Best TWAS P=3.49e-18 · Best GWAS P=1.2e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MED20 | 0.08 | 0.07 | enet | 9 | 0.05 | 4.7e-05 | -5.4 | -5.5 | 3.5e-08 | -0.61 | 0.75 | 0.23 | FALSE |
| 2 | GTEx | Artery Tibial | MED20 | 0.14 | 0.11 | lasso | 2 | 0.09 | 9.7e-08 | -5.4 | -5.4 | 6.6e-08 | -0.59 | 0.98 | 0.02 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | MED20 | 0.11 | 0.05 | lasso | 4 | 0.08 | 9.4e-07 | 7.8 | -7.9 | 2.2e-15 | -0.81 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | USP49 | 0.13 | 0.02 | lasso | 4 | 0.02 | 2.4e-02 | 8.0 | 7.2 | 7.4e-13 | 0.93 | 0.01 | 0.97 | FALSE |
| 5 | GTEx | Colon Transverse | MED20 | 0.17 | 0.01 | enet | 10 | 0.06 | 6.0e-04 | -5.5 | -6.3 | 2.9e-10 | -0.51 | 0.39 | 0.12 | FALSE |
| 6 | GTEx | Esophagus Mucosa | MED20 | 0.09 | 0.07 | enet | 10 | 0.02 | 2.7e-02 | 5.5 | -5.7 | 1.5e-08 | -0.62 | 0.84 | 0.04 | FALSE |
| 7 | GTEx | Esophagus Muscularis | MED20 | 0.15 | 0.05 | lasso | 7 | 0.04 | 1.0e-03 | 5.5 | -5.4 | 6.5e-08 | -0.59 | 0.66 | 0.26 | FALSE |
| 8 | GTEx | Heart Left Ventricle | MED20 | 0.22 | 0.19 | enet | 8 | 0.12 | 5.8e-07 | -5.5 | -5.7 | 1.0e-08 | -0.61 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Lung | BYSL | 0.08 | 0.03 | lasso | 4 | 0.02 | 4.9e-03 | -6.2 | 6.4 | 1.6e-10 | 0.55 | 0.58 | 0.04 | FALSE |
| 10 | GTEx | Lung | USP49 | 0.09 | 0.08 | lasso | 2 | 0.05 | 6.2e-05 | 8.0 | 7.7 | 1.1e-14 | 0.99 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Nerve Tibial | MED20 | 0.13 | 0.11 | enet | 8 | 0.10 | 1.5e-07 | -5.3 | -5.4 | 7.4e-08 | -0.60 | 0.99 | 0.01 | FALSE |
| 12 | GTEx | Testis | MED20 | 0.13 | 0.03 | lasso | 6 | 0.00 | 2.0e-01 | 8.0 | -7.9 | 2.3e-15 | -0.99 | 0.02 | 0.90 | FALSE |
| 13 | GTEx | Thyroid | MED20 | 0.05 | 0.05 | lasso | 2 | 0.02 | 8.1e-03 | -5.5 | -5.8 | 5.6e-09 | -0.62 | 0.67 | 0.14 | FALSE |
| 14 | GTEx | Thyroid | FRS3 | 0.20 | 0.16 | lasso | 4 | 0.16 | 5.2e-12 | -6.6 | -6.5 | 7.4e-11 | -0.35 | 0.99 | 0.01 | FALSE |
| 15 | METSIM | Adipose | MED20 | 0.13 | 0.11 | enet | 27 | 0.11 | 2.3e-16 | -5.3 | -5.8 | 5.1e-09 | -0.75 | 0.99 | 0.01 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | PGC | 0.13 | 0.06 | blup | 520 | 0.06 | 3.2e-08 | -6.6 | 6.3 | 3.6e-10 | 0.57 | 0.98 | 0.02 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCND3 | 0.04 | 0.00 | blup | 99 | 0.01 | 1.8e-03 | 7.9 | -6.3 | 3.7e-10 | -0.69 | 0.01 | 0.55 | FALSE |
| 18 | The Cancer Genome Atlas | Colon Adenocarcinoma | MED20 | 0.05 | 0.00 | blup | 50 | 0.04 | 2.8e-03 | -4.0 | -8.1 | 6.9e-16 | -0.85 | 0.02 | 0.76 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MED20 | 0.04 | 0.03 | lasso | 3 | 0.04 | 7.3e-05 | 7.8 | -7.9 | 3.6e-15 | -0.97 | 0.00 | 0.99 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MED20 | 0.09 | 0.08 | enet | 12 | 0.09 | 5.5e-10 | -5.4 | -6.3 | 3.6e-10 | -0.58 | 1.00 | 0.00 | FALSE |
| 21 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MED20 | 0.09 | 0.07 | lasso | 5 | 0.07 | 3.4e-04 | 8.0 | -8.7 | 3.5e-18 | -0.99 | 0.00 | 0.99 | TRUE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MED20 | 0.04 | 0.06 | enet | 6 | 0.05 | 2.6e-06 | -4.0 | -5.2 | 2.0e-07 | -0.67 | 0.62 | 0.33 | FALSE |
| 23 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MED20 | 0.03 | 0.05 | lasso | 2 | 0.04 | 1.2e-03 | 7.8 | -8.0 | 8.6e-16 | -0.96 | 0.01 | 0.88 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | BYSL | 0.05 | 0.06 | enet | 7 | 0.06 | 4.3e-06 | -5.5 | 5.3 | 1.0e-07 | 0.56 | 0.85 | 0.06 | FALSE |