Best TWAS P=5.45e-11 · Best GWAS P=1.07e-09 conditioned to 0.292
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | STEAP2 | 0.22 | 0.24 | enet | 21 | 0.25 | 2.9e-19 | -4.8 | 5.2 | 2.1e-07 | -0.71 | 0.89 | 0.10 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | STEAP2 | 0.30 | 0.08 | lasso | 4 | 0.15 | 4.1e-05 | -5.6 | 6.6 | 5.4e-11 | -0.84 | 0.03 | 0.90 | TRUE |
3 | GTEx | Cells Transformed fibroblasts | GTPBP10 | 0.13 | 0.13 | lasso | 3 | 0.11 | 7.8e-09 | -5.4 | 5.4 | 5.4e-08 | -0.83 | 0.11 | 0.89 | FALSE |
4 | GTEx | Pituitary | STEAP2 | 0.37 | 0.10 | lasso | 5 | 0.24 | 1.0e-06 | -5.7 | 5.6 | 1.6e-08 | -0.55 | 0.14 | 0.82 | FALSE |
5 | ROSMAP | Brain Pre-frontal Cortex | GTPBP10 | 0.07 | 0.07 | enet | 21 | 0.07 | 1.9e-09 | -5.8 | 6.0 | 2.4e-09 | -0.89 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | GTPBP10 | 0.04 | 0.02 | blup | 61 | 0.03 | 1.1e-03 | -4.4 | 5.7 | 1.5e-08 | -0.55 | 0.04 | 0.58 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GTPBP10 | 0.05 | 0.04 | lasso | 3 | 0.04 | 7.9e-08 | -5.5 | 5.2 | 2.4e-07 | -0.79 | 0.11 | 0.89 | FALSE |
8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GTPBP10 | 0.08 | 0.01 | blup | 61 | 0.03 | 7.8e-03 | -6.1 | 6.0 | 1.7e-09 | -0.83 | 0.01 | 0.93 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GTPBP10 | 0.05 | 0.02 | blup | 60 | 0.03 | 1.2e-04 | -5.1 | 5.9 | 2.7e-09 | -0.63 | 0.02 | 0.92 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | STEAP2 | 0.06 | 0.02 | blup | 77 | 0.05 | 5.2e-04 | -4.5 | 5.3 | 1.3e-07 | -0.63 | 0.04 | 0.76 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GTPBP10 | 0.05 | 0.04 | lasso | 2 | 0.02 | 1.5e-03 | -5.4 | 5.4 | 6.2e-08 | -0.83 | 0.09 | 0.82 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GTPBP10 | 0.03 | 0.03 | lasso | 2 | 0.02 | 5.2e-03 | -5.5 | 5.5 | 4.4e-08 | -0.84 | 0.10 | 0.88 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | GTPBP10 | 0.08 | 0.10 | lasso | 4 | 0.10 | 1.0e-09 | -5.1 | 6.1 | 1.2e-09 | -0.86 | 0.05 | 0.95 | FALSE |