4	0.5	1.3	0.1	1.0	0.3	0.7	1.1	0.7	0.9	0.5	0.4
Number of live births	0.4	0.5	1.2	-0.7	-0.9	-0.3	-0.7	0.7	-0.7	-0.8	-0.2	-1.1
Trunk predicted mass	0.4	2.5	14.3	0.5	-0.9	-3.8	-0.9	-1.1	-1.2	-1.0	-0.6	-1.7
Breastfed as a baby	0.4	0.5	1.5	-0.7	0.6	1.2	0.8	0.1	0.6	0.7	0.9	0.1
Peak expiratory flow (PEF)	0.4	0.9	2.2	1.0	0.9	-1.0	0.5	-0.9	0.4	1.5	1.5	-0.3
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.4	0.4	0.2	-0.5	0.5	1.2	0.6	0.3	0.3	1.1
Medication: Paracetamol	0.4	0.7	1.6	-0.1	0.7	0.5	0.6	1.2	0.6	1.0	1.3	1.0
Body fat percentage	0.4	1.6	7.2	-0.4	1.3	2.7	0.9	0.4	0.8	0.1	-0.9	1.8
Medication: Seretide 50 evohaler	0.4	0.5	1.7	0.7	0.3	-1.0	-0.0	1.3	-0.1	-0.5	-0.7	-0.1
Whole body fat-free mass	0.4	2.2	11.2	0.3	-0.9	-3.4	-1.0	-1.1	-1.2	-1.1	-0.9	-1.5
Eye problems/disorders: Cataract	0.4	0.4	1.0	0.0	0.7	1.0	0.7	-0.4	0.7	0.6	0.3	0.8
Medication: Gliclazide	0.4	0.4	1.4	-0.9	-0.1	0.4	-0.2	-1.2	-0.2	-0.2	-0.4	1.1
Whole body water mass	0.4	2.2	11.1	0.2	-0.9	-3.3	-1.0	-1.0	-1.2	-1.0	-0.9	-1.5
Number of self-reported non-cancer illnesses	0.4	0.8	1.4	-0.5	-0.9	-0.7	-0.9	-0.9	-1.1	-1.2	-1.0	0.0
Age at First Birth	0.3	0.4	1.1	0.6	-0.0	-0.3	-0.1	-0.8	-0.1	-0.8	-1.0	0.9
Body Mass Index (BMI) (2010)	0.3	0.4	1.6	0.0	-0.7	-1.3	-0.7	-0.3	-0.6	-0.6	-0.2	-0.2
HbA1C	0.3	0.3	1.3	0.5	-0.2	-0.0	-0.2	0.7	-0.0	0.6	1.1	0.6
Lupus	0.3	0.5	1.7	-0.7	0.7	1.3	0.5	-0.4	0.5	0.8	0.4	0.7
Primary Biliary Cirrhosis	0.3	0.4	1.2	-0.3	-0.3	-0.5	-0.8	-0.6	-0.7	-0.8	-1.1	0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.6	-0.1	0.7	-0.2	0.7	0.8	0.7	0.7	0.3	0.8
Blood Platelet Count	0.3	3.1	11.9	0.2	-2.5	-1.5	-1.8	-0.1	-1.8	-0.5	1.0	-3.5
Ever had hysterectomy (womb removed)	0.3	0.3	1.4	-1.2	0.0	0.5	-0.0	-0.5	0.1	-0.3	-0.6	0.5
Medication for hormone replacement therapy	0.3	0.3	1.0	0.6	-0.1	-1.0	-0.6	-0.5	-0.5	-0.7	-0.6	-0.0
Supplements: Zinc	0.3	0.3	1.4	-0.4	0.4	0.4	0.5	1.2	0.4	0.1	-0.2	0.4
Medication: Metformin	0.3	0.5	2.3	-0.9	0.0	0.9	-0.3	-0.1	-0.3	0.1	-0.1	1.5
Leg fat-free mass (left)	0.3	1.6	5.9	0.2	-0.8	-2.4	-1.0	-1.0	-1.3	-1.1	-1.2	-1.3
Sitting height	0.3	2.3	4.8	2.2	1.9	-1.5	1.8	-0.4	1.6	1.3	0.7	1.4
Trunk fat mass	0.3	1.3	4.0	0.1	1.6	2.0	1.1	0.2	0.9	0.4	-0.6	1.6
Number of incorrect matches in round	0.3	0.4	1.3	-0.8	-0.2	-0.5	-0.3	-0.1	-0.2	-1.0	-1.2	-0.6
