TWAS hub - FRS3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1470	0.0470	9.8e-04	0.044	NA	0.036	NA	0.021	1.5e-04	NA	5.9e-04	NA	7.5e-03
2	GTEx	Thyroid	0.1960	0.0500	7.1e-06	0.159	NA	0.129	NA	0.156	3.5e-12	NA	4.6e-10	NA	5.2e-12
3	METSIM	Adipose	0.0854	0.0251	2.1e-05	0.042	0.035	0.019	0.034	0.034	6.6e-07	4.2e-06	5.6e-04	6.7e-06	5.9e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Comparative body size at age 10	9.3	25.6	40.2	5.7	6.3	2.0
Leg fat-free mass (right)	8.2	43.8	73.1	7.3	8.6	2.2
Leg predicted mass (right)	8.2	43.9	73.6	7.3	8.6	2.3
Leg fat-free mass (left)	7.8	41.5	70.2	7.0	8.4	2.3
Leg predicted mass (left)	7.8	41.1	69.6	7.0	8.3	2.3
Basal metabolic rate	7.2	40.0	66.4	6.9	8.2	2.4
Whole body water mass	7.1	40.3	67.4	6.9	8.2	2.4
Whole body fat-free mass	6.9	39.3	65.8	6.8	8.1	2.3
Hip circumference	6.8	29.1	52.0	5.4	7.2	2.5
Arm fat-free mass (left)	6.7	33.7	55.4	6.3	7.4	2.4
Arm predicted mass (left)	6.5	33.1	54.5	6.2	7.4	2.5
Forced expiratory volume in 1-second (FEV1), predicted	6.4	13.3	19.7	4.0	4.4	2.0
Arm predicted mass (right)	6.3	32.4	51.1	6.2	7.2	2.9
Ever had bowel cancer screening	6.3	7.4	9.2	-2.8	-2.2	-3.0
Weight	6.2	30.3	53.3	5.8	7.3	2.0
Arm fat-free mass (right)	6.2	32.0	50.8	6.3	7.1	2.4
Number of treatments/medications taken	5.9	10.6	12.5	-3.3	-3.5	-2.9
Trunk predicted mass	5.9	33.7	55.8	6.3	7.5	2.2
Trunk fat-free mass	5.8	33.3	55.1	6.3	7.4	2.1
Medication: Omeprazole (e.g. Zanprol)	5.6	6.9	13.2	-2.1	-3.6	-1.7
Loud music exposure frequency	5.2	5.7	8.3	1.7	2.4	2.9
Supplements: Vitamin C	5.1	6.0	9.7	-3.1	-2.1	-2.0
Impedance of leg (right)	4.8	23.4	43.1	-5.0	-6.6	-1.3
Impedance of leg (left)	4.5	22.0	42.4	-4.7	-6.5	-1.3
Heart disease (siblings)	4.3	5.3	9.4	-3.1	-2.5	-0.5
Medication: Paracetamol	4.2	7.0	9.7	-2.0	-3.1	-2.7
Medication: Omeprazole	4.2	5.1	11.6	-1.3	-3.4	-1.3
Arm fat mass (right)	4.1	17.0	30.2	4.4	5.5	1.2
Body Mass Index (BMI) (2010)	4.0	5.5	8.2	2.7	2.9	0.9
Depression (self-reported)	4.0	4.8	6.8	-2.6	-1.6	-2.2
Migraine (self-reported)	4.0	4.9	11.1	-1.0	-1.6	-3.3
Arm fat mass (left)	3.9	16.2	29.1	4.2	5.4	1.3
Sitting height	3.8	27.1	39.7	5.6	6.3	3.2
Taking other prescription medications	3.7	5.7	7.3	-2.4	-2.7	-2.1
High blood pressure (siblings)	3.6	5.2	10.8	-1.7	-1.4	-3.3
Mineral and other dietary supplements	3.6	4.9	6.4	2.5	1.7	2.3
Illnesses of father: High blood pressure	3.6	4.5	7.3	-2.4	-0.6	-2.7
Illnesses of father: Heart disease	3.5	4.9	5.9	-2.4	-2.4	-1.8
Allergy or Eczema	3.4	8.9	13.4	-3.1	-3.7	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	3.3	4.4	7.0	2.5	2.6	-0.5
Mean Putamen Volume	3.2	3.7	5.8	-2.4	-2.1	-0.9
Medication: Co-codamol	3.2	3.8	7.7	-2.8	-1.8	-0.6
Trunk fat mass	3.2	13.7	23.4	3.9	4.8	1.6
