Best TWAS P=2.17e-10 · Best GWAS P=9.18e-10 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DTX2P1-UPK3BP1-PMS2P11 | 0.18 | 0.09 | enet | 21 | 0.12 | 6.1e-15 | -5.2 | -6.3 | 2.2e-10 | 0.82 | 0.00 | 1.00 | TRUE |
| 6 | GTEx | Skin Sun Exposed Lower leg | DTX2P1 | 0.16 | 0.03 | enet | 22 | 0.05 | 4.8e-05 | -6.1 | -6.2 | 4.2e-10 | 0.70 | 0.00 | 0.99 | TRUE |
| 4 | GTEx | Brain Cerebellum | GSAP | 0.38 | 0.30 | lasso | 4 | 0.31 | 6.4e-10 | -4.8 | 5.4 | 7.4e-08 | -0.01 | 0.29 | 0.69 | TRUE |
| 5 | GTEx | Brain Frontal Cortex BA9 | GSAP | 0.38 | 0.22 | lasso | 6 | 0.21 | 3.0e-06 | -4.7 | 5.3 | 9.0e-08 | -0.13 | 0.12 | 0.30 | TRUE |
| 3 | GTEx | Artery Aorta | GSAP | 0.19 | 0.07 | lasso | 2 | 0.04 | 2.8e-03 | -5.0 | 5.3 | 1.3e-07 | -0.03 | 0.18 | 0.34 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | RP11-467H10.2 | 0.12 | 0.00 | lasso | 6 | 0.01 | 2.1e-02 | -2.3 | -5.1 | 2.8e-07 | 0.05 | 0.12 | 0.11 | FALSE |
| 7 | GTEx | Thyroid | GSAP | 0.19 | 0.08 | lasso | 3 | 0.07 | 3.3e-06 | -5.0 | 5.1 | 2.8e-07 | -0.02 | 0.37 | 0.59 | FALSE |