Forced vital capacity (FVC)	0.3	1.1	5.2	1.0	-0.1	-2.3	-0.0	-0.1	-0.2	0.6	1.0	-1.4
Allergy	0.3	0.8	2.3	-1.5	-1.1	-0.9	-0.8	0.3	-0.9	-0.5	-0.3	-1.0
Neuroticism score	0.3	0.7	2.0	0.8	0.6	0.2	0.6	-0.7	0.7	-0.8	-1.4	1.1
Arm fat percentage (right)	0.3	1.1	3.6	-1.0	-0.7	1.1	-0.9	-0.5	-1.0	-1.3	-1.9	0.1
Worrier / anxious feelings	0.3	0.5	1.8	0.6	0.8	0.8	0.7	0.1	0.5	-0.8	-1.3	0.2
Happiness	0.3	0.4	2.2	0.6	0.1	0.0	-0.1	1.5	-0.2	-0.3	-0.7	0.4
Length of working week for main job	0.3	0.3	2.3	1.5	0.3	0.0	0.0	0.6	0.1	0.1	-0.1	-0.4
Tense / ‘highly strung’	0.3	0.5	1.2	0.7	0.0	-1.0	-0.4	0.8	-0.4	-0.9	-1.1	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	-0.4	0.8	0.5	0.8	0.4	0.7	0.0	-0.8	1.2
Birth weight of first child	0.3	0.6	2.2	0.0	0.2	0.4	0.5	0.9	0.6	-0.8	-1.5	0.7
Medication: Amlodipine	0.3	0.4	1.8	-1.2	-0.2	0.4	-0.2	-1.4	-0.2	-0.3	-0.2	-0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.5	-0.3	-0.4	-0.8	-0.3	-0.4	-0.3	-1.0	-1.2	-0.1
Forced vital capacity (FVC), Best measure	0.3	1.1	3.1	1.3	0.2	-1.8	0.4	0.3	0.3	1.1	1.2	-1.3
Leg fat percentage (right)	0.3	1.2	3.8	-1.5	-0.2	1.1	-0.4	-0.1	-0.5	-1.3	-2.0	1.1
Number of children fathered	0.3	0.4	1.1	0.7	0.7	-0.4	0.6	1.1	0.7	0.3	-0.2	0.1
Health satisfaction	0.3	0.4	1.0	0.4	0.5	1.0	0.5	0.5	0.6	0.4	0.1	1.0
Alcohol intake frequency.	0.3	0.7	2.1	-0.7	-0.6	-1.5	-0.8	0.3	-0.9	-0.8	-0.8	-0.3
Supplements: Vitamin C	0.3	0.4	0.7	-0.8	-0.6	-0.4	-0.9	0.5	-0.8	-0.6	-0.1	-0.1
Leg fat-free mass (right)	0.3	1.4	6.3	0.4	-0.7	-2.5	-0.8	-0.9	-1.0	-1.0	-1.0	-1.2
Diabetes diagnosed by doctor	0.3	0.4	1.7	-1.3	0.0	0.2	-0.4	-0.6	-0.5	-0.3	-0.4	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.2	0.6	-0.6	0.4	-0.4	-1.1	-0.4	-0.4	-0.3	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	-0.3	-0.6	-1.0	-0.6	-0.2	-0.7	-0.7	-0.5	-0.7
Leg fat percentage (left)	0.3	1.1	3.5	-1.3	-0.0	1.2	-0.1	0.0	-0.2	-1.2	-1.9	1.5
Irritability	0.3	0.5	1.1	1.0	0.5	0.3	0.8	-0.6	0.8	-0.2	-0.4	1.0
Pain experienced in last month	0.3	0.4	1.5	-0.4	0.7	1.2	0.4	0.7	0.5	0.7	0.5	0.4
Bipolar Disorder or Schizophrenia	0.2	0.4	3.1	0.1	0.2	1.7	0.2	0.3	0.1	0.2	-0.4	-0.1
Depression (Nagel 2018)	0.2	0.3	1.4	-0.5	-0.2	-0.2	-0.1	-0.4	-0.1	-0.7	-1.2	0.4
Neuroticism (Nagel 2018)	0.2	0.4	1.6	0.3	-0.2	-0.5	-0.4	0.2	-0.4	-1.0	-1.3	0.4