Length of working week for main job	3.1	3.5	5.5	1.9	2.3	1.1
Osteoporosis (self-reported)	3.1	3.9	5.1	-2.2	-2.3	-1.2
Waist circumference	3.0	11.0	19.6	3.6	4.4	0.8
Illnesses of siblings	3.0	4.2	5.9	2.1	1.4	2.4
Whole body fat mass	3.0	12.4	22.3	3.6	4.7	1.4
Medication: Atenolol	2.9	3.6	6.3	-2.5	-2.1	-0.4
Family relationship satisfaction	2.9	3.5	5.1	2.2	2.3	-0.7
Average weekly red wine intake	2.9	4.2	6.5	-2.0	-1.4	-2.5
Medication: Paracetamol	2.9	4.5	6.3	-1.1	-2.5	-2.5
Alcohol drinker status: Previous	2.9	3.3	5.9	-1.8	-2.4	-0.8
Fasting Glucose	2.8	3.4	5.9	-2.4	-1.8	-1.1
Noisy workplace	2.8	3.4	6.0	-2.5	-1.4	-1.5
Standing height	2.8	27.9	44.5	5.8	6.7	2.2
Number of full sisters	2.8	3.4	4.6	2.0	2.2	1.2
Impedance of whole body	2.8	14.2	25.9	-3.9	-5.1	-1.2
Supplements: Zinc	2.5	2.7	4.3	-2.1	-1.6	-1.2
Long-standing illness, disability or infirmity	2.5	3.9	5.2	-1.9	-2.3	-1.6
Leg fat mass (left)	2.5	9.7	16.2	3.4	4.0	1.2
Hayfever, allergic rhinitis or eczema	2.4	5.1	7.3	-2.3	-2.7	-1.7
Body mass index (BMI)	2.4	10.3	19.4	3.3	4.4	0.8
Medication: Seretide 50 evohaler	2.4	2.8	5.2	-2.3	-1.6	-0.8
Leg fat mass (right)	2.4	9.4	16.0	3.3	4.0	1.3
Commuting to job workplace: Walk	2.4	2.6	4.6	-1.1	-2.1	-1.4
Illnesses of father: None of the above (group 1)	2.4	2.9	3.4	1.8	1.5	1.8
Medication for pain relief, constipation, heartburn	2.3	4.0	9.0	0.9	3.0	1.5
Comparative height size at age 10	2.3	12.9	18.0	3.4	4.2	3.0
BMI	2.2	12.8	24.6	3.7	5.0	0.2
Age when periods started (menarche)	2.2	5.2	10.4	2.3	3.2	-0.2
Financial difficulties in last 2 years	2.2	2.9	3.2	-1.8	-1.6	-1.8
Lung cancer (father)	2.2	2.6	5.2	1.5	0.6	2.3
Medication: Amlodipine	2.2	3.2	5.2	-1.6	-1.2	-2.3
Lung FVC	2.0	10.2	14.9	-3.9	-3.8	-0.9
Average weekly beer plus cider intake	2.0	2.9	4.2	1.7	2.0	1.4
Irritability	2.0	3.3	3.9	-1.8	-1.7	-2.0
Relative age voice broke	1.9	2.9	4.8	1.8	2.2	0.8
Medication: Blood pressure	1.9	3.3	6.2	-2.5	-1.4	-1.3
Commuting to job workplace: Car/motor vehicle	1.9	2.1	4.1	0.8	2.0	1.3
Ever taken oral contraceptive pill	1.9	2.1	3.4	-0.4	-1.8	-1.6
Depression (Nagel 2018)	1.8	2.8	3.6	1.8	1.9	-1.2
Schizophrenia (2014)	1.8	4.1	7.7	2.8	2.1	0.2
Severe depression (siblings)	1.8	2.0	2.9	1.6	1.7	0.7
Medication: Ventolin 100micrograms inhaler	1.8	2.3	2.7	-1.6	-1.5	-1.4
Chronic bronchitis/emphysema (mother)	1.8	2.2	5.7	2.4	0.8	-0.5
Arm fat percentage (left)	1.8	7.2	12.5	2.9	3.5	0.8
Supplements: Fish oil (including cod liver oil)	1.8	2.4	4.1	-1.5	-1.0	-2.0
Reaction Time	1.7	3.2	4.7	1.6	1.5	2.2
Height	1.7	32.2	54.8	5.6	7.4	3.1
Had menopause	1.7	2.1	5.2	-0.9	-0.6	-2.3
Allergy	1.7	4.0	4.5	1.9	1.9	2.1
Arm fat percentage (right)	1.7	6.7	12.1	2.8	3.5	0.4
Birth weight	1.6	3.4	4.1	2.0	1.8	1.6
Primary Biliary Cirrhosis	1.5	2.2	4.1	1.4	2.0	-0.6
