[Hub]/) : Traits : Impedance of leg (left) :

chr5:125,679,739-128,220,643

Best TWAS P=4.61e-120 · Best GWAS P=7.35e-116 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FLJ33630 0.06 0.07 lasso 6 0.07 8.6e-09 9.82 15.1 3.3e-51 -0.52 0.62 0.38 FALSE
2 GTEx Adipose Subcutaneous CTC-228N24.3 0.24 0.15 enet 16 0.20 3.4e-16 -22.88 22.2 8.4e-109 -0.97 0.00 1.00 FALSE
3 GTEx Adipose Visceral Omentum CTC-228N24.3 0.24 0.16 enet 19 0.16 1.8e-08 -22.88 20.8 1.9e-96 -0.80 0.00 1.00 TRUE
4 GTEx Adrenal Gland CTC-228N24.3 0.34 0.10 lasso 9 0.09 4.2e-04 -17.81 20.3 4.8e-92 -0.88 0.03 0.96 FALSE
5 GTEx Artery Aorta CTC-228N24.3 0.20 0.04 lasso 8 0.07 7.4e-05 -8.44 20.8 1.1e-95 -0.91 0.11 0.86 FALSE
6 GTEx Artery Coronary CTC-228N24.3 0.31 0.10 lasso 3 0.10 2.9e-04 -22.04 21.6 4.0e-103 -0.86 0.01 0.90 FALSE
7 GTEx Artery Tibial CTC-228N24.3 0.20 0.16 lasso 7 0.14 3.0e-11 -22.88 23.3 4.6e-120 -0.99 0.00 1.00 TRUE
8 GTEx Brain Caudate basal ganglia PRRC1 0.39 0.00 enet 5 0.06 7.1e-03 -7.58 7.6 2.8e-14 -0.19 0.07 0.05 FALSE
9 GTEx Brain Caudate basal ganglia CTC-228N24.3 0.28 -0.01 enet 50 0.05 1.2e-02 6.79 11.1 1.9e-28 -0.30 0.04 0.55 FALSE
10 GTEx Brain Cerebellar Hemisphere SLC12A2 0.45 -0.01 enet 20 0.01 2.1e-01 -16.90 12.0 2.3e-33 -0.46 0.04 0.33 FALSE
11 GTEx Brain Cerebellar Hemisphere CTC-228N24.3 0.25 0.00 lasso 6 0.05 2.2e-02 -0.19 12.9 4.3e-38 -0.49 0.03 0.62 TRUE
12 GTEx Brain Cerebellum C5orf63 0.20 0.07 lasso 3 0.05 1.7e-02 -6.68 6.3 3.6e-10 0.04 0.01 0.96 TRUE
13 GTEx Brain Cerebellum CTC-228N24.3 0.31 0.04 lasso 5 0.12 2.9e-04 -22.88 21.0 1.3e-97 -0.84 0.01 0.97 FALSE
14 GTEx Brain Frontal Cortex BA9 CTC-228N24.3 0.25 0.00 enet 26 0.05 2.2e-02 8.99 10.9 1.8e-27 -0.36 0.08 0.30 FALSE
15 GTEx Brain Nucleus accumbens basal ganglia CTC-228N24.3 0.43 0.13 lasso 6 0.18 1.7e-05 8.99 9.7 2.5e-22 -0.28 0.81 0.03 TRUE
16 GTEx Cells EBV-transformed lymphocytes CTC-228N24.3 0.24 -0.01 enet 26 0.04 2.2e-02 -11.55 12.7 4.3e-37 -0.57 0.03 0.70 FALSE
17 GTEx Cells Transformed fibroblasts SLC12A2 0.08 0.07 enet 19 0.08 1.5e-06 8.97 -8.3 7.0e-17 0.36 0.77 0.05 FALSE
18 GTEx Cells Transformed fibroblasts CTC-228N24.3 0.24 0.16 enet 26 0.16 8.6e-12 -22.88 21.1 1.4e-98 -0.89 0.00 1.00 FALSE
19 GTEx Colon Sigmoid CTC-228N24.3 0.20 0.22 enet 11 0.23 1.1e-08 -22.04 22.0 4.5e-107 -0.92 0.01 0.99 FALSE
20 GTEx Esophagus Gastroesophageal Junction CTC-228N24.3 0.20 0.04 enet 22 0.13 2.1e-05 9.88 17.0 1.3e-64 -0.51 0.05 0.68 FALSE
21 GTEx Esophagus Mucosa CTC-228N24.3 0.18 0.14 enet 11 0.14 9.8e-10 -22.88 22.6 6.9e-113 -0.93 0.00 1.00 FALSE
22 GTEx Esophagus Muscularis CTC-228N24.3 0.24 0.08 enet 29 0.14 1.4e-08 -22.04 20.4 1.6e-92 -0.75 0.01 0.99 FALSE
23 GTEx Heart Atrial Appendage CTC-228N24.3 0.22 0.07 lasso 5 0.07 4.1e-04 -21.85 20.7 2.0e-95 -0.87 0.00 0.99 FALSE
24 GTEx Heart Left Ventricle CTC-228N24.3 0.24 0.15 lasso 7 0.19 1.9e-10 -20.98 21.4 1.2e-101 -0.84 0.01 0.99 FALSE
25 GTEx Lung CTC-228N24.3 0.18 0.14 enet 16 0.14 3.2e-11 -22.88 21.2 7.1e-100 -0.95 0.00 1.00 FALSE
26 GTEx Muscle Skeletal CTC-228N24.3 0.25 0.20 lasso 5 0.21 1.6e-20 -22.88 22.6 2.0e-113 -0.95 0.00 1.00 FALSE
27 GTEx Nerve Tibial CTC-228N24.3 0.32 0.18 lasso 10 0.16 1.6e-11 -22.04 22.1 1.6e-108 -0.96 0.01 0.99 FALSE
