Best TWAS P=6.83e-15 · Best GWAS P=2.99e-13 conditioned to 7.3e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HINT1 | 0.10 | 0.07 | enet | 16 | 0.06 | 8.8e-06 | 6.4 | 7.8 | 6.8e-15 | 0.49 | 0.27 | 0.66 | TRUE |
| 2 | GTEx | Artery Aorta | HINT1 | 0.07 | 0.07 | enet | 8 | 0.06 | 4.7e-04 | 6.9 | 7.5 | 4.4e-14 | 0.75 | 0.05 | 0.74 | FALSE |
| 3 | GTEx | Artery Tibial | HINT1 | 0.11 | 0.04 | enet | 18 | 0.06 | 1.0e-05 | 6.6 | 7.0 | 3.2e-12 | 0.55 | 0.09 | 0.84 | FALSE |
| 4 | GTEx | Artery Tibial | LYRM7 | 0.10 | 0.03 | lasso | 3 | 0.04 | 3.1e-04 | 5.6 | -5.2 | 1.7e-07 | -0.75 | 0.40 | 0.29 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | HINT1 | 0.10 | 0.06 | lasso | 2 | 0.05 | 2.1e-04 | 6.5 | 6.9 | 4.8e-12 | 0.57 | 0.14 | 0.82 | FALSE |
| 6 | GTEx | Testis | RAPGEF6 | 0.50 | 0.35 | lasso | 4 | 0.32 | 6.5e-15 | 5.9 | 6.5 | 8.3e-11 | 0.89 | 0.06 | 0.94 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CDC42SE2 | 0.10 | 0.07 | lasso | 1 | 0.06 | 2.6e-04 | 5.1 | -5.1 | 3.1e-07 | -0.80 | 0.02 | 0.85 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HINT1 | 0.06 | 0.03 | enet | 5 | 0.03 | 5.2e-04 | 4.7 | 5.8 | 8.0e-09 | 0.74 | 0.06 | 0.51 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | LYRM7 | 0.03 | 0.01 | enet | 10 | 0.02 | 7.5e-04 | 4.8 | -6.4 | 1.7e-10 | -0.74 | 0.01 | 0.86 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | HINT1 | 0.07 | 0.04 | lasso | 2 | 0.01 | 1.8e-02 | 6.4 | 6.4 | 1.7e-10 | 0.57 | 0.00 | 0.98 | FALSE |