Relative age of first facial hair	1.5	3.0	5.9	1.7	2.4	0.5
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.9	-0.7	-1.3	-2.0
Mouth/teeth dental problems: Dentures	1.5	2.5	4.0	1.3	1.4	2.0
Medication: Cholesterol lowering	1.5	2.4	3.5	-1.9	-1.7	-0.9
Medication for cholesterol, blood pressure or diabetes	1.5	2.6	3.7	1.9	1.3	1.5
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.0	-1.0	-1.1	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.7	1.9	0.7	-0.7
Guilty feelings	1.5	2.3	3.5	1.2	1.9	1.4
Heart attack	1.4	1.8	2.5	-1.6	-1.0	-1.4
Loneliness, isolation	1.4	2.0	4.6	1.1	2.1	0.2
Frequency of depressed mood in last 2 weeks	1.3	1.8	4.3	0.6	2.1	-0.8
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.7	-0.7	-1.3	-1.6
Ever had hysterectomy (womb removed)	1.3	1.4	2.6	0.8	1.6	1.1
Trunk fat percentage	1.3	5.3	9.3	2.4	3.0	0.9
Impedance of arm (right)	1.3	6.2	10.3	-2.5	-3.2	-1.5
Mean time to correctly identify matches	1.3	2.4	3.8	1.3	1.3	2.0
Friendships satisfaction	1.3	1.6	3.3	1.8	1.2	0.0
Medication: Lisinopril	1.3	1.7	2.8	1.5	1.7	0.2
Age started oral contraceptive pill	1.3	1.6	2.9	-1.7	-1.3	-0.4
Heart attack/myocardial infarction (self-reported)	1.3	1.7	2.6	-1.6	-1.0	-1.1
Alzheimer’s Disease (in father)	1.2	1.3	2.9	1.7	0.9	0.5
HDL Cholesterol	1.2	2.1	3.1	-1.8	-1.4	-1.1
Blood Red Count	1.2	11.9	30.2	0.2	2.3	-5.5
Hand grip strength (right)	1.2	3.2	4.7	1.7	2.2	1.4
Tense / ‘highly strung’	1.2	2.0	2.6	-1.1	-1.4	-1.6
Peak expiratory flow (PEF)	1.2	2.7	7.2	-0.2	-0.9	-2.7
Pulse rate, automated reading	1.2	4.0	7.6	-1.8	-2.8	-1.0
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.0	-0.6	-1.4	-1.4
Eye problems/disorders: Glaucoma	1.2	1.5	2.1	1.4	1.1	-1.1
Schizophrenia (2018)	1.1	2.3	4.0	2.0	1.7	0.3
Age at First Birth	1.1	1.6	2.8	0.6	1.3	-1.7
Waist Hip Ratio (WHR)	1.1	5.0	9.5	-1.4	-3.1	-1.9
Vitamin and mineral supplements	1.1	1.5	2.7	1.6	-0.0	1.4
Multivitamins +/- minerals	1.1	1.4	3.3	0.6	1.8	-0.8
Medication: Lansoprazole	1.1	1.3	2.2	-0.8	-1.0	-1.5
Pulse wave Arterial Stiffness index	1.1	1.3	2.5	1.2	1.6	-0.3
Impedance of arm (left)	1.1	5.3	9.5	-2.3	-3.1	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	2.4	-1.6	-1.4	-0.8
Birth weight of first child	1.1	2.0	4.2	2.0	1.4	-0.0
Age at last live birth	1.1	1.6	2.1	1.2	1.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.2	4.1	-1.6	-2.0	0.1
Number of self-reported non-cancer illnesses	1.1	2.0	4.2	-0.8	-1.1	-2.0
Miserableness	1.1	1.9	3.5	1.1	1.9	1.0
Mother’s age at death	1.1	1.3	2.1	1.2	1.4	0.6
Ovarian Cancer	1.0	1.4	3.2	1.8	0.6	-0.7
Smoking Status	1.0	2.3	2.8	1.5	1.7	1.3
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.2	-0.1	-0.2	-1.8
Supplements: Glucosamine	1.0	1.3	2.3	-1.2	0.1	-1.5
Alcohol usually taken with meals	1.0	1.7	3.6	-0.9	-0.8	-1.9