28 GTEx Pancreas CTC-228N24.3 0.14 0.19 lasso 2 0.17 1.1e-07 -22.88 22.9 7.4e-116 -1.00 0.00 1.00 FALSE
29 GTEx Skin Not Sun Exposed Suprapubic CTC-228N24.3 0.29 0.21 lasso 7 0.22 1.7e-12 -22.88 22.2 3.3e-109 -0.97 0.00 1.00 FALSE
30 GTEx Skin Sun Exposed Lower leg CTC-228N24.3 0.29 0.17 enet 12 0.22 4.3e-18 -21.85 21.2 5.5e-100 -0.90 0.00 1.00 FALSE
31 GTEx Spleen CTC-228N24.3 0.26 0.03 enet 15 0.05 1.8e-02 -8.44 18.1 7.0e-73 -0.66 0.04 0.56 FALSE
32 GTEx Stomach SLC12A2 0.23 0.17 enet 19 0.17 1.6e-08 -13.99 14.1 2.2e-45 -0.45 0.80 0.16 FALSE
33 GTEx Stomach CTC-228N24.3 0.17 0.04 lasso 6 0.08 1.5e-04 -20.98 21.3 1.6e-100 -0.81 0.02 0.95 FALSE
34 GTEx Testis CTC-228N24.3 0.30 0.16 lasso 6 0.14 1.1e-06 -22.88 21.0 2.3e-98 -0.93 0.00 1.00 FALSE
35 GTEx Thyroid CTC-228N24.3 0.31 0.15 enet 32 0.18 4.6e-14 -22.88 20.7 3.6e-95 -0.78 0.00 1.00 FALSE
36 METSIM Adipose CTC-228N24.3 0.17 0.19 lasso 6 0.18 1.9e-26 -22.88 22.8 2.3e-115 -1.00 0.00 1.00 FALSE
37 ROSMAP Brain Pre-frontal Cortex CTC-228N24.3 0.15 0.09 lasso 3 0.12 8.0e-15 -22.88 20.4 1.2e-92 -0.88 0.00 1.00 FALSE
38 The Cancer Genome Atlas Breast Invasive Carcinoma FLJ33630 0.05 0.04 enet 14 0.03 2.1e-07 -22.88 22.0 3.5e-107 -0.88 0.00 1.00 TRUE
39 The Cancer Genome Atlas Glioblastoma Multiforme FLJ33630 0.38 0.20 lasso 5 0.17 6.5e-06 -22.88 22.8 7.6e-115 -0.99 0.00 1.00 FALSE
40 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FLJ33630 0.10 0.07 lasso 3 0.08 7.0e-09 -22.04 21.7 1.8e-104 -0.95 0.00 1.00 FALSE
41 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FLJ33630 0.10 0.06 enet 18 0.08 2.0e-09 -22.88 20.0 2.3e-89 -0.79 0.00 1.00 FALSE
42 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FLJ33630 0.14 0.00 blup 72 0.09 9.1e-06 0.32 7.9 2.2e-15 -0.28 0.06 0.39 FALSE
43 The Cancer Genome Atlas Brain Lower Grade Glioma FBN2 0.12 0.02 enet 17 0.05 1.7e-06 -16.58 10.8 3.4e-27 -0.53 0.04 0.93 FALSE
44 The Cancer Genome Atlas Brain Lower Grade Glioma FLJ33630 0.19 0.16 enet 4 0.16 1.2e-17 -22.86 22.8 4.4e-115 -1.00 0.00 1.00 FALSE
45 The Cancer Genome Atlas Lung Adenocarcinoma FLJ33630 0.07 0.05 lasso 1 0.04 1.3e-05 -22.04 22.0 1.3e-107 -0.96 0.01 0.99 FALSE
46 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FLJ33630 0.09 0.08 lasso 4 0.09 4.9e-10 -22.88 22.8 5.1e-115 -1.00 0.00 1.00 FALSE
47 The Cancer Genome Atlas Pancreatic Adenocarcinoma FLJ33630 0.08 0.03 lasso 2 0.04 5.7e-03 -22.04 22.4 3.8e-111 -0.90 0.01 0.89 FALSE
48 The Cancer Genome Atlas Prostate Adenocarcinoma FLJ33630 0.08 0.05 blup 70 0.04 4.4e-05 -22.04 22.8 6.9e-115 -0.86 0.00 1.00 FALSE
49 The Cancer Genome Atlas Prostate Adenocarcinoma SLC12A2 0.04 0.02 enet 17 0.02 3.3e-03 -22.04 -13.2 1.4e-39 0.69 0.01 0.87 FALSE
50 The Cancer Genome Atlas Stomach Adenocarcinoma FLJ33630 0.07 0.02 blup 70 0.02 1.5e-02 -13.14 17.2 3.8e-66 -0.48 0.12 0.14 FALSE
51 The Cancer Genome Atlas Testicular Germ Cell Tumors FLJ33630 0.26 0.14 lasso 3 0.13 2.2e-05 -22.88 23.1 4.7e-118 -0.99 0.00 1.00 FALSE
52 The Cancer Genome Atlas Thyroid Carcinoma FLJ33630 0.10 0.10 lasso 2 0.09 5.3e-09 -22.86 22.9 3.2e-116 -1.00 0.00 1.00 FALSE
53 The Cancer Genome Atlas Thyroid Carcinoma SLC12A2 0.06 0.08 blup 50 0.07 1.5e-07 9.02 6.2 5.9e-10 -0.16 1.00 0.00 TRUE