[Hub]/) : Traits : Impedance of leg (left) : ← →

chr4:119,408,351-121,242,474

Best TWAS P=5.99e-26 · Best GWAS P=4.89e-25 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	CommonMind	Brain Pre-frontal Cortex	USP53	0.16	0.13	lasso	11	0.20	3.5e-23	7.20	10.5	6.0e-26	-0.72	0.62	0.38	TRUE
82	The Cancer Genome Atlas	Thyroid Carcinoma	USP53	0.11	0.03	blup	88	0.07	5.8e-07	7.09	10.2	1.4e-24	-0.60	0.59	0.33	TRUE
68	GTEx	Vagina	RP11-33B1.1	0.32	0.25	lasso	10	0.27	5.3e-07	-9.30	9.7	3.2e-22	-0.81	0.70	0.23	TRUE
66	GTEx	Thyroid	RP11-33B1.4	0.07	0.07	lasso	3	0.05	1.8e-04	-9.87	9.5	3.2e-21	-0.88	0.20	0.75	TRUE
22	GTEx	Brain Cerebellum	RP11-33B1.4	0.14	-0.01	enet	18	-0.01	7.4e-01	-8.84	-9.5	3.4e-21	0.77	0.11	0.32	TRUE
81	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PDE5A	0.10	0.04	lasso	2	0.04	2.6e-03	-8.65	8.3	1.2e-16	-0.69	0.04	0.33	TRUE
15	GTEx	Artery Tibial	RP11-33B1.4	0.14	0.10	lasso	7	0.06	8.5e-06	-9.30	-8.1	3.9e-16	0.67	0.85	0.12	TRUE
13	GTEx	Artery Tibial	C4orf3	0.04	0.00	enet	7	0.03	3.2e-03	-4.61	-7.4	1.3e-13	0.59	0.10	0.68	TRUE
53	GTEx	Pancreas	RP11-33B1.1	0.13	0.18	lasso	5	0.18	4.7e-08	-8.91	10.1	3.3e-24	-0.80	0.88	0.11	FALSE
46	GTEx	Liver	RP11-33B1.4	0.18	0.14	lasso	6	0.12	3.2e-04	-9.87	10.1	4.5e-24	-0.94	0.05	0.93	FALSE
30	GTEx	Breast Mammary Tissue	RP11-33B1.1	0.19	0.08	lasso	4	0.15	3.7e-08	7.81	9.9	6.1e-23	-0.64	0.84	0.16	FALSE
19	GTEx	Brain Cerebellar Hemisphere	RP11-33B1.1	0.35	0.34	lasso	8	0.33	2.5e-09	-9.30	9.8	7.9e-23	-0.75	0.51	0.40	FALSE
32	GTEx	Cells EBV-transformed lymphocytes	PDE5A	0.25	0.20	lasso	27	0.20	5.1e-07	-8.91	9.8	8.3e-23	-0.85	0.46	0.54	FALSE
51	GTEx	Ovary	RP11-33B1.1	0.26	0.07	enet	33	0.16	1.2e-04	7.19	9.8	9.9e-23	-0.59	0.20	0.31	FALSE
18	GTEx	Brain Caudate basal ganglia	RP11-33B1.4	0.12	0.16	lasso	4	0.15	5.7e-05	-9.37	9.8	1.4e-22	-0.87	0.19	0.65	FALSE
63	GTEx	Testis	RP11-33B1.4	0.23	0.31	enet	16	0.37	1.5e-17	-8.90	9.8	1.7e-22	-0.86	0.51	0.49	FALSE
5	GTEx	Adipose Subcutaneous	RP11-33B1.1	0.23	0.10	lasso	12	0.18	4.7e-15	6.40	9.7	3.1e-22	-0.68	0.74	0.26	FALSE
29	GTEx	Brain Putamen basal ganglia	RP11-33B1.1	0.32	0.16	lasso	7	0.16	9.9e-05	-9.30	9.7	3.2e-22	-0.68	0.31	0.15	FALSE
61	GTEx	Stomach	RP11-33B1.1	0.11	0.08	lasso	3	0.09	4.3e-05	-9.07	9.6	5.0e-22	-0.83	0.61	0.33	FALSE