Hair/balding pattern: Pattern 2	1.0	1.2	2.7	-0.7	-0.7	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.4	1.2	0.7	-1.2
Glaucoma (self-reported)	1.0	1.2	1.6	1.1	0.8	-1.3
Heart disease (mother)	1.0	1.2	2.9	0.0	0.9	1.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.0	-1.4	-1.3	-1.0
Schizophrenia vs Biploar Disorder	0.9	1.2	2.0	1.4	1.2	0.5
Alzheimer’s Disease (including proxy)	0.9	1.3	2.5	1.6	0.2	-1.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.2	-1.0	-0.5	-1.5
Medication: Ramipril	0.9	1.1	3.1	0.5	1.8	0.1
Time employed in main current job	0.9	1.0	2.0	-0.8	-1.4	-0.6
Body fat percentage	0.9	3.7	6.5	2.0	2.5	0.8
Number of children fathered	0.9	1.0	1.6	-1.1	-1.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.9	1.4	0.9	0.6
Wears glasses or contact lenses	0.9	1.0	1.7	-1.1	-1.3	-0.3
Bipolar Disorder or Schizophrenia	0.8	1.9	3.3	1.8	1.5	0.1
Alzheimer’s Disease (in mother)	0.8	0.9	1.8	0.9	0.1	-1.4
Average weekly spirits intake	0.8	1.0	1.7	-1.3	-0.8	0.8
Hair/balding pattern: Pattern 3	0.8	1.1	2.4	-0.1	-1.0	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.3	-0.5	-1.5	-0.5
Medication: Aspirin	0.8	1.1	1.7	-1.3	-0.9	-0.9
Back pain experienced in last month	0.8	1.2	2.5	0.2	-1.0	-1.6
Medication: Atorvastatin	0.8	1.0	2.3	-1.5	-0.8	-0.3
Fractured/broken bones in last 5 years	0.8	1.0	2.3	0.5	1.5	-0.6
Pain experienced in last month	0.8	1.4	3.2	-1.8	-0.7	0.6
LDL Cholesterol	0.7	1.1	2.6	0.4	0.8	1.6
Ulcerative Colitis	0.7	1.1	2.2	1.5	0.0	1.0
Hand grip strength (left)	0.7	1.8	2.3	1.0	1.5	1.4
Diabetes (father)	0.7	0.9	1.4	1.0	1.2	0.4
Medication: Simvastatin	0.7	1.0	1.6	-1.2	-1.3	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.8	-0.7	-0.3	-1.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.9	1.4	0.5	-0.6
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	1.8	-1.2	-1.3	-0.4
Medication: Allopurinol	0.7	1.0	1.5	1.2	1.2	0.1
Alcohol intake frequency.	0.7	1.7	2.2	-1.5	-1.5	-0.9
Smoking status: Previous	0.7	1.0	2.3	0.5	0.7	1.5
Medication for cholesterol	0.7	1.0	3.0	-0.2	-1.7	0.2
Crohns Disease (2017)	0.6	1.3	3.9	-0.2	-0.2	2.0
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.3	0.4	1.0	-1.8
Coronary Artery Disease (CAD)	0.6	0.7	1.5	-1.2	-0.5	0.5
Systolic Blood Pressure	0.6	3.2	6.2	-2.5	-1.8	0.0
Respiratory disease	0.6	1.2	1.6	-1.2	-0.9	-1.3
Sensitivity / hurt feelings	0.6	1.0	1.2	1.1	1.0	-0.9
Medication: Metformin	0.6	0.8	2.4	-0.2	-0.2	1.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.3	-1.1	-0.4	-0.9
Father’s age at death	0.6	0.8	1.9	-1.4	-0.6	-0.2
Blood clot in the leg (DVT)	0.6	0.8	1.6	-0.2	-1.3	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.3	1.1	1.0	-0.1
Pulse wave peak to peak time	0.6	0.7	1.3	-0.6	-1.1	0.6
