TWAS
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Models
Genes
Traits
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Traits
:
Impedance of leg (left)
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chr5:36,410,564-38,450,430
Best TWAS P=2.92e-11 · Best GWAS P=1.05e-11 conditioned to 9.32e-05
36.5M
37M
37.5M
38M
38.5M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells Transformed fibroblasts
WDR70
0.06
0.03
lasso
8
0.03
0.00346
6.1
-6.7
2.9e-11
0.52
0.18
0.73
TRUE
5
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
C5orf42
0.04
0.05
lasso
3
0.04
0.00108
6.6
-6.4
1.2e-10
0.45
0.01
0.73
FALSE
4
GTEx
Whole Blood
C5orf42
0.07
0.00
enet
16
0.01
0.01830
6.6
-6.1
1.1e-09
0.49
0.04
0.59
FALSE
2
GTEx
Nerve Tibial
WDR70
0.17
0.07
lasso
3
0.05
0.00014
-6.1
-6.0
2.2e-09
0.92
0.16
0.61
FALSE
3
GTEx
Whole Blood
NUP155
0.05
0.01
enet
14
0.04
0.00011
6.6
-5.4
7.3e-08
0.40
0.04
0.60
FALSE