Best TWAS P=6.7e-12 · Best GWAS P=2.45e-12 conditioned to 0.377
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | RP1-283E3.4 | 0.26 | 0.05 | enet | 25 | 0.16 | 1.5e-08 | 1.9 | 5.3 | 9.9e-08 | 0.21 | 0.15 | 0.07 | TRUE |
2 | GTEx | Brain Cerebellar Hemisphere | NADK | 0.18 | 0.11 | lasso | 7 | 0.09 | 3.1e-03 | 6.1 | 6.2 | 4.0e-10 | 0.85 | 0.02 | 0.70 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | RP5-890O3.9 | 0.24 | 0.02 | lasso | 9 | 0.02 | 1.3e-01 | 6.9 | -6.9 | 6.7e-12 | -0.91 | 0.01 | 0.75 | TRUE |
4 | GTEx | Cells Transformed fibroblasts | CDK11B | 0.10 | 0.06 | lasso | 4 | 0.05 | 2.1e-04 | -1.7 | 5.1 | 2.8e-07 | 0.85 | 0.02 | 0.90 | FALSE |
5 | GTEx | Esophagus Mucosa | TMEM52 | 0.17 | 0.18 | lasso | 2 | 0.20 | 2.9e-13 | 5.7 | -5.8 | 7.6e-09 | -0.83 | 0.93 | 0.07 | FALSE |
6 | GTEx | Lung | NADK | 0.07 | 0.03 | lasso | 3 | 0.02 | 8.5e-03 | -5.4 | 6.2 | 4.2e-10 | 0.94 | 0.02 | 0.93 | FALSE |
7 | GTEx | Muscle Skeletal | NADK | 0.06 | 0.00 | enet | 9 | 0.00 | 1.3e-01 | 6.1 | 6.1 | 1.1e-09 | 0.79 | 0.04 | 0.85 | FALSE |
8 | GTEx | Muscle Skeletal | TMEM52 | 0.11 | 0.08 | lasso | 6 | 0.10 | 7.2e-10 | 6.4 | -6.3 | 3.2e-10 | -0.84 | 0.34 | 0.66 | FALSE |
9 | GTEx | Pituitary | NADK | 0.21 | 0.09 | enet | 15 | 0.07 | 9.5e-03 | 6.4 | 5.2 | 2.6e-07 | 0.67 | 0.03 | 0.56 | FALSE |
10 | GTEx | Skin Not Sun Exposed Suprapubic | TMEM52 | 0.19 | 0.18 | lasso | 4 | 0.14 | 2.6e-08 | -5.4 | -5.9 | 4.3e-09 | -0.92 | 0.03 | 0.97 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | TMEM52 | 0.17 | 0.14 | lasso | 7 | 0.15 | 2.0e-12 | -6.1 | -6.2 | 6.5e-10 | -0.92 | 0.05 | 0.95 | FALSE |
12 | GTEx | Spleen | RP3-395M20.9 | 0.42 | 0.14 | lasso | 3 | 0.15 | 1.1e-04 | 4.7 | 5.1 | 2.8e-07 | 0.00 | 0.03 | 0.66 | TRUE |
13 | ROSMAP | Brain Pre-frontal Cortex | C1orf222 | 0.11 | 0.14 | enet | 18 | 0.14 | 1.8e-17 | 4.3 | -5.8 | 9.0e-09 | -0.70 | 0.99 | 0.01 | FALSE |
14 | ROSMAP | Brain Pre-frontal Cortex | MMP23B | 0.05 | 0.04 | lasso | 2 | 0.03 | 1.9e-04 | 5.3 | 5.3 | 1.2e-07 | 0.80 | 0.06 | 0.92 | FALSE |
15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC35E2 | 0.03 | 0.03 | blup | 35 | 0.01 | 7.0e-02 | 6.9 | 5.8 | 7.3e-09 | 0.95 | 0.00 | 0.99 | FALSE |
16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM52 | 0.02 | 0.01 | blup | 37 | 0.02 | 6.6e-03 | 5.8 | -6.2 | 7.3e-10 | -0.91 | 0.01 | 0.81 | FALSE |
17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC35E2 | 0.03 | 0.00 | blup | 34 | 0.01 | 5.3e-02 | 5.8 | -5.4 | 8.3e-08 | -0.82 | 0.02 | 0.47 | FALSE |