Best TWAS P=5.49e-19 · Best GWAS P=7.24e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | KIF1B | 0.25 | 0.00 | lasso | 5 | 0.02 | 1.1e-01 | -5.2 | -7.2 | 5.6e-13 | -0.08 | 0.03 | 0.48 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | EXOSC10 | 0.23 | 0.10 | lasso | 3 | 0.12 | 6.4e-04 | -4.8 | -5.2 | 1.6e-07 | -0.02 | 0.19 | 0.05 | FALSE |
| 3 | GTEx | Brain Cerebellum | EXOSC10 | 0.33 | 0.16 | lasso | 6 | 0.18 | 3.8e-06 | -5.0 | -5.2 | 1.9e-07 | -0.01 | 0.78 | 0.01 | FALSE |
| 4 | GTEx | Brain Cerebellum | RP4-635E18.7 | 0.17 | 0.17 | lasso | 5 | 0.09 | 1.3e-03 | -5.0 | -5.2 | 2.3e-07 | -0.02 | 0.38 | 0.03 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | UBE4B | 0.09 | 0.00 | enet | 21 | 0.00 | 1.4e-01 | -5.3 | -5.9 | 4.4e-09 | -0.10 | 0.04 | 0.34 | FALSE |
| 6 | GTEx | Esophagus Mucosa | KIF1B | 0.10 | 0.00 | enet | 17 | 0.01 | 1.2e-01 | -5.7 | -8.9 | 5.5e-19 | -0.13 | 0.08 | 0.64 | TRUE |
| 7 | GTEx | Muscle Skeletal | KIF1B | 0.04 | 0.08 | lasso | 1 | 0.07 | 3.1e-07 | -7.0 | -7.0 | 2.6e-12 | -0.13 | 0.89 | 0.09 | FALSE |
| 8 | GTEx | Nerve Tibial | KIF1B | 0.10 | 0.07 | lasso | 6 | 0.04 | 8.5e-04 | -5.7 | -6.1 | 8.8e-10 | -0.12 | 0.83 | 0.12 | FALSE |
| 9 | GTEx | Thyroid | KIF1B | 0.13 | 0.14 | lasso | 5 | 0.16 | 5.3e-12 | -7.0 | -6.6 | 3.2e-11 | -0.12 | 0.99 | 0.01 | FALSE |
| 10 | METSIM | Adipose | MTOR | 0.04 | 0.02 | bslmm | 434 | 0.02 | 1.5e-04 | -4.6 | -5.3 | 8.6e-08 | -0.01 | 0.90 | 0.00 | TRUE |
| 11 | NTR | Blood | KIF1B | 0.11 | 0.08 | enet | 11 | 0.09 | 3.7e-28 | 7.9 | 7.3 | 3.1e-13 | 0.02 | 0.00 | 1.00 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | KIF1B | 0.06 | 0.08 | bslmm | 401 | 0.07 | 2.1e-09 | -5.7 | -5.2 | 2.2e-07 | -0.13 | 1.00 | 0.00 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | MTOR | 0.07 | 0.05 | bslmm | 423 | 0.04 | 2.0e-06 | -4.6 | -5.2 | 2.2e-07 | -0.02 | 1.00 | 0.00 | FALSE |
| 14 | YFS | Blood | KIF1B | 0.30 | 0.26 | enet | 49 | 0.29 | 7.8e-97 | 7.9 | 6.8 | 1.4e-11 | 0.03 | 0.01 | 0.99 | FALSE |
| 15 | YFS | Blood | SPSB1 | 0.03 | 0.03 | bslmm | 425 | 0.03 | 1.5e-09 | 8.3 | 8.0 | 8.7e-16 | 0.96 | 0.00 | 1.00 | TRUE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MTOR | 0.02 | 0.02 | blup | 54 | 0.02 | 5.4e-03 | -5.0 | -5.2 | 2.2e-07 | 0.00 | 0.03 | 0.85 | FALSE |
| 17 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | H6PD | 0.31 | 0.06 | blup | 64 | 0.14 | 3.8e-06 | 3.3 | -6.0 | 1.4e-09 | -0.49 | 0.04 | 0.52 | FALSE |