Schizophrenia (2018)	0.2	0.4	0.8	-0.6	-0.8	0.2	-0.7	0.4	-0.8	-0.5	-0.9	-0.2
Alzheimer’s Disease (in mother)	0.2	0.3	1.5	-0.6	-0.1	-0.1	0.2	1.2	0.1	0.2	0.5	-0.7
Bipolar Disorder (2011)	0.2	0.2	0.4	0.1	0.3	0.6	0.4	-0.7	0.4	0.6	0.5	-0.5
Crohns Disease (2012)	0.2	0.3	1.4	-0.8	0.0	0.2	0.2	0.2	0.2	0.5	1.2	0.5
HDL Cholesterol	0.2	0.3	1.6	0.3	-0.2	0.4	-0.1	-1.3	-0.2	0.1	0.5	-0.7
Waist Hip Ratio (WHR)	0.2	0.8	3.3	-0.6	0.2	1.8	0.5	0.7	0.5	0.5	1.1	1.0
Allergy or Eczema	0.2	0.6	1.3	0.6	0.8	0.7	0.9	0.2	1.0	1.2	1.0	0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	-0.7	-0.3	-0.1	-0.8	0.1	-0.7	-0.8	-0.9	0.3
Number of treatments/medications taken	0.2	0.4	1.0	0.1	-0.8	-0.5	-0.9	-0.1	-1.0	-0.8	-0.6	0.0
Sensitivity / hurt feelings	0.2	0.3	1.2	0.7	0.2	0.5	0.0	-0.0	0.2	-0.5	-0.5	1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.6	0.3	-0.4	0.3	-0.1	0.6	-0.2	-0.8	-1.2	-0.3
Angina	0.2	0.2	0.7	0.9	0.5	0.1	0.1	-0.5	0.2	0.3	0.2	0.8
Vitamin and mineral supplements	0.2	0.3	0.7	-0.8	0.3	0.3	0.6	0.1	0.7	0.1	0.1	0.8
Medication: Co-codamol	0.2	0.3	0.7	-0.6	-0.2	-0.3	-0.2	-0.8	-0.1	-0.7	-0.8	-0.2
Pack years adult smoking proportion	0.2	0.2	1.1	-0.8	-0.1	-0.3	-0.1	-0.2	0.0	0.4	0.5	1.0
High blood pressure (mother)	0.2	0.3	1.6	-0.1	0.6	0.3	0.5	0.3	0.5	0.6	0.4	1.3
Leg predicted mass (left)	0.2	1.3	5.0	0.3	-0.6	-2.2	-0.8	-1.0	-1.1	-0.9	-1.0	-1.2
Alcohol usually taken with meals	0.2	0.4	1.0	0.5	0.7	0.1	0.6	-0.8	0.6	0.5	0.4	1.0
Nervous feelings	0.2	0.4	1.9	1.4	0.4	0.6	0.5	-0.4	0.4	-0.3	-0.7	0.4
Had other major operations	0.2	0.2	0.8	0.6	0.0	-0.4	0.2	0.5	0.2	0.4	0.6	0.9
Asthma	0.2	0.5	1.4	0.2	-0.5	-0.6	-0.6	-0.5	-0.6	-1.1	-1.2	-0.2
Arm fat mass (right)	0.2	1.0	3.4	-0.9	-0.7	-0.1	-0.9	-0.8	-1.0	-1.4	-1.8	-0.0
Arm fat-free mass (right)	0.2	1.1	7.7	-0.1	-0.4	-2.8	-0.4	-0.5	-0.6	-0.7	-0.5	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	-0.1	0.3	0.9	0.3	-0.9	0.3	-0.3	-0.5	0.2
Shortness of breath walking on level ground	0.2	0.3	1.4	0.7	0.5	0.6	0.2	1.2	0.2	-0.2	-0.1	0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	-0.6	-0.4	-0.1	-0.4	-0.5	-0.4	-0.5	-0.7	0.0
Angina (self-reported)	0.2	0.2	0.9	0.7	0.5	-0.1	0.1	-0.6	0.2	0.2	0.1	1.0
Whole body fat mass	0.2	0.7	2.0	-0.1	1.0	1.4	0.6	0.3	0.5	-0.0	-0.8	1.4
Leg fat mass (right)	0.2	0.6	2.6	-1.0	-0.0	0.3	-0.3	-0.1	-0.4	-1.0	-1.6	0.9