43	GTEx	Heart Atrial Appendage	RP11-33B1.1	0.15	0.08	lasso	3	0.10	4.0e-05	-9.10	9.6	5.9e-22	-0.78	0.57	0.38	FALSE
60	GTEx	Spleen	RP11-33B1.1	0.22	0.03	enet	17	0.02	7.7e-02	7.16	9.6	6.5e-22	-0.66	0.16	0.11	FALSE
9	GTEx	Artery Aorta	RP11-33B1.1	0.12	0.10	lasso	8	0.13	2.0e-07	-8.65	9.6	7.4e-22	-0.82	0.96	0.04	FALSE
21	GTEx	Brain Cerebellum	RP11-33B1.1	0.31	0.30	lasso	11	0.32	2.9e-10	-9.30	9.6	7.5e-22	-0.72	0.86	0.13	FALSE
65	GTEx	Thyroid	RP11-33B1.1	0.18	0.21	lasso	3	0.24	1.0e-18	-9.37	9.6	9.0e-22	-0.72	1.00	0.00	FALSE
39	GTEx	Esophagus Mucosa	RP11-33B1.1	0.25	0.29	lasso	12	0.36	3.3e-25	-8.91	9.6	9.9e-22	-0.73	1.00	0.00	FALSE
44	GTEx	Heart Atrial Appendage	RP11-33B1.4	0.12	0.10	lasso	4	0.05	2.0e-03	-9.30	-9.6	9.9e-22	0.77	0.30	0.35	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-33B1.1	0.23	0.10	lasso	7	0.17	5.2e-09	-8.65	9.6	1.0e-21	-0.66	0.56	0.41	FALSE
14	GTEx	Artery Tibial	RP11-33B1.1	0.22	0.17	lasso	7	0.16	1.4e-12	-8.65	9.5	1.8e-21	-0.75	0.99	0.01	FALSE
17	GTEx	Brain Caudate basal ganglia	RP11-33B1.1	0.27	0.34	lasso	2	0.29	5.9e-09	-9.30	9.5	2.1e-21	-0.77	0.38	0.61	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PDE5A	0.05	0.04	lasso	2	0.03	8.1e-05	-9.30	9.5	3.1e-21	-0.80	0.54	0.44	FALSE
36	GTEx	Colon Sigmoid	RP11-33B1.1	0.25	0.14	lasso	3	0.16	2.3e-06	-9.07	9.4	4.1e-21	-0.74	0.56	0.29	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	RP11-33B1.1	0.22	0.42	lasso	5	0.42	1.4e-59	-8.65	9.4	5.9e-21	-0.80	1.00	0.00	FALSE
40	GTEx	Esophagus Muscularis	RP11-33B1.1	0.10	0.14	lasso	3	0.12	1.4e-07	-9.30	9.4	8.2e-21	-0.80	0.70	0.30	FALSE
54	GTEx	Pancreas	RP11-33B1.4	0.20	0.05	lasso	16	0.05	3.8e-03	-9.24	9.3	1.1e-20	-0.83	0.22	0.68	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	USP53	0.06	0.04	blup	470	0.05	5.7e-07	-10.26	9.3	1.5e-20	-0.82	0.02	0.98	FALSE
20	GTEx	Brain Cerebellar Hemisphere	RP11-33B1.4	0.13	0.05	lasso	4	0.01	1.6e-01	-8.83	-9.3	1.6e-20	0.85	0.08	0.65	FALSE
26	GTEx	Brain Hypothalamus	RP11-33B1.1	0.40	0.24	lasso	6	0.23	4.5e-06	-9.30	9.3	1.8e-20	-0.71	0.30	0.49	FALSE
38	GTEx	Colon Transverse	RP11-33B1.1	0.25	0.31	lasso	10	0.39	7.1e-20	-8.91	9.3	1.8e-20	-0.72	1.00	0.00	FALSE
62	GTEx	Testis	RP11-33B1.1	0.37	0.46	lasso	6	0.47	2.2e-23	-8.89	9.2	2.3e-20	-0.81	1.00	0.00	FALSE
