[Hub]/) : Traits : Impedance of leg (left) : ← →

chr5:125,679,739-128,220,643

Best TWAS P=4.61e-120 · Best GWAS P=7.35e-116 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Artery Tibial	CTC-228N24.3	0.20	0.16	lasso	7	0.14	3.0e-11	-22.88	23.3	4.6e-120	-0.99	0.00	1.00	TRUE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLJ33630	0.05	0.04	enet	14	0.03	2.1e-07	-22.88	22.0	3.5e-107	-0.88	0.00	1.00	TRUE
3	GTEx	Adipose Visceral Omentum	CTC-228N24.3	0.24	0.16	enet	19	0.16	1.8e-08	-22.88	20.8	1.9e-96	-0.80	0.00	1.00	TRUE
11	GTEx	Brain Cerebellar Hemisphere	CTC-228N24.3	0.25	0.00	lasso	6	0.05	2.2e-02	-0.19	12.9	4.3e-38	-0.49	0.03	0.62	TRUE
15	GTEx	Brain Nucleus accumbens basal ganglia	CTC-228N24.3	0.43	0.13	lasso	6	0.18	1.7e-05	8.99	9.7	2.5e-22	-0.28	0.81	0.03	TRUE
12	GTEx	Brain Cerebellum	C5orf63	0.20	0.07	lasso	3	0.05	1.7e-02	-6.68	6.3	3.6e-10	0.04	0.01	0.96	TRUE
53	The Cancer Genome Atlas	Thyroid Carcinoma	SLC12A2	0.06	0.08	blup	50	0.07	1.5e-07	9.02	6.2	5.9e-10	-0.16	1.00	0.00	TRUE
51	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ33630	0.26	0.14	lasso	3	0.13	2.2e-05	-22.88	23.1	4.7e-118	-0.99	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	FLJ33630	0.10	0.10	lasso	2	0.09	5.3e-09	-22.86	22.9	3.2e-116	-1.00	0.00	1.00	FALSE
28	GTEx	Pancreas	CTC-228N24.3	0.14	0.19	lasso	2	0.17	1.1e-07	-22.88	22.9	7.4e-116	-1.00	0.00	1.00	FALSE
36	METSIM	Adipose	CTC-228N24.3	0.17	0.19	lasso	6	0.18	1.9e-26	-22.88	22.8	2.3e-115	-1.00	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ33630	0.19	0.16	enet	4	0.16	1.2e-17	-22.86	22.8	4.4e-115	-1.00	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLJ33630	0.09	0.08	lasso	4	0.09	4.9e-10	-22.88	22.8	5.1e-115	-1.00	0.00	1.00	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLJ33630	0.08	0.05	blup	70	0.04	4.4e-05	-22.04	22.8	6.9e-115	-0.86	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Glioblastoma Multiforme	FLJ33630	0.38	0.20	lasso	5	0.17	6.5e-06	-22.88	22.8	7.6e-115	-0.99	0.00	1.00	FALSE
26	GTEx	Muscle Skeletal	CTC-228N24.3	0.25	0.20	lasso	5	0.21	1.6e-20	-22.88	22.6	2.0e-113	-0.95	0.00	1.00	FALSE
21	GTEx	Esophagus Mucosa	CTC-228N24.3	0.18	0.14	enet	11	0.14	9.8e-10	-22.88	22.6	6.9e-113	-0.93	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FLJ33630	0.08	0.03	lasso	2	0.04	5.7e-03	-22.04	22.4	3.8e-111	-0.90	0.01	0.89	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	CTC-228N24.3	0.29	0.21	lasso	7	0.22	1.7e-12	-22.88	22.2	3.3e-109	-0.97	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	CTC-228N24.3	0.24	0.15	enet	16	0.20	3.4e-16	-22.88	22.2	8.4e-109	-0.97	0.00	1.00	FALSE
27	GTEx	Nerve Tibial	CTC-228N24.3	0.32	0.18	lasso	10	0.16	1.6e-11	-22.04	22.1	1.6e-108	-0.96	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	FLJ33630	0.07	0.05	lasso	1	0.04	1.3e-05	-22.04	22.0	1.3e-107	-0.96	0.01	0.99	FALSE
19	GTEx	Colon Sigmoid	CTC-228N24.3	0.20	0.22	enet	11	0.23	1.1e-08	-22.04	22.0	4.5e-107	-0.92	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ33630	0.10	0.07	lasso	3	0.08	7.0e-09	-22.04	21.7	1.8e-104	-0.95	0.00	1.00	FALSE
6	GTEx	Artery Coronary	CTC-228N24.3	0.31	0.10	lasso	3	0.10	2.9e-04	-22.04	21.6	4.0e-103	-0.86	0.01	0.90	FALSE
24	GTEx	Heart Left Ventricle	CTC-228N24.3	0.24	0.15	lasso	7	0.19	1.9e-10	-20.98	21.4	1.2e-101	-0.84	0.01	0.99	FALSE