Arm predicted mass (right)	0.2	1.2	8.9	-0.2	-0.4	-3.0	-0.4	-0.4	-0.6	-0.7	-0.6	-0.5
Pulse rate, automated reading	0.2	0.6	1.6	-0.1	1.3	1.0	0.8	-0.2	0.8	0.9	0.7	0.0
Leg pain on walking	0.2	0.2	1.0	0.4	0.2	0.2	0.1	-0.1	-0.0	-0.8	-1.0	0.4
Arm fat percentage (left)	0.2	1.0	3.2	-1.0	-0.5	1.3	-0.8	-0.3	-0.9	-1.2	-1.8	0.2
Average weekly red wine intake	0.2	0.3	1.5	0.5	0.2	0.2	0.3	-1.2	0.2	0.2	0.4	0.3
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.7	-0.2	0.4	0.2	-0.1	0.2	0.6	0.6	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	-0.2	0.7	0.7	0.5	0.4	0.4	0.1	-0.1	0.9
Osteoarthritis (self-reported)	0.2	0.3	1.1	-0.4	-0.4	-0.0	-0.4	-1.1	-0.5	-0.5	-0.5	-0.3
Leg predicted mass (right)	0.2	1.3	5.8	0.4	-0.7	-2.4	-0.7	-0.8	-0.9	-0.9	-0.9	-1.2
Wears glasses or contact lenses	0.2	0.2	0.8	-0.9	0.3	0.4	0.0	-0.3	-0.0	-0.5	-0.7	0.2
Medication: Paracetamol	0.2	0.3	1.2	-0.4	0.2	0.2	0.3	0.9	0.3	0.3	0.4	1.1
Basal metabolic rate	0.2	1.4	7.1	0.3	-0.5	-2.7	-0.7	-1.0	-0.9	-0.9	-0.9	-1.0
Arm fat-free mass (left)	0.2	1.0	6.9	0.1	-0.3	-2.6	-0.2	-0.7	-0.4	-0.6	-0.6	-0.4
Unable to work because of sickness or disability	0.2	0.2	0.9	0.2	0.2	0.4	0.1	0.4	-0.1	-0.6	-0.5	1.0
Heart disease (siblings)	0.2	0.2	0.8	0.1	-0.1	-0.2	0.0	0.9	0.0	-0.7	-0.5	-0.5
Leg fat mass (left)	0.2	0.6	2.6	-0.8	0.0	0.3	-0.2	-0.1	-0.3	-1.0	-1.6	1.0
Arm predicted mass (left)	0.2	1.0	7.0	0.2	-0.2	-2.6	-0.2	-0.7	-0.4	-0.5	-0.6	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.2	1.1	-0.1	0.5	0.1	-0.9	0.1	0.3	0.4	-0.4
Worry (Nagel 2018)	0.1	0.2	0.9	1.0	0.5	-0.3	0.3	0.5	0.2	-0.3	-0.7	-0.0
Alzheimer’s Disease (including proxy)	0.1	0.2	0.8	-0.6	-0.2	-0.0	0.1	0.9	-0.0	-0.2	0.1	-0.7
LDL Cholesterol	0.1	0.1	0.3	-0.4	0.5	-0.0	0.2	-0.2	0.1	-0.2	-0.6	0.2
Blood Eosinophil Count	0.1	0.9	4.8	2.2	0.3	0.4	0.6	0.7	0.5	0.9	1.1	0.3
Blood White Count	0.1	0.5	1.4	0.2	-1.0	0.9	-0.3	1.2	-0.3	-0.6	-0.3	-0.6
Hypothyroidism (self reported)	0.1	0.2	0.9	-0.5	0.0	-0.1	0.2	-0.3	0.4	-0.1	-0.0	1.0
Diabetes (mother)	0.1	0.1	0.8	-0.1	-0.1	0.4	0.0	0.9	0.1	-0.3	-0.1	-0.1
Townsend deprivation index at recruitment	0.1	0.2	1.1	1.0	0.5	-0.2	0.3	-0.3	0.1	0.3	0.4	-0.0