59	GTEx	Small Intestine Terminal Ileum	RP11-33B1.1	0.15	0.10	lasso	19	0.09	5.4e-03	-8.88	9.2	2.6e-20	-0.78	0.14	0.43	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LOC645513	0.27	0.50	enet	50	0.51	2.1e-72	-8.90	9.2	3.3e-20	-0.84	1.00	0.00	FALSE
35	GTEx	Cells Transformed fibroblasts	RP11-33B1.1	0.23	0.44	lasso	11	0.45	1.8e-37	-8.91	9.2	3.4e-20	-0.82	1.00	0.00	FALSE
52	GTEx	Ovary	RP11-33B1.4	0.13	0.07	lasso	3	0.02	1.2e-01	-8.26	-9.2	3.5e-20	0.81	0.05	0.62	FALSE
67	GTEx	Uterus	RP11-33B1.4	0.23	0.24	lasso	4	0.16	4.9e-04	-9.06	-9.2	5.3e-20	0.91	0.08	0.55	FALSE
79	The Cancer Genome Atlas	Colon Adenocarcinoma	FABP2	0.24	0.20	lasso	9	0.25	1.8e-14	7.01	-9.1	5.9e-20	0.75	0.08	0.92	FALSE
28	GTEx	Brain Nucleus accumbens basal ganglia	RP11-33B1.1	0.42	0.36	lasso	11	0.33	9.5e-10	-8.91	9.1	6.8e-20	-0.85	0.42	0.57	FALSE
47	GTEx	Lung	RP11-33B1.1	0.16	0.12	lasso	9	0.22	6.0e-17	5.28	9.1	7.6e-20	-0.62	1.00	0.00	FALSE
49	GTEx	Muscle Skeletal	RP11-33B1.1	0.04	0.03	lasso	3	0.02	8.1e-03	-8.90	9.1	7.9e-20	-0.80	0.53	0.40	FALSE
45	GTEx	Liver	RP11-33B1.1	0.18	0.12	enet	31	0.17	1.6e-05	-8.90	9.1	1.3e-19	-0.78	0.22	0.75	FALSE
37	GTEx	Colon Sigmoid	RP11-33B1.4	0.10	0.03	lasso	3	0.04	1.1e-02	-8.65	-9.0	1.4e-19	0.66	0.23	0.33	FALSE
16	GTEx	Brain Caudate basal ganglia	PDE5A	0.13	0.02	enet	12	0.06	6.4e-03	-9.07	9.0	1.8e-19	-0.69	0.19	0.41	FALSE
72	GTEx	Whole Blood	RP11-33B1.4	0.13	0.16	lasso	9	0.15	1.4e-13	-8.90	-9.0	2.9e-19	0.83	1.00	0.00	FALSE
34	GTEx	Cells EBV-transformed lymphocytes	RP11-33B1.1	0.33	0.46	lasso	8	0.44	4.3e-16	-8.91	8.9	4.0e-19	-0.83	0.80	0.20	FALSE
42	GTEx	Heart Atrial Appendage	MYOZ2	0.17	0.01	enet	16	0.02	5.7e-02	-10.34	-8.9	7.6e-19	0.80	0.01	0.97	FALSE
24	GTEx	Brain Frontal Cortex BA9	RP11-33B1.1	0.36	0.28	lasso	8	0.25	2.2e-07	-8.65	8.9	8.1e-19	-0.78	0.91	0.04	FALSE
70	GTEx	Whole Blood	C4orf3	0.11	0.16	lasso	6	0.16	3.0e-14	-9.37	-8.9	8.5e-19	0.85	0.86	0.14	FALSE
11	GTEx	Artery Coronary	RP11-33B1.1	0.21	0.16	lasso	10	0.22	7.4e-08	-8.91	8.8	1.7e-18	-0.72	0.67	0.31	FALSE
7	GTEx	Adrenal Gland	RP11-33B1.1	0.13	0.07	enet	25	0.09	5.5e-04	-8.91	8.7	2.3e-18	-0.75	0.57	0.21	FALSE
48	GTEx	Lung	RP11-33B1.4	0.10	0.10	lasso	5	0.09	4.2e-07	-8.86	-8.7	3.1e-18	0.80	0.96	0.04	FALSE
78	YFS	Blood	USP53	0.06	0.05	bslmm	479	0.06	8.1e-20	7.08	8.7	4.1e-18	-0.33	1.00	0.00	FALSE
73	NTR	Blood	PDE5A	0.03	0.05	lasso	6	0.04	2.0e-13	-8.90	8.7	4.8e-18	-0.81	0.99	0.01	FALSE
