Best TWAS P=2e-09 · Best GWAS P=1.42e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PTPN13 | 0.13 | 0.18 | bslmm | 418 | 0.18 | 6.8e-22 | -5.4 | 6.0 | 2.0e-09 | -0.98 | 0.04 | 0.96 | TRUE |
| 5 | GTEx | Ovary | PTPN13 | 0.18 | -0.01 | enet | 29 | 0.07 | 8.4e-03 | -5.4 | 5.8 | 8.2e-09 | -0.47 | 0.04 | 0.63 | FALSE |
| 6 | GTEx | Thyroid | PTPN13 | 0.41 | 0.31 | lasso | 6 | 0.30 | 3.2e-23 | -5.5 | -5.5 | 4.1e-08 | 0.51 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Colon Sigmoid | MAPK10 | 0.25 | 0.11 | lasso | 8 | 0.07 | 1.6e-03 | -5.5 | 5.4 | 5.8e-08 | -0.59 | 0.04 | 0.91 | FALSE |
| 2 | GTEx | Artery Aorta | MAPK10 | 0.15 | 0.17 | enet | 16 | 0.17 | 1.4e-09 | -5.5 | 5.4 | 7.9e-08 | -0.46 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Brain Caudate basal ganglia | PTPN13 | 0.26 | 0.16 | enet | 17 | 0.11 | 4.6e-04 | -5.6 | 5.3 | 1.3e-07 | -0.92 | 0.03 | 0.93 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | PTPN13 | 0.09 | 0.03 | blup | 409 | 0.07 | 4.7e-09 | -5.4 | 5.3 | 1.3e-07 | -0.87 | 0.04 | 0.96 | FALSE |