Fed-up feelings	0.1	0.1	0.5	0.3	-0.1	-0.3	0.1	-0.2	0.1	-0.6	-0.7	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	0.4	0.3	0.0	0.6	-0.5	0.5	0.2	0.0	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.8	-0.2	0.1	-0.1	-0.3	-0.9	-0.2	0.3	0.6	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.5	1.2	0.1	0.4	0.1	-0.8	0.2	0.3	0.3	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	0.1	-0.6	0.1	-0.6	0.2	-0.6	-0.2	-0.2	-0.0
Medication: Atenolol	0.1	0.1	0.6	-0.6	-0.2	0.4	-0.2	-0.7	-0.2	0.1	0.2	0.1
Medication: Levothyroxine sodium	0.1	0.2	0.9	-0.3	-0.7	-0.9	-0.5	-0.6	-0.3	-0.1	0.4	-0.0
Waist circumference	0.1	0.5	1.6	-0.8	-0.6	-0.1	-0.5	-0.3	-0.6	-1.0	-1.3	0.2
Had menopause	0.1	0.1	0.4	-0.7	-0.4	0.1	0.0	-0.5	-0.2	0.1	0.5	-0.1
Qualifications: None of the above	0.1	0.2	0.6	-0.1	0.3	-0.3	0.6	0.8	0.6	0.5	0.5	0.1
Mouth/teeth dental problems	0.1	0.2	0.4	0.3	0.5	0.4	0.6	0.5	0.6	0.4	0.6	0.1
Weight	0.1	0.3	0.9	0.0	-0.1	-0.9	-0.3	-0.9	-0.5	-0.6	-0.9	-0.2
Hip circumference	0.1	0.5	1.8	0.2	-0.4	-0.8	-0.5	-0.7	-0.7	-0.9	-1.3	-0.0
Mouth/teeth dental problems: Dentures	0.1	0.2	1.6	-0.3	0.2	-0.0	0.2	0.3	0.3	0.2	0.1	1.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.8	0.5	-0.0	-0.5	0.2	0.3	0.4	0.4	0.9	0.6
Wheeze or whistling in the chest in last year	0.1	0.3	1.0	0.3	-0.3	-0.7	-0.2	-1.0	-0.2	-0.4	-0.6	0.1
Age at first live birth	0.1	0.2	0.8	0.8	-0.2	-0.4	-0.0	-0.2	-0.1	-0.3	-0.5	-0.9
Emphysema/chronic bronchitis	0.1	0.1	0.7	0.4	0.1	0.2	0.2	0.4	0.2	-0.3	-0.2	-0.8
Medication for pain relief, constipation, heartburn	0.1	0.2	1.0	-0.3	0.0	0.4	0.2	-0.4	0.3	-0.3	-1.0	-0.0
Long-standing illness, disability or infirmity	0.1	0.2	0.4	-0.3	-0.5	-0.3	-0.6	0.7	-0.6	-0.2	0.1	0.5
Arm fat mass (left)	0.1	0.6	2.4	-0.6	-0.3	0.3	-0.5	-0.6	-0.7	-1.0	-1.6	0.2
Mother’s age at death	0.1	0.1	0.4	-0.2	0.3	0.4	-0.1	0.2	-0.0	-0.1	-0.4	0.7
Financial situation satisfaction	0.1	0.2	0.9	0.2	-0.1	-0.0	-0.1	-0.3	-0.2	0.4	0.4	0.9
Alcohol drinker status: Never	0.1	0.1	0.2	-0.1	-0.0	0.0	-0.5	0.3	-0.4	-0.0	0.2	-0.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.6	0.4	0.1	0.0	-0.1	-0.8	-0.2	0.2	0.2	0.1
Pack years of smoking	0.1	0.2	0.6	-0.7	-0.3	-0.6	-0.2	-0.1	-0.1	0.2	0.5	0.7
Hair Pigment	0.0	0.3	1.0	0.5	-0.0	-0.4	-0.3	0.5	-0.2	-1.0	-1.0	0.3
Tanning	0.0	0.4	3.0	0.2	-0.2	-0.3	-0.3	1.7	-0.3	0.4	0.3	0.4
Hair/balding pattern: Pattern 4	0.0	0.0	0.2	0.3	-0.1	0.1	0.1	0.4	0.2	-0.1	0.0	-0.0

Hub : Genes

CHCHD4

Models

Trait associations