Medication: Ibuprofen	0.6	0.7	1.0	1.0	-0.8	0.6
Eye problems/disorders: Cataract	0.6	0.7	1.7	-1.3	-0.6	0.1
Asthma (self-reported)	0.6	1.1	1.6	-1.3	-0.5	-1.2
Medication: Gliclazide	0.6	0.7	1.7	-0.4	0.3	1.3
Medication: Blood pressure	0.6	1.2	2.2	-1.2	0.0	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.4	-0.3	-1.2	-1.0
Worry (Nagel 2018)	0.5	1.1	1.9	-0.7	-0.9	-1.4
Rheumatoid Arthritis	0.5	0.7	1.7	0.2	-0.5	-1.3
Cardiovascular Disease	0.5	1.7	3.8	-1.1	0.1	-1.9
Average weekly fortified wine intake	0.5	0.6	1.3	0.0	-0.7	1.1
Past tobacco smoking	0.5	0.8	1.5	-0.5	-1.2	-0.9
Diabetes (self-reported)	0.5	0.8	2.3	-0.0	0.0	1.5
Fluid intelligence score	0.5	1.1	2.6	0.6	0.5	-1.6
Alcohol intake versus 10 years previously	0.5	0.7	1.2	-1.1	-0.8	-0.5
Pulse rate	0.5	0.8	2.4	-0.0	-0.3	1.5
Asthma	0.5	1.0	1.4	-1.2	-0.5	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.1	0.3	0.8	-1.1
Suffer from ‘nerves’	0.5	0.7	1.6	1.3	0.5	0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	-1.0	-0.2	0.8
Hypertension (Self-reported)	0.5	1.4	2.4	-1.3	0.0	-1.5
Diabetes diagnosed by doctor	0.5	0.8	1.3	-0.8	-0.7	1.2
Breast cancer (self-reported)	0.5	0.6	1.0	-1.0	0.4	-0.8
Hearing aid user	0.5	0.5	1.3	-0.2	-1.2	-0.4
Alcohol drinker status: Never	0.5	0.7	1.0	0.6	0.7	1.0
Ever smoked	0.5	0.9	1.9	0.8	1.4	0.5
Myopia	0.5	0.7	1.7	-0.5	-0.4	-1.3
Supplements: Calcium	0.5	0.6	1.3	-1.1	-0.6	-0.4
Neuroticism (Nagel 2018)	0.4	0.8	1.7	0.6	0.7	-1.3
Irritable Bowel Disease (IBD)	0.4	1.0	2.8	0.1	-0.5	1.7
Breast Cancer	0.4	1.0	1.6	-1.1	-0.4	-1.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.8	-0.8	-0.4	-0.9
Hypothyroidism (self reported)	0.4	1.0	1.7	1.3	1.0	-0.7
Lung FEV1/FVC ratio	0.4	2.2	3.8	1.9	1.6	0.4
Systolic blood pressure, automated reading	0.4	1.0	1.6	-1.3	-0.7	1.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.7	0.0	-0.8	-0.7
Diabetes (mother)	0.4	0.5	1.5	-0.1	0.2	1.2
Townsend deprivation index at recruitment	0.4	0.6	1.1	-1.0	-0.7	-0.4
Maternal smoking around birth	0.4	0.6	1.8	0.1	-0.0	-1.3
Number of incorrect matches in round	0.4	0.6	1.6	1.3	0.4	-0.1
Worrier / anxious feelings	0.4	0.7	1.4	-0.6	-1.2	0.6
Number of live births	0.4	0.6	1.1	1.0	0.8	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.3	0.6	-1.1	0.0
Exposure to tobacco smoke at home	0.4	0.4	0.6	0.8	-0.7	0.4
Pulse wave reflection index	0.4	0.5	1.1	0.3	1.0	-0.5
Health satisfaction	0.4	0.5	1.0	-1.0	0.6	-0.1
Eye problems/disorders: None of the above	0.4	0.5	1.1	-1.0	-0.5	0.2
Had major operations	0.4	0.5	1.3	-0.2	-0.2	-1.1
Financial situation satisfaction	0.4	0.5	1.1	0.5	1.1	0.3
Risk taking	0.4	0.6	1.3	1.2	-0.0	-0.7
Diastolic blood pressure, automated reading	0.4	1.1	1.4	0.8	1.2	1.1
Cholesterol lowering medication	0.4	0.5	0.6	0.7	0.8	0.7