50	GTEx	Nerve Tibial	RP11-33B1.1	0.42	0.25	enet	32	0.35	1.1e-25	-8.65	8.6	7.2e-18	-0.65	0.99	0.01	FALSE
71	GTEx	Whole Blood	RP11-33B1.1	0.06	0.06	lasso	4	0.05	2.3e-05	-8.83	8.6	8.6e-18	-0.82	0.76	0.24	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	RP11-33B1.1	0.16	0.12	enet	9	0.13	1.0e-07	-8.65	8.6	1.2e-17	-0.70	0.90	0.08	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	PDE5A	0.02	0.00	bslmm	442	0.01	7.3e-03	6.21	8.4	3.4e-17	-0.73	0.08	0.56	FALSE
12	GTEx	Artery Coronary	RP11-33B1.4	0.10	0.02	lasso	2	0.01	1.5e-01	-8.26	-8.3	8.9e-17	0.70	0.18	0.24	FALSE
33	GTEx	Cells EBV-transformed lymphocytes	USP53	0.13	0.01	lasso	5	0.02	8.8e-02	-8.26	8.3	8.9e-17	-0.76	0.08	0.39	FALSE
25	GTEx	Brain Hippocampus	RP11-33B1.1	0.18	0.02	enet	20	0.05	2.2e-02	-9.07	8.3	1.4e-16	-0.76	0.16	0.49	FALSE
31	GTEx	Breast Mammary Tissue (Female)	RP11-33B1.1	0.31	0.29	enet	10	0.24	9.1e-08	7.08	8.2	1.7e-16	-0.45	0.83	0.09	FALSE
80	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	USP53	0.07	0.05	blup	88	0.04	7.9e-06	7.68	8.1	3.8e-16	-0.53	0.69	0.17	FALSE
23	GTEx	Brain Cortex	RP11-33B1.1	0.42	0.24	enet	23	0.28	1.7e-08	-9.30	8.0	1.5e-15	-0.62	0.78	0.15	FALSE
58	GTEx	Skin Sun Exposed Lower leg	RP11-33B1.1	0.12	0.10	lasso	3	0.09	6.6e-08	5.28	7.9	3.4e-15	-0.40	0.99	0.00	FALSE
8	GTEx	Adrenal Gland	RP11-33B1.4	0.11	0.10	enet	20	0.16	3.2e-06	-8.86	7.1	1.1e-12	-0.75	0.28	0.67	FALSE
41	GTEx	Esophagus Muscularis	RP11-33B1.4	0.16	0.00	enet	28	0.00	2.8e-01	-0.42	-7.1	1.4e-12	0.50	0.23	0.08	FALSE
10	GTEx	Artery Aorta	RP11-33B1.4	0.11	0.04	enet	15	0.04	1.7e-03	-8.86	-6.9	7.1e-12	0.77	0.39	0.55	FALSE
74	NTR	Blood	USP53	0.10	0.10	bslmm	482	0.11	2.6e-34	7.08	6.8	9.4e-12	-0.17	1.00	0.00	FALSE
64	GTEx	Thyroid	PDE5A	0.09	0.04	lasso	3	0.04	6.9e-04	5.88	6.3	3.0e-10	-0.32	0.25	0.12	FALSE
4	GTEx	Adipose Subcutaneous	C4orf3	0.11	0.01	lasso	9	0.03	3.4e-03	-4.61	-6.3	3.2e-10	0.62	0.20	0.12	FALSE
27	GTEx	Brain Nucleus accumbens basal ganglia	MYOZ2	0.35	-0.01	enet	34	0.07	5.8e-03	7.01	-6.2	4.1e-10	0.41	0.08	0.37	FALSE
69	GTEx	Whole Blood	USP53	0.09	0.05	enet	11	0.06	3.1e-06	7.09	5.9	3.2e-09	-0.15	0.98	0.00	FALSE
55	GTEx	Pituitary	RP11-33B1.1	0.17	0.15	lasso	3	0.12	8.1e-04	4.98	5.9	4.2e-09	-0.27	0.23	0.24	FALSE
57	GTEx	Skin Sun Exposed Lower leg	USP53	0.07	0.00	enet	26	0.00	2.6e-01	-9.84	-5.4	8.7e-08	0.49	0.14	0.17	FALSE