33	GTEx	Stomach	CTC-228N24.3	0.17	0.04	lasso	6	0.08	1.5e-04	-20.98	21.3	1.6e-100	-0.81	0.02	0.95	FALSE
30	GTEx	Skin Sun Exposed Lower leg	CTC-228N24.3	0.29	0.17	enet	12	0.22	4.3e-18	-21.85	21.2	5.5e-100	-0.90	0.00	1.00	FALSE
25	GTEx	Lung	CTC-228N24.3	0.18	0.14	enet	16	0.14	3.2e-11	-22.88	21.2	7.1e-100	-0.95	0.00	1.00	FALSE
18	GTEx	Cells Transformed fibroblasts	CTC-228N24.3	0.24	0.16	enet	26	0.16	8.6e-12	-22.88	21.1	1.4e-98	-0.89	0.00	1.00	FALSE
34	GTEx	Testis	CTC-228N24.3	0.30	0.16	lasso	6	0.14	1.1e-06	-22.88	21.0	2.3e-98	-0.93	0.00	1.00	FALSE
13	GTEx	Brain Cerebellum	CTC-228N24.3	0.31	0.04	lasso	5	0.12	2.9e-04	-22.88	21.0	1.3e-97	-0.84	0.01	0.97	FALSE
5	GTEx	Artery Aorta	CTC-228N24.3	0.20	0.04	lasso	8	0.07	7.4e-05	-8.44	20.8	1.1e-95	-0.91	0.11	0.86	FALSE
23	GTEx	Heart Atrial Appendage	CTC-228N24.3	0.22	0.07	lasso	5	0.07	4.1e-04	-21.85	20.7	2.0e-95	-0.87	0.00	0.99	FALSE
35	GTEx	Thyroid	CTC-228N24.3	0.31	0.15	enet	32	0.18	4.6e-14	-22.88	20.7	3.6e-95	-0.78	0.00	1.00	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	CTC-228N24.3	0.15	0.09	lasso	3	0.12	8.0e-15	-22.88	20.4	1.2e-92	-0.88	0.00	1.00	FALSE
22	GTEx	Esophagus Muscularis	CTC-228N24.3	0.24	0.08	enet	29	0.14	1.4e-08	-22.04	20.4	1.6e-92	-0.75	0.01	0.99	FALSE
4	GTEx	Adrenal Gland	CTC-228N24.3	0.34	0.10	lasso	9	0.09	4.2e-04	-17.81	20.3	4.8e-92	-0.88	0.03	0.96	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLJ33630	0.10	0.06	enet	18	0.08	2.0e-09	-22.88	20.0	2.3e-89	-0.79	0.00	1.00	FALSE
31	GTEx	Spleen	CTC-228N24.3	0.26	0.03	enet	15	0.05	1.8e-02	-8.44	18.1	7.0e-73	-0.66	0.04	0.56	FALSE
50	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLJ33630	0.07	0.02	blup	70	0.02	1.5e-02	-13.14	17.2	3.8e-66	-0.48	0.12	0.14	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	CTC-228N24.3	0.20	0.04	enet	22	0.13	2.1e-05	9.88	17.0	1.3e-64	-0.51	0.05	0.68	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FLJ33630	0.06	0.07	lasso	6	0.07	8.6e-09	9.82	15.1	3.3e-51	-0.52	0.62	0.38	FALSE
32	GTEx	Stomach	SLC12A2	0.23	0.17	enet	19	0.17	1.6e-08	-13.99	14.1	2.2e-45	-0.45	0.80	0.16	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC12A2	0.04	0.02	enet	17	0.02	3.3e-03	-22.04	-13.2	1.4e-39	0.69	0.01	0.87	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	CTC-228N24.3	0.24	-0.01	enet	26	0.04	2.2e-02	-11.55	12.7	4.3e-37	-0.57	0.03	0.70	FALSE
10	GTEx	Brain Cerebellar Hemisphere	SLC12A2	0.45	-0.01	enet	20	0.01	2.1e-01	-16.90	12.0	2.3e-33	-0.46	0.04	0.33	FALSE
9	GTEx	Brain Caudate basal ganglia	CTC-228N24.3	0.28	-0.01	enet	50	0.05	1.2e-02	6.79	11.1	1.9e-28	-0.30	0.04	0.55	FALSE
14	GTEx	Brain Frontal Cortex BA9	CTC-228N24.3	0.25	0.00	enet	26	0.05	2.2e-02	8.99	10.9	1.8e-27	-0.36	0.08	0.30	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	FBN2	0.12	0.02	enet	17	0.05	1.7e-06	-16.58	10.8	3.4e-27	-0.53	0.04	0.93	FALSE
17	GTEx	Cells Transformed fibroblasts	SLC12A2	0.08	0.07	enet	19	0.08	1.5e-06	8.97	-8.3	7.0e-17	0.36	0.77	0.05	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLJ33630	0.14	0.00	blup	72	0.09	9.1e-06	0.32	7.9	2.2e-15	-0.28	0.06	0.39	FALSE
8	GTEx	Brain Caudate basal ganglia	PRRC1	0.39	0.00	enet	5	0.06	7.1e-03	-7.58	7.6	2.8e-14	-0.19	0.07	0.05	FALSE