Depressed Affect (Nagel 2018)	0.3	0.6	1.0	1.0	0.8	-0.5
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.1	0.4	1.1	-1.0
Ulcerative Colitis (UC)	0.3	0.6	1.3	-0.1	-0.7	1.1
Lupus	0.3	0.5	1.2	-1.1	-0.5	-0.0
Neuroticism (2016)	0.3	0.4	0.9	-0.1	0.6	1.0
Blood Platelet Count	0.3	3.4	4.1	-2.0	-1.4	2.0
Neuroticism	0.3	0.7	2.0	0.4	0.1	-1.4
Tanning	0.3	4.2	6.8	-1.8	-2.6	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.3	0.6	-0.1	-1.1
Serious illness, injury or assault to yourself	0.3	0.4	0.7	-0.2	0.5	0.9
High blood pressure	0.3	0.9	1.4	-1.2	0.2	-1.1
Stomach or abdominal pain in last month	0.3	0.4	1.0	0.3	0.1	-1.0
Chronic bronchitis/emphysema (father)	0.3	0.3	0.5	0.5	0.4	-0.7
Hearing difficulty/problems with background noise	0.3	0.5	1.3	1.1	0.5	-0.2
Had other major operations	0.3	0.4	0.8	0.1	0.9	0.7
Qualifications: None of the above	0.3	0.7	1.1	0.4	0.9	1.0
Happiness	0.3	0.4	0.5	0.6	0.7	-0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	-0.8	-0.5	-0.5
Shortness of breath walking on level ground	0.3	0.3	0.9	0.2	1.0	0.2
Qualifications: College or University degree	0.3	0.9	2.0	0.7	1.4	0.5
Emphysema/chronic bronchitis	0.3	0.4	0.7	-0.6	-0.8	-0.2
Leg pain on walking	0.3	0.4	0.8	-0.1	-0.6	-0.9
Medication: Aspirin	0.3	0.4	0.9	-1.0	-0.6	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.3	-0.1	0.1	-1.1
Leg fat percentage (left)	0.3	1.2	1.6	1.1	1.3	0.8
Number of operations (self-reported)	0.3	0.4	0.8	-0.1	0.6	0.9
Commuting to job workplace: Cycle	0.3	0.4	1.0	0.1	0.4	1.0
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.4	1.2	-0.1	1.0
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	0.4	0.4	0.9
Blood Eosinophil Count	0.2	1.5	1.8	-1.1	-1.2	-1.3
Chronotype (morning person)	0.2	0.6	1.5	-0.1	-1.2	0.4
Hearing difficulty/problems: Yes	0.2	0.4	0.9	0.4	-0.1	1.0
Angina	0.2	0.2	0.4	-0.5	-0.7	-0.1
Medication for hormone replacement therapy	0.2	0.2	0.5	-0.4	0.2	-0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.2	0.7	-0.2
Medication: Levothyroxine sodium	0.2	0.3	0.3	-0.5	-0.5	-0.6
High blood pressure (mother)	0.2	0.2	0.4	-0.7	0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	-0.1	-0.6	-0.8
Mouth/teeth dental problems	0.2	0.3	0.7	-0.1	-0.8	0.6
Falls in the last year	0.2	0.2	0.3	-0.6	0.2	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	0.8	-0.6	-0.9	-0.6
Breastfed as a baby	0.2	0.2	0.5	0.1	-0.3	0.7
Headache pain in last month	0.2	0.3	0.8	0.9	0.1	0.1
Gout (self-reported)	0.2	0.2	0.6	-0.1	-0.0	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.5	0.6	0.7	-0.3
Forced vital capacity (FVC), Best measure	0.2	0.7	1.0	-0.8	-1.0	-0.6
Leg fat percentage (right)	0.2	0.9	1.4	0.7	1.2	0.8
Exposure to tobacco smoke outside home	0.2	0.2	0.5	-0.1	-0.5	0.7
Number of full brothers	0.2	0.3	0.7	-0.3	0.1	-0.8
Wheeze or whistling in the chest in last year	0.2	0.3	0.4	0.5	0.6	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.3	0.4	-0.8
Angina (self-reported)	0.2	0.3	0.4	-0.6	-0.7	-0.0
Qualifications: nursing, teaching	0.2	0.3	0.7	0.2	-0.3	-0.8
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.6	0.8	0.0
Unable to work because of sickness or disability	0.2	0.3	0.6	0.2	0.5	0.8
Bipolar Disorder (2018)	0.1	0.1	0.2	0.4	0.4	-0.1
Major Depression (MDD)	0.1	0.1	0.2	-0.4	-0.3	0.1
HbA1C	0.1	0.1	0.2	-0.1	0.3	0.5
Triglycerides	0.1	0.2	0.5	0.3	-0.2	0.7
Heel T-Score	0.1	0.5	0.9	-0.1	-0.8	-0.9
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	0.4	-0.5	0.6
Pack years adult smoking proportion	0.1	0.1	0.1	0.4	0.3	-0.2
Current tobacco smoking	0.1	0.1	0.2	0.1	0.4	0.4
Fed-up feelings	0.1	0.3	0.5	-0.2	-0.5	-0.7
Qualifications: CSEs or equivalent	0.1	0.1	0.1	-0.3	-0.1	-0.4
Nervous feelings	0.1	0.1	0.2	-0.5	-0.0	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.2	0.4	0.5	-0.4
Forced vital capacity (FVC)	0.1	0.3	0.6	-0.8	-0.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.0	-0.5	-0.1
Pain all over the body in last month	0.1	0.2	0.3	-0.5	-0.3	0.2
Neuroticism score	0.1	0.2	0.5	-0.0	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.9	-0.6	-0.4	-1.0
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	-0.6	0.1	-0.2
Prospective memory result	0.1	0.2	0.3	0.4	0.1	0.6
Worry too long after embarrassment	0.1	0.1	0.2	0.3	0.5	-0.4
Age at first live birth	0.1	0.2	0.3	0.6	0.4	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.2	-0.5	0.4	-0.3
Chest pain or discomfort	0.1	0.1	0.3	-0.3	0.1	-0.5
Knee pain experienced in last month	0.1	0.2	0.3	0.5	0.5	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	-0.5	-0.5	0.2
Illnesses of siblings: Diabetes	0.1	0.2	0.2	0.5	0.5	0.1
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.5	0.2	-0.4
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.5	0.1	0.4
High cholesterol (Self-reported)	0.1	0.2	0.7	-0.1	0.1	-0.8
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.2	-0.4	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.1	0.2	-0.2	0.0	0.5
Blood White Count	0.0	0.1	0.1	-0.4	0.2	-0.0
Hair Pigment	0.0	0.6	1.6	0.2	1.3	-0.5
Illnesses of mother	0.0	0.1	0.1	-0.1	-0.3	-0.2
Hair/balding pattern: Pattern 4	0.0	0.0	0.0	0.1	-0.1	0.1
Neck or shoulder pain in last month	0.0	0.1	0.2	0.4	0.0	-0.1
Overall health rating	0.0	0.1	0.1	-0.2	0.4	0.3
Mood swings	0.0	0.0	0.1	0.2	0.2	0.1
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.1	0.1	-0.3
Smoking status: Current	0.0	0.1	0.2	-0.1	0.4	0.2
Ever depressed for a whole week	0.0	0.1	0.1	-0.2	-0.4	-0.1
Pack years of smoking	0.0	0.1	0.1	0.1	0.1	-0.4

Hub : Genes

FRS3

Models

Trait associations